{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:40:33Z","timestamp":1762522833028},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,3]]},"DOI":"10.7759\/cureus.39923","type":"journal-article","created":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T03:42:23Z","timestamp":1685850143000},"source":"Crossref","is-referenced-by-count":6,"title":["Bullous Pemphigoid and Human Leukocyte Antigen (HLA)-DQA1: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Roksana","family":"Hesari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan","family":"Thibaut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Schur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivani","family":"Thoutireddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Witcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elyse","family":"Julian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20743","article-title":"The global incidence of bullous pemphigoid: a systematic review and meta-analysis","volume":"186","author":"Persson MS","year":"2022","unstructured":"Persson MS, Begum N, Grainge MJ, Harman KE, Grindlay D, Gran S. The global incidence of bullous pemphigoid: a systematic review and meta-analysis. Br J Dermatol. 2022, 186:414-25. 10.1111\/bjd.20743","journal-title":"Br J Dermatol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10101432","article-title":"Bullous pemphigoid: trigger and predisposing factors","volume":"10","author":"Moro F","year":"2020","unstructured":"Moro F, Fania L, Sinagra JL, Salemme A, Di Zenzo G. Bullous pemphigoid: trigger and predisposing factors. Biomolecules. 2020, 10:1432. 10.3390\/biom10101432","journal-title":"Biomolecules"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01506","article-title":"New insights into the pathogenesis of bullous pemphigoid: 2019 update","volume":"10","author":"Genovese G","year":"2019","unstructured":"Genovese G, Di Zenzo G, Cozzani E, Berti E, Cugno M, Marzano AV. New insights into the pathogenesis of bullous pemphigoid: 2019 update. Front Immunol. 2019, 10:1506. 10.3389\/fimmu.2019.01506","journal-title":"Front Immunol"},{"key":"ref4","article-title":"Trends in aging--United States and worldwide","volume":"52","author":"Centers for Disease Control and Prevention","year":"2003","unstructured":"Centers for Disease Control and Prevention. Trends in aging--United States and worldwide.  MMWR Morb Mortal Wkly Rep. 2003, 52:101-104, 106.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02327","article-title":"Genetics and omics analysis of autoimmune skin blistering diseases","volume":"10","author":"Olbrich M","year":"2019","unstructured":"Olbrich M, K\u00fcnstner A, Witte M, Busch H, F\u00e4hnrich A. Genetics and omics analysis of autoimmune skin blistering diseases. Front Immunol. 2019, 10:2327. 10.3389\/fimmu.2019.02327","journal-title":"Front Immunol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12088","article-title":"HLA and disease: guilt by association","volume":"41","author":"Howell WM","year":"2014","unstructured":"Howell WM. HLA and disease: guilt by association. Int J Immunogenet. 2014, 41:1-12. 10.1111\/iji.12088","journal-title":"Int J Immunogenet"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-091212-153455","article-title":"Major histocompatibility complex genomics and human disease","volume":"14","author":"Trowsdale J","year":"2013","unstructured":"Trowsdale J, Knight JC. Major histocompatibility complex genomics and human disease. Annu Rev Genomics Hum Genet. 2013, 14:301-23. 10.1146\/annurev-genom-091212-153455","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.143","article-title":"HLA variation and disease","volume":"18","author":"Dendrou CA","year":"2018","unstructured":"Dendrou CA, Petersen J, Rossjohn J, Fugger L. HLA variation and disease. Nat Rev Immunol. 2018, 18:325-39. 10.1038\/nri.2017.143","journal-title":"Nat Rev Immunol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref10","unstructured":"Cochrane Training. ReviewManager (RevMan). (2023). Accessed: April 21, 2023: https:\/\/training.cochrane.org\/online-learning\/core-software\/revman."},{"key":"ref11","article-title":"","author":"Barendregt JJ","year":"2011","unstructured":"Barendregt JJ, Doi SA. MetaXL User Guide Version 5.3. EpiGear International Pty Ltd, Queensland, Australia; 2011-2016. https:\/\/www.epigear.com\/index_files\/MetaXL%20User%20Guide.pdf."},{"key":"ref12","unstructured":"Study Quality Assessment Tools. (2021). Accessed. May 1, 2021: https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.17504\/protocols.io.14egn2r6pg5d\/v1","article-title":"A systematic review of bullous pemphigoid and HLA-DQA1","author":"Thibaut D","year":"2023","unstructured":"Thibaut D, Hesari R, Schur N, Thoutireddy S, Witcher R, Julian E. A systematic review of bullous pemphigoid and HLA-DQA1. protocols.io. 2023, 10.17504\/protocols.io.14egn2r6pg5d\/v1","journal-title":"protocols.io"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2018.30.1.8","article-title":"HLA-C*17, DQB1*03:01, DQA1*01:03 and DQA1*05:05 alleles associated to bullous pemphigoid in Brazilian population","volume":"30","author":"Chagury AA","year":"2018","unstructured":"Chagury AA, Sennes LU, Gil JM, Kalil J, Rodrigues H, Rosales CB, Miziara ID. HLA-C*17, DQB1*03:01, DQA1*01:03 and DQA1*05:05 alleles associated to bullous pemphigoid in Brazilian population. Ann Dermatol. 2018, 30:8-12. 