{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:32:52Z","timestamp":1762432372781},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,17]]},"DOI":"10.7759\/cureus.37672","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T09:20:49Z","timestamp":1681723249000},"source":"Crossref","is-referenced-by-count":2,"title":["Recent Advancements in Epidural Etanercept for Pain Management in Radiculopathy: A Literature Review"],"prefix":"10.7759","author":[{"given":"Andrew M","family":"Joseph","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Karas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Joubran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar E","family":"Jara Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Cordova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehul","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdus","family":"Salam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa M","family":"Leyva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Quinonez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Ruxmohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","unstructured":"Lumbosacral Radiculopathy. (2022). Accessed. March 2, 2023: http:\/\/gov.ezproxylocal.library.nova.edu\/books\/NBK430837\/."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007431.pub2","article-title":"Physical examination for lumbar radiculopathy due to disc herniation in patients with low-back pain","author":"van der Windt DA","year":"2010","unstructured":"van der Windt DA, Simons E, Riphagen II, et al.. Physical examination for lumbar radiculopathy due to disc herniation in patients with low-back pain. Cochrane Database Syst Rev. 2010, CD007431. 10.1002\/14651858.CD007431.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Clinical Features and Diagnosis of Cervical Radiculopathy. (2022). Accessed. March 1, 2023: http:\/\/com.ezproxylocal.library.nova.edu\/contents\/clinical-features-and-diagnosis-of-cervical-radiculopathy.","DOI":"10.1142\/9789811228599_0001"},{"key":"ref4","unstructured":"Low-Back Pain and Complementary Health Approaches. What You Need to Know. (2020). Accessed: February 27, 2023: https:\/\/www.nccih.nih.gov\/health\/low-back-pain-and-complementary-health-approaches-what-you-need-to-know."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2010.10.002","article-title":"The epidemiology of low back pain","volume":"24","author":"Hoy D","year":"2010","unstructured":"Hoy D, Brooks P, Blyth F, Buchbinder R. The epidemiology of low back pain. Best Pract Res Clin Rheumatol. 2010, 24:769-81. 10.1016\/j.berh.2010.10.002","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000079485.24016.70","article-title":"Brachial plexus variations in human fetuses","volume":"53","author":"Uysal II","year":"2003","unstructured":"Uysal II, Seker M, Karabulut AK, B\u00fcy\u00fckmumcu M, Ziylan T. Brachial plexus variations in human fetuses. Neurosurgery. 2003, 53:676-84; discussion 684. 10.1227\/01.neu.0000079485.24016.70","journal-title":"Neurosurgery"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.021","article-title":"Mechanisms of neuropathic pain","volume":"52","author":"Campbell JN","year":"2006","unstructured":"Campbell JN, Meyer RA. Mechanisms of neuropathic pain. Neuron. 2006, 52:77-92. 10.1016\/j.neuron.2006.09.021","journal-title":"Neuron"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2013.02.007","article-title":"Neurological examination of the peripheral nervous system to diagnose lumbar spinal disc herniation with suspected radiculopathy: a systematic review and meta-analysis","volume":"13","author":"Al Nezari NH","year":"2013","unstructured":"Al Nezari NH, Schneiders AG, Hendrick PA. Neurological examination of the peripheral nervous system to diagnose lumbar spinal disc herniation with suspected radiculopathy: a systematic review and meta-analysis. Spine J. 2013, 13:657-74. 10.1016\/j.spinee.2013.02.007","journal-title":"Spine J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199607010-00004","article-title":"Positions of dorsal root ganglia in the cervical spine. An anatomic and clinical study","volume":"21","author":"Yabuki S","year":"1996","unstructured":"Yabuki S, Kikuchi S. Positions of dorsal root ganglia in the cervical spine. An anatomic and clinical study. Spine (Phila Pa 1976). 1996, 21:1513-7. 10.1097\/00007632-199607010-00004","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3182a7f2c3","article-title":"Pathophysiology and natural history of cervical spondylotic myelopathy","volume":"38","author":"Karadimas SK","year":"2013","unstructured":"Karadimas SK, Erwin WM, Ely CG, Dettori JR, Fehlings MG. Pathophysiology and natural history of cervical spondylotic myelopathy. Spine (Phila Pa 1976). 2013, 38:S21-36. 10.1097\/BRS.0b013e3182a7f2c3","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2007.01.008","article-title":"Lumbosacral radiculopathy","volume":"25","author":"Tarulli AW","year":"2007","unstructured":"Tarulli AW, Raynor EM. Lumbosacral radiculopathy. Neurol Clin. 2007, 25:387-405. 