{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:59:22Z","timestamp":1787032762810,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,20]]},"DOI":"10.7759\/cureus.37862","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T08:57:14Z","timestamp":1681981034000},"source":"Crossref","is-referenced-by-count":1,"title":["Increased Effusion Synovitis for Those With a Dysregulated Inflammatory Response After an Anterior Cruciate Ligament Injury"],"prefix":"10.7759","author":[{"given":"Cale A","family":"Jacobs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin V","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin E. W","family":"Conley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varag","family":"Abed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet  L","family":"Huebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia  B","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy  E","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lattermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2018-099751","article-title":"What's the rate of knee osteoarthritis 10 years after anterior cruciate ligament injury? An updated systematic review","volume":"53","author":"Lie MM","year":"2019","unstructured":"Lie MM, Risberg MA, Storheim K, Engebretsen L, \u00d8iestad BE. What's the rate of knee osteoarthritis 10 years after anterior cruciate ligament injury? An updated systematic review. Br J Sports Med. 2019, 53:1162-7. 10.1136\/bjsports-2018-099751","journal-title":"Br J Sports Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2022-105496","article-title":"Risk factors for knee osteoarthritis after traumatic knee injury: a systematic review and meta-analysis of randomised controlled trials and cohort studies for the OPTIKNEE Consensus","volume":"56","author":"Whittaker JL","year":"2022","unstructured":"Whittaker JL, Losciale JM, Juhl CB, et al.. Risk factors for knee osteoarthritis after traumatic knee injury: a systematic review and meta-analysis of randomised controlled trials and cohort studies for the OPTIKNEE Consensus. Br J Sports Med. 2022, 56:1406-21. 10.1136\/bjsports-2022-105496","journal-title":"Br J Sports Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002161","article-title":"Dysregulated inflammatory response related to cartilage degradation after ACL injury","volume":"52","author":"Jacobs CA","year":"2020","unstructured":"Jacobs CA, Hunt ER, Conley CE, et al.. Dysregulated inflammatory response related to cartilage degradation after ACL injury. Med Sci Sports Exerc. 2020, 52:535-41. 10.1249\/MSS.0000000000002161","journal-title":"Med Sci Sports Exerc"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-022-01661-4","article-title":"The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture","volume":"72","author":"Jacobs CA","year":"2023","unstructured":"Jacobs CA, Olsen ZM, Marchand LS, Kraus VB, Anderson DD, Haller J. The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture. Inflamm Res. 2023, 72:9-11. 10.1007\/s00011-022-01661-4","journal-title":"Inflamm Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360207","article-title":"Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis","volume":"36","author":"Lohmander LS","year":"1993","unstructured":"Lohmander LS, Hoerrner LA, Lark MW. Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis. Arthritis Rheum. 1993, 36:181-9. 10.1002\/art.1780360207","journal-title":"Arthritis Rheum"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.12.003","article-title":"Association between knee inflammation and knee pain in patients with knee osteoarthritis: a systematic review","volume":"30","author":"Dainese P","year":"2022","unstructured":"Dainese P, Wyngaert KV, De Mits S, Wittoek R, Van Ginckel A, Calders P. Association between knee inflammation and knee pain in patients with knee osteoarthritis: a systematic review. Osteoarthritis Cartilage. 2022, 30:516-34. 10.1016\/j.joca.2021.12.003","journal-title":"Osteoarthritis Cartilage"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/art.30137","article-title":"Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms","volume":"63","author":"Scanzello CR","year":"2011","unstructured":"Scanzello CR, McKeon B, Swaim BH, et al.. Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms. Arthritis Rheum. 2011, 63:391-400. 10.1002\/art.30137","journal-title":"Arthritis Rheum"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073903","article-title":"Do synovial inflammation and meniscal degeneration impact clinical outcomes of patients undergoing arthroscopic partial meniscectomy? A histological study","volume":"23","author":"Olivotto E","year":"2022","unstructured":"Olivotto E, Belluzzi E, Pozzuoli A, et al.. Do synovial inflammation and meniscal degeneration impact clinical outcomes of patients undergoing arthroscopic partial meniscectomy? A histological study. Int J Mol Sci. 2022, 23:3903. 10.3390\/ijms23073903","journal-title":"Int J Mol Sci"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516666818","article-title":"A multicenter study of early anti-inflammatory treatment in patients with acute anterior cruciate ligament tear","volume":"45","author":"Lattermann C","year":"2017","unstructured":"Lattermann C, Jacobs CA, Proffitt Bunnell M, et al.. A multicenter study of early anti-inflammatory treatment in patients with acute anterior cruciate ligament tear. Am J Sports Med. 2017, 45:325-33. 