{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:02:24Z","timestamp":1784818944906,"version":"3.55.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,29]]},"DOI":"10.7759\/cureus.39625","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:12:01Z","timestamp":1685355121000},"source":"Crossref","is-referenced-by-count":2,"title":["Clinical and Biochemical Correlation of Intra-articular Platelet-Rich Plasma and Corticosteroid Using Serum Matrix Metalloproteinase 3 (MMP-3) Levels in Osteoarthritis of Knee"],"prefix":"10.7759","author":[{"given":"Vaneet","family":"Arora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manmohan","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Bishnoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vakul","family":"Mahipal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angad S","family":"Sandhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnadev S","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham M","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2008.02.001","article-title":"Cartilage in normal and osteoarthritis conditions","volume":"22","author":"Martel-Pelletier J","year":"2008","unstructured":"Martel-Pelletier J, Boileau C, Pelletier JP, Roughley PJ. Cartilage in normal and osteoarthritis conditions. Best Pract Res Clin Rheumatol. 2008, 22:351-84. 10.1016\/j.berh.2008.02.001","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref2","article-title":"National Collaborating Centre for Chronic Conditions at the Royal College of Physicians. Osteoarthritis: National clinical guideline for care and management in adults","unstructured":"Osteoarthritis. National Clinical Guideline for Care and Management in Adults. NICE Clinical Guidelines, No. 59. Royal College of Physicians, London, UK; https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK48984\/."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-201310160-00010","article-title":"The American Academy of Orthopaedic Surgeons evidence-based guideline on: treatment of osteoarthritis of the knee, 2nd edition","volume":"95","author":"Jevsevar DS","year":"2013","unstructured":"Jevsevar DS, Brown GA, Jones DL, et al.. The American Academy of Orthopaedic Surgeons evidence-based guideline on: treatment of osteoarthritis of the knee, 2nd edition. J Bone Joint Surg Am. 2013, 95:1885-6. 10.2106\/00004623-201310160-00010","journal-title":"J Bone Joint Surg Am"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.01.013","article-title":"OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009","volume":"18","author":"Zhang W","year":"2010","unstructured":"Zhang W, Nuki G, Moskowitz RW, et al.. OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage. 2010, 18:476-99. 10.1016\/j.joca.2010.01.013","journal-title":"Osteoarthritis Cartilage"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1713-8","article-title":"Non-surgical management of early knee osteoarthritis","volume":"20","author":"Kon E","year":"2012","unstructured":"Kon E, Filardo G, Drobnic M, Madry H, Jelic M, van Dijk N, Della Villa S. Non-surgical management of early knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2012, 20:436-49. 10.1007\/s00167-011-1713-8","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-199809020-00002","article-title":"Intra-articular corticosteroids in arthritic disease: a guide to treatment","volume":"9","author":"Ostergaard M","year":"1998","unstructured":"Ostergaard M, Halberg P. Intra-articular corticosteroids in arthritic disease: a guide to treatment. BioDrugs. 1998, 9:95-103. 10.2165\/00063030-199809020-00002","journal-title":"BioDrugs"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199909000-00016","article-title":"Intra-articular corticosteroid treatment in osteoarthritis","volume":"11","author":"Creamer P","year":"1999","unstructured":"Creamer P. Intra-articular corticosteroid treatment in osteoarthritis. Curr Opin Rheumatol. 1999, 11:417-21. 10.1097\/00002281-199909000-00016","journal-title":"Curr Opin Rheumatol"},{"key":"ref8","article-title":"Cellular effects of platelet rich plasma: a study on HL-60 macrophage-like cells","volume":"43","author":"Woodall J Jr","year":"2007","unstructured":"Woodall J Jr, Tucci M, Mishra A, Benghuzzi H. Cellular effects of platelet rich plasma: a study on HL-60 macrophage-like cells. Biomed Sci Instrum. 2007, 43:266-71.","journal-title":"Biomed Sci Instrum"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000151290","article-title":"Influence of platelet-rich plasma on chondrogenic differentiation and proliferation of chondrocytes and mesenchymal stem cells","volume":"189","author":"Drengk A","year":"2009","unstructured":"Drengk A, Zapf A, St\u00fcrmer EK, St\u00fcrmer KM, Frosch KH. Influence of platelet-rich plasma on chondrogenic differentiation and proliferation of chondrocytes and mesenchymal stem cells. Cells Tissues Organs. 2009, 189:317-26. 10.1159\/000151290","journal-title":"Cells Tissues Organs"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-07-0440","article-title":"Autologous platelets as a source of proteins for healing and tissue regeneration","volume":"91","author":"Anitua E","year":"2004","unstructured":"Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost. 2004, 91:4-15. 10.1160\/TH03-07-0440","journal-title":"Thromb Haemost"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/01.scs.0000186454.07097.bf","article-title":"Platelet rich plasma: biology and new technology","volume":"16","author":"Pietrzak WS","year":"2005","unstructured":"Pietrzak WS, Eppley BL. Platelet rich plasma: biology and new technology. J Craniofac Surg. 2005, 16:1043-54. 10.1097\/01.scs.0000186454.07097.bf","journal-title":"J Craniofac Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.6.455","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis","volume":"59","author":"Yoshihara Y","year":"2000","unstructured":"Yoshihara Y, Nakamura H, Obata K, Yamada H, Hayakawa T, Fujikawa K, Okada Y. