{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:38:20Z","timestamp":1791823100638,"version":"4.3.4"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,27]]},"DOI":"10.7759\/cureus.42583","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T23:58:35Z","timestamp":1690502315000},"source":"Crossref","is-referenced-by-count":59,"title":["The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation"],"prefix":"10.7759","author":[{"given":"Gireeja","family":"Walke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar  S","family":"Gaurkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejaswee","family":"Lohakare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayur","family":"Wanjari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"13","author":"Liguori I","year":"2018","unstructured":"Liguori I, Russo G, Curcio F, et al.. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018, 13:757-72. 10.2147\/CIA.S158513","journal-title":"Clin Interv Aging"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.2014.32.1.1","article-title":"Effect of oxidative stress on male reproduction","volume":"32","author":"Agarwal A","year":"2014","unstructured":"Agarwal A, Virk G, Ong C, du Plessis SS. Effect of oxidative stress on male reproduction. World J Mens Health. 2014, 32:1-17. 10.5534\/wjmh.2014.32.1.1","journal-title":"World J Mens Health"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.JHRS_150_18","article-title":"Role of oxidative stress in male infertility: an updated review","volume":"12","author":"Alahmar AT","year":"2019","unstructured":"Alahmar AT. Role of oxidative stress in male infertility: an updated review. J Hum Reprod Sci. 2019, 12:4-18. 10.4103\/jhrs.JHRS_150_18","journal-title":"J Hum Reprod Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1070692","article-title":"Unraveling the harmful effect of oxidative stress on male fertility: a mechanistic insight","volume":"14","author":"Hussain T","year":"2023","unstructured":"Hussain T, Kandeel M, Metwally E, et al.. Unraveling the harmful effect of oxidative stress on male fertility: a mechanistic insight. Front Endocrinol (Lausanne). 2023, 14:1070692. 10.3389\/fendo.2023.1070692","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.581838","article-title":"The role of genetics and oxidative stress in the etiology of male infertility-a unifying hypothesis?","volume":"11","author":"Aitken RJ","year":"2020","unstructured":"Aitken RJ, Baker MA. The role of genetics and oxidative stress in the etiology of male infertility-a unifying hypothesis?. Front Endocrinol (Lausanne). 2020, 11:581838. 10.3389\/fendo.2020.581838","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e3182439613","article-title":"Oxidative stress and antioxidant defense","volume":"5","author":"Birben E","year":"2012","unstructured":"Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012, 5:9-19. 10.1097\/WOX.0b013e3182439613","journal-title":"World Allergy Organ J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00694","article-title":"Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases","volume":"11","author":"Sharifi-Rad M","year":"2020","unstructured":"Sharifi-Rad M, Anil Kumar NV, Zucca P, et al.. Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases. Front Physiol. 2020, 11:694. 10.3389\/fphys.2020.00694","journal-title":"Front Physiol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-2-12","article-title":"Reactive oxygen species and sperm cells","volume":"2","author":"Sanocka D","year":"2004","unstructured":"Sanocka D, Kurpisz M. Reactive oxygen species and sperm cells. Reprod Biol Endocrinol. 2004, 2:12. 10.1186\/1477-7827-2-12","journal-title":"Reprod Biol Endocrinol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen L","year":"2018","unstructured":"Chen L, Deng H, Cui H, et al.. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018, 9:7204-18. 10.18632\/oncotarget.23208","journal-title":"Oncotarget"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0406-2","article-title":"Reactive oxygen species and male reproductive hormones","volume":"16","author":"Darbandi M","year":"2018","unstructured":"Darbandi M, Darbandi S, Agarwal A, Sengupta P, Durairajanayagam D, Henkel R, Sadeghi MR. Reactive oxygen species and male reproductive hormones. Reprod Biol Endocrinol. 2018, 16:87. 10.1186\/s12958-018-0406-2","journal-title":"Reprod Biol Endocrinol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.799294","article-title":"The impact of oxidative stress in male infertility","volume":"8","author":"Mannucci A","year":"2021","unstructured":"Mannucci A, Argento FR, Fini E, Coccia ME, Taddei N, Becatti M, Fiorillo C. The impact of oxidative stress in male infertility. Front Mol Biosci. 2021, 8:799294. 