10.1177\/0363546516666818","journal-title":"Am J Sports Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517749834","article-title":"Synovial fluid profile at the time of anterior cruciate ligament reconstruction and its association with cartilage matrix composition 3 years after surgery","volume":"46","author":"Amano K","year":"2018","unstructured":"Amano K, Huebner JL, Stabler TV, et al.. Synovial fluid profile at the time of anterior cruciate ligament reconstruction and its association with cartilage matrix composition 3 years after surgery. Am J Sports Med. 2018, 46:890-9. 10.1177\/0363546517749834","journal-title":"Am J Sports Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9387809","article-title":"Select biomarkers on the day of anterior cruciate ligament reconstruction predict poor patient-reported outcomes at 2-year follow-up: a pilot study","volume":"2018","author":"Lattermann C","year":"2018","unstructured":"Lattermann C, Conley CE, Johnson DL, et al.. Select biomarkers on the day of anterior cruciate ligament reconstruction predict poor patient-reported outcomes at 2-year follow-up: a pilot study. Biomed Res Int. 2018, 2018:9387809. 10.1155\/2018\/9387809","journal-title":"Biomed Res Int"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209252","article-title":"Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium","volume":"76","author":"Kraus VB","year":"2017","unstructured":"Kraus VB, Collins JE, Hargrove D, et al.. Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium. Ann Rheum Dis. 2017, 76:186-95. 10.1136\/annrheumdis-2016-209252","journal-title":"Ann Rheum Dis"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2015.12.045","article-title":"Early cartilage changes after anterior cruciate ligament injury: evaluation with imaging and serum biomarkers - a pilot study","volume":"32","author":"Palmieri-Smith RM","year":"2016","unstructured":"Palmieri-Smith RM, Wojtys EM, Potter HG. Early cartilage changes after anterior cruciate ligament injury: evaluation with imaging and serum biomarkers - a pilot study. Arthroscopy. 2016, 32:1309-18. 10.1016\/j.arthro.2015.12.045","journal-title":"Arthroscopy"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/ar3216","article-title":"Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)","volume":"12","author":"Catterall JB","year":"2010","unstructured":"Catterall JB, Stabler TV, Flannery CR, Kraus VB. Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254). Arthritis Res Ther. 2010, 12:R229. 10.1186\/ar3216","journal-title":"Arthritis Res Ther"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.03.006","article-title":"Anterior Cruciate Ligament OsteoArthritis Score (ACLOAS): longitudinal MRI-based whole joint assessment of anterior cruciate ligament injury","volume":"22","author":"Roemer FW","year":"2014","unstructured":"Roemer FW, Frobell R, Lohmander LS, Niu J, Guermazi A. Anterior Cruciate Ligament OsteoArthritis Score (ACLOAS): longitudinal MRI-based whole joint assessment of anterior cruciate ligament injury. Osteoarthritis Cartilage. 2014, 22:668-82. 10.1016\/j.joca.2014.03.006","journal-title":"Osteoarthritis Cartilage"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2016.05.009","article-title":"The location and severity of preoperative subchondral bone marrow lesions were not associated with inferior postoperative outcomes after medial unicompartmental knee arthroplasty or total knee arthroplasty","volume":"31","author":"Jacobs CA","year":"2016","unstructured":"Jacobs CA, Berend KR, Lombardi AV Jr, Christensen CP. The location and severity of preoperative subchondral bone marrow lesions were not associated with inferior postoperative outcomes after medial unicompartmental knee arthroplasty or total knee arthroplasty. J Arthroplasty. 2016, 31:2476-80. 10.1016\/j.arth.2016.05.009","journal-title":"J Arthroplasty"},{"key":"ref17","article-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J","year":"1988","unstructured":"Cohen J. Statistical Power Analysis for the Behavioral Sciences. Lawrence Erlbaum Associates, Hillsdale, NJ; 1988."},{"key":"ref18","unstructured":"Outliers. tests for outliers. (2022). Accessed: 2022: https:\/\/cran.r-project.org\/web\/packages\/outliers\/."},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-022-04191-6","article-title":"Structural phenotypes of knee osteoarthritis: potential clinical and research relevance","volume":"[Epub]","author":"Roemer FW","year":"2022","unstructured":"Roemer FW, Jarraya M, Collins JE, Kwoh CK, Hayashi D, Hunter DJ, Guermazi A. Structural phenotypes of knee osteoarthritis: potential clinical and research relevance. Skeletal Radiol. 2022, [Epub]:10.1007\/s00256-022-04191-6","journal-title":"Skeletal Radiol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1923-x","article-title":"Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation","volume":"21","author":"Haraden CA","year":"2019","unstructured":"Haraden CA, Huebner JL, Hsueh MF, Li YJ, Kraus VB. Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation. Arthritis Res Ther. 2019, 21:146. 10.1186\/s13075-019-1923-x","journal-title":"Arthritis Res Ther"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/art.39176","article-title":"What comes first? Multitissue involvement leading to radiographic osteoarthritis: magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative","volume":"67","author":"Roemer FW","year":"2015","unstructured":"Roemer FW, Kwoh CK, Hannon MJ, et al.. What comes first? Multitissue involvement leading to radiographic osteoarthritis: magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative. Arthritis Rheumatol. 2015, 67:2085-96. 