{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:39:06Z","timestamp":1780598346759,"version":"3.54.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,6]]},"DOI":"10.7759\/cureus.37205","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T13:22:18Z","timestamp":1680787338000},"source":"Crossref","is-referenced-by-count":13,"title":["Role of Helicobacter pylori in Gastric Carcinoma: A Review"],"prefix":"10.7759","author":[{"given":"Anukriti","family":"Kesharwani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onkar R","family":"Dighe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashwant","family":"Lamture","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-009-0507-x","article-title":"Helicobacter pylori and gastric cancer","volume":"12","author":"Suzuki H","year":"2009","unstructured":"Suzuki H, Iwasaki E, Hibi T. Helicobacter pylori and gastric cancer. Gastric Cancer. 2009, 12:79-87. 10.1007\/s10120-009-0507-x","journal-title":"Gastric Cancer"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2857","article-title":"Helicobacter pylori: gastric cancer and beyond","volume":"10","author":"Polk DB","year":"2010","unstructured":"Polk DB, Peek RM Jr. Helicobacter pylori: gastric cancer and beyond. Nat Rev Cancer. 2010, 10:403-14. 10.1038\/nrc2857","journal-title":"Nat Rev Cancer"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.26.14668","article-title":"A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains","volume":"97","author":"Salama N","year":"2000","unstructured":"Salama N, Guillemin K, McDaniel TK, Sherlock G, Tompkins L, Falkow S. A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains. Proc Natl Acad Sci U S A. 2000, 97:14668-73. 10.1073\/pnas.97.26.14668","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21731","article-title":"The global health burden of infection-associated cancers in the year 2002","volume":"118","author":"Parkin DM","year":"2006","unstructured":"Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006, 118:3030-44. 10.1002\/ijc.21731","journal-title":"Int J Cancer"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02425.x","article-title":"Missing gastric cancer in dyspepsia","volume":"21","author":"Schmidt N","year":"2005","unstructured":"Schmidt N, Peitz U, Lippert H, Malfertheiner P. Missing gastric cancer in dyspepsia. Aliment Pharmacol Ther. 2005, 21:813-20. 10.1111\/j.1365-2036.2005.02425.x","journal-title":"Aliment Pharmacol Ther"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20925","article-title":"Helicobacter pylori persistence: biology and disease","volume":"113","author":"Blaser MJ","year":"2004","unstructured":"Blaser MJ, Atherton JC. Helicobacter pylori persistence: biology and disease. J Clin Invest. 2004, 113:321-33. 10.1172\/JCI20925","journal-title":"J Clin Invest"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura N","year":"2001","unstructured":"Uemura N, Okamoto S, Yamamoto S, et al.. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001, 345:784-9. 10.1056\/NEJMoa001999","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12083","article-title":"Molecular pathogenesis of gastric cancer","volume":"18","author":"Figueiredo C","year":"2013","unstructured":"Figueiredo C, Garcia-Gonzalez MA, Machado JC. Molecular pathogenesis of gastric cancer. Helicobacter. 2013, 18:28-33. 10.1111\/hel.12083","journal-title":"Helicobacter"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.143","article-title":"Genetics of gastric cancer","volume":"11","author":"McLean MH","year":"2014","unstructured":"McLean MH, El-Omar EM. Genetics of gastric cancer. Nat Rev Gastroenterol Hepatol. 2014, 11:664-74. 10.1038\/nrgastro.2014.143","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1586\/egh.12.7","article-title":"Understanding the genetic basis of gastric cancer: recent advances","volume":"6","author":"Tan IB","year":"2012","unstructured":"Tan IB, Ng I, Tai WM, Tan P. Understanding the genetic basis of gastric cancer: recent advances. Expert Rev Gastroenterol Hepatol. 2012, 6:335-41. 10.1586\/egh.12.7","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504927102","article-title":"Activation of beta-catenin by carcinogenic Helicobacter pylori","volume":"102","author":"Franco AT","year":"2005","unstructured":"Franco AT, Israel DA, Washington MK, et al.. Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci USA. 2005, 102:10646-51. 10.1073\/pnas.0504927102","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-011-0810-y","article-title":"Gastric carcinogenesis","volume":"396","author":"Bornschein J","year":"2011","unstructured":"Bornschein J, Malfertheiner P. Gastric carcinogenesis. Langenbecks Arch Surg. 2011, 396:729-42. 