{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:37:48Z","timestamp":1783741068551,"version":"3.55.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,16]]},"DOI":"10.7759\/cureus.36228","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T12:28:28Z","timestamp":1678969708000},"source":"Crossref","is-referenced-by-count":1,"title":["The Challenging Aspect of Macrophage Activation Syndrome in the Setting of Sepsis or Systemic Inflammatory Response Syndrome (SIRS)"],"prefix":"10.7759","author":[{"given":"Said","family":"Benlamkaddem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djoudline","family":"Doughmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imane","family":"Tlam\u00e7ani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Adnane","family":"Berdai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Harandou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reaurg.2009.03.002","article-title":"Syndrome d\u2019activation macrophagique d\u2019origine infectieuse: \u00e9tiologies et prise en charge [Infection-related hemophagocytic syndrome: aetiologies and management]","volume":"18","author":"Gonzalez F","year":"2009","unstructured":"Gonzalez F, Vincent F, Cohen Y. Syndrome d\u2019activation macrophagique d\u2019origine infectieuse: \u00e9tiologies et prise en charge [Infection-related hemophagocytic syndrome: aetiologies and management]. R\u00e9animation. 2009, 18:284-90. 10.1016\/j.reaurg.2009.03.002","journal-title":"R\u00e9animation"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/25785826.2021.1912893","article-title":"Macrophage activation syndrome in systemic juvenile idiopathic arthritis","volume":"44","author":"Shimizu M","year":"2021","unstructured":"Shimizu M. Macrophage activation syndrome in systemic juvenile idiopathic arthritis. Immunol Med. 2021, 44:237-45. 10.1080\/25785826.2021.1912893","journal-title":"Immunol Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21423","article-title":"Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis","volume":"50","author":"Allen CE","year":"2008","unstructured":"Allen CE, Yu X, Kozinetz CA, McClain KL. Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2008, 50:1227-35. 10.1002\/pbc.21423","journal-title":"Pediatr Blood Cancer"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2004.10.008","article-title":"[Reactive haemophagocytic syndrome and multiple organ failure in intensive care unit patients]","volume":"23","author":"Rekik R","year":"2004","unstructured":"Rekik R, Morazin F, Lumbroso A, Stirnemann J, Montravers P, Gauzit R. [Reactive haemophagocytic syndrome and multiple organ failure in intensive care unit patients]. Ann Fr Anesth Reanim. 2004, 23:1189-91. 10.1016\/j.annfar.2004.10.008","journal-title":"Ann Fr Anesth Reanim"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1086\/516086","article-title":"Role of hemophagocytic histiocytosis in the etiology of thrombocytopenia in patients with sepsis syndrome or septic shock","volume":"25","author":"St\u00e9phan F","year":"1997","unstructured":"St\u00e9phan F, Thioli\u00e8re B, Verdy E, Tulliez M. Role of hemophagocytic histiocytosis in the etiology of thrombocytopenia in patients with sepsis syndrome or septic shock. Clin Infect Dis. 1997, 25:1159-64. 10.1086\/516086","journal-title":"Clin Infect Dis"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000127779.24232.15","article-title":"Multifactorial risk analysis of bone marrow histiocytic hyperplasia with hemophagocytosis in critically ill medical patients--a postmortem clinicopathologic analysis","volume":"32","author":"Strauss R","year":"2004","unstructured":"Strauss R, Neureiter D, Westenburger B, Wehler M, Kirchner T, Hahn EG. Multifactorial risk analysis of bone marrow histiocytic hyperplasia with hemophagocytosis in critically ill medical patients--a postmortem clinicopathologic analysis. Crit Care Med. 2004, 32:1316-21. 10.1097\/01.ccm.0000127779.24232.15","journal-title":"Crit Care Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1111-y","article-title":"Understanding organ dysfunction in hemophagocytic lymphohistiocytosis","volume":"34","author":"Cr\u00e9put C","year":"2008","unstructured":"Cr\u00e9put C, Galicier L, Buyse S, Azoulay E. Understanding organ dysfunction in hemophagocytic lymphohistiocytosis. Intensive Care Med. 2008, 34:1177-87. 10.1007\/s00134-008-1111-y","journal-title":"Intensive Care Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.06.053","article-title":"Hemophagocytic lymphohistiocytosis: advances in pathophysiology, diagnosis, and treatment","volume":"163","author":"Chandrakasan S","year":"2013","unstructured":"Chandrakasan S, Filipovich AH. Hemophagocytic lymphohistiocytosis: advances in pathophysiology, diagnosis, and treatment. J Pediatr. 2013, 163:1253-9. 10.1016\/j.jpeds.2013.06.053","journal-title":"J Pediatr"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.03.002","article-title":"Hemophagocytic syndromes--an update","volume":"28","author":"Janka GE","year":"2014","unstructured":"Janka GE, Lehmberg K. Hemophagocytic syndromes--an update. Blood Rev. 2014, 28:135-42. 