{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T11:00:20Z","timestamp":1710414020048},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"DOI":"10.7759\/cureus.35654","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T19:21:55Z","timestamp":1677698515000},"source":"Crossref","is-referenced-by-count":1,"title":["Potential Prognostic and Predictive Role of Monocyte and Lymphocyte Counts on Presentation in Patients Diagnosed With Diffuse Large B-Cell Lymphoma"],"prefix":"10.7759","author":[{"given":"Darine M","family":"Kharroubi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghazi","family":"Nsouli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeinab","family":"Haroun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the World Health Organization classification of lymphoid neoplasms","volume":"127","author":"Swerdlow SH","year":"2016","unstructured":"Swerdlow SH, Campo E, Pileri SA, et al.. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016, 127:2375-90. 10.1182\/blood-2016-01-643569","journal-title":"Blood"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-577189","article-title":"Diffuse large B-cell lymphoma: optimizing outcome in the context of clinical and biologic heterogeneity","volume":"125","author":"Sehn LH","year":"2015","unstructured":"Sehn LH, Gascoyne RD. Diffuse large B-cell lymphoma: optimizing outcome in the context of clinical and biologic heterogeneity. Blood. 2015, 125:22-32. 10.1182\/blood-2014-05-577189","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-276246","article-title":"Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte","volume":"116","author":"Coiffier B","year":"2010","unstructured":"Coiffier B, Thieblemont C, Van Den Neste E, et al.. Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte. Blood. 2010, 116:2040-5. 10.1182\/blood-2010-03-276246","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.116392","article-title":"The tumor microenvironment at a glance","volume":"125","author":"Balkwill FR","year":"2012","unstructured":"Balkwill FR, Capasso M, Hagemann T. The tumor microenvironment at a glance. J Cell Sci. 2012, 125:5591-6. 10.1242\/jcs.116392","journal-title":"J Cell Sci"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3245","article-title":"The immune contexture in human tumours: impact on clinical outcome","volume":"12","author":"Fridman WH","year":"2012","unstructured":"Fridman WH, Pag\u00e8s F, Saut\u00e8s-Fridman C, Galon J. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer. 2012, 12:298-306. 10.1038\/nrc3245","journal-title":"Nat Rev Cancer"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/501659","article-title":"T-cell traffic jam in Hodgkin's lymphoma: pathogenetic and therapeutic implications","volume":"2011","author":"Fozza C","year":"2011","unstructured":"Fozza C, Longinotti M. T-cell traffic jam in Hodgkin's lymphoma: pathogenetic and therapeutic implications. Adv Hematol. 2011, 2011:501659. 10.1155\/2011\/501659","journal-title":"Adv Hematol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian BZ","year":"2010","unstructured":"Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell. 2010, 141:39-51. 10.1016\/j.cell.2010.03.014","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32831bed7e","article-title":"Corrupt policemen: inflammatory cells promote tumor angiogenesis","volume":"21","author":"Zumsteg A","year":"2009","unstructured":"Zumsteg A, Christofori G. Corrupt policemen: inflammatory cells promote tumor angiogenesis. Curr Opin Oncol. 2009, 21:60-70. 10.1097\/CCO.0b013e32831bed7e","journal-title":"Curr Opin Oncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-038257","article-title":"The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP","volume":"109","author":"Sehn LH","year":"2007","unstructured":"Sehn LH, Berry B, Chhanabhai M, et al.. The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP. Blood. 2007, 109:1857-61. 10.1182\/blood-2006-08-038257","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.2493","article-title":"Standard international prognostic index remains a valid predictor of outcome for patients with aggressive CD20+ B-cell lymphoma in the rituximab era","volume":"28","author":"Ziepert M","year":"2010","unstructured":"Ziepert M, Hasenclever D, Kuhnt E, Glass B, Schmitz N, Pfreundschuh M, Loeffler M. Standard international prognostic index remains a valid predictor of outcome for patients with aggressive CD20+ B-cell lymphoma in the rituximab era. J Clin Oncol. 2010, 28:2373-80. 10.1200\/JCO.2009.26.2493","journal-title":"J Clin Oncol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3442","article-title":"Rituximab plus CHOP (R-CHOP) overcomes bcl-2--associated resistance to chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL)","volume":"101","author":"Mounier N","year":"2003","unstructured":"Mounier N, Briere J, Gisselbrecht C, et al.. Rituximab plus CHOP (R-CHOP) overcomes bcl-2--associated resistance to chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL). Blood. 