10.1007\/s00423-011-0810-y","journal-title":"Langenbecks Arch Surg"},{"key":"ref13","article-title":"Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils","volume":"58","author":"Honda S","year":"1998","unstructured":"Honda S, Fujioka T, Tokieda M, Satoh R, Nishizono A, Nasu M. Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils. Cancer Res. 1998, 58:4255-9.","journal-title":"Cancer Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41688.x","article-title":"Helicobacter pylori eradication has the potential to prevent gastric cancer: a state-of-the-art critique","volume":"100","author":"Malfertheiner P","year":"2005","unstructured":"Malfertheiner P, Sipponen P, Naumann M, et al.. Helicobacter pylori eradication has the potential to prevent gastric cancer: a state-of-the-art critique. Am J Gastroenterol. 2005, 100:2100-15. 10.1111\/j.1572-0241.2005.41688.x","journal-title":"Am J Gastroenterol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603517","article-title":"Helicobacter pylori and oesophageal and gastric cancers in a prospective study in China","volume":"96","author":"Kamangar F","year":"2007","unstructured":"Kamangar F, Qiao YL, Blaser MJ, et al.. Helicobacter pylori and oesophageal and gastric cancers in a prospective study in China. Br J Cancer. 2007, 96:172-6. 10.1038\/sj.bjc.6603517","journal-title":"Br J Cancer"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1351-x","article-title":"H. pylori infection is a key risk factor for proximal gastric cancer","volume":"55","author":"Bornschein J","year":"2010","unstructured":"Bornschein J, Selgrad M, Warnecke M, Kuester D, Wex T, Malfertheiner P. H. pylori infection is a key risk factor for proximal gastric cancer. Dig Dis Sci. 2010, 55:3124-31. 10.1007\/s10620-010-1351-x","journal-title":"Dig Dis Sci"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19124109","article-title":"Types of gastric carcinomas","volume":"19","author":"Waldum HL","year":"2018","unstructured":"Waldum HL, Fossmark R. Types of gastric carcinomas. Int J Mol Sci. 2018, 19:4109. 10.3390\/ijms19124109","journal-title":"Int J Mol Sci"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.23.1777","article-title":"Helicobacter pylori and atrophic gastritis: importance of the cagA status","volume":"87","author":"Kuipers EJ","year":"1995","unstructured":"Kuipers EJ, P\u00e9rez-P\u00e9rez GI, Meuwissen SG, Blaser MJ. Helicobacter pylori and atrophic gastritis: importance of the cagA status. J Natl Cancer Inst. 1995, 87:1777-80. 10.1093\/jnci\/87.23.1777","journal-title":"J Natl Cancer Inst"},{"key":"ref19","article-title":"Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach","volume":"55","author":"Blaser M","year":"1995","unstructured":"Blaser M, Perez-Perez GI, Kleanthous H, et al.. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 1995, 55:2111-5.","journal-title":"Cancer Res"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90477-7","article-title":"Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology","volume":"338","author":"Crabtree JE","year":"1991","unstructured":"Crabtree JE, Taylor JD, Wyatt JI, et al.. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology. Lancet. 1991, 338:332-5. 10.1016\/0140-6736(91)90477-7","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.3.297","article-title":"Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection","volume":"40","author":"Parsonnet J","year":"1997","unstructured":"Parsonnet J, Friedman GD, Orentreich N, Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut. 1997, 40:297-301. 10.1136\/gut.40.3.297","journal-title":"Gut"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-009-0772-y","article-title":"The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the Middle East","volume":"28","author":"Sugimoto M","year":"2009","unstructured":"Sugimoto M, Zali MR, Yamaoka Y. The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the Middle East. Eur J Clin Microbiol Infect Dis. 2009, 28:1227-36. 10.1007\/s10096-009-0772-y","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.11.009","article-title":"Host-bacterial interactions in Helicobacter pylori infection","volume":"134","author":"Amieva MR","year":"2008","unstructured":"Amieva MR, El-Omar EM. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology. 2008, 134:306-23. 10.1053\/j.gastro.2007.11.009","journal-title":"Gastroenterology"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010027","article-title":"Helicobacter pylori virulence factors-mechanisms of bacterial pathogenicity in the gastric microenvironment","volume":"10","author":"Baj J","year":"2020","unstructured":"Baj J, Forma A, Sitarz M, Portincasa P, Garruti G, Krasowska D, Maciejewski R. Helicobacter pylori virulence factors-mechanisms of bacterial pathogenicity in the gastric microenvironment. Cells. 