{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:48:36Z","timestamp":1777636116025,"version":"3.51.4"},"reference-count":139,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,9]]},"DOI":"10.7759\/cureus.35958","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:35:41Z","timestamp":1678408541000},"source":"Crossref","is-referenced-by-count":8,"title":["A Systematic Review of Second-Line Treatments in Antiviral Resistant Strains of HSV-1, HSV-2, and VZV"],"prefix":"10.7759","author":[{"given":"Kimberly C","family":"Lince","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virgil K","family":"DeMario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George T","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita T","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel T","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob N","family":"Sanderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Pittman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca L","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.08.024","article-title":"Brincidofovir (CMX-001) for refractory and resistant CMV and HSV infections in immunocompromised cancer patients: a single-center experience","volume":"134","author":"El-Haddad D","year":"2016","unstructured":"El-Haddad D, El Chaer F, Vanichanan J, et al.. Brincidofovir (CMX-001) for refractory and resistant CMV and HSV infections in immunocompromised cancer patients: a single-center experience. Antiviral Res. 2016, 134:58-62. 10.1016\/j.antiviral.2016.08.024","journal-title":"Antiviral Res"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-018-04118-4","article-title":"Preparation of a monoPEGylated derivative of cyanovirin-N and its virucidal effect on acyclovir-resistant strains of herpes simplex virus type 1","volume":"164","author":"Lei Y","year":"2019","unstructured":"Lei Y, Chen W, Liang H, et al.. Preparation of a monoPEGylated derivative of cyanovirin-N and its virucidal effect on acyclovir-resistant strains of herpes simplex virus type 1. Arch Virol. 2019, 164:1259-69. 10.1007\/s00705-018-04118-4","journal-title":"Arch Virol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3039","article-title":"Aminomethylnaphthoquinones and HSV-1: in vitro and in silico evaluations of potential antivirals","volume":"21","author":"Pires de Mello CP","year":"2016","unstructured":"Pires de Mello CP, Sardoux NS, Terra L, et al.. Aminomethylnaphthoquinones and HSV-1: in vitro and in silico evaluations of potential antivirals. Antivir Ther. 2016, 21:507-15. 10.3851\/IMP3039","journal-title":"Antivir Ther"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"62","author":"Moher D","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009, 62:1006-12. 10.1016\/j.jclinepi.2009.06.005","journal-title":"J Clin Epidemiol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins JP","year":"2011","unstructured":"Higgins JP, Altman DG, G\u00f8tzsche PC, et al.. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011, 343:d5928. 10.1136\/bmj.d5928","journal-title":"BMJ"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2015.137","article-title":"Pentagalloylglucose blocks the nuclear transport and the process of nucleocapsid egress to inhibit HSV-1 infection","volume":"69","author":"Jin F","year":"2016","unstructured":"Jin F, Ma K, Chen M, Zou M, Wu Y, Li F, Wang Y. Pentagalloylglucose blocks the nuclear transport and the process of nucleocapsid egress to inhibit HSV-1 infection. Jpn J Infect Dis. 2016, 69:135-42. 10.7883\/yoken.JJID.2015.137","journal-title":"Jpn J Infect Dis"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.11.001","article-title":"Basic chemokine-derived glycosaminoglycan binding peptides exert antiviral properties against dengue virus serotype 2, herpes simplex virus-1 and respiratory syncytial virus","volume":"100","author":"Vanheule V","year":"2016","unstructured":"Vanheule V, Vervaeke P, Mortier A, et al.. Basic chemokine-derived glycosaminoglycan binding peptides exert antiviral properties against dengue virus serotype 2, herpes simplex virus-1 and respiratory syncytial virus. Biochem Pharmacol. 2016, 100:73-85. 10.1016\/j.bcp.2015.11.001","journal-title":"Biochem Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00591-16","article-title":"Antiviral activity of myticin c peptide from mussel: an ancient defense against herpesviruses","volume":"90","author":"Novoa B","year":"2016","unstructured":"Novoa B, Romero A, \u00c1lvarez \u00c1L, et al.. Antiviral activity of myticin c peptide from mussel: an ancient defense against herpesviruses. J Virol. 2016, 90:7692-702. 10.1128\/JVI.00591-16","journal-title":"J Virol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02675-15","article-title":"Synthetic \u03b1-hydroxytropolones inhibit replication of wild-type and acyclovir-resistant herpes simplex viruses","volume":"60","author":"Ireland PJ","year":"2016","unstructured":"Ireland PJ, Tavis JE, D'Erasmo MP, et al.. Synthetic \u03b1-hydroxytropolones inhibit replication of wild-type and acyclovir-resistant herpes simplex viruses. Antimicrob Agents Chemother. 2016, 60:2140-9. 10.1128\/AAC.02675-15","journal-title":"Antimicrob Agents Chemother"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-016-0168-x","article-title":"Molecular docking study and antiviral evaluation of 2-thioxo-benzo[g]quinazolin-4(3H)-one derivatives","volume":"10","author":"Al-Salahi R","year":"2016","unstructured":"Al-Salahi R, Abuelizz HA, Ghabbour HA, El-Dib R, Marzouk M. Molecular docking study and antiviral evaluation of 2-thioxo-benzo[g]quinazolin-4(3H)-one derivatives. Chem Cent J. 2016, 10:21. 10.1186\/s13065-016-0168-x","journal-title":"Chem Cent J"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.05.009","article-title":"Development and evaluation of a host-targeted antiviral that abrogates herpes simplex virus replication through modulation of arginine-associated metabolic pathways","volume":"132","author":"Sanchez MD","year":"2016","unstructured":"Sanchez MD, Ochoa AC, Foster TP. Development and evaluation of a host-targeted antiviral that abrogates herpes simplex virus replication through modulation of arginine-associated metabolic pathways. Antiviral Res. 2016, 132:13-25. 10.1016\/j.antiviral.2016.05.009","journal-title":"Antiviral Res"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2016.09.013","article-title":"Herpes simplex virus type 1 (HSV-1) specific T-cell generation from HLA-A1- and HLA-A2-positive donors for adoptive immunotherapy","volume":"19","author":"Ma CK","year":"2017","unstructured":"Ma CK, Clancy L, Deo S, Blyth E, Micklethwaite KP, Gottlieb DJ. Herpes simplex virus type 1 (HSV-1) specific T-cell generation from HLA-A1- and HLA-A2-positive donors for adoptive immunotherapy. Cytotherapy. 2017, 19:107-18. 10.1016\/j.jcyt.2016.09.013","journal-title":"Cytotherapy"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.32607\/20758251-2016-8-1-74-81","article-title":"Study of antiherpetic efficiency of phosphite of acycloguanosine able to over come the barrier of resistance to acyclovir","volume":"8","author":"Andronova VL","year":"2016","unstructured":"Andronova VL, Jasko MV, Kukhanova MK, Galegov GA, Skoblov YS, Kochetkov SN. Study of antiherpetic efficiency of phosphite of acycloguanosine able to over come the barrier of resistance to acyclovir. Acta Naturae. 2016, 8:74-81.","journal-title":"Acta Naturae"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.07.012","article-title":"3,19-Isopropylideneandrographolide suppresses early gene expression of drug-resistant and wild type herpes simplex viruses","volume":"132","author":"Kongyingyoes B","year":"2016","unstructured":"Kongyingyoes B, Priengprom T, Pientong C, Aromdee C, Suebsasana S, Ekalaksananan T. 3,19-Isopropylideneandrographolide suppresses early gene expression of drug-resistant and wild type herpes simplex viruses. Antiviral Res. 2016, 132:281-6. 10.1016\/j.antiviral.2016.07.012","journal-title":"Antiviral Res"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-016-0964-6","article-title":"In vitro and in vivo antiherpetic effects of (1R,2R)-1-(5'-methylful-3'-yl)propane-1,2,3-triol","volume":"70","author":"Sasaki K","year":"2016","unstructured":"Sasaki K, Hayashi K, Matsuya Y, Sugimoto K, Lee JB, Kurosaki F, Hayashi T. In vitro and in vivo antiherpetic effects of (1R,2R)-1-(5'-methylful-3'-yl)propane-1,2,3-triol. J Nat Med. 2016, 70:217-24. 10.1007\/s11418-016-0964-6","journal-title":"J Nat Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-016-2867-y","article-title":"Polyhydroxylated sulfated steroids derived from 5\u03b1-cholestanes as antiviral agents against herpes simplex virus","volume":"161","author":"Pujol CA","year":"2016","unstructured":"Pujol CA, Sep\u00falveda CS, Richmond V, Maier MS, Damonte EB. Polyhydroxylated sulfated steroids derived from 5\u03b1-cholestanes as antiviral agents against herpes simplex virus. Arch Virol. 