{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:44:56Z","timestamp":1783464296404,"version":"3.55.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,5]]},"DOI":"10.7759\/cureus.40004","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T21:31:25Z","timestamp":1686000685000},"source":"Crossref","is-referenced-by-count":5,"title":["Methotrexate-Induced Stroke-Like Syndrome: A Typical Presentation of a Rare Complication"],"prefix":"10.7759","author":[{"given":"Mariana","family":"Leit\u00e3o Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lia","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Acute methotrexate neurotoxicity: findings on diffusion-weighted imaging and correlation with clinical outcome","volume":"25","author":"Rollins N","year":"2004","unstructured":"Rollins N, Winick N, Bash R, Booth T. Acute methotrexate neurotoxicity: findings on diffusion-weighted imaging and correlation with clinical outcome. AJNR Am J Neuroradiol. 2004, 25:1688-95.","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-214677","article-title":"Alternating hemiparesis and orolingual apraxia as manifestations of methotrexate neurotoxicity in a paediatric case of acute lymphoblastic leukaemia","volume":"2016","author":"Yap SM","year":"2016","unstructured":"Yap SM, MacEneaney P, Ryan C, O'Toole O. Alternating hemiparesis and orolingual apraxia as manifestations of methotrexate neurotoxicity in a paediatric case of acute lymphoblastic leukaemia. BMJ Case Rep. 2016, 2016:bcr2016214677. 10.1136\/bcr-2016-214677","journal-title":"BMJ Case Rep"},{"key":"ref3","article-title":"Diffusion-weighted MR imaging of early methotrexate-related neurotoxicity in children","volume":"26","author":"Fisher MJ","year":"2005","unstructured":"Fisher MJ, Khademian ZP, Simon EM, Zimmerman RA, Bilaniuk LT.  Diffusion-weighted MR imaging of early methotrexate-related neurotoxicity in children. AJNR Am J Neuroradiol. 2005, 26:1686-9.","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2021000269","article-title":"Managing therapy-associated neurotoxicity in children with ALL","volume":"2021","author":"Bhojwani D","year":"2021","unstructured":"Bhojwani D, Bansal R, Wayne AS. Managing therapy-associated neurotoxicity in children with ALL. Hematology Am Soc Hematol Educ Program. 2021, 2021:376-83. 10.1182\/hematology.2021000269","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.920214","article-title":"The clinical impact of methotrexate-induced stroke-like neurotoxicity in paediatric departments: an Italian multi-centre case-series","volume":"13","author":"Santangelo A","year":"2022","unstructured":"Santangelo A, Bartolini E, Nuzzi G, et al.. The clinical impact of methotrexate-induced stroke-like neurotoxicity in paediatric departments: an Italian multi-centre case-series. Front Neurol. 2022, 13:920214. 10.3389\/fneur.2022.920214","journal-title":"Front Neurol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.268565","article-title":"Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia","volume":"107","author":"Mateos MK","year":"2022","unstructured":"Mateos MK, Marshall GM, Barbaro PM, et al.. Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia. Haematologica. 2022, 107:635-43. 10.3324\/haematol.2020.268565","journal-title":"Haematologica"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1505","article-title":"Demyelination and single-carbon transfer pathway metabolites during the treatment of acute lymphoblastic leukemia: CSF studies","volume":"16","author":"Surtees R","year":"1998","unstructured":"Surtees R, Clelland J, Hann I. Demyelination and single-carbon transfer pathway metabolites during the treatment of acute lymphoblastic leukemia: CSF studies. J Clin Oncol. 1998, 16:1505-11. 10.1200\/JCO.1998.16.4.1505","journal-title":"J Clin Oncol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001706","article-title":"Severe, fatal methotrexate-related neurotoxicity in 2 adolescent patients with ALL","volume":"42","author":"Dabagh S","year":"2020","unstructured":"Dabagh S, David H, Young S, Doan A, Bhojwani D. Severe, fatal methotrexate-related neurotoxicity in 2 adolescent patients with ALL. J Pediatr Hematol Oncol. 2020, 42:e839-44. 10.1097\/MPH.0000000000001706","journal-title":"J Pediatr Hematol Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/158820-methotrexate-induced-stroke-like-syndrome-a-typical-presentation-of-a-rare-complication","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:01:14Z","timestamp":1707508874000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/158820-methotrexate-induced-stroke-like-syndrome-a-typical-presentation-of-a-rare-complication"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,5]]},"references-count":8,"URL":"https:\/\/doi.org\/10.7759\/cureus.40004","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6,5]]}}}