{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:56:21Z","timestamp":1770728181998,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,21]]},"DOI":"10.7759\/cureus.36464","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T13:11:48Z","timestamp":1679404308000},"source":"Crossref","is-referenced-by-count":2,"title":["Incidence of Symptomatic Venous Thromboembolism (VTE) in 8,885 Elective Total Hip Arthroplasty Patients Receiving Post-operative Aspirin VTE Prophylaxis"],"prefix":"10.7759","author":[{"given":"Eamonn I","family":"Coveney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Hutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimesh","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L","family":"Whitehouse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R","family":"Howell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J","family":"Hubble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Charity","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Al-Amin M","family":"Kassam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.2106\/00004623-198466020-00005","article-title":"Deep-vein thrombosis following total knee replacement. An analysis of six hundred and thirty-eight arthroplasties","volume":"66","author":"Stulberg BN","year":"1984","unstructured":"Stulberg BN, Insall JN, Williams GW, Ghelman B. Deep-vein thrombosis following total knee replacement. An analysis of six hundred and thirty-eight arthroplasties. J Bone Joint Surg. 1984, 66:194-201.","journal-title":"J Bone Joint Surg"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.artd.2018.02.014","article-title":"What are the incidence and risk factors of in-hospital mortality after venous thromboembolism events in total hip and knee arthroplasty patients?","volume":"4","author":"Shahi A","year":"2018","unstructured":"Shahi A, Bradbury TL, Guild GN 3rd, Saleh UH, Ghanem E, Oliashirazi A. What are the incidence and risk factors of in-hospital mortality after venous thromboembolism events in total hip and knee arthroplasty patients?. Arthroplast Today. 2018, 4:343-7. 10.1016\/j.artd.2018.02.014","journal-title":"Arthroplast Today"},{"key":"ref3","unstructured":"American Academy of Orthopaedic Surgeons. Clinical practice guideline on preventing thromboembolic disease in patients undergoing elective hip and knee arthroplasty. (2011). https:\/\/www.aaos.org\/quality\/quality-programs\/tumor-infection-and-military-medicine-programs\/venous-thromboembolic-di...."},{"key":"ref4","unstructured":"National Institute for Health and Care Excellence (NICE). Clinical Guidance [CG46]: Venous thromboembolism (surgical). (2007). https:\/\/www.nice.org.uk\/guidance\/cg46."},{"key":"ref5","unstructured":"National Institute for Health and Care Excellence (NICE). NICE Guideline [NG89]: Venous thromboembolism in over 16s: reducing the risk of hospital-aquired deep vein thrombosis or pulmonary embolism. (2018). https:\/\/www.nice.org.uk\/guidance\/ng89\/chapter\/Recommendations."},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2016.02.074","article-title":"Aspirin is as effective as and safer than warfarin for patients at higher risk of venous thromboembolism undergoing total joint arthroplasty","volume":"31","author":"Huang RC","year":"2016","unstructured":"Huang RC, Parvizi J, Hozack WJ, Chen AF, Austin MS. Aspirin is as effective as and safer than warfarin for patients at higher risk of venous thromboembolism undergoing total joint arthroplasty. J Arthroplasty. 2016, 31:83-6. 10.1016\/j.arth.2016.02.074","journal-title":"J Arthroplasty"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02110-3","article-title":"Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial","volume":"355","author":"Pulmonary\u00a0Embolism\u00a0Prevention\u00a0(PEP)\u00a0Trial\u00a0Collaborative\u00a0Group","year":"2000","unstructured":"Pulmonary\u00a0Embolism\u00a0Prevention\u00a0(PEP)\u00a0Trial\u00a0Collaborative\u00a0Group. Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial. Lancet. 2000, 355:1295-1302. 