{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:59:23Z","timestamp":1787032763018,"version":"build-2736575974"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,20]]},"DOI":"10.7759\/cureus.36383","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T03:22:19Z","timestamp":1679282539000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Intravenous Granisetron and Ondansetron on Hemodynamics and Sensory Motor Block After Spinal Anaesthesia With Hyperbaric Bupivacaine in Patients Undergoing Elective Surgery: A Randomized Double-Blind Study"],"prefix":"10.7759","author":[{"given":"Usha","family":"Shukla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapil K","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay Brijesh Singh","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s1521-6896(02)00116-7","article-title":"Spinal anaesthesia for obstetrics","volume":"17","author":"Gogarten W","year":"2003","unstructured":"Gogarten W. Spinal anaesthesia for obstetrics. Best Pract Res Clin Anaesthesiol. 2003, 17:377-92. 10.1016\/s1521-6896(02)00116-7","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1097\/00115550-200005000-00005","article-title":"Low-dose bupivacaine-fentanyl spinal anesthesia for cesarean delivery","volume":"25","author":"Ben-David B","year":"2000","unstructured":"Ben-David B, Miller G, Gavriel R, Gurevitch A. Low-dose bupivacaine-fentanyl spinal anesthesia for cesarean delivery. Reg Anesth Pain Med. 2000, 25:235-9.","journal-title":"Reg Anesth Pain Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v3.i1.58","article-title":"Vasopressors in obstetric anesthesia: a current perspective","volume":"3","author":"Nag DS","year":"2015","unstructured":"Nag DS, Samaddar DP, Chatterjee A, Kumar H, Dembla A. Vasopressors in obstetric anesthesia: a current perspective. World J Clin Cases. 2015, 3:58-64. 10.12998\/wjcc.v3.i1.58","journal-title":"World J Clin Cases"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200011000-00029","article-title":"The use of intravenous atropine after a saline infusion in the prevention of spinal anesthesia-induced hypotension in elderly patients","volume":"91","author":"Lim HH","year":"2000","unstructured":"Lim HH, Ho KM, Choi WY, Teoh GS, Chiu KY. The use of intravenous atropine after a saline infusion in the prevention of spinal anesthesia-induced hypotension in elderly patients. Anesth Analg. 2000, 91:1203-6. 10.1097\/00000539-200011000-00029","journal-title":"Anesth Analg"},{"key":"ref5","article-title":"Serotonin 5-HT(3) receptor mediation of pain and anti-nociception: implications for clinical therapeutics","volume":"7","author":"Giordano J","year":"2004","unstructured":"Giordano J, Schultea T. Serotonin 5-HT(3) receptor mediation of pain and anti-nociception: implications for clinical therapeutics. Pain Physician. 2004, 7:141-7.","journal-title":"Pain Physician"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318165e012","article-title":"The effects of intravenous granisetron on the sensory and motor blockade produced by intrathecal bupivacaine","volume":"106","author":"Mowafi HA","year":"2008","unstructured":"Mowafi HA, Arab SA, Ismail SA, Al-Ghamdi A. The effects of intravenous granisetron on the sensory and motor blockade produced by intrathecal bupivacaine. Anesth Analg. 2008, 106:1322-5, table of contents. 10.1213\/ane.0b013e318165e012","journal-title":"Anesth Analg"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/158061","article-title":"Effect of ondansetron on the occurrence of hypotension and on neonatal parameters during spinal anesthesia for elective caesarean section: a prospective, randomized, controlled, double-blind study","volume":"2015","author":"Trabelsi W","year":"2015","unstructured":"Trabelsi W, Romdhani C, Elaskri H, Sammoud W, Bensalah M, Labbene I, Ferjani M. Effect of ondansetron on the occurrence of hypotension and on neonatal parameters during spinal anesthesia for elective caesarean section: a prospective, randomized, controlled, double-blind study. Anesthesiol Res Pract. 2015, 2015:158061. 10.1155\/2015\/158061","journal-title":"Anesthesiol Res Pract"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.21608\/ZUMJ.2019.11672.1199","article-title":"A comparative study of two different doses of intravenous ondansetron for prevention of post-spinal anesthesia shivering in inguinal hernia repair surgery","volume":"26","author":"alrjael J","year":"2020","unstructured":"alrjael J, Attia Z, Elsawy A, AbdAllah M. A comparative study of two different doses of intravenous ondansetron for prevention of post-spinal anesthesia shivering in inguinal hernia repair surgery. Zagazig Uni Med J. 2020, 26:612-19. 