10.1016\/j.ncl.2007.01.008","journal-title":"Neurol Clin"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.2.325","article-title":"Epidemiology of cervical radiculopathy. A population-based study from Rochester, Minnesota, 1976 through 1990","volume":"117","author":"Radhakrishnan K","year":"1994","unstructured":"Radhakrishnan K, Litchy WJ, O'Fallon WM, Kurland LT. Epidemiology of cervical radiculopathy. A population-based study from Rochester, Minnesota, 1976 through 1990. Brain. 1994, 117:325-35. 10.1093\/brain\/117.2.325","journal-title":"Brain"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.7.10.673","article-title":"Significance of symptoms and signs in localization of involved root in cervical disk protrusion","volume":"7","author":"Yoss RE","year":"1957","unstructured":"Yoss RE, Corbin KB, Maccarty CS, Love JG. Significance of symptoms and signs in localization of involved root in cervical disk protrusion. Neurology. 1957, 7:673-83. 10.1212\/wnl.7.10.673","journal-title":"Neurology"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnz127","article-title":"The effectiveness of fluoroscopically guided cervical transforaminal epidural steroid injection for the treatment of radicular pain; a systematic review and meta-analysis","volume":"21","author":"Conger A","year":"2020","unstructured":"Conger A, Cushman DM, Speckman RA, Burnham T, Teramoto M, McCormick ZL. The effectiveness of fluoroscopically guided cervical transforaminal epidural steroid injection for the treatment of radicular pain; a systematic review and meta-analysis. Pain Med. 2020, 21:41-54. 10.1093\/pm\/pnz127","journal-title":"Pain Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2021.676730","article-title":"Parasagittal approach of epidural steroid injection as a treatment for chronic low back pain: A systematic review and meta-analysis","volume":"2","author":"Knezevic NN","year":"2021","unstructured":"Knezevic NN, Paredes S, Cantillo S, Hamid A, Candido KD. Parasagittal approach of epidural steroid injection as a treatment for chronic low back pain: A systematic review and meta-analysis. Front Pain Res (Lausanne). 2021, 2:676730. 10.3389\/fpain.2021.676730","journal-title":"Front Pain Res (Lausanne)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2022.35.1.97","article-title":"Outcomes of epidural steroids following percutaneous transforaminal endoscopic discectomy: a meta-analysis and systematic review","volume":"35","author":"Song Y","year":"2022","unstructured":"Song Y, Li C, Guan J, et al.. Outcomes of epidural steroids following percutaneous transforaminal endoscopic discectomy: a meta-analysis and systematic review. Korean J Pain. 2022, 35:97-105. 10.3344\/kjp.2022.35.1.97","journal-title":"Korean J Pain"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000001005","article-title":"Postoperative pain treatment after spinal fusion surgery: a systematic review with meta-analyses and trial sequential analyses","volume":"7","author":"Geisler A","year":"2022","unstructured":"Geisler A, Zachodnik J, K\u00f8ppen K, Chakari R, Bech-Azeddine R. Postoperative pain treatment after spinal fusion surgery: a systematic review with meta-analyses and trial sequential analyses. Pain Rep. 2022, 7:e1005. 10.1097\/PR9.0000000000001005","journal-title":"Pain Rep"},{"key":"ref18","article-title":"Long-term outcomes of epidurals with lidocaine with or without steroids for lumbar disc herniation and spinal stenosis: a meta-analysis","volume":"23","author":"Zhao W","year":"2020","unstructured":"Zhao W, Wang Y, Wu J, et al.. Long-term outcomes of epidurals with lidocaine with or without steroids for lumbar disc herniation and spinal stenosis: a meta-analysis. Pain Physician. 2020, 23:365-74.","journal-title":"Pain Physician"},{"key":"ref19","article-title":"Comparison of clinical efficacy of epidural injection with or without steroids in the treatment of degenerative disc disease: meta-analysis","volume":"25","author":"Fang Z","year":"2022","unstructured":"Fang Z, Yuan C, Cheng L, et al.. Comparison of clinical efficacy of epidural injection with or without steroids in the treatment of degenerative disc disease: meta-analysis. Pain Physician. 2022, 25:145-60.","journal-title":"Pain Physician"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.10.079","article-title":"Effect of first-line ziconotide intrathecal drug therapy for neuropathic pain on disability, emotional well-being, and pain catastrophizing","volume":"145","author":"Shao MM","year":"2021","unstructured":"Shao MM, Khazen O, Hellman A, et al.. Effect of first-line ziconotide intrathecal drug therapy for neuropathic pain on disability, emotional well-being, and pain catastrophizing. World Neurosurg. 2021, 145:e340-7. 