10.1016\/S0140-6736(00)02110-3","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-3135-z","article-title":"Aspirin: an alternative for pulmonary embolism prophylaxis after arthroplasty?","volume":"472","author":"Raphael IJ","year":"2014","unstructured":"Raphael IJ, Tischler EH, Huang R, Rothman RH, Hozack WJ, Parvizi J. Aspirin: an alternative for pulmonary embolism prophylaxis after arthroplasty?. Clin Orthop Relat Res. 2014, 472:482-8. 10.1007\/s11999-013-3135-z","journal-title":"Clin Orthop Relat Res"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-012-1588-4","article-title":"Aspirin for elective hip and knee arthroplasty: a multimodal thromboprophylaxis protocol","volume":"36","author":"Vulcano E","year":"2012","unstructured":"Vulcano E, Gesell M, Esposito A, Ma Y, Memtsoudis SG, Gonzalez Della Valle A. Aspirin for elective hip and knee arthroplasty: a multimodal thromboprophylaxis protocol. Int Orthop. 2012, 36:1995-2002. 10.1007\/s00264-012-1588-4","journal-title":"Int Orthop"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2015.07.001","article-title":"Administration of aspirin as a prophylaxis agent against venous thromboembolism results in lower incidence of periprosthetic joint infection","volume":"30","author":"Huang R","year":"2015","unstructured":"Huang R, Buckley PS, Scott B, Parvizi J, Purtill JJ. Administration of aspirin as a prophylaxis agent against venous thromboembolism results in lower incidence of periprosthetic joint infection. J Arthroplasty. 2015, 30:39-41. 10.1016\/j.arth.2015.07.001","journal-title":"J Arthroplasty"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.01253","article-title":"Venous thromboembolism following hip and knee arthroplasty: the role of Aspirin","volume":"99","author":"Parvizi J","year":"2017","unstructured":"Parvizi J, Ceylan HH, Kucukdurmaz F, Merli G, Tuncay I, Beverland D. Venous thromboembolism following hip and knee arthroplasty: the role of Aspirin. J Bone Joint Surg Am. 2017, 99:961-72. 10.2106\/JBJS.16.01253","journal-title":"J Bone Joint Surg Am"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.21.01531","article-title":"Recommendations from the ICM-VTE: hip and knee","volume":"104","year":"2022","unstructured":"Recommendations from the ICM-VTE. hip and knee. J Bone Joint Surg Am. 2022, 104:180-231. 10.2106\/JBJS.21.01531","journal-title":"J Bone Joint Surg Am"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-020-3100-4","article-title":"Venous thromboembolism rates after hip and knee arthroplasty and hip fractures","volume":"21","author":"Mula V","year":"2020","unstructured":"Mula V, Parikh S, Suresh S, Bottle A, Loeffler M, Alam M. Venous thromboembolism rates after hip and knee arthroplasty and hip fractures. BMC Musculoskelet Disord. 2020, 21:95. 10.1186\/s12891-020-3100-4","journal-title":"BMC Musculoskelet Disord"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.91B5.21939","article-title":"The incidence of fatal pulmonary embolism after primary hip and knee replacement in a consecutive series of 4253 patients","volume":"91","author":"Cusick LA","year":"2009","unstructured":"Cusick LA, Beverland DE. The incidence of fatal pulmonary embolism after primary hip and knee replacement in a consecutive series of 4253 patients. J Bone Joint Surg Br. 2009, 91:645-8. 10.1302\/0301-620X.91B5.21939","journal-title":"J Bone Joint Surg Br"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2021.0157","article-title":"Does the publication of NICE guidelines for venous thromboembolism chemical prophylaxis influence the prescribing patterns of UK hip and knee surgeons?","volume":"104","author":"Matharu GS","year":"2022","unstructured":"Matharu GS, Blom AW, Board T, Whitehouse MR. Does the publication of NICE guidelines for venous thromboembolism chemical prophylaxis influence the prescribing patterns of UK hip and knee surgeons?. Ann R Coll Surg Engl. 2022, 104:195-201. 10.1308\/rcsann.2021.0157","journal-title":"Ann R Coll Surg Engl"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.13416","article-title":"Effect of aspirin vs enoxaparin on symptomatic venous thromboembolism in patients undergoing hip or knee arthroplasty: the CRISTAL randomized trial","volume":"328","author":"Sidhu VS","year":"2022","unstructured":"Sidhu VS, Kelly TL, Pratt N, et al.. Effect of aspirin vs enoxaparin on symptomatic venous thromboembolism in patients undergoing hip or knee arthroplasty: the CRISTAL randomized trial. JAMA. 2022, 328:719-27. 