{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T04:25:42Z","timestamp":1729830342448,"version":"3.28.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,22]]},"DOI":"10.7759\/cureus.42314","type":"journal-article","created":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T06:27:22Z","timestamp":1690093642000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparative Evaluation of Tetracycline Hydrochloride Fiber and Simvastatin Gel as an Adjunct to Scaling and Root Planing in Periodontitis Patients"],"prefix":"10.7759","author":[{"given":"Samidha","family":"Jambhekar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrunmayee","family":"Soman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratika","family":"Shrivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roja","family":"Ventrapragada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shweta","family":"Sarate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tejaswi","family":"Kodem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb02076.x","article-title":"Multicenter evaluation of tetracycline fiber therapy: II. Clinical response","volume":"26","author":"Goodson JM","year":"1991","unstructured":"Goodson JM, Cugini MA, Kent RL, et al.. Multicenter evaluation of tetracycline fiber therapy: II. Clinical response. J Periodontal Res. 1991, 26:371-9. 10.1111\/j.1600-0765.1991.tb02076.x","journal-title":"J Periodontal Res"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.8.692","article-title":"Evaluation of periodontal treatments using controlled-release tetracycline fibers: clinical response","volume":"66","author":"Drisko CL","year":"1995","unstructured":"Drisko CL, Cobb CM, Killoy WJ, et al.. Evaluation of periodontal treatments using controlled-release tetracycline fibers: clinical response. J Periodontol. 1995, 66:692-9. 10.1902\/jop.1995.66.8.692","journal-title":"J Periodontol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090429","article-title":"Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial","volume":"81","author":"Pradeep AR","year":"2010","unstructured":"Pradeep AR, Thorat MS. Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial. J Periodontol. 2010, 81:214-22. 10.1902\/jop.2009.090429","journal-title":"J Periodontol"},{"key":"ref4","doi-asserted-by":"crossref","DOI":"10.4103\/2231-0762.142011","article-title":"Effect of tetracycline HCl in the treatment of chronic periodontitis - a clinical study","volume":"4","author":"Sinha S","year":"2014","unstructured":"Sinha S, Kumar S, Dagli N, Dagli RJ. Effect of tetracycline HCl in the treatment of chronic periodontitis - a clinical study. J Int Soc Prev Community Dent. 2014, 4:149-53.","journal-title":"J Int Soc Prev Community Dent"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280104.x","article-title":"Topical antiseptics and antibiotics in the initial therapy of chronic adult periodontitis: microbiological aspects","volume":"28","author":"Quirynen M","year":"2002","unstructured":"Quirynen M, Teughels W, De Soete M, van Steenberghe D. Topical antiseptics and antibiotics in the initial therapy of chronic adult periodontitis: microbiological aspects. Periodontol 2000. 2002, 28:72-90. 10.1034\/j.1600-0757.2002.280104.x","journal-title":"Periodontol 2000"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2008.874","article-title":"Full-mouth treatment versus quadrant root surface debridement in the treatment of chronic periodontitis: a systematic review","volume":"205","author":"Farman M","year":"2008","unstructured":"Farman M, Joshi RI. Full-mouth treatment versus quadrant root surface debridement in the treatment of chronic periodontitis: a systematic review. Br Dent J. 2008, 205:E18; discussion 496-7. 10.1038\/sj.bdj.2008.874","journal-title":"Br Dent J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.05.022","article-title":"Effect of 1.2% of simvastatin gel as a local drug delivery system on gingival crevicular fluid interleukin-6 & interleukin-8 levels in non surgical treatment of chronic periodontitis patients","volume":"82","author":"Gunjiganur Vemanaradhya G","year":"2017","unstructured":"Gunjiganur Vemanaradhya G, Emani S, Mehta DS, Bhandari S. Effect of 1.2% of simvastatin gel as a local drug delivery system on gingival crevicular fluid interleukin-6 & interleukin-8 levels in non surgical treatment of chronic periodontitis patients. Arch Oral Biol. 2017, 82:55-61. 10.1016\/j.archoralbio.2017.05.022","journal-title":"Arch Oral Biol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(98)00040-0","article-title":"Therapeutic efficacy of the lipid-lowering armamentarium: the clinical benefits of aggressive lipid-lowering therapy","volume":"104","author":"Hunninghake DB","year":"1998","unstructured":"Hunninghake DB. Therapeutic efficacy of the lipid-lowering armamentarium: the clinical benefits of aggressive lipid-lowering therapy. Am J Med. 1998, 104:9S-13S. 10.1016\/s0002-9343(98)00040-0","journal-title":"Am J Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1023\/b:pham.0000033006.11619.07","article-title":"Rheological characterization of topical carbomer gels neutralized to different pH","volume":"21","author":"Islam MT","year":"2004","unstructured":"Islam MT, Rodr\u00edguez-Hornedo N, Ciotti S, Ackermann C. Rheological characterization of topical carbomer gels neutralized to different pH. Pharm Res. 2004, 21:1192-9. 