10.1016\/j.wneu.2020.10.079","journal-title":"World Neurosurg"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnaa076","article-title":"Effects of bupivacaine on opioid patient-controlled intrathecal analgesia in chronic pain patients implanted with drug delivery systems","volume":"22","author":"Hayek SM","year":"2021","unstructured":"Hayek SM, McEwan MT, Veizi E, DeLozier SJ, Pogrebetskaya M. Effects of bupivacaine on opioid patient-controlled intrathecal analgesia in chronic pain patients implanted with drug delivery systems. Pain Med. 2021, 22:22-33. 10.1093\/pm\/pnaa076","journal-title":"Pain Med"},{"key":"ref22","unstructured":"Spinal Pain. (2012). Accessed. March 2, 2023: https:\/\/www.aans.org\/en\/Patients\/Neurosurgical-Conditions-and-Treatments\/Spinal-Pain."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2016.10.004","article-title":"Transforaminal epidural Etanercept for the treatment of prolapsed lumbar intervertebral disc induced sciatica","volume":"8","author":"Dagar A","year":"2017","unstructured":"Dagar A, Kumar R, Kashyap A, Prabhat V, Lal H, Kumar L. Transforaminal epidural Etanercept for the treatment of prolapsed lumbar intervertebral disc induced sciatica. J Clin Orthop Trauma. 2017, 8:148-52. 10.1016\/j.jcot.2016.10.004","journal-title":"J Clin Orthop Trauma"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2017.08.002","article-title":"Targeting cytokines for treatment of neuropathic pain","volume":"17","author":"Hung AL","year":"2017","unstructured":"Hung AL, Lim M, Doshi TL. Targeting cytokines for treatment of neuropathic pain. Scand J Pain. 2017, 17:287-93. 10.1016\/j.sjpain.2017.08.002","journal-title":"Scand J Pain"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1080\/02688697.2020.1713990","article-title":"Randomized trial of 3-drug combination for lumbar nerve root epidural injections with a TNF-\u03b1 inhibitor in treatment of lumbar stenosis","volume":"34","author":"Wei P","year":"2020","unstructured":"Wei P, Xu Y, Yao Q, Wang L. Randomized trial of 3-drug combination for lumbar nerve root epidural injections with a TNF-\u03b1 inhibitor in treatment of lumbar stenosis. Br J Neurosurg. 2020, 34:168-71. 10.1080\/02688697.2020.1713990","journal-title":"Br J Neurosurg"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000181","article-title":"Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor","volume":"156","author":"Gerard E","year":"2015","unstructured":"Gerard E, Spengler RN, Bonoiu AC, et al.. Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor. Pain. 2015, 156:1320-33. 10.1097\/j.pain.0000000000000181","journal-title":"Pain"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-017-9441-4","article-title":"Lumbar disc herniation","volume":"10","author":"Amin RM","year":"2017","unstructured":"Amin RM, Andrade NS, Neuman BJ. Lumbar disc herniation. Curr Rev Musculoskelet Med. 2017, 10:507-16. 10.1007\/s12178-017-9441-4","journal-title":"Curr Rev Musculoskelet Med"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.22203\/ecm.v030a08","article-title":"Disc in flames: roles of TNF-\u03b1 and IL-1\u03b2 in intervertebral disc degeneration","volume":"30","author":"Johnson ZI","year":"2015","unstructured":"Johnson ZI, Schoepflin ZR, Choi H, Shapiro IM, Risbud MV. Disc in flames: roles of TNF-\u03b1 and IL-1\u03b2 in intervertebral disc degeneration. Eur Cell Mater. 2015, 30:104-16; discussion 116-7. 10.22203\/ecm.v030a08","journal-title":"Eur Cell Mater"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.37897\/RJN.2020.4.3","article-title":"Disentangling the lumbar PIVD puzzle: a narrative review","volume":"19","author":"Singh V","year":"2020","unstructured":"Singh V, Malik M, Kaur J, et al.. Disentangling the lumbar PIVD puzzle: a narrative review. Ro J Neurol. 2020, 19:10.37897\/RJN.2020.4.3","journal-title":"Ro J Neurol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.4103\/aer.AER_160_17","article-title":"Comparison of the intravenous and epidural administration of tumor necrosis factor-alpha antagonists in an experimental rat pain model","volume":"11","author":"Beyaz SG","year":"2017","unstructured":"Beyaz SG, \u0130nanmaz ME, Erg\u00f6nen\u00e7 T, Palab\u0131y\u0131k O, Tomak Y, Tuna AT. Comparison of the intravenous and epidural administration of tumor necrosis factor-alpha antagonists in an experimental rat pain model. Anesth Essays Res. 2017, 11:898-901. 10.4103\/aer.AER_160_17","journal-title":"Anesth Essays Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/147600-recent-advancements-in-epidural-etanercept-for-pain-management-in-radiculopathy-a-literature-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:59:17Z","timestamp":1707508757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/147600-recent-advancements-in-epidural-etanercept-for-pain-management-in-radiculopathy-a-literature-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.37672","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4,17]]}}}