10.1001\/jama.2022.13416","journal-title":"JAMA"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-22-00708","article-title":"Trends of venous thromboembolism after total hip arthroplasty in the United States: analysis from 2011 to 2019","author":"Agarwal AR","year":"2023","unstructured":"Agarwal AR, Das A, Harris A, Campbell JC, Golladay GJ, Thakkar SC. Trends of venous thromboembolism after total hip arthroplasty in the United States: analysis from 2011 to 2019. J Am Acad Orthop Surg. 2023, 10.5435\/JAAOS-D-22-00708","journal-title":"J Am Acad Orthop Surg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-007-0092-4","article-title":"Potent anticoagulants are associated with a higher all-cause mortality rate after hip and knee arthroplasty","volume":"466","author":"Sharrock NE","year":"2008","unstructured":"Sharrock NE, Gonzalez Della Valle A, Go G, Lyman S, Salvati EA. Potent anticoagulants are associated with a higher all-cause mortality rate after hip and knee arthroplasty. Clin Orthop Relat Res. 2008, 466:714-21. 10.1007\/s11999-007-0092-4","journal-title":"Clin Orthop Relat Res"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.18.00143","article-title":"The use of Aspirin for prophylaxis against venous thromboembolism decreases mortality following primary total joint arthroplasty","volume":"101","author":"Rondon AJ","year":"2019","unstructured":"Rondon AJ, Shohat N, Tan TL, Goswami K, Huang RC, Parvizi J. The use of Aspirin for prophylaxis against venous thromboembolism decreases mortality following primary total joint arthroplasty. J Bone Joint Surg Am. 2019, 101:504-13. 10.2106\/JBJS.18.00143","journal-title":"J Bone Joint Surg Am"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B5.34996","article-title":"Fatal pulmonary embolism following elective total hip arthroplasty: a 12-year study","volume":"98-B","author":"Bayley E","year":"2016","unstructured":"Bayley E, Brown S, Bhamber NS, Howard PW. Fatal pulmonary embolism following elective total hip arthroplasty: a 12-year study. Bone Joint J. 2016, 98-B:585-8. 10.1302\/0301-620X.98B5.34996","journal-title":"Bone Joint J"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B12.16298","article-title":"Venous thromboembolism associated with hip and knee replacement over a ten-year period: a population-based study","volume":"87","author":"Howie C","year":"2005","unstructured":"Howie C, Hughes H, Watts AC. Venous thromboembolism associated with hip and knee replacement over a ten-year period: a population-based study. J Bone Joint Surg Br. 2005, 87:1675-80. 10.1302\/0301-620X.87B12.16298","journal-title":"J Bone Joint Surg Br"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.90B3.19935","article-title":"Ninety-day mortality after elective total hip replacement: 1549 patients using aspirin as a thromboprophylactic agent","volume":"90","author":"Parry M","year":"2008","unstructured":"Parry M, Wylde V, Blom AW. Ninety-day mortality after elective total hip replacement: 1549 patients using aspirin as a thromboprophylactic agent. J Bone Joint Surg Br. 2008, 90:306-7. 10.1302\/0301-620X.90B3.19935","journal-title":"J Bone Joint Surg Br"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.96B1.31569","article-title":"Thromboprophylaxis with dabigatran leads to an increased incidence of wound leakage and an increased length of stay after total joint replacement","volume":"96-B","author":"Bloch BV","year":"2014","unstructured":"Bloch BV, Patel V, Best AJ. Thromboprophylaxis with dabigatran leads to an increased incidence of wound leakage and an increased length of stay after total joint replacement. Bone Joint J. 2014, 96-B:122-6. 10.1302\/0301-620X.96B1.31569","journal-title":"Bone Joint J"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000121","article-title":"Administering aspirin, rivaroxaban and low-molecular-weight heparin to prevent deep venous thrombosis after total knee arthroplasty","volume":"25","author":"Zou Y","year":"2014","unstructured":"Zou Y, Tian S, Wang Y, Sun K. Administering aspirin, rivaroxaban and low-molecular-weight heparin to prevent deep venous thrombosis after total knee arthroplasty. Blood Coagul Fibrinolysis. 