{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:00:54Z","timestamp":1787032854897,"version":"build-2736575974"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,24]]},"DOI":"10.7759\/cureus.42409","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:07:33Z","timestamp":1690247253000},"source":"Crossref","is-referenced-by-count":3,"title":["Comparison of the Efficacy of Opioid-Free Anesthesia With Conventional Opioid-Based Anesthesia for Nasal Surgeries - A Prospective Randomized Parallel Arm Triple-Blinded Study"],"prefix":"10.7759","author":[{"given":"Hariharan  S","family":"S","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arul  M","family":"Ramasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Parameswari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Kumar Kodali V","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Vakamudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.02.018","article-title":"Are opioids indispensable for general anaesthesia?","volume":"122","author":"Egan TD","year":"2019","unstructured":"Egan TD. Are opioids indispensable for general anaesthesia?. Br J Anaesth. 2019, 122:e127-35. 10.1016\/j.bja.2019.02.018","journal-title":"Br J Anaesth"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2017.01.014","article-title":"Pharmacogenomics in anesthesia","volume":"35","author":"Saba R","year":"2017","unstructured":"Saba R, Kaye AD, Urman RD. Pharmacogenomics in anesthesia. Anesthesiol Clin. 2017, 35:285-94. 10.1016\/j.anclin.2017.01.014","journal-title":"Anesthesiol Clin"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s42077-022-00218-1","article-title":"Comparing opioid free general anesthesia to traditional balanced general anesthesia regarding achievement of enhanced recovery in laparoscopic bariatric surgeries","volume":"14","author":"Soudi AM","year":"2022","unstructured":"Soudi AM, Hammad RA, ElShafie MA, Ahmed IMAS, Alhadidy MA. Comparing opioid free general anesthesia to traditional balanced general anesthesia regarding achievement of enhanced recovery in laparoscopic bariatric surgeries. Ain-Shams Journal of Anesthesiology. 2022, 14:1-7. 10.1186\/s42077-022-00218-1","journal-title":"Ain-Shams Journal of Anesthesiology"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000878","article-title":"Opioid free anesthesia: feasible?","volume":"33","author":"Chia PA","year":"2020","unstructured":"Chia PA, Cannesson M, Bui CC. Opioid free anesthesia: feasible?. Curr Opin Anaesthesiol. 2020, 33:512-7. 10.1097\/ACO.0000000000000878","journal-title":"Curr Opin Anaesthesiol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-022-06012-0","article-title":"Opioid-free anesthesia in bariatric surgery: a propensity score-matched analysis","volume":"32","author":"Torre A","year":"2022","unstructured":"Torre A, Marengo M, Ledingham NS, Ajani C, Volont\u00e8 F, Garofalo F, Mongelli F. Opioid-free anesthesia in bariatric surgery: a propensity score-matched analysis. Obes Surg. 2022, 32:1673-80. 10.1007\/s11695-022-06012-0","journal-title":"Obes Surg"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2022.110906","article-title":"Effects of opioid-free anesthesia on postoperative morphine consumption after bariatric surgery","volume":"81","author":"Berlier J","year":"2022","unstructured":"Berlier J, Carabalona JF, T\u00eate H, et al.. Effects of opioid-free anesthesia on postoperative morphine consumption after bariatric surgery. J Clin Anesth. 2022, 81:110906. 10.1016\/j.jclinane.2022.110906","journal-title":"J Clin Anesth"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-023-06584-5","article-title":"The performance of opioid-free anesthesia for bariatric surgery in clinical practice","volume":"33","author":"Ulbing S","year":"2023","unstructured":"Ulbing S, Infanger L, Fleischmann E, Prager G, Hamp T. The performance of opioid-free anesthesia for bariatric surgery in clinical practice. Obes Surg. 2023, 33:1687-93. 10.1007\/s11695-023-06584-5","journal-title":"Obes Surg"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.23937\/2377-4630\/1410120","article-title":"Opioid-free anesthesia in bariatric surgery: a retrospective cohort study","volume":"8","author":"Aronsohn J","year":"2021","unstructured":"Aronsohn J, Zeltsman M, Gerasimov M, Palleschi G, Yang P, Dowling O. Opioid-free anesthesia in bariatric surgery: a retrospective cohort study. Int J Anesth Anesth. 2021, 8:120. 