{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:27:11Z","timestamp":1791977231042,"version":"4.4.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,10]]},"DOI":"10.7759\/cureus.41655","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T18:54:04Z","timestamp":1689015244000},"source":"Crossref","is-referenced-by-count":2,"title":["Larsen Syndrome and Associated Spinal Deformities"],"prefix":"10.7759","author":[{"given":"Angeliki","family":"Siafaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Piagkou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Apostolopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Troupis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Filippou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181ab64e9","article-title":"Spine deformities in rare congenital syndromes: clinical issues","volume":"34","author":"Campbell RM Jr","year":"2009","unstructured":"Campbell RM Jr. Spine deformities in rare congenital syndromes: clinical issues. Spine (Phila Pa 1976). 2009, 34:1815-27. 10.1097\/BRS.0b013e3181ab64e9","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e318278e59d","article-title":"Larsen syndrome with C3-C4 spondyloptosis and atlantoaxial dislocation in an adult","volume":"38","author":"Roopesh Kumar VR","year":"2013","unstructured":"Roopesh Kumar VR, Madhguiri VS, Sasidharan GM, Gundamaneni SK, Yadav AK. Larsen syndrome with C3-C4 spondyloptosis and atlantoaxial dislocation in an adult. Spine (Phila Pa 1976). 2013, 38:E43-7. 10.1097\/BRS.0b013e318278e59d","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2006.043687","article-title":"A molecular and clinical study of Larsen syndrome caused by mutations in FLNB","volume":"44","author":"Bicknell LS","year":"2007","unstructured":"Bicknell LS, Farrington-Rock C, Shafeghati Y, et al.. A molecular and clinical study of Larsen syndrome caused by mutations in FLNB. J Med Genet. 2007, 44:89-98. 10.1136\/jmg.2006.043687","journal-title":"J Med Genet"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4103\/jcvjs.JCVJS_164_20","article-title":"Craniovertebral junction instability in Larsen syndrome: an institutional series and review of literature","volume":"11","author":"Singh S","year":"2020","unstructured":"Singh S, Sardhara J, Raiyani V, et al.. Craniovertebral junction instability in Larsen syndrome: an institutional series and review of literature. J Craniovertebr Junction Spine. 2020, 11:276-86. 10.4103\/jcvjs.JCVJS_164_20","journal-title":"J Craniovertebr Junction Spine"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0952-8180(96)00021-9","article-title":"Anesthetic implications of Larsen syndrome","volume":"8","author":"Tobias JD","year":"1996","unstructured":"Tobias JD. Anesthetic implications of Larsen syndrome. J Clin Anesth. 1996, 8:255-7. 10.1016\/0952-8180(96)00021-9","journal-title":"J Clin Anesth"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2002.00920.x","article-title":"Larsen syndrome and its anaesthetic considerations","volume":"12","author":"Malik P","year":"2002","unstructured":"Malik P, Choudhry DK. Larsen syndrome and its anaesthetic considerations. Paediatr Anaesth. 2002, 12:632-6. 10.1046\/j.1460-9592.2002.00920.x","journal-title":"Paediatr Anaesth"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0000000000000186","article-title":"Dural ectasia in a child with Larsen syndrome","volume":"34","author":"Jain VV","year":"2014","unstructured":"Jain VV, Anadio JM, Chan G, Sturm PF, Crawford AH. Dural ectasia in a child with Larsen syndrome. J Pediatr Orthop. 2014, 34:e44-9. 10.1097\/BPO.0000000000000186","journal-title":"J Pediatr Orthop"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.103372","article-title":"Surgical management of cervical kyphosis in larsen syndrome. Case report and review of literature","volume":"75","author":"Armouti M","year":"2022","unstructured":"Armouti M, Hirbawi H, Jadaan M, Hashem H, Muhsen BA. Surgical management of cervical kyphosis in larsen syndrome. Case report and review of literature. Ann Med Surg (Lond). 2022, 75:103372. 10.1016\/j.amsu.2022.103372","journal-title":"Ann Med Surg (Lond)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005505","article-title":"Spine malformation complex in 3 diverse syndromic entities: case reports","volume":"95","author":"Kaissi AA","year":"2016","unstructured":"Kaissi AA, van Egmond-Fr\u00f6hlich A, Ryabykh S, et al.. Spine malformation complex in 3 diverse syndromic entities: case reports. Medicine (Baltimore). 2016, 95:e5505. 10.1097\/MD.0000000000005505","journal-title":"Medicine (Baltimore)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31823b3ded","article-title":"Review of cervical spine anomalies in genetic syndromes","volume":"37","author":"McKay SD","year":"2012","unstructured":"McKay SD, Al-Omari A, Tomlinson LA, Dormans JP. Review of cervical spine anomalies in genetic syndromes. Spine (Phila Pa 1976). 