{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T18:04:44Z","timestamp":1764785084283},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,18]]},"DOI":"10.7759\/cureus.37761","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T13:01:57Z","timestamp":1681822917000},"source":"Crossref","is-referenced-by-count":3,"title":["Assessment of the Diagnostic Utility of GeneXpert Mycobacterium tuberculosis\/Rifampicin (MTB\/RIF) Assay in the Suspected Cases of Tuberculous Meningitis"],"prefix":"10.7759","author":[{"given":"Sakshi","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malti","family":"Dadheech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand K","family":"Maurya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitendra","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashank","family":"Purwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirendra","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radha","family":"Sarawagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagar","family":"Khadanga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Tuberculous Meningitis","author":"Slane VH","year":"2022","unstructured":"Slane VH, Unakal CG. Tuberculous Meningitis. StatPearls Publishing, Treasure Island, FL; 2022."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00042-07","article-title":"Central nervous system tuberculosis: pathogenesis and clinical aspects","volume":"21","author":"Rock RB","year":"2008","unstructured":"Rock RB, Olin M, Baker CA, Molitor TW, Peterson PK. Central nervous system tuberculosis: pathogenesis and clinical aspects. Clin Microbiol Rev. 2008, 21:243-61, table of contents. 10.1128\/CMR.00042-07","journal-title":"Clin Microbiol Rev"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0820","article-title":"Current concepts in the management of tuberculosis","volume":"86","author":"Sia IG","year":"2011","unstructured":"Sia IG, Wieland ML. Current concepts in the management of tuberculosis. Mayo Clin Proc. 2011, 86:348-61. 10.4065\/mcp.2010.0820","journal-title":"Mayo Clin Proc"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/798764","article-title":"Tuberculous meningitis: diagnosis and treatment overview","volume":"2011","author":"Marx GE","year":"2011","unstructured":"Marx GE, Chan ED. Tuberculous meningitis: diagnosis and treatment overview. Tuberc Res Treat. 2011, 2011:798764. 10.1155\/2011\/798764","journal-title":"Tuberc Res Treat"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000606","article-title":"Tuberculous meningitis: a neglected tropical disease?","volume":"9","author":"Chin JH","year":"2019","unstructured":"Chin JH. Tuberculous meningitis: a neglected tropical disease?. Neurol Clin Pract. 2019, 9:152-4. 10.1212\/CPJ.0000000000000606","journal-title":"Neurol Clin Pract"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198695","article-title":"Evaluation of the GeneXpert MTB\/RIF in patients with presumptive tuberculous meningitis","volume":"13","author":"Metcalf T","year":"2018","unstructured":"Metcalf T, Soria J, Montano SM, et al.. Evaluation of the GeneXpert MTB\/RIF in patients with presumptive tuberculous meningitis. PLoS One. 2018, 13:e0198695. 10.1371\/journal.pone.0198695","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4297\/najms.2011.3281","article-title":"Direct molecular detection of Mycobacterium tuberculosis complex from clinical samples - an adjunct to cultural method of laboratory diagnosis of tuberculosis","volume":"3","author":"Alli OA","year":"2011","unstructured":"Alli OA, Ogbolu OD, Alaka OO. Direct molecular detection of Mycobacterium tuberculosis complex from clinical samples - an adjunct to cultural method of laboratory diagnosis of tuberculosis. N Am J Med Sci. 2011, 3:281-8. 10.4297\/najms.2011.3281","journal-title":"N Am J Med Sci"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.07.007","article-title":"Detection of Mycobacterium tuberculosis in urine by Xpert MTB\/RIF ultra: a useful adjunctive diagnostic tool in HIV-associated tuberculosis","volume":"75","author":"Atherton RR","year":"2018","unstructured":"Atherton RR, Cresswell FV, Ellis J, et al.. Detection of Mycobacterium tuberculosis in urine by Xpert MTB\/RIF ultra: a useful adjunctive diagnostic tool in HIV-associated tuberculosis. Int J Infect Dis. 2018, 75:92-4. 10.1016\/j.ijid.2018.07.007","journal-title":"Int J Infect Dis"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01771-20","article-title":"Tuberculous meningitis: pathogenesis, immune responses, diagnostic challenges, and the potential of biomarker-based approaches","volume":"59","author":"Manyelo CM","year":"2021","unstructured":"Manyelo CM, Solomons RS, Walzl G, Chegou NN. Tuberculous meningitis: pathogenesis, immune responses, diagnostic challenges, and the potential of biomarker-based approaches. J Clin Microbiol. 2021, 59:01771-20. 10.1128\/JCM.01771-20","journal-title":"J Clin Microbiol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a017863","article-title":"Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis","volume":"5","author":"Seung KJ","year":"2015","unstructured":"Seung KJ, Keshavjee S, Rich ML. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. Cold Spring Harb Perspect Med. 2015, 5:a017863. 10.1101\/cshperspect.a017863","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.12701\/yujm.2020.00626","article-title":"Diagnosis and treatment of multidrug-resistant tuberculosis","volume":"37","author":"Jang JG","year":"2020","unstructured":"Jang JG, Chung JH. Diagnosis and treatment of multidrug-resistant tuberculosis. Yeungnam Univ J Med. 2020, 37:277-85. 10.12701\/yujm.2020.00626","journal-title":"Yeungnam Univ J Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jctube.2020.100164","article-title":"Challenges in the diagnosis of tuberculous meningitis","volume":"20","author":"Foppiano Palacios C","year":"2020","unstructured":"Foppiano Palacios C, Saleeb PG. Challenges in the diagnosis of tuberculous meningitis. J Clin Tuberc Other Mycobact Dis. 2020, 20:100164. 10.1016\/j.jctube.2020.100164","journal-title":"J Clin Tuberc Other Mycobact Dis"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15535.1","article-title":"The current global situation for tuberculous meningitis: epidemiology, diagnostics, treatment and outcomes","volume":"4","author":"Seddon JA","year":"2019","unstructured":"Seddon JA, Tugume L, Solomons R, Prasad K, Bahr NC. The current global situation for tuberculous meningitis: epidemiology, diagnostics, treatment and outcomes. Wellcome Open Res. 2019, 4:167. 10.12688\/wellcomeopenres.15535.1","journal-title":"Wellcome Open Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6496","article-title":"Tuberculous meningitis diagnosis and treatment in adults: a series of 189 suspected cases","volume":"16","author":"Luo M","year":"2018","unstructured":"Luo M, Wang W, Zeng Q, Luo Y, Yang H, Yang X. Tuberculous meningitis diagnosis and treatment in adults: a series of 189 suspected cases. Exp Ther Med. 2018, 16:2770-6. 10.3892\/etm.2018.6496","journal-title":"Exp Ther Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70008-2","article-title":"Advances in tuberculosis diagnostics: the Xpert MTB\/RIF assay and future prospects for a point-of-care test","volume":"13","author":"Lawn SD","year":"2013","unstructured":"Lawn SD, Mwaba P, Bates M, et al.. Advances in tuberculosis diagnostics: the Xpert MTB\/RIF assay and future prospects for a point-of-care test. Lancet Infect Dis. 2013, 13:349-61. 10.1016\/S1473-3099(13)70008-2","journal-title":"Lancet Infect Dis"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70138-9","article-title":"Tuberculous meningitis: a uniform case definition for use in clinical research","volume":"10","author":"Marais S","year":"2010","unstructured":"Marais S, Thwaites G, Schoeman JF, et al.. Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infect Dis. 2010, 10:803-12. 10.1016\/S1473-3099(10)70138-9","journal-title":"Lancet Infect Dis"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05188-11","article-title":"Direct drug susceptibility testing of Mycobacterium tuberculosis for rapid detection of multidrug resistance using the Bactec MGIT 960 system: a multicenter study","volume":"50","author":"Siddiqi S","year":"2012","unstructured":"Siddiqi S, Ahmed A, Asif S, et al.. Direct drug susceptibility testing of Mycobacterium tuberculosis for rapid detection of multidrug resistance using the Bactec MGIT 960 system: a multicenter study. J Clin Microbiol. 2012, 50:435-40. 10.1128\/JCM.05188-11","journal-title":"J Clin Microbiol"},{"key":"ref18","unstructured":"Tuberculosis - Major Infectious Diseases. (2023). Accessed. February 28, 2023: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK525174\/."},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v14i1.22","article-title":"Presentation and outcome of tuberculous meningitis among children: experiences from a tertiary children's hospital","volume":"14","author":"Nabukeera-Barungi N","year":"2014","unstructured":"Nabukeera-Barungi N, Wilmshurst J, Rudzani M, Nuttall J. Presentation and outcome of tuberculous meningitis among children: experiences from a tertiary children's hospital. Afr Health Sci. 2014, 14:143-9. 10.4314\/ahs.v14i1.22","journal-title":"Afr Health Sci"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29353-x","article-title":"Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics","volume":"13","author":"Ramachandran PS","year":"2022","unstructured":"Ramachandran PS, Ramesh A, Creswell FV, et al.. Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics. Nat Commun. 2022, 13:1675. 10.1038\/s41467-022-29353-x","journal-title":"Nat Commun"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05756-11","article-title":"A highly efficient Ziehl-Neelsen stain: identifying de novo intracellular Mycobacterium tuberculosis and improving detection of extracellular M. tuberculosis in cerebrospinal fluid","volume":"50","author":"Chen P","year":"2012","unstructured":"Chen P, Shi M, Feng GD, et al.. A highly efficient Ziehl-Neelsen stain: identifying de novo intracellular Mycobacterium tuberculosis and improving detection of extracellular M. tuberculosis in cerebrospinal fluid. J Clin Microbiol. 