2016, 161:1993-9. 10.1007\/s00705-016-2867-y","journal-title":"Arch Virol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4149\/av_2016_01_41","article-title":"Accumulation of a\u00a0soluble form of human nectin-2 is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells","volume":"60","author":"Fujimoto Y","year":"2016","unstructured":"Fujimoto Y, Ozaki K, Iwamori N, Takakuwa H, Ono E. Accumulation of a\u00a0soluble form of human nectin-2 is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells. Acta Virol. 2016, 60:41-8. 10.4149\/av_2016_01_41","journal-title":"Acta Virol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3118","article-title":"Antiviral potential and mode of action of Indigofera heterantha against HSV-2 by targeting the early stages of infection","volume":"22","author":"Kaushik NK","year":"2017","unstructured":"Kaushik NK, Guha R, Thomas BM. Antiviral potential and mode of action of Indigofera heterantha against HSV-2 by targeting the early stages of infection. Antivir Ther. 2017, 22:381-91. 10.3851\/IMP3118","journal-title":"Antivir Ther"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/srep19977","article-title":"Broad and potent antiviral activity of the NAE inhibitor MLN4924","volume":"6","author":"Le-Trilling VT","year":"2016","unstructured":"Le-Trilling VT, Megger DA, Katschinski B, et al.. Broad and potent antiviral activity of the NAE inhibitor MLN4924. Sci Rep. 2016, 6:19977. 10.1038\/srep19977","journal-title":"Sci Rep"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-016-3032-3","article-title":"Ficus religiosa L. bark extracts inhibit infection by herpes simplex virus type 2 in vitro","volume":"161","author":"Ghosh M","year":"2016","unstructured":"Ghosh M, Civra A, Ritt\u00e0 M, et al.. Ficus religiosa L. bark extracts inhibit infection by herpes simplex virus type 2 in vitro. Arch Virol. 2016, 161:3509-14. 10.1007\/s00705-016-3032-3","journal-title":"Arch Virol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2017.53.11.2724803","article-title":"Helicase-primase inhibitor amenamevir for herpesvirus infection: towards practical application for treating herpes zoster","volume":"53","author":"Shiraki K","year":"2017","unstructured":"Shiraki K. Helicase-primase inhibitor amenamevir for herpesvirus infection: towards practical application for treating herpes zoster. Drugs Today (Barc). 2017, 53:573-84. 10.1358\/dot.2017.53.11.2724803","journal-title":"Drugs Today (Barc)"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3153","article-title":"Topical treatment of herpes simplex virus infection with enzymatically created siRNA swarm","volume":"22","author":"Paavilainen H","year":"2017","unstructured":"Paavilainen H, Lehtinen J, Romanovskaya A, Nyg\u00e5rdas M, Bamford DH, Poranen MM, Hukkanen V. Topical treatment of herpes simplex virus infection with enzymatically created siRNA swarm. Antivir Ther. 2017, 22:631-7. 10.3851\/IMP3153","journal-title":"Antivir Ther"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/bip.22871","article-title":"Linear antimicrobial peptides with activity against herpes simplex virus 1 and Aichi virus","volume":"108","author":"Vilas Boas LC","year":"2017","unstructured":"Vilas Boas LC, de Lima LM, Migliolo L, Mendes GD, de Jesus MG, Franco OL, Silva PA. Linear antimicrobial peptides with activity against herpes simplex virus 1 and Aichi virus. Biopolymers. 2017, 108:10.1002\/bip.22871","journal-title":"Biopolymers"},{"key":"ref24","article-title":"Antiviral screening of four plant extracts against acyclovir resistant herpes simplex virus type-1","volume":"30","author":"Parsania M","year":"2017","unstructured":"Parsania M, Rezaee MB, Monavari SH, Jaimand K, Mousavi-Jazayeri SM, Razazian M, Nadjarha MH. Antiviral screening of four plant extracts against acyclovir resistant herpes simplex virus type-1. Pak J Pharm Sci. 2017, 30:1407-11.","journal-title":"Pak J Pharm Sci"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2017.06.010","article-title":"Anti-herpes simplex virus type 1 activity of Houttuynoid A,\u00a0a\u00a0flavonoid from Houttuynia cordata Thunb","volume":"144","author":"Li T","year":"2017","unstructured":"Li T, Liu L, Wu H, et al.. Anti-herpes simplex virus type 1 activity of Houttuynoid A,\u00a0a\u00a0flavonoid from Houttuynia cordata Thunb. Antiviral Res. 2017, 144:273-80. 10.1016\/j.antiviral.2017.06.010","journal-title":"Antiviral Res"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/v9070178","article-title":"Almond skin extracts abrogate HSV-1 replication by blocking virus binding to the cell","volume":"9","author":"Bisignano C","year":"2017","unstructured":"Bisignano C, Mandalari G, Smeriglio A, Trombetta D, Pizzo MM, Pennisi R, Sciortino MT. Almond skin extracts abrogate HSV-1 replication by blocking virus binding to the cell. Viruses. 2017, 9:10.3390\/v9070178","journal-title":"Viruses"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2017.09.021","article-title":"Antibody-based immunotherapy of aciclovir resistant ocular herpes simplex virus infections","volume":"512","author":"Bauer D","year":"2017","unstructured":"Bauer D, Keller J, Alt M, et al.. Antibody-based immunotherapy of aciclovir resistant ocular herpes simplex virus infections. Virology. 2017, 512:194-200. 10.1016\/j.virol.2017.09.021","journal-title":"Virology"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000804","article-title":"Comparison of the antiviral potential among soluble forms of herpes simplex virus type-2 glycoprotein D receptors, herpes virus entry mediator A, nectin-1 and nectin-2, in transgenic mice","volume":"98","author":"Fujimoto Y","year":"2017","unstructured":"Fujimoto Y, Tomioka Y, Ozaki K, et al.. Comparison of the antiviral potential among soluble forms of herpes simplex virus type-2 glycoprotein D receptors, herpes virus entry mediator A, nectin-1 and nectin-2, in transgenic mice. J Gen Virol. 2017, 98:1815-22. 10.1099\/jgv.0.000804","journal-title":"J Gen Virol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-017-8472-5","article-title":"Anti-herpes simplex virus 1 and immunomodulatory activities of a poly-\u03b3- glutamic acid from Bacillus horneckiae strain APA of shallow vent origin","volume":"101","author":"Marino-Merlo F","year":"2017","unstructured":"Marino-Merlo F, Papaianni E, Maugeri TL, et al.. Anti-herpes simplex virus 1 and immunomodulatory activities of a poly-\u03b3- glutamic acid from Bacillus horneckiae strain APA of shallow vent origin. Appl Microbiol Biotechnol. 2017, 101:7487-96. 10.1007\/s00253-017-8472-5","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179291","article-title":"Potentiated virucidal activity of pomegranate rind extract (PRE) and punicalagin against herpes simplex virus (HSV) when co-administered with zinc (II) ions, and antiviral activity of PRE against HSV and aciclovir-resistant HSV","volume":"12","author":"Houston DM","year":"2017","unstructured":"Houston DM, Bugert JJ, Denyer SP, Heard CM. Potentiated virucidal activity of pomegranate rind extract (PRE) and punicalagin against herpes simplex virus (HSV) when co-administered with zinc (II) ions, and antiviral activity of PRE against HSV and aciclovir-resistant HSV. PLoS One. 2017, 12:e0179291. 10.1371\/journal.pone.0179291","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172322","article-title":"In vitro anti-herpes simplex virus-2 activity of Salvia desoleana Atzei & V. Picci essential oil","volume":"12","author":"Cagno V","year":"2017","unstructured":"Cagno V, Sgorbini B, Sanna C, et al.. In vitro anti-herpes simplex virus-2 activity of Salvia desoleana Atzei &amp; V. Picci essential oil. PLoS One. 2017, 12:e0172322. 10.1371\/journal.pone.0172322","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.12.017","article-title":"Anti HSV-2 activity of Peganum harmala (L.) and isolation of the active compound","volume":"114","author":"Benzekri R","year":"2018","unstructured":"Benzekri R, Bouslama L, Papetti A, Hammami M, Smaoui A, Limam F. Anti HSV-2 activity of Peganum harmala (L.) and isolation of the active compound. Microb Pathog. 2018, 114:291-8. 10.1016\/j.micpath.2017.12.017","journal-title":"Microb Pathog"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2017.11.012","article-title":"A new promising candidate to overcome drug resistant herpes simplex virus infections","volume":"149","author":"Zinser E","year":"2018","unstructured":"Zinser E, Krawczyk A, M\u00fchl-Z\u00fcrbes P, et al.. A new promising candidate to overcome drug resistant herpes simplex virus infections. Antiviral Res. 2018, 149:202-10. 