10.3389\/fmolb.2021.799294","journal-title":"Front Mol Biosci"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9020111","article-title":"The importance of oxidative stress in determining the functionality of mammalian spermatozoa: a two-edged sword","volume":"9","author":"Aitken RJ","year":"2020","unstructured":"Aitken RJ, Drevet JR. The importance of oxidative stress in determining the functionality of mammalian spermatozoa: a two-edged sword. Antioxidants (Basel). 2020, 9:10.3390\/antiox9020111","journal-title":"Antioxidants (Basel)"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9020134","article-title":"Molecular changes induced by oxidative stress that impair human sperm motility","volume":"9","author":"Nowicka-Bauer K","year":"2020","unstructured":"Nowicka-Bauer K, Nixon B. Molecular changes induced by oxidative stress that impair human sperm motility. Antioxidants (Basel). 2020, 9:10.3390\/antiox9020134","journal-title":"Antioxidants (Basel)"},{"key":"ref14","article-title":"Oxidative stress induced sperm DNA damage, a possible reason for male infertility","volume":"13","author":"Hosen MB","year":"2015","unstructured":"Hosen MB, Islam MR, Begum F, Kabir Y, Howlader MZ. Oxidative stress induced sperm DNA damage, a possible reason for male infertility. Iran J Reprod Med. 2015, 13:525-32.","journal-title":"Iran J Reprod Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/686137","article-title":"Impacts of oxidative stress and antioxidants on semen functions","volume":"2010","author":"Bansal AK","year":"2010","unstructured":"Bansal AK, Bilaspuri GS. Impacts of oxidative stress and antioxidants on semen functions. Vet Med Int. 2010, 2010:10.4061\/2011\/686137","journal-title":"Vet Med Int"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020306","article-title":"Male infertility and oxidative stress: a focus on the underlying mechanisms","volume":"11","author":"Aitken RJ","year":"2022","unstructured":"Aitken RJ, Drevet JR, Moazamian A, Gharagozloo P. Male infertility and oxidative stress: a focus on the underlying mechanisms. Antioxidants (Basel). 2022, 11:10.3390\/antiox11020306","journal-title":"Antioxidants (Basel)"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/and.13706","article-title":"Etiologies of sperm DNA damage and its impact on male infertility","volume":"53","author":"Panner Selvam MK","year":"2021","unstructured":"Panner Selvam MK, Ambar RF, Agarwal A, Henkel R. Etiologies of sperm DNA damage and its impact on male infertility. Andrologia. 2021, 53:e13706. 10.1111\/and.13706","journal-title":"Andrologia"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.02.004","article-title":"Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility","volume":"28","author":"Wright C","year":"2014","unstructured":"Wright C, Milne S, Leeson H. Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility. Reprod Biomed Online. 2014, 28:684-703. 10.1016\/j.rbmo.2014.02.004","journal-title":"Reprod Biomed Online"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5173\/ceju.2013.01.art19","article-title":"The role of oxidative stress and antioxidants in male fertility","volume":"66","author":"Walczak-Jedrzejowska R","year":"2013","unstructured":"Walczak-Jedrzejowska R, Wolski JK, Slowikowska-Hilczer J. The role of oxidative stress and antioxidants in male fertility. Cent Eur J Urol. 2013, 66:60-7. 10.5173\/ceju.2013.01.art19","journal-title":"Cent Eur J Urol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajme.2017.09.001","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid","volume":"54","author":"Ighodaro OM","year":"2018","unstructured":"Ighodaro OM, Akinloye OA. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alex J Med. 2018, 54:287-93. 10.1016\/j.ajme.2017.09.001","journal-title":"Alex J Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.70902","article-title":"Free radicals, antioxidants and functional foods: Impact on human health","volume":"4","author":"Lobo V","year":"2010","unstructured":"Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010, 4:118-26. 10.4103\/0973-7847.70902","journal-title":"Pharmacogn Rev"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00795-w","article-title":"The role of the natural antioxidant mechanism in sperm cells","volume":"29","author":"Kowalczyk A","year":"2022","unstructured":"Kowalczyk A. The role of the natural antioxidant mechanism in sperm cells. Reprod Sci. 2022, 29:1387-94. 10.1007\/s43032-021-00795-w","journal-title":"Reprod Sci"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1590\/s1677-55382007000500002","article-title":"Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis","volume":"33","author":"Cocuzza M","year":"2007","unstructured":"Cocuzza M, Sikka SC, Athayde KS, Agarwal A. Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis. Int Braz J Urol. 2007, 33:603-21. 