{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:29:58Z","timestamp":1793690998595,"version":"4.5.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,5]]},"DOI":"10.7759\/cureus.41398","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T08:00:56Z","timestamp":1688544056000},"source":"Crossref","is-referenced-by-count":6,"title":["Comparing Triple Combination Drug Therapy and Traditional Monotherapy for Better Survival in Patients With High-Risk Hypertension: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Mustafa Abrar","family":"Zaman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimra","family":"Awais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Satnarine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areeg","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepkumar","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Dheeraj","family":"Gutlapalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grethel N","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kofi","family":"Seffah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safeera","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/08037051.2022.2095254","article-title":"Single-pill combinations, hypertension control and clinical outcomes: potential, pitfalls and solutions","volume":"31","author":"Egan BM","year":"2022","unstructured":"Egan BM, Kjeldsen SE, Narkiewicz K, Kreutz R, Burnier M. Single-pill combinations, hypertension control and clinical outcomes: potential, pitfalls and solutions. Blood Press. 2022, 31:164-8. 10.1080\/08037051.2022.2095254","journal-title":"Blood Press"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-014-0223-0","article-title":"Triple combination therapy in hypertension: the antihypertensive efficacy of treatment with perindopril, amlodipine, and indapamide SR","volume":"34","author":"P\u00e1ll D","year":"2014","unstructured":"P\u00e1ll D, Sz\u00e1nt\u00f3 I, Szab\u00f3 Z. Triple combination therapy in hypertension: the antihypertensive efficacy of treatment with perindopril, amlodipine, and indapamide SR. Clin Drug Investig. 2014, 34:701-8. 10.1007\/s40261-014-0223-0","journal-title":"Clin Drug Investig"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.184182","article-title":"Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries","volume":"310","author":"Chow CK","year":"2013","unstructured":"Chow CK, Teo KK, Rangarajan S, et al.. Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. JAMA. 2013, 310:959-68. 10.1001\/jama.2013.184182","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2017.5","article-title":"Triple-combination therapy in the treatment of hypertension: a review of the evidence","volume":"31","author":"D\u00fcsing R","year":"2017","unstructured":"D\u00fcsing R, Waeber B, Destro M, Santos Maia C, Brunel P. Triple-combination therapy in the treatment of hypertension: a review of the evidence. J Hum Hypertens. 2017, 31:501-10. 10.1038\/jhh.2017.5","journal-title":"J Hum Hypertens"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.09.779","article-title":"Comparative effectiveness of triple antihypertensive combination therapy for patients with resistant hypertension in taiwan","volume":"18","author":"Lin C","year":"2015","unstructured":"Lin C, Tsai M, Chen W, Chuang P, Tang C. Comparative effectiveness of triple antihypertensive combination therapy for patients with resistant hypertension in taiwan. Value Health. 2015, 18:375. 10.1016\/j.jval.2015.09.779","journal-title":"Value Health"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2019.03.002","article-title":"New approach to blood pressure control: triple combination pill","volume":"30","author":"Volpe M","year":"2020","unstructured":"Volpe M, Gallo G, Tocci G. New approach to blood pressure control: triple combination pill. Trends Cardiovasc Med. 2020, 30:72-77. 10.1016\/j.tcm.2019.03.002","journal-title":"Trends Cardiovasc Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0511-1","article-title":"Fixed-dose triple combination of antihypertensive drugs improves blood pressure control: from clinical trials to clinical practice","volume":"34","author":"Mazza A","year":"2017","unstructured":"Mazza A, Lenti S, Schiavon L, Sacco AP, Dell'Avvocata F, Rigatelli G, Ramazzina E. Fixed-dose triple combination of antihypertensive drugs improves blood pressure control: from clinical trials to clinical practice. Adv Ther. 2017, 34:975-85. 10.1007\/s12325-017-0511-1","journal-title":"Adv Ther"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-013-0020-9","article-title":"Combination therapy in hypertension","volume":"30","author":"Gorostidi M","year":"2013","unstructured":"Gorostidi M, de la Sierra A. Combination therapy in hypertension. Adv Ther. 2013, 30:320-36. 10.1007\/s12325-013-0020-9","journal-title":"Adv Ther"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.10.020","article-title":"TRIple pill vs Usual care Management for Patients with mild-to-moderate Hypertension (TRIUMPH): study protocol","volume":"167","author":"Salam A","year":"2014","unstructured":"Salam A, Webster R, Singh K, et al.. TRIple pill vs Usual care Management for Patients with mild-to-moderate Hypertension (TRIUMPH): study protocol. Am Heart J. 2014, 167:127-32. 