10.1016\/j.antiviral.2017.11.012","journal-title":"Antiviral Res"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2017.63.8.10","article-title":"Susceptibility of herpes simplex virus type 1 to monoterpenes thymol, carvacrol, p-cymene and essential oils of Sinapis arvensis L., Lallemantia royleana Benth. and Pulicaria vulgaris Gaertn","volume":"63","author":"Sharifi-Rad J","year":"2017","unstructured":"Sharifi-Rad J, Salehi B, Schnitzler P, et al.. Susceptibility of herpes simplex virus type 1 to monoterpenes thymol, carvacrol, p-cymene and essential oils of Sinapis arvensis L., Lallemantia royleana Benth. and Pulicaria vulgaris Gaertn. Cell Mol Biol (Noisy-le-grand). 2017, 63:42-7. 10.14715\/cmb\/2017.63.8.10","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2017.11.002","article-title":"Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis","volume":"149","author":"Quenelle DC","year":"2018","unstructured":"Quenelle DC, Birkmann A, Goldner T, et al.. Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis. Antiviral Res. 2018, 149:1-6. 10.1016\/j.antiviral.2017.11.002","journal-title":"Antiviral Res"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02108","article-title":"Pharmacological induction of heme oxygenase-1 impairs nuclear accumulation of herpes simplex virus capsids upon infection","volume":"8","author":"Ib\u00e1\u00f1ez FJ","year":"2017","unstructured":"Ib\u00e1\u00f1ez FJ, Far\u00edas MA, Retamal-D\u00edaz A, Espinoza JA, Kalergis AM, Gonz\u00e1lez PA. Pharmacological induction of heme oxygenase-1 impairs nuclear accumulation of herpes simplex virus capsids upon infection. Front Microbiol. 2017, 8:2108. 10.3389\/fmicb.2017.02108","journal-title":"Front Microbiol"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2305-0","article-title":"Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo","volume":"17","author":"Hou J","year":"2017","unstructured":"Hou J, Zhang Z, Huang Q, et al.. Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo. BMC Infect Dis. 2017, 17:217. 10.1186\/s12879-017-2305-0","journal-title":"BMC Infect Dis"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2017.04.003","article-title":"Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity","volume":"143","author":"Hutterer C","year":"2017","unstructured":"Hutterer C, Milbradt J, Hamilton S, et al.. Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity. Antiviral Res. 2017, 143:113-21. 10.1016\/j.antiviral.2017.04.003","journal-title":"Antiviral Res"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.11.039","article-title":"The traditional use of Vachellia nilotica for sexually transmitted diseases is substantiated by the antiviral activity of its bark extract against sexually transmitted viruses","volume":"213","author":"Donalisio M","year":"2018","unstructured":"Donalisio M, Cagno V, Civra A, et al.. The traditional use of Vachellia nilotica for sexually transmitted diseases is substantiated by the antiviral activity of its bark extract against sexually transmitted viruses. J Ethnopharmacol. 2018, 213:403-8. 10.1016\/j.jep.2017.11.039","journal-title":"J Ethnopharmacol"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6161230","article-title":"Volatile acid-solvent evaporation (VASE): molecularly homogeneous distribution of acyclovir in a bioerodable polymer matrix for long-term treatment of herpes simplex virus-1 infections","volume":"2018","author":"Stegman JR","year":"2018","unstructured":"Stegman JR, Badin JK, Biles KA, et al.. Volatile acid-solvent evaporation (VASE): molecularly homogeneous distribution of acyclovir in a bioerodable polymer matrix for long-term treatment of herpes simplex virus-1 infections. J Drug Deliv. 2018, 2018:6161230. 10.1155\/2018\/6161230","journal-title":"J Drug Deliv"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.12.014","article-title":"Antiviral activities of Janus-type nucleosides and their related oxime-intermediates","volume":"27","author":"Liu J","year":"2019","unstructured":"Liu J, Zhao H, Zhou X, He Y, Chen Q. Antiviral activities of Janus-type nucleosides and their related oxime-intermediates. Bioorg Med Chem. 2019, 27:2332-9. 10.1016\/j.bmc.2018.12.014","journal-title":"Bioorg Med Chem"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.03.018","article-title":"Chemoenzymatic synthesis of new derivatives of glycyrrhetinic acid with antiviral activity. Molecular docking study","volume":"78","author":"Z\u00edgolo MA","year":"2018","unstructured":"Z\u00edgolo MA, Salinas M, Alch\u00e9 L, Baldessari A, Li\u00f1ares GG. Chemoenzymatic synthesis of new derivatives of glycyrrhetinic acid with antiviral activity. Molecular docking study. Bioorg Chem. 2018, 78:210-9. 10.1016\/j.bioorg.2018.03.018","journal-title":"Bioorg Chem"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.10.024","article-title":"Antiviral efficacy of the helicase-primase inhibitor amenamevir in murine models of severe herpesvirus infection","volume":"158","author":"Katsumata K","year":"2018","unstructured":"Katsumata K, Chono K, Suzuki H. Antiviral efficacy of the helicase-primase inhibitor amenamevir in murine models of severe herpesvirus infection. Biochem Pharmacol. 2018, 158:201-6. 10.1016\/j.bcp.2018.10.024","journal-title":"Biochem Pharmacol"},{"key":"ref44","article-title":"Hemidesmus indicus (L.) R. Br. extract inhibits the early step of herpes simplex type 1 and type 2 replication","volume":"41","author":"Bonvicini F","year":"2018","unstructured":"Bonvicini F, Lianza M, Mandrone M, Poli F, Gentilomi GA, Antognoni F. Hemidesmus indicus (L.) R. Br. extract inhibits the early step of herpes simplex type 1 and type 2 replication. New Microbiol. 2018, 41:187-94.","journal-title":"New Microbiol"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06349-0","article-title":"Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo","volume":"9","author":"Derby N","year":"2018","unstructured":"Derby N, Lal M, Aravantinou M, et al.. Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo. Nat Commun. 2018, 9:3881. 10.1038\/s41467-018-06349-0","journal-title":"Nat Commun"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.01.009","article-title":"Synergy evaluation of anti-herpes simplex virus type 1 and 2 compounds acting on different steps of virus life cycle","volume":"151","author":"Criscuolo E","year":"2018","unstructured":"Criscuolo E, Clementi N, Mancini N, Burioni R, Miduri M, Castelli M, Clementi M. Synergy evaluation of anti-herpes simplex virus type 1 and 2 compounds acting on different steps of virus life cycle. Antiviral Res. 2018, 151:71-7. 10.1016\/j.antiviral.2018.01.009","journal-title":"Antiviral Res"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33904-y","article-title":"R430: a potent inhibitor of DNA and RNA viruses","volume":"8","author":"D'Aiuto L","year":"2018","unstructured":"D'Aiuto L, McNulty J, Hartline C, et al.. R430: a potent inhibitor of DNA and RNA viruses. Sci Rep. 2018, 8:16662. 10.1038\/s41598-018-33904-y","journal-title":"Sci Rep"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12977","article-title":"Efficacy of brincidofovir as prophylaxis against HSV and VZV in hematopoietic cell transplant recipients","volume":"20","author":"Lee YJ","year":"2018","unstructured":"Lee YJ, Neofytos D, Kim SJ, et al.. Efficacy of brincidofovir as prophylaxis against HSV and VZV in hematopoietic cell transplant recipients. Transpl Infect Dis. 2018, 20:e12977. 10.1111\/tid.12977","journal-title":"Transpl Infect Dis"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix605","article-title":"The anti-human immunodeficiency virus drug tenofovir, a reverse transcriptase inhibitor, also targets the herpes simplex virus DNA polymerase","volume":"217","author":"Andrei G","year":"2018","unstructured":"Andrei G, Gillemot S, Topalis D, Snoeck R. The anti-human immunodeficiency virus drug tenofovir, a reverse transcriptase inhibitor, also targets the herpes simplex virus DNA polymerase. J Infect Dis. 2018, 217:790-801. 10.1093\/infdis\/jix605","journal-title":"J Infect Dis"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1712.12052","article-title":"Antiviral effect of retro-2.1 against herpes simplex virus type 2 in vitro","volume":"28","author":"Dai W","year":"2018","unstructured":"Dai W, Wu Y, Bi J, et al.. Antiviral effect of retro-2.1 against herpes simplex virus type 2 in vitro. J Microbiol Biotechnol. 2018, 28:849-59. 10.4014\/jmb.1712.12052","journal-title":"J Microbiol Biotechnol"},{"key":"ref51","doi-asserted-by":"crossref","DOI":"10.14715\/cmb\/2018.64.8.2","article-title":"Antiviral activity of Veronica persica Poir. on herpes virus infection","volume":"64","author":"Sharifi-Rad J","year":"2018","unstructured":"Sharifi-Rad J, Iriti M, Setzer WN, Sharifi-Rad M, Roointan A, Salehi B. Antiviral activity of Veronica persica Poir. on herpes virus infection. Cell Mol Biol (Noisy-le-grand). 