2012, 37:E269-77. 10.1097\/BRS.0b013e31823b3ded","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199609000-00012","article-title":"Joint hypermobility syndromes","volume":"8","author":"Raff ML","year":"1996","unstructured":"Raff ML, Byers PH. Joint hypermobility syndromes. Curr Opin Rheumatol. 1996, 8:459-66. 10.1097\/00002281-199609000-00012","journal-title":"Curr Opin Rheumatol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2017.04.007","article-title":"Filamin B: the next hotspot in skeletal research?","volume":"44","author":"Xu Q","year":"2017","unstructured":"Xu Q, Wu N, Cui L, Wu Z, Qiu G. Filamin B: the next hotspot in skeletal research?. J Genet Genomics. 2017, 44:335-42. 10.1016\/j.jgg.2017.04.007","journal-title":"J Genet Genomics"},{"key":"ref13","article-title":"FLNB Disorders","author":"Robertson S","year":"2020","unstructured":"Robertson S. FLNB Disorders. GeneReviews\u00ae (Internet). Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A (ed): University of Washington, Seattle; 2020."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13252","article-title":"Seven additional families with spondylocarpotarsal synostosis syndrome with novel biallelic deleterious variants in FLNB","volume":"94","author":"Salian S","year":"2018","unstructured":"Salian S, Shukla A, Shah H, et al.. Seven additional families with spondylocarpotarsal synostosis syndrome with novel biallelic deleterious variants in FLNB. Clin Genet. 2018, 94:159-64. 10.1111\/cge.13252","journal-title":"Clin Genet"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608360104","article-title":"Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development","volume":"104","author":"Zhou X","year":"2007","unstructured":"Zhou X, Tian F, Sandz\u00e9n J, et al.. Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development. Proc Natl Acad Sci U S A. 2007, 104:3919-24. 10.1073\/pnas.0608360104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4076\/1757-1626-2-6729","article-title":"Significant traumatic atrophy of the spinal cord in connection with severe cervical vertebral body hypoplasia in a boy with Larsen syndrome: a case report and review of the literature","volume":"2","author":"Al Kaissi A","year":"2009","unstructured":"Al Kaissi A, Altenhuber J, Grill F, Klaushofer K. Significant traumatic atrophy of the spinal cord in connection with severe cervical vertebral body hypoplasia in a boy with Larsen syndrome: a case report and review of the literature. Cases J. 2009, 2:6729. 10.4076\/1757-1626-2-6729","journal-title":"Cases J"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33641","article-title":"Phenotypic features of carbohydrate sulfotransferase 3 (CHST3) deficiency in 24 patients: congenital dislocations and vertebral changes as principal diagnostic features","volume":"152A","author":"Unger S","year":"2010","unstructured":"Unger S, Lausch E, Rossi A, et al.. Phenotypic features of carbohydrate sulfotransferase 3 (CHST3) deficiency in 24 patients: congenital dislocations and vertebral changes as principal diagnostic features. Am J Med Genet A. 2010, 152A:2543-9. 10.1002\/ajmg.a.33641","journal-title":"Am J Med Genet A"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.25.7.499","article-title":"A further patient with the lethal type of Larsen syndrome","volume":"25","author":"Clayton-Smith J","year":"1988","unstructured":"Clayton-Smith J, Donnai D. A further patient with the lethal type of Larsen syndrome. J Med Genet. 1988, 25:499-500. 10.1136\/jmg.25.7.499","journal-title":"J Med Genet"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.05.006","article-title":"Congenital joint dislocations caused by carbohydrate sulfotransferase 3 deficiency in recessive Larsen syndrome and humero-spinal dysostosis","volume":"82","author":"Hermanns P","year":"2008","unstructured":"Hermanns P, Unger S, Rossi A, et al.. Congenital joint dislocations caused by carbohydrate sulfotransferase 3 deficiency in recessive Larsen syndrome and humero-spinal dysostosis. Am J Hum Genet. 2008, 82:1368-74. 10.1016\/j.ajhg.2008.05.006","journal-title":"Am J Hum Genet"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470212","article-title":"Long-term follow-up of two sibs with Larsen syndrome possibly due to parental germ-line mosaicism","volume":"47","author":"Petrella R","year":"1993","unstructured":"Petrella R, Rabinowitz JG, Steinmann B, Hirschhorn K. Long-term follow-up of two sibs with Larsen syndrome possibly due to parental germ-line mosaicism. Am J Med Genet. 1993, 47:187-97. 10.1002\/ajmg.1320470212","journal-title":"Am J Med Genet"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3171\/PED-08\/01\/107","article-title":"Ulnar nerve palsy in a child with Larsen syndrome","volume":"1","author":"Tubbs RS","year":"2008","unstructured":"Tubbs RS, Oakes WJ, Wellons JC, Grabb PA. Ulnar nerve palsy in a child with Larsen syndrome. J Neurosurg Pediatr. 