10.1016\/j.blre.2014.03.002","journal-title":"Blood Rev"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter JI","year":"2007","unstructured":"Henter JI, Horne A, Aric\u00f3 M, et al.. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007, 48:124-31. 10.1002\/pbc.21039","journal-title":"Pediatr Blood Cancer"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705225","article-title":"Histiocytic disorders of children and adults: basic science, clinical features and therapy","volume":"37","author":"Roberts I","year":"2006","unstructured":"Roberts I. Histiocytic disorders of children and adults: basic science, clinical features and therapy. Bone Marrow Transplant. 2006, 37:437-437. 10.1038\/sj.bmt.1705225","journal-title":"Bone Marrow Transplant"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0619","article-title":"Hemophagocytic lymphohistiocytosis: a potentially underrecognized association with systemic inflammatory response syndrome, severe sepsis, and septic shock in adults","volume":"140","author":"Raschke RA","year":"2011","unstructured":"Raschke RA, Garcia-Orr R. Hemophagocytic lymphohistiocytosis: a potentially underrecognized association with systemic inflammatory response syndrome, severe sepsis, and septic shock in adults. Chest. 2011, 140:933-8. 10.1378\/chest.11-0619","journal-title":"Chest"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181a1ae08","article-title":"Secondary hemophagocytic lymphohistiocytosis and severe sepsis\/systemic inflammatory response syndrome\/multiorgan dysfunction syndrome\/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation","volume":"10","author":"Castillo L","year":"2009","unstructured":"Castillo L, Carcillo J. Secondary hemophagocytic lymphohistiocytosis and severe sepsis\/systemic inflammatory response syndrome\/multiorgan dysfunction syndrome\/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation. Pediatr Crit Care Med. 2009, 10:387-92. 10.1097\/PCC.0b013e3181a1ae08","journal-title":"Pediatr Crit Care Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000209520.82377.41","article-title":"Peripheral hemophagocytosis: an early indicator of advanced systemic inflammatory response syndrome\/hemophagocytic syndrome","volume":"25","author":"Kuwata K","year":"2006","unstructured":"Kuwata K, Yamada S, Kinuwaki E, Naito M, Mitsuya H. Peripheral hemophagocytosis: an early indicator of advanced systemic inflammatory response syndrome\/hemophagocytic syndrome. Shock. 2006, 25:344-50. 10.1097\/01.shk.0000209520.82377.41","journal-title":"Shock"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(02)00673-2","article-title":"Syndrome d\u2019activation macrophagique","volume":"23","author":"Karras A","year":"2002","unstructured":"Karras A, Hermine O. Syndrome d\u2019activation macrophagique. Rev M\u00e9decine Interne. 2002, 23:768-78. 10.1016\/S0248-8663(02)00673-2","journal-title":"Rev M\u00e9decine Interne"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.12.002","article-title":"Macrophage activation syndrome following Acinetobacter baumannii sepsis","volume":"16","author":"John TM","year":"2012","unstructured":"John TM, Jacob CN, Ittycheria CC, et al.. Macrophage activation syndrome following Acinetobacter baumannii sepsis. Int J Infect Dis. 2012, 16:e223-4. 10.1016\/j.ijid.2011.12.002","journal-title":"Int J Infect Dis"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-1936-z","article-title":"Critical care management of patients with hemophagocytic lymphohistiocytosis","volume":"36","author":"Buyse S","year":"2010","unstructured":"Buyse S, Teixeira L, Galicier L, et al.. Critical care management of patients with hemophagocytic lymphohistiocytosis. Intensive Care Med. 2010, 36:1695-702. 10.1007\/s00134-010-1936-z","journal-title":"Intensive Care Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22774","article-title":"Rate of decline of ferritin in patients with hemophagocytic lymphohistiocytosis as a prognostic variable for mortality","volume":"56","author":"Lin TF","year":"2011","unstructured":"Lin TF, Ferlic-Stark LL, Allen CE, Kozinetz CA, McClain KL. Rate of decline of ferritin in patients with hemophagocytic lymphohistiocytosis as a prognostic variable for mortality. Pediatr Blood Cancer. 2011, 56:154-5. 10.1002\/pbc.22774","journal-title":"Pediatr Blood Cancer"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/142099-the-challenging-aspect-of-macrophage-activation-syndrome-in-the-setting-of-sepsis-or-systemic-inflammatory-response-syndrome-sirs","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:55:41Z","timestamp":1707508541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/142099-the-challenging-aspect-of-macrophage-activation-syndrome-in-the-setting-of-sepsis-or-systemic-inflammatory-response-syndrome-sirs"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,16]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.36228","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,16]]}}}