2018, 64:11-7.","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.03.052","article-title":"Study on antiviral activities, drug-likeness and molecular docking of bioactive compounds of Punica granatum L. to Herpes simplex virus - 2 (HSV-2)","volume":"118","author":"Arunkumar J","year":"2018","unstructured":"Arunkumar J, Rajarajan S. Study on antiviral activities, drug-likeness and molecular docking of bioactive compounds of Punica granatum L. to Herpes simplex virus - 2 (HSV-2). Microb Pathog. 2018, 118:301-9. 10.1016\/j.micpath.2018.03.052","journal-title":"Microb Pathog"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04379-2","article-title":"MxB is an interferon-induced restriction factor of human herpesviruses","volume":"9","author":"Crameri M","year":"2018","unstructured":"Crameri M, Bauer M, Caduff N, et al.. MxB is an interferon-induced restriction factor of human herpesviruses. Nat Commun. 2018, 9:1980. 10.1038\/s41467-018-04379-2","journal-title":"Nat Commun"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02367-17","article-title":"The amphibian antimicrobial peptide Temporin b inhibits in vitro herpes simplex virus 1 infection","volume":"62","author":"Marcocci ME","year":"2018","unstructured":"Marcocci ME, Amatore D, Villa S, et al.. The amphibian antimicrobial peptide Temporin b inhibits in vitro herpes simplex virus 1 infection. Antimicrob Agents Chemother. 2018, 62:10.1128\/AAC.02367-17","journal-title":"Antimicrob Agents Chemother"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.3390\/v10100532","article-title":"Photodynamic inactivation of herpes simplex viruses","volume":"10","author":"Monjo AL","year":"2018","unstructured":"Monjo AL, Pringle ES, Thornbury M, et al.. Photodynamic inactivation of herpes simplex viruses. Viruses. 2018, 10:10.3390\/v10100532","journal-title":"Viruses"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan5861","article-title":"An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye","volume":"10","author":"Jaishankar D","year":"2018","unstructured":"Jaishankar D, Yakoub AM, Yadavalli T, et al.. An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye. Sci Transl Med. 2018, 10:10.1126\/scitranslmed.aan5861","journal-title":"Sci Transl Med"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.16157.1","article-title":"Clinical management of herpes simplex virus infections: past, present, and future","volume":"7","author":"Whitley R","year":"2018","unstructured":"Whitley R, Baines J. Clinical management of herpes simplex virus infections: past, present, and future. F1000Res. 2018, 7:10.12688\/f1000research.16157.1","journal-title":"F1000Res"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.3390\/v10030119","article-title":"Antiviral effects of ABMA against herpes simplex virus type 2 in vitro and in vivo","volume":"10","author":"Dai W","year":"2018","unstructured":"Dai W, Wu Y, Bi J, et al.. Antiviral effects of ABMA against herpes simplex virus type 2 in vitro and in vivo. Viruses. 2018, 10:10.3390\/v10030119","journal-title":"Viruses"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.3390\/v10110580","article-title":"Herbal gel formulation developed for anti-human immunodeficiency virus (HIV)-1 activity also inhibits in vitro HSV-2 infection","volume":"10","author":"Mishra NN","year":"2018","unstructured":"Mishra NN, Kesharwani A, Agarwal A, Polachira SK, Nair R, Gupta SK. Herbal gel formulation developed for anti-human immunodeficiency virus (HIV)-1 activity also inhibits in vitro HSV-2 infection. Viruses. 2018, 10:10.3390\/v10110580","journal-title":"Viruses"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3254","article-title":"Antiviral effects of Cacicol\u00ae, a heparan sulfate biomimetic for corneal regeneration therapy, for herpes simplex virus type-1 and varicella zoster virus infection","volume":"23","author":"Deback C","year":"2018","unstructured":"Deback C, Rousseau A, Breckler M, et al.. Antiviral effects of Cacicol\u00ae, a heparan sulfate biomimetic for corneal regeneration therapy, for herpes simplex virus type-1 and varicella zoster virus infection. Antivir Ther. 2018, 23:665-75. 10.3851\/IMP3254","journal-title":"Antivir Ther"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198478","article-title":"Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides","volume":"13","author":"Tintori C","year":"2018","unstructured":"Tintori C, Iovenitti G, Ceresola ER, et al.. Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides. PLoS One. 2018, 13:e0198478. 10.1371\/journal.pone.0198478","journal-title":"PLoS One"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.3390\/v10110601","article-title":"The natural compound homoharringtonine presents broad antiviral activity in vitro and in vivo","volume":"10","author":"Dong HJ","year":"2018","unstructured":"Dong HJ, Wang ZH, Meng W, Li CC, Hu YX, Zhou L, Wang XJ. The natural compound homoharringtonine presents broad antiviral activity in vitro and in vivo. Viruses. 2018, 10:10.3390\/v10110601","journal-title":"Viruses"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2018.03.015","article-title":"Herpes simplex virus virucidal activity of MST-312 and epigallocatechin gallate","volume":"249","author":"Pradhan P","year":"2018","unstructured":"Pradhan P, Nguyen ML. Herpes simplex virus virucidal activity of MST-312 and epigallocatechin gallate. Virus Res. 2018, 249:93-8. 10.1016\/j.virusres.2018.03.015","journal-title":"Virus Res"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.06.040","article-title":"Evaluation of anti-HSV-1 activity and toxicity of hydroethanolic extract of Tanacetum parthenium (L.) Sch.Bip. (Asteraceae)","volume":"55","author":"Benassi-Zanqueta \u00c9","year":"2019","unstructured":"Benassi-Zanqueta \u00c9, Marques CF, Valone LM, et al.. Evaluation of anti-HSV-1 activity and toxicity of hydroethanolic extract of Tanacetum parthenium (L.) Sch.Bip. (Asteraceae). Phytomedicine. 2019, 55:249-54. 10.1016\/j.phymed.2018.06.040","journal-title":"Phytomedicine"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2019.02.011","article-title":"Drug repurposing for new, efficient, broad spectrum antivirals","volume":"264","author":"Garc\u00eda-Serradilla M","year":"2019","unstructured":"Garc\u00eda-Serradilla M, Risco C, Pacheco B. Drug repurposing for new, efficient, broad spectrum antivirals. Virus Res. 2019, 264:22-31. 10.1016\/j.virusres.2019.02.011","journal-title":"Virus Res"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24234264","article-title":"Antiviral, antimicrobial and antibiofilm activity of selenoesters and selenoanhydrides","volume":"24","author":"Spengler G","year":"2019","unstructured":"Spengler G, Kincses A, Mosolyg\u00f3 T, et al.. Antiviral, antimicrobial and antibiofilm activity of selenoesters and selenoanhydrides. Molecules. 2019, 24:10.3390\/molecules24234264","journal-title":"Molecules"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.3390\/v11050466","article-title":"Amentoflavone inhibits HSV-1 and ACV-resistant strain infection by suppressing viral early infection","volume":"11","author":"Li F","year":"2019","unstructured":"Li F, Song X, Su G, et al.. Amentoflavone inhibits HSV-1 and ACV-resistant strain infection by suppressing viral early infection. Viruses. 2019, 11:10.3390\/v11050466","journal-title":"Viruses"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102355","article-title":"The antimicrobial and antiviral activity of polyphenols from almond (Prunus dulcis L.) skin","volume":"11","author":"Musarra-Pizzo M","year":"2019","unstructured":"Musarra-Pizzo M, Ginestra G, Smeriglio A, Pennisi R, Sciortino MT, Mandalari G. The antimicrobial and antiviral activity of polyphenols from almond (Prunus dulcis L.) skin. Nutrients. 2019, 11:10.3390\/nu11102355","journal-title":"Nutrients"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.02.005","article-title":"Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives","volume":"27","author":"Mohammed AF","year":"2019","unstructured":"Mohammed AF, Andrei G, Hayallah AM, Abdel-Moty SG, Snoeck R, Simons C. Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives. Bioorg Med Chem. 2019, 27:1023-33. 10.1016\/j.bmc.2019.02.005","journal-title":"Bioorg Med Chem"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2019.113688","article-title":"Inhibition of herpes simplex virus type 1 by copper oxide nanoparticles","volume":"275","author":"Tavakoli A","year":"2020","unstructured":"Tavakoli A, Hashemzadeh MS. Inhibition of herpes simplex virus type 1 by copper oxide nanoparticles. J Virol Methods. 2020, 275:113688. 