10.21608\/ZUMJ.2019.11672.1199","journal-title":"Zagazig Uni Med J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200519030-00004","article-title":"Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same?","volume":"19","author":"Gan TJ","year":"2005","unstructured":"Gan TJ. Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same?. CNS Drugs. 2005, 19:225-38. 10.2165\/00023210-200519030-00004","journal-title":"CNS Drugs"},{"key":"ref10","article-title":"Effect of different doses of granisetron on preventing postoperative shivering in patients undergoing septorhinoplasty under general anesthesia","volume":"5","author":"Gargari RM","year":"2017","unstructured":"Gargari RM, Anvari HMP. Effect of different doses of granisetron on preventing postoperative shivering in patients undergoing septorhinoplasty under general anesthesia. Adv Biosci Clin Med. 2017, 5:21-6.","journal-title":"Adv Biosci Clin Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000152616.57107.F6","article-title":"Systemic ondansetron antagonizes the sensory block produced by intrathecal lidocaine","volume":"100","author":"Fassoulaki A","year":"2005","unstructured":"Fassoulaki A, Melemeni A, Zotou M, Sarantopoulos C. Systemic ondansetron antagonizes the sensory block produced by intrathecal lidocaine. Anesth Analg. 2005, 100:1817-21. 10.1213\/01.ANE.0000152616.57107.F6","journal-title":"Anesth Analg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199207030-00003","article-title":"Adverse effects of local anaesthetics","volume":"7","author":"McCaughey W","year":"1992","unstructured":"McCaughey W. Adverse effects of local anaesthetics. Drug Saf. 1992, 7:178-89. 10.2165\/00002018-199207030-00003","journal-title":"Drug Saf"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)90059-0","article-title":"Molecular biology of 5-HT receptors","volume":"33","author":"Boess FG","year":"1994","unstructured":"Boess FG, Martin IL. Molecular biology of 5-HT receptors. Neuropharmacology. 1994, 33:275-317. 10.1016\/0028-3908(94)90059-0","journal-title":"Neuropharmacology"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4103\/1687-7934.156667","article-title":"A comparative study of prophylactic intra-venous granisetron, ondansetron, and ephedrine in attenuating hypotension and its effect on motor and sensory block in elective cesarean section under spinal anesthesia","volume":"8","author":"Khalifa OS","year":"2015","unstructured":"Khalifa OS. A comparative study of prophylactic intra-venous granisetron, ondansetron, and ephedrine in attenuating hypotension and its effect on motor and sensory block in elective cesarean section under spinal anesthesia. Ain Shams Med J. 2015, 8:166-72. 10.4103\/1687-7934.156667","journal-title":"Ain Shams Med J"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20191695","article-title":"A comparative evaluation of effect of intravenous premedication with ondansetron versus granisetron on hemodynamics and sensory-motor blockade produced by intrathecal hyperbaric 0.5% bupivacaine","volume":"7","author":"Kumar A","year":"2019","unstructured":"Kumar A, Inayat U, Rastogi B, Gupta K, Jain M, Tayal A. A comparative evaluation of effect of intravenous premedication with ondansetron versus granisetron on hemodynamics and sensory-motor blockade produced by intrathecal hyperbaric 0.5% bupivacaine. Int J Res Med Sci. 2019, 7:1886-93. 10.18203\/2320-6012.ijrms20191695","journal-title":"Int J Res Med Sci"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.31838\/jcdr,2021.12.03.257","article-title":"Intravenous ondansetron versus granisetron on hemodynamic changes induced by spinal anesthesia in elderly patients undergoing lower limb surgeries","volume":"12","author":"Mostafa AA","year":"2021","unstructured":"Mostafa AA, Attia ZM, Moniem OA, Mohamed R. Intravenous ondansetron versus granisetron on hemodynamic changes induced by spinal anesthesia in elderly patients undergoing lower limb surgeries. J Cardiovasc Dis Res. 2021, 12:0976-2833. 