{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:41:28Z","timestamp":1777603288506,"version":"3.51.4"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,22]]},"DOI":"10.7759\/cureus.39324","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T09:22:54Z","timestamp":1684747374000},"source":"Crossref","is-referenced-by-count":3,"title":["New Promising Therapeutic Approach for Refractory Corneal Epithelial Defects"],"prefix":"10.7759","author":[{"given":"Rodrigo","family":"Vilares Morgado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Falc\u00e3o-Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Pinheiro-Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(03)00085-0","article-title":"Corneal cells: chatty in development, homeostasis, wound healing, and disease","volume":"136","author":"Wilson SE","year":"2003","unstructured":"Wilson SE, Netto M, Ambr\u00f3sio R Jr. Corneal cells: chatty in development, homeostasis, wound healing, and disease. Am J Ophthalmol. 2003, 136:530-6. 10.1016\/s0002-9394(03)00085-0","journal-title":"Am J Ophthalmol"},{"key":"ref2","article-title":"Persistent Epithelial Defect","author":"Golhait P","year":"2022","unstructured":"Golhait P, Peseyie R. Persistent Epithelial Defect. StatPearls Publishing, Treasure Island, FL; 2022."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000509030","article-title":"A systematic review on cornea epithelial-stromal homeostasis","volume":"64","author":"Wong HL","year":"2021","unstructured":"Wong HL, Poon SH, Bu Y, Lo AC, Jhanji V, Chan YK, Shih KC. A systematic review on cornea epithelial-stromal homeostasis. Ophthalmic Res. 2021, 64:178-91. 10.1159\/000509030","journal-title":"Ophthalmic Res"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2018.04.003","article-title":"Neurotrophic keratopathy","volume":"66","author":"Dua HS","year":"2018","unstructured":"Dua HS, Said DG, Messmer EM, et al.. Neurotrophic keratopathy. Prog Retin Eye Res. 2018, 66:107-31. 10.1016\/j.preteyeres.2018.04.003","journal-title":"Prog Retin Eye Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S45921","article-title":"Diagnosis and management of neurotrophic keratitis","volume":"8","author":"Sacchetti M","year":"2014","unstructured":"Sacchetti M, Lambiase A. Diagnosis and management of neurotrophic keratitis. Clin Ophthalmol. 2014, 8:571-9. 10.2147\/OPTH.S45921","journal-title":"Clin Ophthalmol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2022.06.019","article-title":"Neurotrophic keratopathy in the United States: an intelligent research in sight registry analysis","volume":"129","author":"Bian Y","year":"2022","unstructured":"Bian Y, Ma KK, Hall NE, et al.. Neurotrophic keratopathy in the United States: an intelligent research in sight registry analysis. Ophthalmology. 2022, 129:1255-62. 10.1016\/j.ophtha.2022.06.019","journal-title":"Ophthalmology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-022-05602-z","article-title":"Efficacy of treatments for neurotrophic keratopathy: a systematic review and meta-analysis","volume":"260","author":"Roumeau S","year":"2022","unstructured":"Roumeau S, Dutheil F, Sapin V, et al.. Efficacy of treatments for neurotrophic keratopathy: a systematic review and meta-analysis. Graefes Arch Clin Exp Ophthalmol. 2022, 260:2623-37. 10.1007\/s00417-022-05602-z","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2017.0010","article-title":"Neurotrophic keratopathy: Therapeutic approach using a novel matrix regenerating agent","volume":"33","author":"Guerra M","year":"2017","unstructured":"Guerra M, Marques S, Gil JQ, et al.. Neurotrophic keratopathy: Therapeutic approach using a novel matrix regenerating agent. J Ocul Pharmacol Ther. 2017, 33:662-9. 10.1089\/jop.2017.0010","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9094","article-title":"Assessment of vision-related quality of life in dry eye patients","volume":"53","author":"Li M","year":"2012","unstructured":"Li M, Gong L, Chapin WJ, Zhu M. Assessment of vision-related quality of life in dry eye patients. Invest Ophthalmol Vis Sci. 2012, 53:5722-7. 10.1167\/iovs.11-9094","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2016.06.003","article-title":"Therapeutic outcomes of combined topical autologous serum eye drops with silicone-hydrogel soft contact lenses in the treatment of corneal persistent epithelial defects: a preliminary study","volume":"39","author":"Lee YK","year":"2016","unstructured":"Lee YK, Lin YC, Tsai SH, Chen WL, Chen YM. Therapeutic outcomes of combined topical autologous serum eye drops with silicone-hydrogel soft contact lenses in the treatment of corneal persistent epithelial defects: a preliminary study. Cont Lens Anterior Eye. 2016, 39:425-30. 