10.1002\/art.39176","journal-title":"Arthritis Rheumatol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24457","article-title":"Role of inflammation and the immune system in the progression of osteoarthritis","volume":"38","author":"Woodell-May JE","year":"2020","unstructured":"Woodell-May JE, Sommerfeld SD. Role of inflammation and the immune system in the progression of osteoarthritis. J Orthop Res. 2020, 38:253-7. 10.1002\/jor.24457","journal-title":"J Orthop Res"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.09.008","article-title":"Concentrations of synovial fluid biomarkers and the prediction of knee osteoarthritis 16\u00a0years after anterior cruciate ligament injury","volume":"25","author":"Neuman P","year":"2017","unstructured":"Neuman P, Dahlberg LE, Englund M, Struglics A. Concentrations of synovial fluid biomarkers and the prediction of knee osteoarthritis 16\u00a0years after anterior cruciate ligament injury. Osteoarthritis Cartilage. 2017, 25:492-8. 10.1016\/j.joca.2016.09.008","journal-title":"Osteoarthritis Cartilage"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.022434","article-title":"MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis","volume":"64","author":"Tchetverikov I","year":"2005","unstructured":"Tchetverikov I, Lohmander LS, Verzijl N, Huizinga TW, TeKoppele JM, Hanemaaijer R, DeGroot J. MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis. Ann Rheum Dis. 2005, 64:694-8. 10.1136\/ard.2004.022434","journal-title":"Ann Rheum Dis"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.03.014","article-title":"Synovial fluid concentrations of matrix Metalloproteinase-3 and Interluekin-6 following anterior cruciate ligament injury associate with gait biomechanics 6 months following reconstruction","volume":"29","author":"Evans-Pickett A","year":"2021","unstructured":"Evans-Pickett A, Longobardi L, Spang JT, et al.. Synovial fluid concentrations of matrix Metalloproteinase-3 and Interluekin-6 following anterior cruciate ligament injury associate with gait biomechanics 6 months following reconstruction. Osteoarthritis Cartilage. 2021, 29:1006-19. 10.1016\/j.joca.2021.03.014","journal-title":"Osteoarthritis Cartilage"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1177\/19417381221139478","article-title":"Pain early after anterior cruciate ligament reconstruction is associated with 6-month loading mechanics during running","volume":"[Epub]","author":"Johnson AK","year":"2022","unstructured":"Johnson AK, Heebner NR, Hunt ER, et al.. Pain early after anterior cruciate ligament reconstruction is associated with 6-month loading mechanics during running. Sports Health. 2022, [Epub]:10.1177\/19417381221139478","journal-title":"Sports Health"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1177\/23259671211016424","article-title":"Association of jump-landing biomechanics with tibiofemoral articular cartilage composition 12 months after ACL reconstruction","volume":"9","author":"Pfeiffer SJ","year":"2021","unstructured":"Pfeiffer SJ, Spang JT, Nissman D, et al.. Association of jump-landing biomechanics with tibiofemoral articular cartilage composition 12 months after ACL reconstruction. Orthop J Sports Med. 2021, 9:23259671211016424. 10.1177\/23259671211016424","journal-title":"Orthop J Sports Med"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2018.07.033","article-title":"Abnormal biomechanics at 6 months are associated with cartilage degeneration at 3 years after anterior cruciate ligament reconstruction","volume":"35","author":"Shimizu T","year":"2019","unstructured":"Shimizu T, Samaan MA, Tanaka MS, Pedoia V, Souza RB, Li X, Ma CB. Abnormal biomechanics at 6 months are associated with cartilage degeneration at 3 years after anterior cruciate ligament reconstruction. Arthroscopy. 2019, 35:511-20. 10.1016\/j.arthro.2018.07.033","journal-title":"Arthroscopy"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/art.40687","article-title":"Molecular and structural biomarkers of inflammation at two years after acute anterior cruciate ligament injury do not predict structural knee osteoarthritis at five years","volume":"71","author":"Roemer FW","year":"2019","unstructured":"Roemer FW, Englund M, Turkiewicz A, et al.. Molecular and structural biomarkers of inflammation at two years after acute anterior cruciate ligament injury do not predict structural knee osteoarthritis at five years. Arthritis Rheumatol. 2019, 71:238-43. 10.1002\/art.40687","journal-title":"Arthritis Rheumatol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3390\/genes12070989","article-title":"Synovium-synovial fluid axis in osteoarthritis pathology: a key regulator of the cartilage degradation process","volume":"12","author":"Ingale D","year":"2021","unstructured":"Ingale D, Kulkarni P, Electricwala A, et al.. Synovium-synovial fluid axis in osteoarthritis pathology: a key regulator of the cartilage degradation process. Genes (Basel). 2021, 12:989. 10.3390\/genes12070989","journal-title":"Genes (Basel)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/151339-increased-effusion-synovitis-for-those-with-a-dysregulated-inflammatory-response-after-an-anterior-cruciate-ligament-injury","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T14:59:31Z","timestamp":1707490771000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/151339-increased-effusion-synovitis-for-those-with-a-dysregulated-inflammatory-response-after-an-anterior-cruciate-ligament-injury"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,20]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.37862","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4,20]]}}}