2012, 50:1166-70. 10.1128\/JCM.05756-11","journal-title":"J Clin Microbiol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1177\/2058738419827174","article-title":"Detection of Mycobacterium tuberculosis in AFB smear-negative sputum specimens through MTB culture and GeneXpert(\u00ae) MTB\/RIF assay","volume":"33","author":"Rasool G","year":"2019","unstructured":"Rasool G, Khan AM, Mohy-Ud-Din R, Riaz M. Detection of Mycobacterium tuberculosis in AFB smear-negative sputum specimens through MTB culture and GeneXpert(\u00ae) MTB\/RIF assay. Int J Immunopathol Pharmacol. 2019, 33:2058738419827174. 10.1177\/2058738419827174","journal-title":"Int J Immunopathol Pharmacol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1145_19","article-title":"Microbiological diagnosis of tuberculous meningitis: phenotype to genotype","volume":"150","author":"Garg RK","year":"2019","unstructured":"Garg RK. Microbiological diagnosis of tuberculous meningitis: phenotype to genotype. Indian J Med Res. 2019, 150:448-57. 10.4103\/ijmr.IJMR_1145_19","journal-title":"Indian J Med Res"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2014.03.002","article-title":"What is the most reliable solid culture medium for tuberculosis treatment trials?","volume":"94","author":"Joloba ML","year":"2014","unstructured":"Joloba ML, Johnson JL, Feng PJ, et al.. What is the most reliable solid culture medium for tuberculosis treatment trials?. Tuberculosis (Edinb). 2014, 94:311-6. 10.1016\/j.tube.2014.03.002","journal-title":"Tuberculosis (Edinb)"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4687-7","article-title":"Evaluation of GeneXpert MTB\/RIF system performances in the diagnosis of extrapulmonary tuberculosis","volume":"19","author":"Mechal Y","year":"2019","unstructured":"Mechal Y, Benaissa E, El Mrimar N, et al.. Evaluation of GeneXpert MTB\/RIF system performances in the diagnosis of extrapulmonary tuberculosis. BMC Infect Dis. 2019, 19:1069. 10.1186\/s12879-019-4687-7","journal-title":"BMC Infect Dis"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2017.04.010","article-title":"Diagnostic usefulness of Xpert MTB\/RIF assay for detection of tuberculous meningitis using cerebrospinal fluid","volume":"75","author":"Rufai SB","year":"2017","unstructured":"Rufai SB, Singh A, Singh J, Kumar P, Sankar MM, Singh S. Diagnostic usefulness of Xpert MTB\/RIF assay for detection of tuberculous meningitis using cerebrospinal fluid. J Infect. 2017, 75:125-31. 10.1016\/j.jinf.2017.04.010","journal-title":"J Infect"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X20160119","article-title":"Red blood cells in cerebrospinal fluid as possible inhibitory factor for enterovirus RT-PCR","volume":"74","author":"Almeida SM","year":"2016","unstructured":"Almeida SM, Raboni SM, Nogueira MB, Vidal LR. Red blood cells in cerebrospinal fluid as possible inhibitory factor for enterovirus RT-PCR. Arq Neuropsiquiatr. 2016, 74:810-5. 10.1590\/0004-282X20160119","journal-title":"Arq Neuropsiquiatr"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01834-13","article-title":"Evaluation of GeneXpert MTB\/RIF for diagnosis of tuberculous meningitis","volume":"52","author":"Nhu NT","year":"2014","unstructured":"Nhu NT, Heemskerk D, Thu do DA, et al.. Evaluation of GeneXpert MTB\/RIF for diagnosis of tuberculous meningitis. J Clin Microbiol. 2014, 52:226-33. 10.1128\/JCM.01834-13","journal-title":"J Clin Microbiol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02319-10","article-title":"Xpert MTB\/RIF: a new pillar in diagnosis of extrapulmonary tuberculosis?","volume":"49","author":"Vadwai V","year":"2011","unstructured":"Vadwai V, Boehme C, Nabeta P, Shetty A, Alland D, Rodrigues C. Xpert MTB\/RIF: a new pillar in diagnosis of extrapulmonary tuberculosis?. J Clin Microbiol. 2011, 49:2540-5. 10.1128\/JCM.02319-10","journal-title":"J Clin Microbiol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.14.0805","article-title":"Appropriate use of the Xpert\u00ae MTB\/RIF assay in suspected tuberculous meningitis","volume":"19","author":"Boyles TH","year":"2015","unstructured":"Boyles TH, Thwaites GE. Appropriate use of the Xpert\u00ae MTB\/RIF assay in suspected tuberculous meningitis. Int J Tuberc Lung Dis. 2015, 19:276-7. 10.5588\/ijtld.14.0805","journal-title":"Int J Tuberc Lung Dis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/143285-assessment-of-the-diagnostic-utility-of-genexpert-mycobacterium-tuberculosisrifampicin-mtbrif-assay-in-the-suspected-cases-of-tuberculous-meningitis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:00:13Z","timestamp":1707508813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/143285-assessment-of-the-diagnostic-utility-of-genexpert-mycobacterium-tuberculosisrifampicin-mtbrif-assay-in-the-suspected-cases-of-tuberculous-meningitis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,18]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.37761","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4,18]]}}}