10.5021\/ad.2018.30.1.8","journal-title":"Ann Dermatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.11.014","article-title":"Association of HLA class I and class II alleles with bullous pemphigoid in Chinese Hans","volume":"89","author":"Fang H","year":"2018","unstructured":"Fang H, Shen S, Zheng X, et al.. Association of HLA class I and class II alleles with bullous pemphigoid in Chinese Hans. J Dermatol Sci. 2018, 89:258-62. 10.1016\/j.jdermsci.2017.11.014","journal-title":"J Dermatol Sci"},{"key":"ref16","article-title":"Association between HLA-DQB1* 03: 01 and bullous pemphigoid in Iranian patients","volume":"10","author":"Esmaili N","year":"2013","unstructured":"Esmaili N, Mortazavi H, Chams-Davatchi C, et al.. Association between HLA-DQB1* 03: 01 and bullous pemphigoid in Iranian patients. Iran J Immunol. 2013, 10:1-9.","journal-title":"Iran J Immunol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-021-01863-9","article-title":"Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans","volume":"16","author":"Schwarm C","year":"2021","unstructured":"Schwarm C, Gola D, Holtsche MM, et al.. Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans. Orphanet J Rare Dis. 2021, 16:228. 10.1186\/s13023-021-01863-9","journal-title":"Orphanet J Rare Dis"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.11.023","article-title":"HLA-DQB1*03:01 as a biomarker for genetic susceptibility to bullous pemphigoid induced by DPP-4 inhibitors","volume":"138","author":"Ujiie H","year":"2018","unstructured":"Ujiie H, Muramatsu K, Mushiroda T, et al.. HLA-DQB1*03:01 as a biomarker for genetic susceptibility to bullous pemphigoid induced by DPP-4 inhibitors. J Invest Dermatol. 2018, 138:1201-4. 10.1016\/j.jid.2017.11.023","journal-title":"J Invest Dermatol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14503","article-title":"Mortality in bullous pemphigoid: a systematic review and meta-analysis of standardized mortality ratios","volume":"45","author":"Kridin K","year":"2018","unstructured":"Kridin K, Schwartz N, Cohen AD, Zelber-Sagi S. Mortality in bullous pemphigoid: a systematic review and meta-analysis of standardized mortality ratios. J Dermatol. 2018, 45:1094-1100. 10.1111\/1346-8138.14503","journal-title":"J Dermatol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14312","article-title":"Multimorbidity in bullous pemphigoid: a case-control analysis of bullous pemphigoid patients with age- and gender-matched controls","volume":"31","author":"Sim B","year":"2017","unstructured":"Sim B, Fook-Chong S, Phoon YW, Koh HY, Thirumoorthy T, Pang SM, Lee HY. Multimorbidity in bullous pemphigoid: a case-control analysis of bullous pemphigoid patients with age- and gender-matched controls. J Eur Acad Dermatol Venereol. 2017, 31:1709-14. 10.1111\/jdv.14312","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13660","article-title":"Bullous pemphigoid and its association with neurological diseases: a systematic review and meta-analysis","volume":"30","author":"Lai YC","year":"2016","unstructured":"Lai YC, Yew YW, Lambert WC. Bullous pemphigoid and its association with neurological diseases: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2016, 30:2007-15. 10.1111\/jdv.13660","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.09.048","article-title":"Dipeptidyl-peptidase IV inhibitor-associated bullous pemphigoid: a systematic review and meta-analysis","volume":"85","author":"Kridin K","year":"2021","unstructured":"Kridin K, Cohen AD. Dipeptidyl-peptidase IV inhibitor-associated bullous pemphigoid: a systematic review and meta-analysis. J Am Acad Dermatol. 2021, 85:501-3. 10.1016\/j.jaad.2018.09.048","journal-title":"J Am Acad Dermatol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13984","article-title":"A review of bullous pemphigoid associated with PD-1 and PD-L1 inhibitors","volume":"57","author":"Lopez AT","year":"2018","unstructured":"Lopez AT, Khanna T, Antonov N, Audrey-Bayan C, Geskin L. A review of bullous pemphigoid associated with PD-1 and PD-L1 inhibitors. Int J Dermatol. 2018, 57:664-9. 10.1111\/ijd.13984","journal-title":"Int J Dermatol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.01037.x","article-title":"HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China","volume":"27","author":"Gao XH","year":"2002","unstructured":"Gao XH, Winsey S, Li G, et al.. HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China. Clin Exp Dermatol. 2002, 27:319-21. 10.1046\/j.1365-2230.2002.01037.x","journal-title":"Clin Exp Dermatol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X-ANP-2020-0487","article-title":"HLA-DQA1*04:01 is related to a higher multiple sclerosis lesion load on T2\/Flair MRI sequences","volume":"79","author":"Noro F","year":"2021","unstructured":"Noro F, Alves-Leon SV, Fontes-Dantas FL, et al.. HLA-DQA1*04:01 is related to a higher multiple sclerosis lesion load on T2\/Flair MRI sequences. Arq Neuropsiquiatr. 2021, 79:1109-15. 10.1590\/0004-282X-ANP-2020-0487","journal-title":"Arq Neuropsiquiatr"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/158433-bullous-pemphigoid-and-human-leukocyte-antigen-hla-dqa1-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:00:03Z","timestamp":1707508803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/158433-bullous-pemphigoid-and-human-leukocyte-antigen-hla-dqa1-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,3]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.39923","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6,3]]}}}