{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:50:42Z","timestamp":1791827442728,"version":"4.3.4"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,12]]},"DOI":"10.7759\/cureus.37465","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T07:57:01Z","timestamp":1681286221000},"source":"Crossref","is-referenced-by-count":5,"title":["Atypical Presentation of Herpes Simplex Virus Infection in an Immunocompromised Patient"],"prefix":"10.7759","author":[{"given":"Nada","family":"Alghamdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulelah","family":"Albaqami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmajeed","family":"Alharbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Human herpesviruses","author":"Bolognia JL","year":"2017","unstructured":"Bolognia JL, Schaffer JV, Cerroni L. Human herpesviruses. Dermatology, Fourth Edition. Elsevier, Philadelphia, PA; 2017."},{"key":"ref2","article-title":"Fields Virology","author":"Fields BN","year":"2013","unstructured":"Fields BN, Knipe DM, Howley PM. Fields Virology. Wolters Kluwer Health\/Lippincott Williams & Wilkins, Philadelphia, PA; 2013."},{"key":"ref3","article-title":"Herpes simplex virus","author":"Kliegman R","year":"2016","unstructured":"Kliegman R,  Stanton B, St. Geme J, et al.. Herpes simplex virus. Nelson Textbook of Pediatrics, 20th Edition. Elsevier, Philadelphia, PA; 2016."},{"key":"ref4","unstructured":"Herpes simplex virus. (2022). Accessed. March 27, 2023: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/herpes-simplex-virus."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003547","article-title":"Local CD4 and CD8 T-cell reactivity to HSV-1 antigens documents broad viral protein expression and immune competence in latently infected human trigeminal ganglia","volume":"9","author":"van Velzen M","year":"2013","unstructured":"van Velzen M, Jing L, Osterhaus AD, Sette A, Koelle DM, Verjans GM. Local CD4 and CD8 T-cell reactivity to HSV-1 antigens documents broad viral protein expression and immune competence in latently infected human trigeminal ganglia. PLoS Pathog. 2013, 9:e1003547. 10.1371\/journal.ppat.1003547","journal-title":"PLoS Pathog"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nature12110","article-title":"Immune surveillance by CD8\u03b1\u03b1+ skin-resident T cells in human herpes virus infection","volume":"497","author":"Zhu J","year":"2013","unstructured":"Zhu J, Peng T, Johnston C, et al.. Immune surveillance by CD8\u03b1\u03b1+ skin-resident T cells in human herpes virus infection. Nature. 2013, 497:494-7. 10.1038\/nature12110","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(87)70272-2","article-title":"Acyclovir resistance in a patient with chronic mucocutaneous herpes simplex infection","volume":"17","author":"Westheim AI","year":"1987","unstructured":"Westheim AI, Tenser RB, Marks JG. Acyclovir resistance in a patient with chronic mucocutaneous herpes simplex infection. J Am Acad Dermatol. 1987, 17:875-80. 10.1016\/s0190-9622(87)70272-2","journal-title":"J Am Acad Dermatol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90335-9","article-title":"Foscarnet treatment of acyclovir-resistant herpes simplex virus infection in patients with acquired immunodeficiency syndrome: preliminary results of a controlled, randomized, regimen-comparative trial","volume":"92","author":"Hardy WD","year":"1992","unstructured":"Hardy WD. Foscarnet treatment of acyclovir-resistant herpes simplex virus infection in patients with acquired immunodeficiency syndrome: preliminary results of a controlled, randomized, regimen-comparative trial. Am J Med. 1992, 92:S30-5. 10.1016\/0002-9343(92)90335-9","journal-title":"Am J Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp023065","article-title":"Genital herpes","volume":"350","author":"Kimberlin DW","year":"2004","unstructured":"Kimberlin DW, Rouse DJ. Genital herpes. N Engl J Med. 2004, 350:1970-7. 