10.23937\/2377-4630\/1410120","journal-title":"Int J Anesth Anesth"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2018\/29619.11080","article-title":"Opioid sparing effect of anaesthesia on postoperative inflammatory cytokine response in oral cancer surgery.","volume":"12","author":"Gupta M","year":"2018","unstructured":"Gupta M, Kushwaha JK, Singh PK, et al.. Opioid sparing effect of anaesthesia on postoperative inflammatory cytokine response in oral cancer surgery.. JCDR. 2018, 12:10-4. 10.7860\/JCDR\/2018\/29619.11080","journal-title":"JCDR"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2022.0694","article-title":"The effect of opioid-free anesthesia on the post-operative opioid consumption in laparoscopic bariatric surgeries: a randomized controlled double-blind study","volume":"18","author":"Ahmed SA","year":"2022","unstructured":"Ahmed SA, Abdelghany MS, Afandy ME. The effect of opioid-free anesthesia on the post-operative opioid consumption in laparoscopic bariatric surgeries: a randomized controlled double-blind study. J Opioid Manag. 2022, 18:47-56. 10.5055\/jom.2022.0694","journal-title":"J Opioid Manag"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14657","article-title":"Intra-operative analgesia with remifentanil vs. dexmedetomidine: a systematic review and meta-analysis with trial sequential analysis","volume":"74","author":"Grape S","year":"2019","unstructured":"Grape S, Kirkham KR, Frauenknecht J, Albrecht E. Intra-operative analgesia with remifentanil vs. dexmedetomidine: a systematic review and meta-analysis with trial sequential analysis. Anaesthesia. 2019, 74:793-800. 10.1111\/anae.14657","journal-title":"Anaesthesia"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2017.02.025","article-title":"Perioperative analgesic profile of dexmedetomidine infusions in morbidly obese undergoing bariatric surgery: a meta-analysis and trial sequential analysis","volume":"13","author":"Singh PM","year":"2017","unstructured":"Singh PM, Panwar R, Borle A, Mulier JP, Sinha A, Goudra B. Perioperative analgesic profile of dexmedetomidine infusions in morbidly obese undergoing bariatric surgery: a meta-analysis and trial sequential analysis. Surg Obes Relat Dis. 2017, 13:1434-46. 10.1016\/j.soard.2017.02.025","journal-title":"Surg Obes Relat Dis"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2016.31.9.1485","article-title":"Comparison of an intraoperative infusion of dexmedetomidine, fentanyl, and remifentanil on perioperative hemodynamics, sedation quality, and postoperative pain control","volume":"31","author":"Choi JW","year":"2016","unstructured":"Choi JW, Joo JD, Kim DW, et al.. Comparison of an intraoperative infusion of dexmedetomidine, fentanyl, and remifentanil on perioperative hemodynamics, sedation quality, and postoperative pain control. J Korean Med Sci. 2016, 31:1485-90. 10.3346\/jkms.2016.31.9.1485","journal-title":"J Korean Med Sci"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9185.117066","article-title":"The effect of dexmedetomidine continuous infusion as an adjuvant to general anesthesia on sevoflurane requirements: a study based on entropy analysis","volume":"29","author":"Patel CR","year":"2013","unstructured":"Patel CR, Engineer SR, Shah BJ, Madhu S. The effect of dexmedetomidine continuous infusion as an adjuvant to general anesthesia on sevoflurane requirements: a study based on entropy analysis. J Anaesthesiol Clin Pharmacol. 2013, 29:318-22. 10.4103\/0970-9185.117066","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2006.05.019","article-title":"Autonomic activity during dexmedetomidine or fentanyl infusion with desflurane anesthesia","volume":"19","author":"Feld J","year":"2007","unstructured":"Feld J, Hoffman WE, Paisansathan C, Park H, Ananda RC. Autonomic activity during dexmedetomidine or fentanyl infusion with desflurane anesthesia. J Clin Anesth. 2007, 19:30-6. 10.1016\/j.jclinane.2006.05.019","journal-title":"J Clin Anesth"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2008.04.008","article-title":"Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations","volume":"20","author":"Ayoglu H","year":"2008","unstructured":"Ayoglu H, Yapakci O, Ugur MB, et al.. Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations. J Clin Anesth. 2008, 20:437-41. 