{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:58:10Z","timestamp":1789441090324,"version":"build-2803163510"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,22]]},"DOI":"10.7759\/cureus.39352","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T21:29:01Z","timestamp":1684790941000},"source":"Crossref","is-referenced-by-count":2,"title":["Iodine-Induced Hypothyroidism After Chemoembolization With Ethiodized Oil: A Case of Failure to Escape From Wolff-Chaikoff Effect (WCE)"],"prefix":"10.7759","author":[{"given":"Ana de Carmo","family":"Campos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Cruz Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sarmento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.251","article-title":"Consequences of excess iodine","volume":"10","author":"Leung AM","year":"2014","unstructured":"Leung AM, Braverman LE. Consequences of excess iodine. Nat Rev Endocrinol. 2014, 10:136-142. 10.1038\/nrendo.2013.251","journal-title":"Nat Rev Endocrinol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-45-5-504","article-title":"The temporary nature of the inhibitory action of excess iodine on organic iodine synthesis in the normal thyroid","volume":"45","author":"WO J","year":"1949","unstructured":"WO J, CH IL. The temporary nature of the inhibitory action of excess iodine on organic iodine synthesis in the normal thyroid. Endocrinology. 1949, 45:504-513, illust.. 10.1210\/endo-45-5-504","journal-title":"Endocrinology"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000490384","article-title":"2018 European Thyroid Association Guideline for the management of Graves' hyperthyroidism","volume":"7","author":"Kahaly GJ","year":"2018","unstructured":"Kahaly GJ, Bartalena L, Heged\u00fcs L, Leenhardt L, Poppe K, Pearce SH. 2018 European Thyroid Association Guideline for the management of Graves' hyperthyroidism. Eur Thyroid J. 2018, 7:167-186. 10.1159\/000490384","journal-title":"Eur Thyroid J"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1089\/105072501300176462","article-title":"Iodine-induced hypothyroidism","volume":"11","author":"Markou K","year":"2001","unstructured":"Markou K, Georgopoulos N, Kyriazopoulou V, Vagenakis AG. Iodine-induced hypothyroidism. Thyroid. 2001, 11:501-510. 10.1089\/105072501300176462","journal-title":"Thyroid"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3292","article-title":"A review: radiographic iodinated contrast media-induced thyroid dysfunction","volume":"100","author":"Lee SY","year":"2015","unstructured":"Lee SY, Rhee CM, Leung AM, Braverman LE, Brent GA, Pearce EN. A review: radiographic iodinated contrast media-induced thyroid dysfunction. J Clin Endocrinol Metab. 2015, 100:376-383. 10.1210\/jc.2014-3292","journal-title":"J Clin Endocrinol Metab"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.8.6893","article-title":"Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium\/iodide symporter messenger ribonucleic acid and protein","volume":"140","author":"Eng PH","year":"1999","unstructured":"Eng PH, Cardona GR, Fang SL, et al.. Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium\/iodide symporter messenger ribonucleic acid and protein. Endocrinology. 1999, 140:3404-3410. 10.1210\/endo.140.8.6893","journal-title":"Endocrinology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1665","article-title":"The acute inhibitory effect of iodide excess on sodium\/iodide symporter expression and activity involves the PI3K\/Akt signaling pathway","volume":"155","author":"Serrano-Nascimento C","year":"2014","unstructured":"Serrano-Nascimento C, da Silva Teixeira S, Nicola JP, Nachbar RT, Masini-Repiso AM, Nunes MT. The acute inhibitory effect of iodide excess on sodium\/iodide symporter expression and activity involves the PI3K\/Akt signaling pathway. Endocrinology. 2014, 155:1145-1156. 10.1210\/en.2013-1665","journal-title":"Endocrinology"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.677","article-title":"Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism","volume":"172","author":"Rhee CM","year":"2012","unstructured":"Rhee CM, Bhan I, Alexander EK, Brunelli SM. Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism. Arch Intern Med. 2012, 172:153-159. 10.1001\/archinternmed.2011.677","journal-title":"Arch Intern Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/JC.2015-2329","article-title":"Iodinated contrast media increased the risk of thyroid dysfunction: a 6-year retrospective cohort study","volume":"100","author":"Kornelius E","year":"2015","unstructured":"Kornelius E, Chiou JY, Yang YS, Peng CH, Lai YR, Huang CN. Iodinated contrast media increased the risk of thyroid dysfunction: a 6-year retrospective cohort study. J Clin Endocrinol Metab. 2015, 100:3372-3379. 10.1210\/JC.2015-2329","journal-title":"J Clin Endocrinol Metab"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002279","article-title":"Iodinated contrast medium exposure during computed tomography increase the risk of subsequent development of thyroid disorders in patients without known thyroid disease: a nationwide population-based, propensity score-matched, longitudinal follow-up study","volume":"94","author":"Hsieh MS","year":"2015","unstructured":"Hsieh MS, Chiu CS, Chen WC, et al.. Iodinated contrast medium exposure during computed tomography increase the risk of subsequent development of thyroid disorders in patients without known thyroid disease: a nationwide population-based, propensity score-matched, longitudinal follow-up study. Medicine (Baltimore). 