10.1590\/s1677-55382007000500002","journal-title":"Int Braz J Urol"},{"key":"ref24","article-title":"Antioxidant supplements and semen parameters: An evidence based review","volume":"14","author":"Ahmadi S","year":"2016","unstructured":"Ahmadi S, Bashiri R, Ghadiri-Anari A, Nadjarzadeh A. Antioxidant supplements and semen parameters: An evidence based review. Int J Reprod Biomed. 2016, 14:729-36.","journal-title":"Int J Reprod Biomed"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/biology9040077","article-title":"Oxidative stress in male infertility: causes, effects in assisted reproductive techniques, and protective support of antioxidants","volume":"9","author":"Ribas-Maynou J","year":"2020","unstructured":"Ribas-Maynou J, Yeste M. Oxidative stress in male infertility: causes, effects in assisted reproductive techniques, and protective support of antioxidants. Biology (Basel). 2020, 9:10.3390\/biology9040077","journal-title":"Biology (Basel)"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3945\/an.112.002154","article-title":"Health benefits of fruits and vegetables","volume":"3","author":"Slavin JL","year":"2012","unstructured":"Slavin JL, Lloyd B. Health benefits of fruits and vegetables. Adv Nutr. 2012, 3:506-16. 10.3945\/an.112.002154","journal-title":"Adv Nutr"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/nu2070652","article-title":"Health benefits of nut consumption","volume":"2","author":"Ros E","year":"2010","unstructured":"Ros E. Health benefits of nut consumption. Nutrients. 2010, 2:652-82. 10.3390\/nu2070652","journal-title":"Nutrients"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.132944","article-title":"Putting the whole grain puzzle together: health benefits associated with whole grains\u2014summary of American Society for Nutrition 2010 Satellite Symposium","volume":"141","author":"Jonnalagadda SS","year":"2011","unstructured":"Jonnalagadda SS, Harnack L, Liu RH, McKeown N, Seal C, Liu S, Fahey GC. Putting the whole grain puzzle together: health benefits associated with whole grains\u2014summary of American Society for Nutrition 2010 Satellite Symposium. J Nutr. 2011, 141:1011-22S. 10.3945\/jn.110.132944","journal-title":"J Nutr"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020519","article-title":"Health benefits of plant-based nutrition: focus on beans in cardiometabolic diseases","volume":"13","author":"Mullins AP","year":"2021","unstructured":"Mullins AP, Arjmandi BH. Health benefits of plant-based nutrition: focus on beans in cardiometabolic diseases. Nutrients. 2021, 13:10.3390\/nu13020519","journal-title":"Nutrients"},{"key":"ref30","article-title":"Turmeric, the Golden Spice","author":"Prasad S","year":"2011","unstructured":"Prasad S, Aggarwal BB. Turmeric, the Golden Spice. Herbal Medicine: Biomolecular and Clinical Aspects. Benzie IFF, Wachtel-Galor S (ed): CRC Press, Boca Raton, FL, USA; 2011. 2:512."},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/and.13012","article-title":"Reactive oxygen species impact on sperm DNA and its role in male infertility","volume":"50","author":"Bui AD","year":"2018","unstructured":"Bui AD, Sharma R, Henkel R, Agarwal A. Reactive oxygen species impact on sperm DNA and its role in male infertility. Andrologia. 2018, 50:e13012. 10.1111\/and.13012","journal-title":"Andrologia"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1080\/2090598X.2019.1599624","article-title":"Oxidative stress and sperm function: a systematic review on evaluation and management","volume":"17","author":"Dutta S","year":"2019","unstructured":"Dutta S, Majzoub A, Agarwal A. Oxidative stress and sperm function: a systematic review on evaluation and management. Arab J Urol. 2019, 17:87-97. 10.1080\/2090598X.2019.1599624","journal-title":"Arab J Urol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2020.01.31","article-title":"Relationship between sperm morphology and sperm DNA dispersion","volume":"9","author":"Jakubik-Uljasz J","year":"2020","unstructured":"Jakubik-Uljasz J, Gill K, Rosiak-Gill A, Piasecka M. Relationship between sperm morphology and sperm DNA dispersion. Transl Androl Urol. 2020, 9:405-15. 10.21037\/tau.2020.01.31","journal-title":"Transl Androl Urol"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms131114026","article-title":"Types, causes, detection and repair of DNA fragmentation in animal and human sperm cells","volume":"13","author":"Gonz\u00e1lez-Mar\u00edn C","year":"2012","unstructured":"Gonz\u00e1lez-Mar\u00edn C, Gos\u00e1lvez J, Roy R. Types, causes, detection and repair of DNA fragmentation in animal and human sperm cells. Int J Mol Sci. 2012, 13:14026-52. 10.3390\/ijms131114026","journal-title":"Int J Mol Sci"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010097","article-title":"Oxidation of sperm DNA and male infertility","volume":"10","author":"Rashki Ghaleno L","year":"2021","unstructured":"Rashki Ghaleno L, Alizadeh A, Drevet JR, Shahverdi A, Valojerdi MR. Oxidation of sperm DNA and male infertility. Antioxidants (Basel). 