2014, 25:660-4. 10.1097\/MBC.0000000000000121","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.6108","article-title":"Clinical effectiveness and safety of Aspirin for venous thromboembolism prophylaxis after total hip and knee replacement: a systematic review and meta-analysis of randomized clinical trials","volume":"180","author":"Matharu GS","year":"2020","unstructured":"Matharu GS, Kunutsor SK, Judge A, Blom AW, Whitehouse MR. Clinical effectiveness and safety of Aspirin for venous thromboembolism prophylaxis after total hip and knee replacement: a systematic review and meta-analysis of randomized clinical trials. JAMA Intern Med. 2020, 180:376-84. 10.1001\/jamainternmed.2019.6108","journal-title":"JAMA Intern Med"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.07.004","article-title":"Persistent wound drainage among total joint arthroplasty patients receiving Aspirin vs Coumadin","volume":"35","author":"Singh V","year":"2020","unstructured":"Singh V, Shahi A, Saleh U, Tarabichi S, Oliashirazi A. Persistent wound drainage among total joint arthroplasty patients receiving Aspirin vs Coumadin. J Arthroplasty. 2020, 35:3743-6. 10.1016\/j.arth.2020.07.004","journal-title":"J Arthroplasty"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1308\/003588408X285946","article-title":"Gastric protection and gastrointestinal bleeding with aspirin thromboprophylaxis in hip and knee joint replacements","volume":"90","author":"Madhusudhan TR","year":"2008","unstructured":"Madhusudhan TR, Rangan A, Gregg PJ. Gastric protection and gastrointestinal bleeding with aspirin thromboprophylaxis in hip and knee joint replacements. Ann R Coll Surg Engl. 2008, 90:332-5. 10.1308\/003588408X285946","journal-title":"Ann R Coll Surg Engl"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2015.04.048","article-title":"Direct costs of Aspirin versus warfarin for venous thromboembolism prophylaxis after total knee or hip arthroplasty","volume":"30","author":"Gutowski CJ","year":"2015","unstructured":"Gutowski CJ, Zmistowski BM, Lonner JH, Purtill JJ, Parvizi J. Direct costs of Aspirin versus warfarin for venous thromboembolism prophylaxis after total knee or hip arthroplasty. J Arthroplasty. 2015, 30:36-8. 10.1016\/j.arth.2015.04.048","journal-title":"J Arthroplasty"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.35.2000225","article-title":"Evidence-base for aspirin as venous thromboembolic prophylaxis following joint replacement","volume":"3","author":"Jameson SS","year":"2014","unstructured":"Jameson SS, Baker PN, Deehan DJ, Port A, Reed MR. Evidence-base for aspirin as venous thromboembolic prophylaxis following joint replacement. Bone Joint Res. 2014, 3:146-9. 10.1302\/2046-3758.35.2000225","journal-title":"Bone Joint Res"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1530\/EOR-22-0053","article-title":"Clinical effectiveness and safety of aspirin and other anticoagulants for venous thromboembolism prophylaxis after major orthopedic surgery: a systematic review and meta-analysis of randomized clinical trials","volume":"7","author":"Singjie LC","year":"2022","unstructured":"Singjie LC, Halomoan R, Saleh I, Sumargono E, Kholinne E. Clinical effectiveness and safety of aspirin and other anticoagulants for venous thromboembolism prophylaxis after major orthopedic surgery: a systematic review and meta-analysis of randomized clinical trials. EFORT Open Rev. 2022, 7:792-9. 10.1530\/EOR-22-0053","journal-title":"EFORT Open Rev"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/129993-incidence-of-symptomatic-venous-thromboembolism-vte-in-8885-elective-total-hip-arthroplasty-patients-receiving-post-operative-aspirin-vte-prophylaxis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:56:25Z","timestamp":1707508585000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/129993-incidence-of-symptomatic-venous-thromboembolism-vte-in-8885-elective-total-hip-arthroplasty-patients-receiving-post-operative-aspirin-vte-prophylaxis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,21]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.36464","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,21]]}}}