10.1016\/j.clae.2016.06.003","journal-title":"Cont Lens Anterior Eye"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e318233c9bb","article-title":"Combined application of autologous serum eye drops and silicone hydrogel lenses for the treatment of persistent epithelial defects","volume":"37","author":"Choi JA","year":"2011","unstructured":"Choi JA, Chung SH. Combined application of autologous serum eye drops and silicone hydrogel lenses for the treatment of persistent epithelial defects. Eye Contact Lens. 2011, 37:370-3. 10.1097\/ICL.0b013e318233c9bb","journal-title":"Eye Contact Lens"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6600788","article-title":"Use of autologous serum eye drops with contact lenses in the treatment of chemical burn-induced bilateral corneal persistent epithelial defects","volume":"2022","author":"Chen YM","year":"2022","unstructured":"Chen YM, Wang WY, Lin YC, Tsai SH, Lou YT. Use of autologous serum eye drops with contact lenses in the treatment of chemical burn-induced bilateral corneal persistent epithelial defects. Biomed Res Int. 2022, 2022:6600788. 10.1155\/2022\/6600788","journal-title":"Biomed Res Int"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000261","article-title":"Autologous serum eye drops combined with silicone hydrogen lenses for the treatment of postinfectious corneal persistent epithelial defects","volume":"43","author":"Wang WY","year":"2017","unstructured":"Wang WY, Lee YK, Tsai SH, Lin YC, Chen YM. Autologous serum eye drops combined with silicone hydrogen lenses for the treatment of postinfectious corneal persistent epithelial defects. Eye Contact Lens. 2017, 43:225-9. 10.1097\/ICL.0000000000000261","journal-title":"Eye Contact Lens"},{"key":"ref14","article-title":"The cause of midday visual fogging in scleral gas permeable lens wearers","volume":"54","author":"McKinney A","year":"2013","unstructured":"McKinney A, Miller W, Leach N, Polizzi C, van der Worp E, Bergmanson J. The cause of midday visual fogging in scleral gas permeable lens wearers. Investig Ophthalmol Vis Sci. 2013, 54:5483.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2014.02.002","article-title":"Modern scleral contact lenses: a review","volume":"37","author":"van der Worp E","year":"2014","unstructured":"van der Worp E, Bornman D, Ferreira DL, Faria-Ribeiro M, Garcia-Porta N, Gonz\u00e1lez-Meijome JM. Modern scleral contact lenses: a review. Cont Lens Anterior Eye. 2014, 37:240-50. 10.1016\/j.clae.2014.02.002","journal-title":"Cont Lens Anterior Eye"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.410","article-title":"Amniotic membrane in ophthalmology: indications and limitations","volume":"23","author":"Rahman I","year":"2009","unstructured":"Rahman I, Said DG, Maharajan VS, Dua HS. Amniotic membrane in ophthalmology: indications and limitations. Eye (Lond). 2009, 23:1954-61. 10.1038\/eye.2008.410","journal-title":"Eye (Lond)"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2015.02.016","article-title":"Plasma rich in growth factors (PRGF) eye drops stimulates scarless regeneration compared to autologous serum in the ocular surface stromal fibroblasts","volume":"135","author":"Anitua E","year":"2015","unstructured":"Anitua E, de la Fuente M, Muruzabal F, Riestra A, Merayo-Lloves J, Orive G. Plasma rich in growth factors (PRGF) eye drops stimulates scarless regeneration compared to autologous serum in the ocular surface stromal fibroblasts. Exp Eye Res. 2015, 135:118-26. 10.1016\/j.exer.2015.02.016","journal-title":"Exp Eye Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/156410-new-promising-therapeutic-approach-for-refractory-corneal-epithelial-defects","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:01:20Z","timestamp":1707508880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/156410-new-promising-therapeutic-approach-for-refractory-corneal-epithelial-defects"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,22]]},"references-count":17,"URL":"https:\/\/doi.org\/10.7759\/cureus.39324","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5,22]]}}}