{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:22:08Z","timestamp":1784758928727,"version":"3.55.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,10]]},"DOI":"10.7759\/cureus.35979","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T15:34:31Z","timestamp":1678462471000},"source":"Crossref","is-referenced-by-count":2,"title":["Multiple Brown Tumors in Primary Hyperparathyroidism Causing Pathological Fracture: A Case Report of a 21-Year-Old Adult Male"],"prefix":"10.7759","author":[{"given":"Sultan","family":"Aldosari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham A","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Alragea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2012.03.006","article-title":"Pathology of the parathyroid glands","volume":"18","author":"van der Walt J","year":"2012","unstructured":"van der Walt J. Pathology of the parathyroid glands. Diagn Histopathol. 2012, 18:221-33. 10.1016\/j.mpdhp.2012.03.006","journal-title":"Diagn Histopathol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.k05-175","article-title":"Multiple brown tumors in primary hyperparathyroidism caused by an adenoma mimicking metastatic bone disease with false positive results on computed tomography and Tc-99m sestamibi imaging: MR findings","volume":"54","author":"Miyakoshi M","year":"2007","unstructured":"Miyakoshi M, Kamoi K, Takano T, et al.. Multiple brown tumors in primary hyperparathyroidism caused by an adenoma mimicking metastatic bone disease with false positive results on computed tomography and Tc-99m sestamibi imaging: MR findings. Endocr J. 2007, 54:205-10. 10.1507\/endocrj.k05-175","journal-title":"Endocr J"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4081\/cp.2012.e48","article-title":"Primary hyperparathyroidism with rare presentation as multiple brown tumours","volume":"2","author":"Doshi S","year":"2012","unstructured":"Doshi S, Vadi A, Mahajan A, Nagpal T. Primary hyperparathyroidism with rare presentation as multiple brown tumours. Clin Pract. 2012, 2:e48. 10.4081\/cp.2012.e48","journal-title":"Clin Pract"},{"key":"ref4","article-title":"Ectopic intrathyroid parathyroid adenoma: diagnostic and therapeutic challenges due to multiple osteolytic lesions. Case report","volume":"13","author":"Silaghi H","year":"2011","unstructured":"Silaghi H, Valea A, Ghervan C, Silaghi AC. Ectopic intrathyroid parathyroid adenoma: diagnostic and therapeutic challenges due to multiple osteolytic lesions. Case report. Med Ultrason. 2011, 13:241-4.","journal-title":"Med Ultrason"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-018-1723-y","article-title":"Osteolytic lesions (brown tumors) of primary hyperparathyroidism misdiagnosed as multifocal giant cell tumor of the distal ulna and radius: a case report","volume":"12","author":"Panagopoulos A","year":"2018","unstructured":"Panagopoulos A, Tatani I, Kourea HP, Kokkalis ZT, Panagopoulos K, Megas P. Osteolytic lesions (brown tumors) of primary hyperparathyroidism misdiagnosed as multifocal giant cell tumor of the distal ulna and radius: a case report. J Med Case Rep. 2018, 12:176. 10.1186\/s13256-018-1723-y","journal-title":"J Med Case Rep"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0528","article-title":"Hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literature","volume":"168","author":"Witteveen JE","year":"2013","unstructured":"Witteveen JE, van Thiel S, Romijn JA, Hamdy NA. Hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literature. Eur J Endocrinol. 2013, 168:R45-53. 10.1530\/EJE-12-0528","journal-title":"Eur J Endocrinol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1726-4901(10)70035-6","article-title":"Primary hyperparathyroidism with brown tumor mimicking metastatic bone malignancy","volume":"73","author":"Su AW","year":"2010","unstructured":"Su AW, Chen CF, Huang CK, Chen PC, Chen WM, Chen TH. Primary hyperparathyroidism with brown tumor mimicking metastatic bone malignancy. J Chin Med Assoc. 2010, 73:177-80. 10.1016\/S1726-4901(10)70035-6","journal-title":"J Chin Med Assoc"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-012-0364-2","article-title":"A case of multiple brown tumors with primary hyperparathyroidism","volume":"31","author":"Mori H","year":"2013","unstructured":"Mori H, Okada Y, Arao T, Shimaziri S, Tanaka Y. A case of multiple brown tumors with primary hyperparathyroidism. J Bone Miner Metab. 2013, 31:123-7. 10.1007\/s00774-012-0364-2","journal-title":"J Bone Miner Metab"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2011.09.005","article-title":"Brown tumour presenting as a soft-tissue mass","volume":"67","author":"Ergen FB","year":"2012","unstructured":"Ergen FB, Ayvaz M, Yildiz AE, Aydingoz U, Gedikoglu G. Brown tumour presenting as a soft-tissue mass. Clin Radiol. 2012, 67:286-9. 