2021, 10:10.3390\/antiox10010097","journal-title":"Antioxidants (Basel)"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3389\/frph.2022.822257","article-title":"Oxidative stress and male infertility: evidence from a research perspective","volume":"4","author":"Ayad B","year":"2022","unstructured":"Ayad B, Omolaoye TS, Louw N, Ramsunder Y, Skosana BT, Oyeipo PI, Du Plessis SS. Oxidative stress and male infertility: evidence from a research perspective. Front Reprod Health. 2022, 4:822257. 10.3389\/frph.2022.822257","journal-title":"Front Reprod Health"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1111\/and.12762","article-title":"Oxidative stress status and sperm DNA fragmentation in fertile and infertile men","volume":"49","author":"Dorostghoal M","year":"2017","unstructured":"Dorostghoal M, Kazeminejad SR, Shahbazian N, Pourmehdi M, Jabbari A. Oxidative stress status and sperm DNA fragmentation in fertile and infertile men. Andrologia. 2017, 49:10.1111\/and.12762","journal-title":"Andrologia"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081283","article-title":"Oxidative stress and male fertility: role of antioxidants and inositols","volume":"10","author":"De Luca MN","year":"2021","unstructured":"De Luca MN, Colone M, Gambioli R, Stringaro A, Unfer V. Oxidative stress and male fertility: role of antioxidants and inositols. Antioxidants (Basel). 2021, 10:10.3390\/antiox10081283","journal-title":"Antioxidants (Basel)"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/956792","article-title":"Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants","volume":"2013","author":"Poljsak B","year":"2013","unstructured":"Poljsak B, \u0160uput D, Milisav I. Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants. Oxid Med Cell Longev. 2013, 2013:956792. 10.1155\/2013\/956792","journal-title":"Oxid Med Cell Longev"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.3934\/publichealth.2020009","article-title":"Effect of antioxidant supplements on sperm parameters in infertile male smokers: a single-blinded clinical trial","volume":"7","author":"Sadaghiani S","year":"2020","unstructured":"Sadaghiani S, Fallahi S, Heshmati H, et al.. Effect of antioxidant supplements on sperm parameters in infertile male smokers: a single-blinded clinical trial. AIMS Public Health. 2020, 7:92-9. 10.3934\/publichealth.2020009","journal-title":"AIMS Public Health"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.810242","article-title":"The effect of antioxidants on sperm quality parameters and pregnancy rates for idiopathic male infertility: a network meta-analysis of randomized controlled trials","volume":"13","author":"Li KP","year":"2022","unstructured":"Li KP, Yang XS, Wu T. The effect of antioxidants on sperm quality parameters and pregnancy rates for idiopathic male infertility: a network meta-analysis of randomized controlled trials. Front Endocrinol (Lausanne). 2022, 13:810242. 10.3389\/fendo.2022.810242","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102071","article-title":"Male subfertility and oxidative stress","volume":"46","author":"Evans EP","year":"2021","unstructured":"Evans EP, Scholten JT, Mzyk A, et al.. Male subfertility and oxidative stress. Redox Biol. 2021, 46:102071. 10.1016\/j.redox.2021.102071","journal-title":"Redox Biol"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8080268","article-title":"Role of selenium and selenoproteins in male reproductive function: a review of past and present evidences","volume":"8","author":"Qazi IH","year":"2019","unstructured":"Qazi IH, Angel C, Yang H, et al.. Role of selenium and selenoproteins in male reproductive function: a review of past and present evidences. Antioxidants (Basel). 2019, 8:10.3390\/antiox8080268","journal-title":"Antioxidants (Basel)"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.5152\/tud.2022.22058","article-title":"Antioxidant supplementation on sperm DNA fragmentation and sperm parameters: a systematic review and meta-analysis","volume":"48","author":"Noegroho BS","year":"2022","unstructured":"Noegroho BS, Siregar S, Tampubolon KA. Antioxidant supplementation on sperm DNA fragmentation and sperm parameters: a systematic review and meta-analysis. Turk J Urol. 2022, 48:375-84. 10.5152\/tud.2022.22058","journal-title":"Turk J Urol"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040836","article-title":"Antioxidant supplementation on male fertility-a systematic review","volume":"12","author":"Dimitriadis F","year":"2023","unstructured":"Dimitriadis F, Borgmann H, Struck JP, Salem J, Kuru TH. Antioxidant supplementation on male fertility-a systematic review. Antioxidants (Basel). 