2015, 94:e2279. 10.1097\/MD.0000000000002279","journal-title":"Medicine (Baltimore)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.917498","article-title":"Impact of iodinated contrast media in patients received percutaneous coronary intervention: focus on thyroid disease","volume":"13","author":"Chen Y","year":"2022","unstructured":"Chen Y, Zheng X, Li N, et al.. Impact of iodinated contrast media in patients received percutaneous coronary intervention: focus on thyroid disease. Front Endocrinol (Lausanne). 2022, 13:917498. 10.3389\/fendo.2022.917498","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2022.0393","article-title":"Iodinated contrast administration and risks of thyroid dysfunction: a retrospective cohort analysis of the U.S. veterans health administration system","volume":"33","author":"Inoue K","year":"2023","unstructured":"Inoue K, Guo R, Lee ML, et al.. Iodinated contrast administration and risks of thyroid dysfunction: a retrospective cohort analysis of the U.S. veterans health administration system. Thyroid. 2023, 33:230-238. 10.1089\/thy.2022.0393","journal-title":"Thyroid"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000517175","article-title":"2021 European Thyroid Association Guidelines for the management of iodine-based contrast media-induced thyroid dysfunction","volume":"10","author":"Bednarczuk T","year":"2021","unstructured":"Bednarczuk T, Brix TH, Schima W, Zettinig G, Kahaly GJ. 2021 European Thyroid Association Guidelines for the management of iodine-based contrast media-induced thyroid dysfunction. Eur Thyroid J. 2021, 10:269-284. 10.1159\/000517175","journal-title":"Eur Thyroid J"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2020.101515","article-title":"Hemophagocytic lymphohistiocytosis: an update on pathogenesis, diagnosis, and therapy","volume":"34","author":"Griffin G","year":"2020","unstructured":"Griffin G, Shenoi S, Hughes GC. Hemophagocytic lymphohistiocytosis: an update on pathogenesis, diagnosis, and therapy. Best Pract Res Clin Rheumatol. 2020, 34:101515. 10.1016\/j.berh.2020.101515","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/cc11151","article-title":"Relationship between thyroid function and ICU mortality: a prospective observation study","volume":"16","author":"Wang F","year":"2012","unstructured":"Wang F, Pan W, Wang H, Wang S, Pan S, Ge J. Relationship between thyroid function and ICU mortality: a prospective observation study. Crit Care. 2012, 16:R11. 10.1186\/cc11151","journal-title":"Crit Care"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S361791","article-title":"The changes of thyroid function and related factors in critical patients without thyroid illness in ICU: a retrospective cross-sectional study","volume":"18","author":"Zhang JN","year":"2022","unstructured":"Zhang JN, Zhao XL. The changes of thyroid function and related factors in critical patients without thyroid illness in ICU: a retrospective cross-sectional study. Ther Clin Risk Manag. 2022, 18:571-578. 10.2147\/TCRM.S361791","journal-title":"Ther Clin Risk Manag"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.754781","article-title":"Preliminary exploration of transpedal lymphangiography with high-dose ethiodized oil application in the treatment of postoperative chylothorax","volume":"8","author":"Li L","year":"2021","unstructured":"Li L, Wu X, Liu D, Zhang W, Yang L, Pan F. Preliminary exploration of transpedal lymphangiography with high-dose ethiodized oil application in the treatment of postoperative chylothorax. Front Med (Lausanne). 2021, 8:754781. 10.3389\/fmed.2021.754781","journal-title":"Front Med (Lausanne)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000031383","article-title":"Invasive treatment of persistent postoperative chylothorax secondary to thoracic duct variation injury: two case reports and literature review","volume":"101","author":"Yang Q","year":"2022","unstructured":"Yang Q, Bai X, Bao H, et al.. Invasive treatment of persistent postoperative chylothorax secondary to thoracic duct variation injury: two case reports and literature review. Medicine (Baltimore). 2022, 101:e31383. 10.1097\/MD.0000000000031383","journal-title":"Medicine (Baltimore)"},{"key":"ref19","unstructured":"LIPIODOL\u00ae (Ethiodized Oil) Injection. (2015). Accessed. May 8, 2023: https:\/\/www.fda.gov\/media\/92225\/download ."},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.107.047621","article-title":"Iodinated contrast media and their adverse reactions","volume":"36","author":"Singh J","year":"2008","unstructured":"Singh J, Daftary A. Iodinated contrast media and their adverse reactions. J Nucl Med Technol. 2008, 36:69-74; quiz 76-77. 10.2967\/jnmt.107.047621","journal-title":"J Nucl Med Technol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/154216-iodine-induced-hypothyroidism-after-chemoembolization-with-ethiodized-oil-a-case-of-failure-to-escape-from-wolff-chaikoff-effect-wce","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:01:31Z","timestamp":1707508891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/154216-iodine-induced-hypothyroidism-after-chemoembolization-with-ethiodized-oil-a-case-of-failure-to-escape-from-wolff-chaikoff-effect-wce"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,22]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.39352","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5,22]]}}}