10.1016\/j.crad.2011.09.005","journal-title":"Clin Radiol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5371\/hp.2018.30.2.120","article-title":"Subchondral bone restoration of supra-acetabular brown tumor secondary to parathyroid carcinoma: a case report","volume":"30","author":"Park YJ","year":"2018","unstructured":"Park YJ, Yoon TR, Park KS, Ko JW. Subchondral bone restoration of supra-acetabular brown tumor secondary to parathyroid carcinoma: a case report. Hip Pelvis. 2018, 30:120-4. 10.5371\/hp.2018.30.2.120","journal-title":"Hip Pelvis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-007-0312-0","article-title":"A case of multiple skeletal lesions of brown tumors, mimicking carcinoma metastases","volume":"128","author":"Hoshi M","year":"2008","unstructured":"Hoshi M, Takami M, Kajikawa M, Teramura K, Okamoto T, Yanagida I, Matsumura A. A case of multiple skeletal lesions of brown tumors, mimicking carcinoma metastases. Arch Orthop Trauma Surg. 2008, 128:149-54. 10.1007\/s00402-007-0312-0","journal-title":"Arch Orthop Trauma Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-004-0697-y","article-title":"Pathologic fracture of the distal femur in osteitis fibrosa cystica simulating metastatic disease","volume":"124","author":"Hsieh MC","year":"2004","unstructured":"Hsieh MC, Ko JY, Eng HL. Pathologic fracture of the distal femur in osteitis fibrosa cystica simulating metastatic disease. Arch Orthop Trauma Surg. 2004, 124:498-501. 10.1007\/s00402-004-0697-y","journal-title":"Arch Orthop Trauma Surg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jecr.2019.100054","article-title":"Case report- primary hyperparathyroidism with brown tumors masquerading skeletal metastases - role of functional imaging in diagnosis and management","volume":"14","author":"Bal J","year":"2019","unstructured":"Bal J, Goel G, Tiwari A, Chawla M, Dougall P, Chaturvedi H. Case report- primary hyperparathyroidism with brown tumors masquerading skeletal metastases - role of functional imaging in diagnosis and management. J Clin Transl Endocrinol Case Rep. 2019, 14:100054. 10.1016\/j.jecr.2019.100054","journal-title":"J Clin Transl Endocrinol Case Rep"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2011.10.010","article-title":"Imaging techniques in parathyroid surgery for primary hyperparathyroidism","volume":"33","author":"Mohebati A","year":"2011","unstructured":"Mohebati A, Shaha AR. Imaging techniques in parathyroid surgery for primary hyperparathyroidism. Am J Otolaryngol. 2011, 33:457-68. 10.1016\/j.amjoto.2011.10.010","journal-title":"Am J Otolaryngol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1326-4","article-title":"In brief: classifications in brief: Mirels' classification: metastatic disease in long bones and impending pathologic fracture","volume":"468","author":"Jawad MU","year":"2010","unstructured":"Jawad MU, Scully SP. In brief: classifications in brief: Mirels' classification: metastatic disease in long bones and impending pathologic fracture. Clin Orthop Relat Res. 2010, 468:2825-7. 10.1007\/s11999-010-1326-4","journal-title":"Clin Orthop Relat Res"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199407000-00016","article-title":"Multiple brown tumors in unsuspected primary hyperparathyroidism mimicking metastatic disease on radiograph and bone scan","volume":"19","author":"Joyce JM","year":"1994","unstructured":"Joyce JM, Idea RJ, Grossman SJ, Liss RG, Lyons JB. Multiple brown tumors in unsuspected primary hyperparathyroidism mimicking metastatic disease on radiograph and bone scan. Clin Nucl Med. 1994, 19:630-5. 10.1097\/00003072-199407000-00016","journal-title":"Clin Nucl Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrnm.2016.03.001","article-title":"Multiple brown tumors mistaken for bone metastases. Computed tomography imaging findings","volume":"47","author":"Mor\u00e1n L","year":"2016","unstructured":"Mor\u00e1n L, Moeinvaziri M, Fern\u00e1ndez A, S\u00e1nchez R. Multiple brown tumors mistaken for bone metastases. Computed tomography imaging findings. Egypt J Radiol Nucl Med. 2016, 47:537-41. 10.1016\/j.ejrnm.2016.03.001","journal-title":"Egypt J Radiol Nucl Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/128077-multiple-brown-tumors-in-primary-hyperparathyroidism-causing-pathological-fracture-a-case-report-of-a-21-year-old-adult-male","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:54:57Z","timestamp":1707508497000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/128077-multiple-brown-tumors-in-primary-hyperparathyroidism-causing-pathological-fracture-a-case-report-of-a-21-year-old-adult-male"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,10]]},"references-count":17,"URL":"https:\/\/doi.org\/10.7759\/cureus.35979","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,10]]}}}