10.1016\/j.jclinane.2008.04.008","journal-title":"J Clin Anesth"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4220-1","article-title":"Surgical conditions during FESS; comparison of dexmedetomidine and remifentanil","volume":"274","author":"Karabayirli S","year":"2017","unstructured":"Karabayirli S, Ugur KS, Demircioglu RI, Muslu B, Usta B, Sert H, Ark N. Surgical conditions during FESS; comparison of dexmedetomidine and remifentanil. Eur Arch Otorhinolaryngol. 2017, 274:239-45. 10.1007\/s00405-016-4220-1","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref18","article-title":"A randomized controlled, double-blind trial evaluating the effect of opioid-free versus opioid general anaesthesia on postoperative pain and discomfort measured by the QoR-40","volume":"2","author":"Mulier JP","year":"2018","unstructured":"Mulier JP, Wouters R, Dekock M. A randomized controlled, double-blind trial evaluating the effect of opioid-free versus opioid general anaesthesia on postoperative pain and discomfort measured by the QoR-40. J Clin Anesth Pain Manag. 2018, 2:1-6.","journal-title":"J Clin Anesth Pain Manag"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4103\/sjamf.sjamf_55_19","article-title":"Comparative study between the effect of opioid-free anesthesia versus opioid-based anesthesia in morbid obese patients","volume":"3","author":"Elsaye RM","year":"2019","unstructured":"Elsaye RM, Gaafary AmM, Elsaeid AM. Comparative study between the effect of opioid-free anesthesia versus opioid-based anesthesia in morbid obese patients. Scientific Journal of Al-Azhar Medical Faculty, Girls. 2019, 3:457. 10.4103\/sjamf.sjamf_55_19","journal-title":"Scientific Journal of Al-Azhar Medical Faculty, Girls"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet551","article-title":"Opioid-free total intravenous anaesthesia reduces postoperative nausea and vomiting in bariatric surgery beyond triple prophylaxis","volume":"112","author":"Ziemann-Gimmel P","year":"2014","unstructured":"Ziemann-Gimmel P, Goldfarb AA, Koppman J, Marema RT. Opioid-free total intravenous anaesthesia reduces postoperative nausea and vomiting in bariatric surgery beyond triple prophylaxis. Br J Anaesth. 2014, 112:906-11. 10.1093\/bja\/aet551","journal-title":"Br J Anaesth"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.4103\/1687-7934.156699","article-title":"Comparison of dexmedetomidine and fentanyl for attenuation of the hemodynamic response to laryngoscopy and tracheal intubation","volume":"8","author":"Jain V","year":"2015","unstructured":"Jain V, Chandak A, Ghosh A, Golhar M. Comparison of dexmedetomidine and fentanyl for attenuation of the hemodynamic response to laryngoscopy and tracheal intubation. Ain Shams J Anesthesiol. 2015, 8:236. 10.4103\/1687-7934.156699","journal-title":"Ain Shams J Anesthesiol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.94750","article-title":"Current role of dexmedetomidine in clinical anesthesia and intensive care","volume":"5","author":"Kaur M","year":"2011","unstructured":"Kaur M, Singh PM. Current role of dexmedetomidine in clinical anesthesia and intensive care. Anesth Essays Res. 2011, 5:128-33. 10.4103\/0259-1162.94750","journal-title":"Anesth Essays Res"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2017\/27020.10578","article-title":"Comparative study of the effect of dexmedetomidine vs. fentanyl on haemodynamic response in patients undergoing elective laparoscopic surgery","volume":"11","author":"Vaswani JP","year":"2017","unstructured":"Vaswani JP, Debata D, Vyas V, Pattil S. Comparative study of the effect of dexmedetomidine vs. fentanyl on haemodynamic response in patients undergoing elective laparoscopic surgery. J Clin Diagn Res. 2017, 11:UC04-8. 10.7860\/JCDR\/2017\/27020.10578","journal-title":"J Clin Diagn Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/169547-comparison-of-the-efficacy-of-opioid-free-anesthesia-with-conventional-opioid-based-anesthesia-for-nasal-surgeries---a-prospective-randomized-parallel-arm-triple-blinded-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T15:02:27Z","timestamp":1707490947000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/169547-comparison-of-the-efficacy-of-opioid-free-anesthesia-with-conventional-opioid-based-anesthesia-for-nasal-surgeries---a-prospective-randomized-parallel-arm-triple-blinded-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,24]]},"references-count":23,"URL":"https:\/\/doi.org\/10.7759\/cureus.42409","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,24]]}}}