10.1016\/j.ahj.2013.10.020","journal-title":"Am Heart J"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/1753944713498638","article-title":"Management of hypertension with fixed-dose triple-combination treatments","volume":"7","author":"Epstein BJ","year":"2013","unstructured":"Epstein BJ, Shah NK, Borja-Hart NL. Management of hypertension with fixed-dose triple-combination treatments. Ther Adv Cardiovasc Dis. 2013, 7:246-59. 10.1177\/1753944713498638","journal-title":"Ther Adv Cardiovasc Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/cl2.1230","article-title":"PRISMA2020: an R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis","volume":"18","author":"Haddaway NR","year":"2022","unstructured":"Haddaway NR, Page MJ, Pritchard CC, McGuinness LA. PRISMA2020: an R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis. Campbell Syst Rev. 2022, 18:e1230. 10.1002\/cl2.1230","journal-title":"Campbell Syst Rev"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000838684.83670.d8","article-title":"Clinical efficacy and safety of amlodipine\/bisoprolol\/perindopril single-pill and free combination therapy in patients with uncontrolled essential hypertension","volume":"40","author":"Konradi A","year":"2022","unstructured":"Konradi A, Hassan Y, Lefay D, Isachenko E, Jamois A. Clinical efficacy and safety of amlodipine\/bisoprolol\/perindopril single-pill and free combination therapy in patients with uncontrolled essential hypertension. J Hypertens. 2022, 40:303. 10.1097\/01.hjh.0000838684.83670.d8","journal-title":"J Hypertens"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0000000000002132","article-title":"Antihypertensive treatment escalation","volume":"37","author":"Thomopoulos C","year":"2019","unstructured":"Thomopoulos C, Michalopoulou H, Makris T. Antihypertensive treatment escalation. J Hypertens. 2019, 37:1587-9. 10.1097\/hjh.0000000000002132","journal-title":"J Hypertens"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S11235","article-title":"Treatment options for hypertension in high-risk patients","volume":"7","author":"Tsai WC","year":"2011","unstructured":"Tsai WC. Treatment options for hypertension in high-risk patients. Vasc Health Risk Manag. 2011, 7:137-41. 10.2147\/VHRM.S11235","journal-title":"Vasc Health Risk Manag"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2017.20","article-title":"How to conduct and interpret systematic reviews and meta-analyses","volume":"8","author":"Singh S","year":"2017","unstructured":"Singh S. How to conduct and interpret systematic reviews and meta-analyses. Clin Transl Gastroenterol. 2017, 8:e93. 10.1038\/ctg.2017.20","journal-title":"Clin Transl Gastroenterol"},{"key":"ref16","unstructured":"Goetsch MR, Tumarkin E, Blumenthal RS, Whelton SP. New Guidance on Blood Pressure Management in Low-Risk Adults With Stage 1 Hypertension. [online] American College of Cardiology. (2021). Accessed. May 9, 2023: https:\/\/www.acc.org\/latest-in-cardiology\/articles\/2021\/06\/21\/13\/05\/new-guidance-on-bp-management-in-low-risk-adults-w...."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2008.114","article-title":"Single-pill amlodipine\/atorvastatin helps patients of diverse ethnicity attain recommended goals for blood pressure and lipids (the Gemini-AALA study)","volume":"23","author":"Erdine S","year":"2009","unstructured":"Erdine S, Ro YM, Tse HF, et al.. Single-pill amlodipine\/atorvastatin helps patients of diverse ethnicity attain recommended goals for blood pressure and lipids (the Gemini-AALA study). J Hum Hypertens. 2009, 23:196-210. 10.1038\/jhh.2008.114","journal-title":"J Hum Hypertens"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.53555\/nnmhs.v9i3.1616","article-title":"Nonalcoholic fatty liver disease and risk of incident hypertension: a systematic review","volume":"9(3)","author":"Rossiyah N","year":"2023","unstructured":"Rossiyah N. Nonalcoholic fatty liver disease and risk of incident hypertension: a systematic review. J. Adv. Med. 2023, 9(3):74-9. 10.53555\/nnmhs.v9i3.1616","journal-title":"J. Adv. Med"},{"key":"ref19","article-title":"Newcastle-Ottawa Scale Assessment of Cohort Studies","author":"Abou-Setta AM","year":"2011","unstructured":"Abou-Setta AM, Beaupre LA, Jones CA, et al.. Newcastle-Ottawa Scale Assessment of Cohort Studies. Agency for Healthcare Research and Quality (US), Rockville (MD); 2011."},{"key":"ref20","unstructured":"Cochrane Methods Bias. Risk of Bias Tool . Accessed. June 12, 2023: https:\/\/methods.cochrane.org\/bias\/risk-bias-tool."},{"key":"ref21","unstructured":"AMSTAR Checklist for the Quality Assessment of Systematic Reviews. (2014). Accessed. June 12, 2023:  https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK263391\/."}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/138563-comparing-triple-combination-drug-therapy-and-traditional-monotherapy-for-better-survival-in-patients-with-high-risk-hypertension-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:06:26Z","timestamp":1793689586000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/138563-comparing-triple-combination-drug-therapy-and-traditional-monotherapy-for-better-survival-in-patients-with-high-risk-hypertension-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,5]]},"references-count":21,"URL":"https:\/\/doi.org\/10.7759\/cureus.41398","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,5]]}}}