10.1056\/NEJMcp023065","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2165\/00128072-200103080-00004","article-title":"Clinical aspects and antiviral therapy in primary herpetic gingivostomatitis","volume":"3","author":"Amir J","year":"2001","unstructured":"Amir J. Clinical aspects and antiviral therapy in primary herpetic gingivostomatitis. Paediatr Drugs. 2001, 3:593-7. 10.2165\/00128072-200103080-00004","journal-title":"Paediatr Drugs"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/136.5.689","article-title":"Herpetic whitlow as part of genital virus infection","volume":"136","author":"Glogau R","year":"1977","unstructured":"Glogau R, Hanna L, Jawetz E. Herpetic whitlow as part of genital virus infection. J Infect Dis. 1977, 136:689-92. 10.1093\/infdis\/136.5.689","journal-title":"J Infect Dis"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.1999.00072.x","article-title":"The natural history of primary herpes simplex type 1 gingivostomatitis in children","volume":"16","author":"Amir J","year":"1999","unstructured":"Amir J, Harel L, Smetana Z, Varsano I. The natural history of primary herpes simplex type 1 gingivostomatitis in children. Pediatr Dermatol. 1999, 16:259-63. 10.1046\/j.1525-1470.1999.00072.x","journal-title":"Pediatr Dermatol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2004.12.003","article-title":"Generalized herpes simplex virus infection in an immunocompromised patient - report of a case and review of the literature","volume":"201","author":"Herget GW","year":"2005","unstructured":"Herget GW, Riede UN, Schmitt-Gr\u00e4ff A, L\u00fcbbert M, Neumann-Haefelin D, K\u00f6hler G. Generalized herpes simplex virus infection in an immunocompromised patient - report of a case and review of the literature. Pathol Res Pract. 2005, 201:123-9. 10.1016\/j.prp.2004.12.003","journal-title":"Pathol Res Pract"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(89)80195-1","article-title":"Atypical herpes simplex infection in patients with acute myelogenous leukemia recovering from chemotherapy","volume":"20","author":"Burgoyne M","year":"1989","unstructured":"Burgoyne M, Burke W. Atypical herpes simplex infection in patients with acute myelogenous leukemia recovering from chemotherapy. J Am Acad Dermatol. 1989, 20:1125-7. 10.1016\/s0190-9622(89)80195-1","journal-title":"J Am Acad Dermatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.192","article-title":"Treatment of herpes simplex virus infections in pediatric patients: current status and future needs","volume":"88","author":"James SH","year":"2010","unstructured":"James SH, Whitley RJ. Treatment of herpes simplex virus infections in pediatric patients: current status and future needs. Clin Pharmacol Ther. 2010, 88:720-4. 10.1038\/clpt.2010.192","journal-title":"Clin Pharmacol Ther"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(00)04638-9","article-title":"Herpes simplex virus infections","volume":"357","author":"Whitley RJ","year":"2001","unstructured":"Whitley RJ, Roizman B. Herpes simplex virus infections. Lancet. 2001, 357:1513-8. 10.1016\/s0140-6736(00)04638-9","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03337.x","article-title":"Comparison of the Tzanck test and polymerase chain reaction in the diagnosis of cutaneous herpes simplex and varicella zoster virus infections","volume":"46","author":"Ozcan A","year":"2007","unstructured":"Ozcan A, Senol M, Saglam H, Seyhan M, Durmaz R, Aktas E, Ozerol IH. Comparison of the Tzanck test and polymerase chain reaction in the diagnosis of cutaneous herpes simplex and varicella zoster virus infections. Int J Dermatol. 2007, 46:1177-9. 10.1111\/j.1365-4632.2007.03337.x","journal-title":"Int J Dermatol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/148217-atypical-presentation-of-herpes-simplex-virus-infection-in-an-immunocompromised-patient","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:59:23Z","timestamp":1707508763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/148217-atypical-presentation-of-herpes-simplex-virus-infection-in-an-immunocompromised-patient"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,12]]},"references-count":17,"URL":"https:\/\/doi.org\/10.7759\/cureus.37465","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4,12]]}}}