2003, 101:4279-84. 10.1182\/blood-2002-11-3442","journal-title":"Blood"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4222","article-title":"Prognostic significance of Bcl-6 protein expression in DLBCL treated with CHOP or R-CHOP: a prospective correlative study","volume":"107","author":"Winter JN","year":"2006","unstructured":"Winter JN, Weller EA, Horning SJ, et al.. Prognostic significance of Bcl-6 protein expression in DLBCL treated with CHOP or R-CHOP: a prospective correlative study. Blood. 2006, 107:4207-13. 10.1182\/blood-2005-10-4222","journal-title":"Blood"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-322362","article-title":"Gene-expression profiling and not immunophenotypic algorithms predicts prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy","volume":"117","author":"Guti\u00e9rrez-Garc\u00eda G","year":"2011","unstructured":"Guti\u00e9rrez-Garc\u00eda G, Cardesa-Salzmann T, Climent F, et al.. Gene-expression profiling and not immunophenotypic algorithms predicts prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy. Blood. 2011, 117:4836-43. 10.1182\/blood-2010-12-322362","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051862","article-title":"Cutoff Finder: a comprehensive and straightforward Web application enabling rapid biomarker cutoff optimization","volume":"7","author":"Budczies J","year":"2012","unstructured":"Budczies J, Klauschen F, Sinn BV, Gy\u0151rffy B, Schmitt WD, Darb-Esfahani S, Denkert C. Cutoff Finder: a comprehensive and straightforward Web application enabling rapid biomarker cutoff optimization. PLoS One. 2012, 7:e51862. 10.1371\/journal.pone.0051862","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041869","article-title":"Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells","volume":"351","author":"Dave SS","year":"2004","unstructured":"Dave SS, Wright G, Tan B, et al.. Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med. 2004, 351:2159-69. 10.1056\/NEJMoa041869","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802885","article-title":"Stromal gene signatures in large-B-cell lymphomas","volume":"359","author":"Lenz G","year":"2008","unstructured":"Lenz G, Wright G, Dave SS, et al.. Stromal gene signatures in large-B-cell lymphomas. N Engl J Med. 2008, 359:2313-23. 10.1056\/NEJMoa0802885","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404819","article-title":"Absolute lymphocyte count predicts therapeutic efficacy and survival at the time of radioimmunotherapy in patients with relapsed follicular lymphomas","volume":"21","author":"Porrata LF","year":"2007","unstructured":"Porrata LF, Ristow K, Witzig TE, et al.. Absolute lymphocyte count predicts therapeutic efficacy and survival at the time of radioimmunotherapy in patients with relapsed follicular lymphomas. Leukemia. 2007, 21:2554-6. 10.1038\/sj.leu.2404819","journal-title":"Leukemia"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.112","article-title":"The absolute monocyte and lymphocyte prognostic score predicts survival and identifies high-risk patients in diffuse large-B-cell lymphoma","volume":"25","author":"Wilcox RA","year":"2011","unstructured":"Wilcox RA, Ristow K, Habermann TM, et al.. The absolute monocyte and lymphocyte prognostic score predicts survival and identifies high-risk patients in diffuse large-B-cell lymphoma. Leukemia. 2011, 25:1502-9. 10.1038\/leu.2011.112","journal-title":"Leukemia"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-004-0041-4","article-title":"Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation","volume":"4","author":"Porrata LF","year":"2004","unstructured":"Porrata LF, Markovic SN. Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation. Clin Exp Med. 2004, 4:78-85. 10.1007\/s10238-004-0041-4","journal-title":"Clin Exp Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2010.01.011","article-title":"Rituximab: mechanism of action","volume":"47","author":"Weiner GJ","year":"2010","unstructured":"Weiner GJ. Rituximab: mechanism of action. Semin Hematol. 2010, 47:115-23. 10.1053\/j.seminhematol.2010.01.011","journal-title":"Semin Hematol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V124.21.5379.5379","article-title":"The analysis of prognostic significance of absolute lymphocyte count and lymphocyte-to-monocyte ratio in diffuse large B-cell lymphoma","volume":"124","author":"Huang H","year":"2014","unstructured":"Huang H, Liu Y, Jin Z, Depei W. The analysis of prognostic significance of absolute lymphocyte count and lymphocyte-to-monocyte ratio in diffuse large B-cell lymphoma. Blood. 2014, 124:5379. 