2020, 10:27. 10.3390\/cells10010027","journal-title":"Cells"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S194153","article-title":"Oral microbiota and gastrointestinal cancer","volume":"12","author":"Zhang Y","year":"2019","unstructured":"Zhang Y, Niu Q, Fan W, Huang F, He H. Oral microbiota and gastrointestinal cancer. Onco Targets Ther. 2019, 12:4721-8. 10.2147\/OTT.S194153","journal-title":"Onco Targets Ther"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-021-02130-4","article-title":"Oral microbiota and Helicobacter pylori in gastric carcinogenesis: what do we know and where next?","volume":"21","author":"Bakhti SZ","year":"2021","unstructured":"Bakhti SZ, Latifi-Navid S. Oral microbiota and Helicobacter pylori in gastric carcinogenesis: what do we know and where next?. BMC Microbiol. 2021, 21:71. 10.1186\/s12866-021-02130-4","journal-title":"BMC Microbiol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2017.06.002","article-title":"Human gut microbiota and gastrointestinal cancer","volume":"16","author":"Meng C","year":"2018","unstructured":"Meng C, Bai C, Brown TD, Hood LE, Tian Q. Human gut microbiota and gastrointestinal cancer. Genom Proteom Bioinform. 2018, 16:33-49. 10.1016\/j.gpb.2017.06.002","journal-title":"Genom Proteom Bioinform"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4209","article-title":"Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum\u00a0promote tumor progression in an oral-specific chemical carcinogenesis model","volume":"6","author":"Binder Gallimidi A","year":"2015","unstructured":"Binder Gallimidi A, Fischman S, Revach B, et al.. Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum\u00a0promote tumor progression in an oral-specific chemical carcinogenesis model. Oncotarget. 2015, 6:22613-23. 10.18632\/oncotarget.4209","journal-title":"Oncotarget"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.01.024","article-title":"An oral commensal associates with disease: chicken, egg, or red herring?","volume":"42","author":"Colucci F","year":"2015","unstructured":"Colucci F. An oral commensal associates with disease: chicken, egg, or red herring?. Immunity. 2015, 42:208-10. 10.1016\/j.immuni.2015.01.024","journal-title":"Immunity"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7010020","article-title":"Role of oral microbiota in cancer development","volume":"7","author":"Karpi\u0144ski TM","year":"2019","unstructured":"Karpi\u0144ski TM. Role of oral microbiota in cancer development. Microorganisms. 2019, 7:20. 10.3390\/microorganisms7010020","journal-title":"Microorganisms"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1177\/106689690601400105","article-title":"Genetics, pathology, and clinics of familial gastric cancer","volume":"14","author":"Oliveira C","year":"2006","unstructured":"Oliveira C, Seruca R, Carneiro F. Genetics, pathology, and clinics of familial gastric cancer. Int J Surg Pathol. 2006, 14:21-33. 10.1177\/106689690601400105","journal-title":"Int J Surg Pathol"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.2217\/14796694.2.3.363","article-title":"Genetics of hereditary diffuse gastric cancer: progress and future challenges","volume":"2","author":"Suriano G","year":"2006","unstructured":"Suriano G, Ferreira P, Mateus AR, Correia J, Henriques L, Seruca R. Genetics of hereditary diffuse gastric cancer: progress and future challenges. Future Oncol. 2006, 2:363-70. 10.2217\/14796694.2.3.363","journal-title":"Future Oncol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(03)00899-0","article-title":"A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma","volume":"125","author":"Machado JC","year":"2003","unstructured":"Machado JC, Figueiredo C, Canedo P, et al.. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma\r\n. Gastroenterol. 2003, 125:364-71. 10.1016\/s0016-5085(03)00899-0","journal-title":"Gastroenterol"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.22.1680","article-title":"Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma","volume":"94","author":"Figueiredo C","year":"2002","unstructured":"Figueiredo C, Machado JC, Pharoah P, et al.. Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst. 2002, 94:1680-7. 10.1093\/jnci\/94.22.1680","journal-title":"J Natl Cancer Inst"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34156","article-title":"Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan","volume":"123","author":"Furuta T","year":"2002","unstructured":"Furuta T, El-Omar EM, Xiao F, Shirai N, Takashima M, Sugimura H. Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. Gastroenterology. 2002, 123:92-105. 10.1053\/gast.2002.34156","journal-title":"Gastroenterology"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.12.1684","article-title":"Association of interleukin 1B gene polymorphism and gastric cancers in high and low prevalence regions in China","volume":"52","author":"Zeng ZR","year":"2003","unstructured":"Zeng ZR, Hu PJ, Hu S, Pang RP, Chen MH, Ng M, Sung JJ. Association of interleukin 1B gene polymorphism and gastric cancers in high and low prevalence regions in China. Gut. 2003, 52:1684-9. 10.1136\/gut.52.12.1684","journal-title":"Gut"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21822","article-title":"A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: the Hisayama study","volume":"119","author":"Shikata K","year":"2006","unstructured":"Shikata K, Kiyohara Y, Kubo M, et al.. A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: the Hisayama study. Int J Cancer. 2006, 119:196-201. 10.1002\/ijc.21822","journal-title":"Int J Cancer"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.14670\/HH-23.593","article-title":"Synergistic upregulation of inducible nitric oxide synthase and cyclooxygenase-2 in gastric mucosa of Mongolian gerbils by a high-salt diet and Helicobacter pylori infection","volume":"23","author":"Toyoda T","year":"2008","unstructured":"Toyoda T, Tsukamoto T, Hirano N, et al.. Synergistic upregulation of inducible nitric oxide synthase and cyclooxygenase-2 in gastric mucosa of Mongolian gerbils by a high-salt diet and Helicobacter pylori infection. Histol Histopathol. 2008, 23:593-9. 10.14670\/HH-23.593","journal-title":"Histol Histopathol"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9132-y","article-title":"Smoking and gastric cancer: systematic review and meta-analysis of cohort studies","volume":"19","author":"Ladeiras-Lopes R","year":"2008","unstructured":"Ladeiras-Lopes R, Pereira AK, Nogueira A, Pinheiro-Torres T, Pinto I, Santos-Pereira R, Lunet N. Smoking and gastric cancer: systematic review and meta-analysis of cohort studies. Cancer Causes Control. 2008, 19:689-701. 10.1007\/s10552-008-9132-y","journal-title":"Cancer Causes Control"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1992.263.5.G719","article-title":"Helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury","volume":"263","author":"Suzuki M","year":"1992","unstructured":"Suzuki M, Miura S, Suematsu M, et al.. Helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury. Am J Physiol. 1992, 263:G719-25. 10.1152\/ajpgi.1992.263.5.G719","journal-title":"Am J Physiol"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.11-115SR","article-title":"Roles of oxidative stress in stomach disorders","volume":"50","author":"Suzuki H","year":"2012","unstructured":"Suzuki H, Nishizawa T, Tsugawa H, Mogami S, Hibi T. Roles of oxidative stress in stomach disorders. J Clin Biochem Nutr. 2012, 50:35-9. 10.3164\/jcbn.11-115SR","journal-title":"J Clin Biochem Nutr"},{"key":"ref42","article-title":"Diagnosis of Helicobacter pylori infection: current options and developments","volume":"21","author":"Wang YK","year":"2015","unstructured":"Wang YK, Kuo FC, Liu CJ, et al.. Diagnosis of Helicobacter pylori infection: current options and developments. World J Gastroenterol. 2015, 21:11221-35.","journal-title":"World J Gastroenterol"},{"key":"ref43","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v20.i7.1635","article-title":"Treatment of gastric cancer","volume":"20","author":"Orditura M","year":"2014","unstructured":"Orditura M, Galizia G, Sforza V, et al.. Treatment of gastric cancer. World J Gastroenterol. 2014, 20:1635-49.","journal-title":"World J Gastroenterol"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.15430\/JCP.2015.20.2.92","article-title":"Anticancer effect of lycopene in gastric carcinogenesis","volume":"20","author":"Kim MJ","year":"2015","unstructured":"Kim MJ, Kim H. Anticancer effect of lycopene in gastric carcinogenesis. J Cancer Prev. 2015, 20:92-6. 10.15430\/JCP.2015.20.2.92","journal-title":"J Cancer Prev"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/130772-role-of-helicobacter-pylori-in-gastric-carcinoma-a-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:57:37Z","timestamp":1707508657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/130772-role-of-helicobacter-pylori-in-gastric-carcinoma-a-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,6]]},"references-count":44,"URL":"https:\/\/doi.org\/10.7759\/cureus.37205","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4,6]]}}}