2008, 1:107. 10.3171\/PED-08\/01\/107","journal-title":"J Neurosurg Pediatr"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8237.181869","article-title":"Atlantoaxial dislocation adjacent to kyphotic deformity in a case of adult Larsen syndrome","volume":"7","author":"Sahoo SK","year":"2016","unstructured":"Sahoo SK, Deepak AN, Salunke P. Atlantoaxial dislocation adjacent to kyphotic deformity in a case of adult Larsen syndrome. J Craniovertebr Junction Spine. 2016, 7:109-10. 10.4103\/0974-8237.181869","journal-title":"J Craniovertebr Junction Spine"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199604000-00007","article-title":"Cervical kyphosis in patients who have Larsen syndrome","volume":"78","author":"Johnston CE 2nd","year":"1996","unstructured":"Johnston CE 2nd, Birch JG, Daniels JL. Cervical kyphosis in patients who have Larsen syndrome. J Bone Joint Surg Am. 1996, 78:538-45. 10.2106\/00004623-199604000-00007","journal-title":"J Bone Joint Surg Am"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.CC.21.00236","article-title":"Severe cervical kyphosis and spondyloptosis with myelopathy in Larsen syndrome: a report of 2 cases","volume":"11","author":"Merrill RK","year":"2021","unstructured":"Merrill RK, Ishmael TG, Samdani AF, Hwang SW, Pahys JM. Severe cervical kyphosis and spondyloptosis with myelopathy in Larsen syndrome: a report of 2 cases. JBJS Case Connect. 2021, 11:10.2106\/JBJS.CC.21.00236","journal-title":"JBJS Case Connect"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2000.19.6.419","article-title":"Prenatal sonographic diagnosis of Larsen syndrome","volume":"19","author":"Tongsong T","year":"2000","unstructured":"Tongsong T, Wanapirak C, Pongsatha S, Sudasana J. Prenatal sonographic diagnosis of Larsen syndrome. J Ultrasound Med. 2000, 19:419-21. 10.7863\/jum.2000.19.6.419","journal-title":"J Ultrasound Med"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3171\/PED\/2008\/1\/4\/320","article-title":"Management of severe cervical kyphosis in a patient with Larsen syndrome. Case report","volume":"1","author":"Madera M","year":"2008","unstructured":"Madera M, Crawford A, Mangano FT. Management of severe cervical kyphosis in a patient with Larsen syndrome. Case report. J Neurosurg Pediatr. 2008, 1:320-4. 10.3171\/PED\/2008\/1\/4\/320","journal-title":"J Neurosurg Pediatr"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000250103.88392.8e","article-title":"Surgical treatment of cervical kyphosis in Larsen syndrome: report of 3 cases and review of the literature","volume":"32","author":"Sakaura H","year":"2007","unstructured":"Sakaura H, Matsuoka T, Iwasaki M, Yonenobu K, Yoshikawa H. Surgical treatment of cervical kyphosis in Larsen syndrome: report of 3 cases and review of the literature. Spine (Phila Pa 1976). 2007, 32:E39-44. 10.1097\/01.brs.0000250103.88392.8e","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.96438","article-title":"Management of upper cervical kyphosis in an adolescent with Larsen's syndrome","volume":"60","author":"Mohindra S","year":"2012","unstructured":"Mohindra S, Savardekar A. Management of upper cervical kyphosis in an adolescent with Larsen's syndrome. Neurol India. 2012, 60:262-4. 10.4103\/0028-3886.96438","journal-title":"Neurol India"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000216447.42297.17","article-title":"Surgical treatment of scoliosis in larsen syndrome with bilateral hip dislocation","volume":"31","author":"Hosoe H","year":"2006","unstructured":"Hosoe H, Miyamoto K, Wada E, Shimizu K. Surgical treatment of scoliosis in larsen syndrome with bilateral hip dislocation. Spine (Phila Pa 1976). 2006, 31:E302-6. 10.1097\/01.brs.0000216447.42297.17","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000164267.30422.a9","article-title":"Sternal split approach to the cervicothoracic junction in children","volume":"30","author":"Mulpuri K","year":"2005","unstructured":"Mulpuri K, LeBlanc JG, Reilly CW, Poskitt KJ, Choit RL, Sahajpal V, Tredwell SJ. Sternal split approach to the cervicothoracic junction in children. Spine (Phila Pa 1976). 2005, 30:E305-10. 10.1097\/01.brs.0000164267.30422.a9","journal-title":"Spine (Phila Pa 1976)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/141116-larsen-syndrome-and-associated-spinal-deformities","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:03:58Z","timestamp":1707509038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/141116-larsen-syndrome-and-associated-spinal-deformities"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,10]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.41655","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,10]]}}}