10.31838\/jcdr,2021.12.03.257","journal-title":"J Cardiovasc Dis Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.egja.2013.04.004","article-title":"Effects of intravenous ondansetron and granisetron on hemodynamic changes and motor and sensory blockade induced by spinal anesthesia in parturients undergoing cesarean section","volume":"29","author":"Rashad MM","year":"2013","unstructured":"Rashad MM, Farmawy MS. Effects of intravenous ondansetron and granisetron on hemodynamic changes and motor and sensory blockade induced by spinal anesthesia in parturients undergoing cesarean section. Egypt J Anaesth. 2013, 29:369-74. 10.1016\/j.egja.2013.04.004","journal-title":"Egypt J Anaesth"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.18231\/j.ijca.2019.063","article-title":"Comparison of injection ondansetron with granisetron on maternal haemodynamics and regression of sensory and motor blockade in elective caesarean section: a randomised non inferiority exploratory trial","volume":"6","author":"Ray D","year":"2019","unstructured":"Ray D, Saha M, Chakraborty A, Mandal MC. Comparison of injection ondansetron with granisetron on maternal haemodynamics and regression of sensory and motor blockade in elective caesarean section: a randomised non inferiority exploratory trial. Indian J Clin Anaesth. 2019, 6:328-31. 10.18231\/j.ijca.2019.063","journal-title":"Indian J Clin Anaesth"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.36106\/ijsr","article-title":"Comparison of intravenous ondansetron and granisetron in prevention of hypotension after spinal anesthesia during LSCS. A randomised double-blind placebo-controlled study","volume":"11","author":"Kumawat DK","year":"2022","unstructured":"Kumawat DK, Meena S, Chittora S. Comparison of intravenous ondansetron and granisetron in prevention of hypotension after spinal anesthesia during LSCS. A randomised double-blind placebo-controlled study. Int J Sci Res. 2022, 11:56-8. 10.36106\/ijsr","journal-title":"Int J Sci Res"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7537\/marsnys100617.02.","article-title":"Clinical comparative study of the effects of intravenous ondansetron and granisetron on hemodynamic changes, shivering, and motor and sensory blockade induced by spinal anesthesia in women undergoing cesarean section","volume":"10","author":"Megahed MAB","year":"2017","unstructured":"Megahed MAB, Hady AMA, Sayed AEDM, et al.. Clinical comparative study of the effects of intravenous ondansetron and granisetron on hemodynamic changes, shivering, and motor and sensory blockade induced by spinal anesthesia in women undergoing cesarean section. N Y Sci J. 2017, 10:7-16. 10.7537\/marsnys100617.02.","journal-title":"N Y Sci J"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.29322\/IJSRP.8.3.2018.p7518","article-title":"Post operative nausea and vomiting: a comparison between ondansetron and palonosetron after tympanoplasty","volume":"8","author":"Puri A","year":"2018","unstructured":"Puri A, Singh G, Dwivedi MB. Post operative nausea and vomiting: a comparison between ondansetron and palonosetron after tympanoplasty. Int J Sci Res Publ. 2018, 8:108-13. 10.29322\/IJSRP.8.3.2018.p7518","journal-title":"Int J Sci Res Publ"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.19056\/ijmdsjssmes\/2017\/v6i1\/125556","article-title":"Comparative efficacy of ondansetron versus granisetron to prevent perioperative nausea and vomiting in patients undergoing gynaecological surgery under spinal anaesthesia","volume":"6","author":"Makker R","year":"2017","unstructured":"Makker R, Bhardwaj A, Singh Ap, Anand A. Comparative efficacy of ondansetron versus granisetron to prevent perioperative nausea and vomiting in patients undergoing gynaecological surgery under spinal anaesthesia. Int J Med and Dent Sci. 2017, 6:1371-5. 10.19056\/ijmdsjssmes\/2017\/v6i1\/125556","journal-title":"Int J Med and Dent Sci"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/144118-comparison-of-intravenous-granisetron-and-ondansetron-on-hemodynamics-and-sensory-motor-block-after-spinal-anaesthesia-with-hyperbaric-bupivacaine-in-patients-undergoing-elective-surgery-a-randomized-double-blind-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T14:56:14Z","timestamp":1707490574000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/144118-comparison-of-intravenous-granisetron-and-ondansetron-on-hemodynamics-and-sensory-motor-block-after-spinal-anaesthesia-with-hyperbaric-bupivacaine-in-patients-undergoing-elective-surgery-a-randomized-double-blind-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,20]]},"references-count":22,"URL":"https:\/\/doi.org\/10.7759\/cureus.36383","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,20]]}}}