10.1016\/j.jviromet.2019.113688","journal-title":"J Virol Methods"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.4103\/1735-5362.253364","article-title":"Inhibition of herpes simplex virus type 1 replication by novel hsa-miR-7704 in vitro","volume":"14","author":"Shabani M","year":"2019","unstructured":"Shabani M, Nasr Esfahani B, Sadegh Ehdaei B, Moghim S, Mirzaei A, Sharifi M, Mouhebat L. Inhibition of herpes simplex virus type 1 replication by novel hsa-miR-7704 in vitro. Res Pharm Sci. 2019, 14:167-74. 10.4103\/1735-5362.253364","journal-title":"Res Pharm Sci"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216384","article-title":"Simulated human digestion of N1-aryl-2-arylthioacetamidobenzimidazoles and their activity against Herpes-simplex virus 1 in vitro","volume":"14","author":"Mandalari G","year":"2019","unstructured":"Mandalari G, Bisignano C, Smeriglio A, et al.. Simulated human digestion of N1-aryl-2-arylthioacetamidobenzimidazoles and their activity against Herpes-simplex virus 1 in vitro. PLoS One. 2019, 14:e0216384. 10.1371\/journal.pone.0216384","journal-title":"PLoS One"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25384","article-title":"Evaluation of the antiviral potential of the soluble forms of glycoprotein D receptors on ocular herpes caused by HSV-1 and HSV-2 infections in a transgenic mouse model","volume":"91","author":"Fujimoto Y","year":"2019","unstructured":"Fujimoto Y, Hikita SI, Takeda K, et al.. Evaluation of the antiviral potential of the soluble forms of glycoprotein D receptors on ocular herpes caused by HSV-1 and HSV-2 infections in a transgenic mouse model. J Med Virol. 2019, 91:820-8. 10.1002\/jmv.25384","journal-title":"J Med Virol"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.07.084","article-title":"Botryosphaeran and sulfonated derivatives as novel antiviral agents for herpes simplex and dengue fever","volume":"138","author":"Sacchelli BA","year":"2019","unstructured":"Sacchelli BA, Faccin-Galhardi LC, Ito VY, Lopes JL, Dekker RF, Barbosa-Dekker AM, Orsato A. Botryosphaeran and sulfonated derivatives as novel antiviral agents for herpes simplex and dengue fever. Int J Biol Macromol. 2019, 138:334-9. 10.1016\/j.ijbiomac.2019.07.084","journal-title":"Int J Biol Macromol"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109359","article-title":"Assessment of a new arbidol derivative against herpes simplex virus II in human cervical epithelial cells and in BALB\/c mice","volume":"118","author":"Ma N","year":"2019","unstructured":"Ma N, Shen M, Chen T, et al.. Assessment of a new arbidol derivative against herpes simplex virus II in human cervical epithelial cells and in BALB\/c mice. Biomed Pharmacother. 2019, 118:109359. 10.1016\/j.biopha.2019.109359","journal-title":"Biomed Pharmacother"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13458","article-title":"Enzymatic synthesis of novel purine nucleosides bearing a chiral benzoxazine fragment","volume":"93","author":"Eletskaya BZ","year":"2019","unstructured":"Eletskaya BZ, Gruzdev DA, Krasnov VP, et al.. Enzymatic synthesis of novel purine nucleosides bearing a chiral benzoxazine fragment. Chem Biol Drug Des. 2019, 93:605-16. 10.1111\/cbdd.13458","journal-title":"Chem Biol Drug Des"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2019.104598","article-title":"Cellular signaling analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation","volume":"171","author":"Ding X","year":"2019","unstructured":"Ding X, Krutzik PO, Ghaffari AA, et al.. Cellular signaling analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation. Antiviral Res. 2019, 171:104598. 10.1016\/j.antiviral.2019.104598","journal-title":"Antiviral Res"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2019.05.006","article-title":"Amidic derivatives of valproic acid, valpromide and valnoctamide, inhibit HSV-1 infection in oligodendrocytes","volume":"168","author":"Praena B","year":"2019","unstructured":"Praena B, Bello-Morales R, de Castro F, L\u00f3pez-Guerrero JA. Amidic derivatives of valproic acid, valpromide and valnoctamide, inhibit HSV-1 infection in oligodendrocytes. Antiviral Res. 2019, 168:91-9. 10.1016\/j.antiviral.2019.05.006","journal-title":"Antiviral Res"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1134\/S0026898419010051","article-title":"A Plasmid-Expressed CRISPR\/Cas9 System Suppresses Replication of HSV Type I in a Vero Cell Culture (Article in Russian)","volume":"53","author":"Karpov DS","year":"2019","unstructured":"Karpov DS, Karpov VL, Klimova RR, Demidova NA, Kushch AA. A Plasmid-Expressed CRISPR\/Cas9 System Suppresses Replication of HSV Type I in a Vero Cell Culture (Article in Russian). Mol Biol (Mosk). 2019, 53:91-100. 10.1134\/S0026898419010051","journal-title":"Mol Biol (Mosk)"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2018.04.013","article-title":"pH-responsive delivery of Griffithsin from electrospun fibers","volume":"138","author":"Tyo KM","year":"2019","unstructured":"Tyo KM, Duan J, Kollipara P, Dela Cerna MV, Lee D, Palmer KE, Steinbach-Rankins JM. pH-responsive delivery of Griffithsin from electrospun fibers. Eur J Pharm Biopharm. 2019, 138:64-74. 10.1016\/j.ejpb.2018.04.013","journal-title":"Eur J Pharm Biopharm"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.09.043","article-title":"The antiviral activity of arbidol hydrochloride against herpes simplex virus type II (HSV-2) in a mouse model of vaginitis","volume":"68","author":"Du Q","year":"2019","unstructured":"Du Q, Gu Z, Leneva I, Jiang H, Li R, Deng L, Yang Z. The antiviral activity of arbidol hydrochloride against herpes simplex virus type II (HSV-2) in a mouse model of vaginitis. Int Immunopharmacol. 2019, 68:58-67. 10.1016\/j.intimp.2018.09.043","journal-title":"Int Immunopharmacol"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00619-19","article-title":"Discovery of small-molecule inhibitors targeting the E3 ubiquitin ligase activity of the herpes simplex virus 1 ICP0 protein using an in vitro high-throughput screening assay","volume":"93","author":"Deschamps T","year":"2019","unstructured":"Deschamps T, Waisner H, Dogrammatzis C, et al.. Discovery of small-molecule inhibitors targeting the E3 ubiquitin ligase activity of the herpes simplex virus 1 ICP0 protein using an in vitro high-throughput screening assay. J Virol. 2019, 93:10.1128\/JVI.00619-19","journal-title":"J Virol"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00732-19","article-title":"Early steps in herpes simplex virus infection blocked by a proteasome inhibitor","volume":"10","author":"Schneider SM","year":"2019","unstructured":"Schneider SM, Pritchard SM, Wudiri GA, Trammell CE, Nicola AV. Early steps in herpes simplex virus infection blocked by a proteasome inhibitor. mBio. 2019, 10:10.1128\/mBio.00732-19","journal-title":"mBio"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2019.05.012","article-title":"UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients","volume":"168","author":"Labrunie T","year":"2019","unstructured":"Labrunie T, Ducastelle S, Domenech C, Ader F, Morfin F, Frobert E. UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients. Antiviral Res. 2019, 168:114-20. 10.1016\/j.antiviral.2019.05.012","journal-title":"Antiviral Res"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112296","article-title":"Multiple In vitro biological effects of phenolic compounds from Morus alba root bark","volume":"248","author":"\u010culenov\u00e1 M","year":"2020","unstructured":"\u010culenov\u00e1 M, Sychrov\u00e1 A, Hassan ST, et al.. Multiple In vitro biological effects of phenolic compounds from Morus alba root bark. J Ethnopharmacol. 2020, 248:112296. 10.1016\/j.jep.2019.112296","journal-title":"J Ethnopharmacol"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-019-1639-8","article-title":"Antiviral activity of mitoxantrone dihydrochloride against human herpes simplex virus mediated by suppression of the viral immediate early genes","volume":"19","author":"Huang Q","year":"2019","unstructured":"Huang Q, Hou J, Yang P, et al.. Antiviral activity of mitoxantrone dihydrochloride against human herpes simplex virus mediated by suppression of the viral immediate early genes. BMC Microbiol. 2019, 19:274. 10.1186\/s12866-019-1639-8","journal-title":"BMC Microbiol"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76151-w","article-title":"Anti-herpes virus activity of the carnivorous botanical, Sarracenia purpurea","volume":"10","author":"Kannan L","year":"2020","unstructured":"Kannan L, Kumar A, Kumar A, Jacobs B, Langland J. Anti-herpes virus activity of the carnivorous botanical, Sarracenia purpurea. Sci Rep. 2020, 10:18953. 10.1038\/s41598-020-76151-w","journal-title":"Sci Rep"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8562309","article-title":"Efficacy of pleuran (\u03b2-glucan from Pleurotus ostreatus) in the management of herpes simplex virus type 1 infection","volume":"2020","author":"Urbancikova I","year":"2020","unstructured":"Urbancikova I, Hudackova D, Majtan J, Rennerova Z, Banovcin P, Jesenak M. Efficacy of pleuran (\u03b2-glucan from Pleurotus ostreatus) in the management of herpes simplex virus type 1 infection. Evid Based Complement Alternat Med. 2020, 2020:8562309. 