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis. 2000, 59:455-61. 10.1136\/ard.59.6.455","journal-title":"Ann Rheum Dis"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390919","article-title":"Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis","volume":"39","author":"Ahrens D","year":"1996","unstructured":"Ahrens D, Koch AE, Pope RM, Stein-Picarella M, Niedbala MJ. Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis. Arthritis Rheum. 1996, 39:1576-87. 10.1002\/art.1780390919","journal-title":"Arthritis Rheum"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/art.20567","article-title":"Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis","volume":"50","author":"Liu M","year":"2004","unstructured":"Liu M, Sun H, Wang X, et al.. Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis. Arthritis Rheum. 2004, 50:3112-7. 10.1002\/art.20567","journal-title":"Arthritis Rheum"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341106","article-title":"Radiographic grading of the severity of knee osteoarthritis: relation of the Kellgren and Lawrence grade to a grade based on joint space narrowing, and correlation with arthroscopic evidence of articular cartilage degeneration","volume":"34","author":"Brandt KD","year":"1991","unstructured":"Brandt KD, Fife RS, Braunstein EM, Katz B. Radiographic grading of the severity of knee osteoarthritis: relation of the Kellgren and Lawrence grade to a grade based on joint space narrowing, and correlation with arthroscopic evidence of articular cartilage degeneration. Arthritis Rheum. 1991, 34:1381-6. 10.1002\/art.1780341106","journal-title":"Arthritis Rheum"},{"key":"ref16","unstructured":"Research Randomizer. (2020). https.\/\/www.randomizer.org\/."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20543","article-title":"Measures of adult pain: visual analog scale for pain (VAS Pain), numeric rating scale for pain (NRS Pain), McGill pain questionnaire (MPQ), short-form McGill pain questionnaire (SF-MPQ), chronic pain grade scale (CPGS), short form-36 bodily pain scale (SF-36 BPS), and measure of intermittent and constant osteoarthritis pain (ICOAP)","volume":"63 Suppl 11","author":"Hawker GA","year":"2011","unstructured":"Hawker GA, Mian S, Kendzerska T, French M. Measures of adult pain: visual analog scale for pain (VAS Pain), numeric rating scale for pain (NRS Pain), McGill pain questionnaire (MPQ), short-form McGill pain questionnaire (SF-MPQ), chronic pain grade scale (CPGS), short form-36 bodily pain scale (SF-36 BPS), and measure of intermittent and constant osteoarthritis pain (ICOAP). Arthritis Care Res (Hoboken). 2011, 63 Suppl 11:S240-52. 10.1002\/acr.20543","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref18","article-title":"WOMAC: a 20-year experiential review of a patient-centered self-reported health status questionnaire","volume":"29","author":"Bellamy N","year":"2002","unstructured":"Bellamy N. WOMAC: a 20-year experiential review of a patient-centered self-reported health status questionnaire. J Rheumatol. 2002, 29:2473-6.","journal-title":"J Rheumatol"},{"key":"ref19","doi-asserted-by":"crossref","DOI":"10.4103\/injr.injr_159_19","article-title":"Comparison of intra articular autologous platelet-rich plasma with steroids in osteoarthritis knee: experience from a North Indian tertiary care center","volume":"15","author":"Arjun MN","year":"2020","unstructured":"Arjun MN, Vasdev V, Kishore K, et al.. Comparison of intra articular autologous platelet-rich plasma with steroids in osteoarthritis knee: experience from a North Indian tertiary care center. Indian J Rheumatol. 2020, 15:165-70.","journal-title":"Indian J Rheumatol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.33545\/orthor.2019.v3.i4b.188","article-title":"A comparative study of functional outcome of osteoarthritis knee post intraarticular injection of PRP and corticosteroid with minimum six months of follow-up","volume":"3","author":"Bharath N","year":"2019","unstructured":"Bharath N, Uidesh Y. A comparative study of functional outcome of osteoarthritis knee post intraarticular injection of PRP and corticosteroid with minimum six months of follow-up. Nat J Clin Orthop. 2019, 3:110-4. 10.33545\/orthor.2019.v3.i4b.188","journal-title":"Nat J Clin Orthop"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-04308-3","article-title":"Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis","volume":"22","author":"McLarnon M","year":"2021","unstructured":"McLarnon M, Heron N. Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis. BMC Musculoskelet Disord. 2021, 22:550. 10.1186\/s12891-021-04308-3","journal-title":"BMC Musculoskelet Disord"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245801","article-title":"Effect of intra-articular injection of platelet-rich plasma on the serum levels of osteoarthritic biomarkers in patients with unilateral knee osteoarthritis","volume":"10","author":"Lacko M","year":"2021","unstructured":"Lacko M, Harvanov\u00e1 D, Slovinsk\u00e1 L, et al.. Effect of intra-articular injection of platelet-rich plasma on the serum levels of osteoarthritic biomarkers in patients with unilateral knee osteoarthritis. J Clin Med. 2021, 10:5801. 10.3390\/jcm10245801","journal-title":"J Clin Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/146449-clinical-and-biochemical-correlation-of-intra-articular-platelet-rich-plasma-and-corticosteroid-using-serum-matrix-metalloproteinase-3-mmp-3-levels-in-osteoarthritis-of-knee","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:02:17Z","timestamp":1707508937000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/146449-clinical-and-biochemical-correlation-of-intra-articular-platelet-rich-plasma-and-corticosteroid-using-serum-matrix-metalloproteinase-3-mmp-3-levels-in-osteoarthritis-of-knee"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,29]]},"references-count":22,"URL":"https:\/\/doi.org\/10.7759\/cureus.39625","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5,29]]}}}