10.1023\/b:pham.0000033006.11619.07","journal-title":"Pharm Res"},{"key":"ref10","article-title":"Simvastatin: its potential new role in periodontal regeneration","volume":"3","author":"Kinra P","year":"2011","unstructured":"Kinra P, Khan S. Simvastatin: its potential new role in periodontal regeneration. Biol Med. 2011, 3:215-21.","journal-title":"Biol Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120114","article-title":"Protective mechanisms of simvastatin in experimental periodontal disease","volume":"84","author":"Dalcico R","year":"2013","unstructured":"Dalcico R, de Menezes AM, Deocleciano OB, Ori\u00e1 RB, Vale ML, Ribeiro RA, Brito GA. Protective mechanisms of simvastatin in experimental periodontal disease. J Periodontol. 2013, 84:1145-57. 10.1902\/jop.2012.120114","journal-title":"J Periodontol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.2.295","article-title":"Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells","volume":"76","author":"Yazawa H","year":"2005","unstructured":"Yazawa H, Zimmermann B, Asami Y, Bernimoulin JP. Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells. J Periodontol. 2005, 76:295-302. 10.1902\/jop.2005.76.2.295","journal-title":"J Periodontol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20110118","article-title":"Mechanisms of bone anabolism regulated by statins","volume":"32","author":"Ruan F","year":"2012","unstructured":"Ruan F, Zheng Q, Wang J. Mechanisms of bone anabolism regulated by statins. Biosci Rep. 2012, 32:511-9. 10.1042\/BSR20110118","journal-title":"Biosci Rep"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2011.43.11.067","article-title":"Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species","volume":"43","author":"Moon HJ","year":"2011","unstructured":"Moon HJ, Kim SE, Yun YP, Hwang YS, Bang JB, Park JH, Kwon IK. Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species. Exp Mol Med. 2011, 43:605-12. 10.3858\/emm.2011.43.11.067","journal-title":"Exp Mol Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.137959","article-title":"Determination of the antibacterial activity of simvastatin against periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans: an in vitro study","volume":"5","author":"Emani S","year":"2014","unstructured":"Emani S, Gunjiganur GV, Mehta DS. Determination of the antibacterial activity of simvastatin against periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans: an in vitro study. Contemp Clin Dent. 2014, 5:377-82. 10.4103\/0976-237X.137959","journal-title":"Contemp Clin Dent"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.004","article-title":"Tetracyclines: nonantibiotic properties and their clinical implications","volume":"54","author":"Sapadin AN","year":"2006","unstructured":"Sapadin AN, Fleischmajer R. Tetracyclines: nonantibiotic properties and their clinical implications. J Am Acad Dermatol. 2006, 54:258-65. 10.1016\/j.jaad.2005.10.004","journal-title":"J Am Acad Dermatol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660080401","article-title":"A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity","volume":"66","author":"Golub LM","year":"1987","unstructured":"Golub LM, McNamara TF, D'Angelo G, Greenwald RA, Ramamurthy NS. A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity. J Dent Res. 1987, 66:1310-4. 10.1177\/00220345870660080401","journal-title":"J Dent Res"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2174\/1874210600802010005","article-title":"A role for non-antimicrobial actions of tetracyclines in combating oxidative stress in periodontal and metabolic diseases: a literature review","volume":"2","author":"Soory M","year":"2008","unstructured":"Soory M. A role for non-antimicrobial actions of tetracyclines in combating oxidative stress in periodontal and metabolic diseases: a literature review. Open Dent J. 2008, 2:5-12. 10.2174\/1874210600802010005","journal-title":"Open Dent J"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/08959374980120010501","article-title":"Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms","volume":"12","author":"Golub LM","year":"1998","unstructured":"Golub LM, Lee HM, Ryan ME, Giannobile WV, Payne J, Sorsa T. Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv Dent Res. 1998, 12:12-26. 10.1177\/08959374980120010501","journal-title":"Adv Dent Res"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31821201a5","article-title":"Procalcitonin for reduced antibiotic exposure in the critical care setting: a systematic review and an economic evaluation","volume":"39","author":"Heyland DK","year":"2011","unstructured":"Heyland DK, Johnson AP, Reynolds SC, Muscedere J. Procalcitonin for reduced antibiotic exposure in the critical care setting: a systematic review and an economic evaluation. Crit Care Med. 2011, 39:1792-9. 10.1097\/CCM.0b013e31821201a5","journal-title":"Crit Care Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/168764-comparative-evaluation-of-tetracycline-hydrochloride-fiber-and-simvastatin-gel-as-an-adjunct-to-scaling-and-root-planing-in-periodontitis-patients","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T21:05:18Z","timestamp":1729803918000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/168764-comparative-evaluation-of-tetracycline-hydrochloride-fiber-and-simvastatin-gel-as-an-adjunct-to-scaling-and-root-planing-in-periodontitis-patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,22]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.42314","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2023,7,22]]}}}