10.1155\/2020\/8562309","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000260","article-title":"Synthesis of antiviral perfluoroalkyl derivatives of teicoplanin and vancomycin","volume":"15","author":"Bereczki I","year":"2020","unstructured":"Bereczki I, Cs\u00e1v\u00e1s M, Sz\u0171cs Z, et al.. Synthesis of antiviral perfluoroalkyl derivatives of teicoplanin and vancomycin. ChemMedChem. 2020, 15:1661-71. 10.1002\/cmdc.202000260","journal-title":"ChemMedChem"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.601555","article-title":"A novel, broad-acting peptide inhibitor of double-stranded dna virus gene expression and replication","volume":"11","author":"Ruzsics Z","year":"2020","unstructured":"Ruzsics Z, Hoffmann K, Riedl A, et al.. A novel, broad-acting peptide inhibitor of double-stranded dna virus gene expression and replication. Front Microbiol. 2020, 11:601555. 10.3389\/fmicb.2020.601555","journal-title":"Front Microbiol"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1055\/a-1087-8303","article-title":"Antiviral activity of a Arisaema tortuosum leaf extract and some of its constituents against herpes simplex virus type 2","volume":"86","author":"Ritt\u00e0 M","year":"2020","unstructured":"Ritt\u00e0 M, Marengo A, Civra A, et al.. Antiviral activity of a Arisaema tortuosum leaf extract and some of its constituents against herpes simplex virus type 2. Planta Med. 2020, 86:267-75. 10.1055\/a-1087-8303","journal-title":"Planta Med"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3315","article-title":"Perillyl alcohol and perillic acid exert efficient action upon HSV-1 maturation and release of infective virus","volume":"25","author":"Mello CP","year":"2020","unstructured":"Mello CP, Quirico-Santos T, Amorim LF, Silva VG, Fragel LM, Bloom DC, Paix\u00e3o IP. Perillyl alcohol and perillic acid exert efficient action upon HSV-1 maturation and release of infective virus. Antivir Ther. 2020, 25:1-11. 10.3851\/IMP3315","journal-title":"Antivir Ther"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax9318","article-title":"Modified cyclodextrins as broad-spectrum antivirals","volume":"6","author":"Jones ST","year":"2020","unstructured":"Jones ST, Cagno V, Jane\u010dek M, et al.. Modified cyclodextrins as broad-spectrum antivirals. Sci Adv. 2020, 6:eaax9318. 10.1126\/sciadv.aax9318","journal-title":"Sci Adv"},{"key":"ref94","article-title":"Evaluation of the effect of hydro alcoholic extract of cinnamon on herpes simplex virus-1","volume":"17","author":"Moshaverinia M","year":"2020","unstructured":"Moshaverinia M, Rastegarfar M, Moattari A, Lavaee F. Evaluation of the effect of hydro alcoholic extract of cinnamon on herpes simplex virus-1. Dent Res J (Isfahan). 2020, 17:114-9.","journal-title":"Dent Res J (Isfahan)"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104754","article-title":"Acyclovir, cidofovir, and amenamevir have additive antiviral effects on herpes simplex virus type 1","volume":"176","author":"Greeley ZW","year":"2020","unstructured":"Greeley ZW, Giannasca NJ, Porter MJ, Margulies BJ. Acyclovir, cidofovir, and amenamevir have additive antiviral effects on herpes simplex virus type 1. Antiviral Res. 2020, 176:104754. 10.1016\/j.antiviral.2020.104754","journal-title":"Antiviral Res"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3387","article-title":"Antiviral activity of 1,4-disubstituted-1,2,3-triazoles against HSV-1 in vitro","author":"Viegas DJ","year":"2020","unstructured":"Antiviral activity of 1,4-disubstituted-1,2,3-triazoles against HSV-1 in vitro. 2020, 25.399-410. 10.3851\/IMP3387"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.10.003","article-title":"Anti-HSV-1 effect of dihydromyricetin from Ampelopsis grossedentata via the TLR9-dependent anti-inflammatory pathway","volume":"23","author":"Zhou HY","year":"2020","unstructured":"Zhou HY, Gao SQ, Gong YS, et al.. Anti-HSV-1 effect of dihydromyricetin from Ampelopsis grossedentata via the TLR9-dependent anti-inflammatory pathway. J Glob Antimicrob Resist. 2020, 23:370-6. 10.1016\/j.jgar.2020.10.003","journal-title":"J Glob Antimicrob Resist"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.3390\/v12121434","article-title":"Herpes simplex virus type 1 clinical isolates respond to UL29-targeted siRNA swarm treatment independent of their acyclovir sensitivity","volume":"12","author":"Kalke K","year":"2020","unstructured":"Kalke K, Lehtinen J, Gnjatovic J, et al.. Herpes simplex virus type 1 clinical isolates respond to UL29-targeted siRNA swarm treatment independent of their acyclovir sensitivity. Viruses. 2020, 12:10.3390\/v12121434","journal-title":"Viruses"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63438-1","article-title":"MG132 exerts anti-viral activity against HSV-1 by overcoming virus-mediated suppression of the ERK signaling pathway","volume":"10","author":"Ishimaru H","year":"2020","unstructured":"Ishimaru H, Hosokawa K, Sugimoto A, Tanaka R, Watanabe T, Fujimuro M. MG132 exerts anti-viral activity against HSV-1 by overcoming virus-mediated suppression of the ERK signaling pathway. Sci Rep. 2020, 10:6671. 10.1038\/s41598-020-63438-1","journal-title":"Sci Rep"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00245-20","article-title":"In vitro and in vivo activity, tolerability, and mechanism of action of BX795 as an antiviral against herpes simplex virus 2 genital infection","volume":"64","author":"Hopkins J","year":"2020","unstructured":"Hopkins J, Yadavalli T, Suryawanshi R, et al.. In vitro and in vivo activity, tolerability, and mechanism of action of BX795 as an antiviral against herpes simplex virus 2 genital infection. Antimicrob Agents Chemother. 2020, 64:10.1128\/AAC.00245-20","journal-title":"Antimicrob Agents Chemother"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9110756","article-title":"Novel antiviral and antibacterial activities of Hibiscus schizopetalus","volume":"9","author":"El-Shiekh RA","year":"2020","unstructured":"El-Shiekh RA, Abdelmohsen UR, Ashour HM, Ashour RM. Novel antiviral and antibacterial activities of Hibiscus schizopetalus. Antibiotics (Basel). 2020, 9:10.3390\/antibiotics9110756","journal-title":"Antibiotics (Basel)"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173782","article-title":"T-type calcium channels blockers inhibit HSV-2 infection at the late stage of genome replication","volume":"892","author":"Ding L","year":"2021","unstructured":"Ding L, Jiang P, Xu X, et al.. T-type calcium channels blockers inhibit HSV-2 infection at the late stage of genome replication. Eur J Pharmacol. 2021, 892:173782. 10.1016\/j.ejphar.2020.173782","journal-title":"Eur J Pharmacol"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X21500099","article-title":"Mori ramulus and its major component morusin inhibit herpes simplex virus type 1 replication and the virus-induced reactive oxygen species","volume":"49","author":"Kim TI","year":"2021","unstructured":"Kim TI, Kwon EB, Oh YC, Go Y, Choi JG. Mori ramulus and its major component morusin inhibit herpes simplex virus type 1 replication and the virus-induced reactive oxygen species. Am J Chin Med. 2021, 49:163-79. 10.1142\/S0192415X21500099","journal-title":"Am J Chin Med"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104818","article-title":"Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts","volume":"179","author":"Alvarez DM","year":"2020","unstructured":"Alvarez DM, Duarte LF, Corrales N, Smith PC, Gonz\u00e1lez PA. Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts. Antiviral Res. 2020, 179:104818. 10.1016\/j.antiviral.2020.104818","journal-title":"Antiviral Res"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1908.08047","article-title":"Inhibition of herpes simplex viruses, types 1 and 2, by ginsenoside 20(S)-Rg3","volume":"30","author":"Wright S","year":"2020","unstructured":"Wright S, Altman E. Inhibition of herpes simplex viruses, types 1 and 2, by ginsenoside 20(S)-Rg3. J Microbiol Biotechnol. 2020, 30:101-8. 10.4014\/jmb.1908.08047","journal-title":"J Microbiol Biotechnol"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115304","article-title":"Mangiferin: a promising natural xanthone from Mangifera indica for the control of acyclovir - resistant herpes simplex virus 1 infection","volume":"28","author":"Rechenchoski DZ","year":"2020","unstructured":"Rechenchoski DZ, Agostinho KF, Faccin-Galhardi LC, et al.. Mangiferin: a promising natural xanthone from Mangifera indica for the control of acyclovir - resistant herpes simplex virus 1 infection. Bioorg Med Chem. 2020, 28:115304. 