10.1182\/blood.V124.21.5379.5379","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0902436","article-title":"The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization","volume":"74","author":"Tsutsumi C","year":"2003","unstructured":"Tsutsumi C, Sonoda KH, Egashira K, et al.. The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization. J Leukoc Biol. 2003, 74:25-32. 10.1189\/jlb.0902436","journal-title":"J Leukoc Biol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0762","article-title":"Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome","volume":"104","author":"Novak AJ","year":"2004","unstructured":"Novak AJ, Grote DM, Stenson M, et al.. Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome. Blood. 2004, 104:2247-53. 10.1182\/blood-2004-02-0762","journal-title":"Blood"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-220111","article-title":"Monocytes promote tumor cell survival in T-cell lymphoproliferative disorders and are impaired in their ability to differentiate into mature dendritic cells","volume":"114","author":"Wilcox RA","year":"2009","unstructured":"Wilcox RA, Wada DA, Ziesmer SC, et al.. Monocytes promote tumor cell survival in T-cell lymphoproliferative disorders and are impaired in their ability to differentiate into mature dendritic cells. Blood. 2009, 114:2936-44. 10.1182\/blood-2009-05-220111","journal-title":"Blood"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041658","article-title":"Blood lymphocyte-to-monocyte ratio identifies high-risk patients in diffuse large B-cell lymphoma treated with R-CHOP","volume":"7","author":"Li ZM","year":"2012","unstructured":"Li ZM, Huang JJ, Xia Y, et al.. Blood lymphocyte-to-monocyte ratio identifies high-risk patients in diffuse large B-cell lymphoma treated with R-CHOP. PLoS One. 2012, 7:e41658. 10.1371\/journal.pone.0041658","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23566","article-title":"The lymphocyte to monocyte ratio improves the IPI-risk definition of diffuse large B-cell lymphoma when rituximab is added to chemotherapy","volume":"88","author":"Rambaldi A","year":"2013","unstructured":"Rambaldi A, Boschini C, Gritti G, et al.. The lymphocyte to monocyte ratio improves the IPI-risk definition of diffuse large B-cell lymphoma when rituximab is added to chemotherapy. Am J Hematol. 2013, 88:1062-7. 10.1002\/ajh.23566","journal-title":"Am J Hematol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2020.03.007","article-title":"Prognostic significance of absolute lymphocyte count, absolute monocyte count, and absolute lymphocyte count to absolute monocyte count ratio in follicular non-Hodgkin lymphoma","volume":"20","author":"Mohsen A","year":"2020","unstructured":"Mohsen A, Taalab M, Abousamra N, Mabed M. Prognostic significance of absolute lymphocyte count, absolute monocyte count, and absolute lymphocyte count to absolute monocyte count ratio in follicular non-Hodgkin lymphoma. Clin Lymphoma Myeloma Leuk. 2020, 20:e606-15. 10.1016\/j.clml.2020.03.007","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.12066","article-title":"Prognostic significance of lymphocyte-to-monocyte ratio in diffuse large B-cell lymphoma: a systematic review and meta-analysis","volume":"6","author":"Xia WK","year":"2016","unstructured":"Xia WK, Lin QF, Shen D, Liu ZL, Su J, Mao WD. Prognostic significance of lymphocyte-to-monocyte ratio in diffuse large B-cell lymphoma: a systematic review and meta-analysis. FEBS Open Bio. 2016, 6:558-65. 10.1002\/2211-5463.12066","journal-title":"FEBS Open Bio"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032520","article-title":"Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes","volume":"350","author":"Lossos IS","year":"2004","unstructured":"Lossos IS, Czerwinski DK, Alizadeh AA, Wechser MA, Tibshirani R, Botstein D, Levy R. Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes. N Engl J Med. 2004, 350:1828-37. 10.1056\/NEJMoa032520","journal-title":"N Engl J Med"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3774","article-title":"The tumour microenvironment in B cell lymphomas","volume":"14","author":"Scott DW","year":"2014","unstructured":"Scott DW, Gascoyne RD. The tumour microenvironment in B cell lymphomas. Nat Rev Cancer. 2014, 14:517-34. 10.1038\/nrc3774","journal-title":"Nat Rev Cancer"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/136095-potential-prognostic-and-predictive-role-of-monocyte-and-lymphocyte-counts-on-presentation-in-patients-diagnosed-with-diffuse-large-b-cell-lymphoma","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:59:50Z","timestamp":1707508790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/136095-potential-prognostic-and-predictive-role-of-monocyte-and-lymphocyte-counts-on-presentation-in-patients-diagnosed-with-diffuse-large-b-cell-lymphoma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.35654","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,1]]}}}