10.1016\/j.bmc.2020.115304","journal-title":"Bioorg Med Chem"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-020-01315-z","article-title":"Anti-HSV-1 activity of aspergillipeptide D, a cyclic pentapepetide isolated from fungus Aspergillus sp. SCSIO 41501","volume":"17","author":"Wang Z","year":"2020","unstructured":"Wang Z, Jia J, Wang L, et al.. Anti-HSV-1 activity of aspergillipeptide D, a cyclic pentapepetide isolated from fungus Aspergillus sp. SCSIO 41501. Virol J. 2020, 17:41. 10.1186\/s12985-020-01315-z","journal-title":"Virol J"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14918","article-title":"Guanidine modifications enhance the anti-herpes simplex virus activity of (E,E)-4,6-bis(styryl)-pyrimidine derivatives in vitro and in vivo","volume":"177","author":"Wang W","year":"2020","unstructured":"Wang W, Xu C, Zhang J, et al.. Guanidine modifications enhance the anti-herpes simplex virus activity of (E,E)-4,6-bis(styryl)-pyrimidine derivatives in vitro and in vivo. Br J Pharmacol. 2020, 177:1568-88. 10.1111\/bph.14918","journal-title":"Br J Pharmacol"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00251-20","article-title":"Bacterial pigment prodigiosin demonstrates a unique antiherpesvirus activity that is mediated through inhibition of prosurvival signal transducers","volume":"94","author":"Suryawanshi RK","year":"2020","unstructured":"Suryawanshi RK, Koujah L, Patil CD, et al.. Bacterial pigment prodigiosin demonstrates a unique antiherpesvirus activity that is mediated through inhibition of prosurvival signal transducers. J Virol. 2020, 94:10.1128\/JVI.00251-20","journal-title":"J Virol"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.02006","article-title":"Anti-herpetic activity of Macrocystis pyrifera and Durvillaea antarctica algae extracts against HSV-1 and HSV-2","volume":"11","author":"Castillo E","year":"2020","unstructured":"Castillo E, Duarte LF, Corrales N, et al.. Anti-herpetic activity of Macrocystis pyrifera and Durvillaea antarctica algae extracts against HSV-1 and HSV-2. Front Microbiol. 2020, 11:2006. 10.3389\/fmicb.2020.02006","journal-title":"Front Microbiol"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26102988","article-title":"Synthesis and evaluation of some uracil nucleosides as promising anti-herpes simplex virus 1 agents","volume":"26","author":"Awad SM","year":"2021","unstructured":"Awad SM, Ali SM, Mansour YE, Fatahala SS. Synthesis and evaluation of some uracil nucleosides as promising anti-herpes simplex virus 1 agents. Molecules. 2021, 26:10.3390\/molecules26102988","journal-title":"Molecules"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.00473-21","article-title":"Targeting aryl hydrocarbon receptor signaling enhances type i interferon-independent resistance to herpes simplex virus","volume":"9","author":"Chen J","year":"2021","unstructured":"Chen J, Liang J, Xu H, et al.. Targeting aryl hydrocarbon receptor signaling enhances type i interferon-independent resistance to herpes simplex virus. Microbiol Spectr. 2021, 9:e0047321. 10.1128\/Spectrum.00473-21","journal-title":"Microbiol Spectr"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-020-02316-5","article-title":"Study of the extremely-tolerant brevibacterium linens AE038-8 with antiviral activity against herpes simplex virus type 1","volume":"78","author":"Maizel D","year":"2021","unstructured":"Maizel D, Salinas FM, Sol\u00f3rzano I, Raiger Iustman L, Ferrero MA, Mauas PJ, Alch\u00e9 LE. Study of the extremely-tolerant brevibacterium linens AE038-8 with antiviral activity against herpes simplex virus type 1. Curr Microbiol. 2021, 78:688-95. 10.1007\/s00284-020-02316-5","journal-title":"Curr Microbiol"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1159\/000512956","article-title":"Cellular miR-101-1 reduces efficiently the replication of HSV-1 in HeLa cells","volume":"64","author":"Sadegh Ehdaei B","year":"2021","unstructured":"Sadegh Ehdaei B, Pirouzmand A, Shabani M, Mirzaei A, Moghim S. Cellular miR-101-1 reduces efficiently the replication of HSV-1 in HeLa cells. Intervirology. 2021, 64:88-95. 10.1159\/000512956","journal-title":"Intervirology"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.4149\/av_2021_302","article-title":"Lupeol impairs herpes simplex virus type 1 replication by inhibiting the promoter activity of the viral immediate early gene \u03b10","volume":"65","author":"Ye J","year":"2021","unstructured":"Ye J, Wang Z, Jia J, et al.. Lupeol impairs herpes simplex virus type 1 replication by inhibiting the promoter activity of the viral immediate early gene \u03b10. Acta Virol. 2021, 65:254-63. 10.4149\/av_2021_302","journal-title":"Acta Virol"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.722748","article-title":"Harringtonine inhibits herpes simplex virus type 1 infection by reducing herpes virus entry mediator expression","volume":"12","author":"Liu Y","year":"2021","unstructured":"Liu Y, You Q, Zhang F, Chen D, Huang Z, Wu Z. Harringtonine inhibits herpes simplex virus type 1 infection by reducing herpes virus entry mediator expression. Front Microbiol. 2021, 12:722748. 10.3389\/fmicb.2021.722748","journal-title":"Front Microbiol"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b21-00054","article-title":"NSC23766 and Ehop016 suppress herpes simplex virus-1 replication by inhibiting Rac1 activity","volume":"44","author":"Zhang F","year":"2021","unstructured":"Zhang F, Liu Y, You Q, et al.. NSC23766 and Ehop016 suppress herpes simplex virus-1 replication by inhibiting Rac1 activity. Biol Pharm Bull. 2021, 44:1263-71. 10.1248\/bpb.b21-00054","journal-title":"Biol Pharm Bull"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26164927","article-title":"Synthesis and biological evaluation of amidinourea derivatives against herpes simplex viruses","volume":"26","author":"Toscani A","year":"2021","unstructured":"Toscani A, Denaro R, Pacheco SF, Biolatti M, Anselmi S, Dell'Oste V, Castagnolo D. Synthesis and biological evaluation of amidinourea derivatives against herpes simplex viruses. Molecules. 2021, 26:10.3390\/molecules26164927","journal-title":"Molecules"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1016\/j.explore.2021.01.003","article-title":"The efficacy of olive leaf extract on healing herpes simplex virus labialis: a randomized double-blind study","volume":"18","author":"Toulabi T","year":"2022","unstructured":"Toulabi T, Delfan B, Rashidipour M, Yarahmadi S, Ravanshad F, Javanbakht A, Almasian M. The efficacy of olive leaf extract on healing herpes simplex virus labialis: a randomized double-blind study. Explore (NY). 2022, 18:287-92. 10.1016\/j.explore.2021.01.003","journal-title":"Explore (NY)"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.3390\/v13010086","article-title":"Ginkgolic acid inhibits herpes simplex virus type 1 skin infection and prevents zosteriform spread in mice","volume":"13","author":"Bhutta MS","year":"2021","unstructured":"Bhutta MS, Shechter O, Gallo ES, Martin SD, Jones E, Doncel GF, Borenstein R. Ginkgolic acid inhibits herpes simplex virus type 1 skin infection and prevents zosteriform spread in mice. Viruses. 2021, 13:10.3390\/v13010086","journal-title":"Viruses"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.3390\/v13081547","article-title":"Amenamevir, a helicase-primase inhibitor, for the optimal treatment of herpes zoster","volume":"13","author":"Shiraki K","year":"2021","unstructured":"Shiraki K, Yasumoto S, Toyama N, Fukuda H. Amenamevir, a helicase-primase inhibitor, for the optimal treatment of herpes zoster. Viruses. 2021, 13:10.3390\/v13081547","journal-title":"Viruses"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9020434","article-title":"In vitro analysis of the antioxidant and antiviral activity of embelin against herpes simplex virus-1","volume":"9","author":"Elias T","year":"2021","unstructured":"Elias T, Lee LH, Rossi M, Caruso F, Adams SD. In vitro analysis of the antioxidant and antiviral activity of embelin against herpes simplex virus-1. Microorganisms. 2021, 9:10.3390\/microorganisms9020434","journal-title":"Microorganisms"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnab013","article-title":"Cucumis melo pectin as potential candidate to control herpes simplex virus infection","volume":"368","author":"Agostinho KF","year":"2021","unstructured":"Agostinho KF, Rechenchoski DZ, Faccin-Galhardi LC, et al.. Cucumis melo pectin as potential candidate to control herpes simplex virus infection. FEMS Microbiol Lett. 2021, 368:10.1093\/femsle\/fnab013","journal-title":"FEMS Microbiol Lett"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.598884","article-title":"Poly(dA:dT) suppresses HSV-2 infection of human cervical epithelial cells through RIG-I activation","volume":"11","author":"Shao DD","year":"2020","unstructured":"Shao DD, Meng FZ, Liu Y, et al.. Poly(dA:dT) suppresses HSV-2 infection of human cervical epithelial cells through RIG-I activation. Front Immunol. 2020, 11:598884. 10.3389\/fimmu.2020.598884","journal-title":"Front Immunol"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.3390\/v13061085","article-title":"Phytochemical characterization of Olea europea leaf extracts and assessment of their anti-microbial and anti-HSV-1 activity","volume":"13","author":"Ben-Amor I","year":"2021","unstructured":"Ben-Amor I, Musarra-Pizzo M, Smeriglio A, et al.. Phytochemical characterization of Olea europea leaf extracts and assessment of their anti-microbial and anti-HSV-1 activity. Viruses. 2021, 13:10.3390\/v13061085","journal-title":"Viruses"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1007\/s42770-021-00612-1","article-title":"In vitro effects of bufotenine against RNA and DNA viruses","volume":"52","author":"Barboza CM","year":"2021","unstructured":"Barboza CM, Pimenta DC, Vigerelli H, et al.. In vitro effects of bufotenine against RNA and DNA viruses. Braz J Microbiol. 2021, 52:2475-82. 10.1007\/s42770-021-00612-1","journal-title":"Braz J Microbiol"},{"key":"ref127","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10101638","article-title":"Quercus acuta Thunb. (Fagaceae) and its component, isoquercitrin, inhibit HSV-1 replication by suppressing virus-induced ROS production and NF-\u03baB activation","volume":"10","author":"Kim B","year":"2021","unstructured":"Kim B, Kim YS, Hwang YH, et al.. Quercus acuta Thunb. (Fagaceae) and its component, isoquercitrin, inhibit HSV-1 replication by suppressing virus-induced ROS production and NF-\u03baB activation. Antioxidants (Basel). 2021, 10:10.3390\/antiox10101638","journal-title":"Antioxidants (Basel)"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011013","article-title":"Sulfonated and carboxymethylated \u03b2-glucan derivatives with inhibitory activity against herpes and dengue viruses","volume":"22","author":"Lopes JL","year":"2021","unstructured":"Lopes JL, Quinteiro VS, Wouk J, et al.. Sulfonated and carboxymethylated \u03b2-glucan derivatives with inhibitory activity against herpes and dengue viruses. Int J Mol Sci. 2021, 22:10.3390\/ijms222011013","journal-title":"Int J Mol Sci"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2021.105057","article-title":"Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication","volume":"189","author":"Luganini A","year":"2021","unstructured":"Luganini A, Sibille G, Mognetti B, et al.. Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication. Antiviral Res. 2021, 189:105057. 10.1016\/j.antiviral.2021.105057","journal-title":"Antiviral Res"},{"key":"ref130","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.689607","article-title":"Viral UL8 is involved in the antiviral activity of oleanolic acid against HSV-1 infection","volume":"12","author":"Shan T","year":"2021","unstructured":"Shan T, Ye J, Jia J, et al.. Viral UL8 is involved in the antiviral activity of oleanolic acid against HSV-1 infection. Front Microbiol. 2021, 12:689607. 10.3389\/fmicb.2021.689607","journal-title":"Front Microbiol"},{"key":"ref131","doi-asserted-by":"publisher","DOI":"10.3390\/biology10080746","article-title":"Antiviral activity of Rosa damascena Mill. and Rosa alba L. essential oils against the multiplication of herpes simplex virus type 1 strains sensitive and resistant to acyclovir","volume":"10","author":"Vilhelmova-Ilieva N","year":"2021","unstructured":"Vilhelmova-Ilieva N, Dobreva A, Doynovska R, Krastev D, Mileva M. Antiviral activity of Rosa damascena Mill. and Rosa alba L. essential oils against the multiplication of herpes simplex virus type 1 strains sensitive and resistant to acyclovir. Biology (Basel). 2021, 10:10.3390\/biology10080746","journal-title":"Biology (Basel)"},{"key":"ref132","doi-asserted-by":"publisher","DOI":"10.47176\/mjiri.35.9","article-title":"Inhibition of herpes simplex virus type 1 infection by Sambucus ebulus extract in vitro","volume":"35","author":"Ghaffari H","year":"2021","unstructured":"Ghaffari H, Ataei-Pirkooh A, Mirghazanfari SM, Barati M. Inhibition of herpes simplex virus type 1 infection by Sambucus ebulus extract in vitro. Med J Islam Repub Iran. 2021, 35:9. 10.47176\/mjiri.35.9","journal-title":"Med J Islam Repub Iran"},{"key":"ref133","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-021-01581-5","article-title":"Inhibition of herpes simplex virus-1 infection by MBZM-N-IBT: in silico and in vitro studies","volume":"18","author":"Kumar A","year":"2021","unstructured":"Kumar A, De S, Moharana AK, et al.. Inhibition of herpes simplex virus-1 infection by MBZM-N-IBT: in silico and in vitro studies. Virol J. 2021, 18:103. 10.1186\/s12985-021-01581-5","journal-title":"Virol J"},{"key":"ref134","doi-asserted-by":"publisher","DOI":"10.3390\/v13081422","article-title":"Peptide inhibitor of complement C1, RLS-0071, reduces zosteriform spread of herpes simplex virus type 1 skin infection and promotes survival in infected mice","volume":"13","author":"Bhutta MS","year":"2021","unstructured":"Bhutta MS, Sausen DG, Reed KM, et al.. Peptide inhibitor of complement C1, RLS-0071, reduces zosteriform spread of herpes simplex virus type 1 skin infection and promotes survival in infected mice. Viruses. 2021, 13:10.3390\/v13081422","journal-title":"Viruses"},{"key":"ref135","doi-asserted-by":"publisher","DOI":"10.3390\/biom11050745","article-title":"Antimicrobial activity of cyclic-monomeric and dimeric derivatives of the snail-derived peptide Cm-p5 against viral and multidrug-resistant bacterial strains","volume":"11","author":"Gonz\u00e1lez-Garc\u00eda M","year":"2021","unstructured":"Gonz\u00e1lez-Garc\u00eda M, Morales-Vicente F, Pico ED, et al.. Antimicrobial activity of cyclic-monomeric and dimeric derivatives of the snail-derived peptide Cm-p5 against viral and multidrug-resistant bacterial strains. Biomolecules. 2021, 11:10.3390\/biom11050745","journal-title":"Biomolecules"},{"key":"ref136","doi-asserted-by":"publisher","DOI":"10.3390\/v13091685","article-title":"The molecular tweezer CLR01 inhibits antibody-resistant cell-to-cell spread of human cytomegalovirus","volume":"13","author":"Brenner S","year":"2021","unstructured":"Brenner S, Braun B, Read C, et al.. The molecular tweezer CLR01 inhibits antibody-resistant cell-to-cell spread of human cytomegalovirus. Viruses. 2021, 13:10.3390\/v13091685","journal-title":"Viruses"},{"key":"ref137","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2021.105190","article-title":"Helicase primase inhibitors (HPIs) are efficacious for therapy of human herpes simplex virus (HSV) disease in an infection mouse model","volume":"195","author":"Uhlig N","year":"2021","unstructured":"Uhlig N, Donner AK, Gege C, Lange F, Kleymann G, Grunwald T. Helicase primase inhibitors (HPIs) are efficacious for therapy of human herpes simplex virus (HSV) disease in an infection mouse model. Antiviral Res. 2021, 195:105190. 10.1016\/j.antiviral.2021.105190","journal-title":"Antiviral Res"},{"key":"ref138","doi-asserted-by":"publisher","DOI":"10.3390\/v10070360","article-title":"Anti-infectivity against herpes simplex virus and selected microbes and anti-inflammatory activities of compounds isolated from Eucalyptus globulus Labill","volume":"10","author":"Brez\u00e1ni V","year":"2018","unstructured":"Brez\u00e1ni V, Lel\u00e1kov\u00e1 V, Hassan ST, et al.. Anti-infectivity against herpes simplex virus and selected microbes and anti-inflammatory activities of compounds isolated from Eucalyptus globulus Labill. Viruses. 2018, 10:10.3390\/v10070360","journal-title":"Viruses"},{"key":"ref139","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00295-18","article-title":"Varicella-zoster virus orf9p binding to cellular adaptor protein complex 1 is important for viral infectivity","volume":"92","author":"Lebrun M","year":"2018","unstructured":"Lebrun M, Lambert J, Riva L, et al.. Varicella-zoster virus orf9p binding to cellular adaptor protein complex 1 is important for viral infectivity. J Virol. 2018, 92:10.1128\/JVI.00295-18","journal-title":"J Virol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/139444-a-systematic-review-of-second-line-treatments-in-antiviral-resistant-strains-of-hsv-1-hsv-2-and-vzv","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:50:52Z","timestamp":1707508252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/139444-a-systematic-review-of-second-line-treatments-in-antiviral-resistant-strains-of-hsv-1-hsv-2-and-vzv"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,9]]},"references-count":139,"URL":"https:\/\/doi.org\/10.7759\/cureus.35958","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,9]]}}}