2023, 12:10.3390\/antiox12040836","journal-title":"Antioxidants (Basel)"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.25122\/jml-2019-0107","article-title":"Protective effect of vitamin C and zinc as an antioxidant against chemotherapy-induced male reproductive toxicity","volume":"13","author":"Hajjar T","year":"2020","unstructured":"Hajjar T, Soleymani F, Vatanchian M. Protective effect of vitamin C and zinc as an antioxidant against chemotherapy-induced male reproductive toxicity. J Med Life. 2020, 13:138-43. 10.25122\/jml-2019-0107","journal-title":"J Med Life"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.18502\/ijrm.v19i6.9374","article-title":"Protective effect of vitamin E on sperm parameters, chromatin quality, and DNA fragmentation in mice treated with different doses of ethanol: an experimental study","volume":"19","author":"Doostabadi MR","year":"2021","unstructured":"Doostabadi MR, Hassanzadeh-Taheri M, Asgharzadeh M, Mohammadzadeh M. Protective effect of vitamin E on sperm parameters, chromatin quality, and DNA fragmentation in mice treated with different doses of ethanol: an experimental study. Int J Reprod Biomed. 2021, 19:525-36. 10.18502\/ijrm.v19i6.9374","journal-title":"Int J Reprod Biomed"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7050066","article-title":"Selenium-dependent antioxidant enzymes: actions and properties of selenoproteins","volume":"7","author":"Zoidis E","year":"2018","unstructured":"Zoidis E, Seremelis I, Kontopoulos N, Danezis GP. Selenium-dependent antioxidant enzymes: actions and properties of selenoproteins. Antioxidants (Basel). 2018, 7:10.3390\/antiox7050066","journal-title":"Antioxidants (Basel)"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.84471","article-title":"Coenzyme Q10: the essential nutrient","volume":"3","author":"Saini R","year":"2011","unstructured":"Saini R. Coenzyme Q10: the essential nutrient. J Pharm Bioallied Sci. 2011, 3:466-7. 10.4103\/0975-7406.84471","journal-title":"J Pharm Bioallied Sci"},{"key":"ref50","unstructured":"Office of Dietary Supplements - Vitamin E. (2023). Accessed. June 30, 2023: https:\/\/ods.od.nih.gov\/factsheets\/VitaminE-HealthProfessional\/."},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.18714","article-title":"Effect of folic acid and zinc supplementation in men on semen quality and live birth among couples undergoing infertility treatment: a randomized clinical trial","volume":"323","author":"Schisterman EF","year":"2020","unstructured":"Schisterman EF, Sjaarda LA, Clemons T, et al.. Effect of folic acid and zinc supplementation in men on semen quality and live birth among couples undergoing infertility treatment: a randomized clinical trial. JAMA. 2020, 323:35-48. 10.1001\/jama.2019.18714","journal-title":"JAMA"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-49","article-title":"The effects of oxidative stress on female reproduction: a review","volume":"10","author":"Agarwal A","year":"2012","unstructured":"Agarwal A, Aponte-Mellado A, Premkumar BJ, Shaman A, Gupta S. The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol. 2012, 10:49. 10.1186\/1477-7827-10-49","journal-title":"Reprod Biol Endocrinol"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1111\/and.12927","article-title":"Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: a double-blind placebo-controlled study","volume":"50","author":"Busetto GM","year":"2018","unstructured":"Busetto GM, Agarwal A, Virmani A, et al.. Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: a double-blind placebo-controlled study. Andrologia. 2018, 50:10.1111\/and.12927","journal-title":"Andrologia"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8040089","article-title":"Antioxidants and male fertility: from molecular studies to clinical evidence","volume":"8","author":"Martin-Hidalgo D","year":"2019","unstructured":"Martin-Hidalgo D, Bragado MJ, Batista AR, Oliveira PF, Alves MG. Antioxidants and male fertility: from molecular studies to clinical evidence. Antioxidants (Basel). 2019, 8:10.3390\/antiox8040089","journal-title":"Antioxidants (Basel)"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.200196","article-title":"Utility of antioxidants in the treatment of male infertility: clinical guidelines based on a systematic review and analysis of evidence","volume":"39","author":"Agarwal A","year":"2021","unstructured":"Agarwal A, Leisegang K, Majzoub A, et al.. Utility of antioxidants in the treatment of male infertility: clinical guidelines based on a systematic review and analysis of evidence. World J Mens Health. 2021, 39:233-90. 10.5534\/wjmh.200196","journal-title":"World J Mens Health"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1123\/ijsnem.20.1.2","article-title":"Experimental guidelines for studies designed to investigate the impact of antioxidant supplementation on exercise performance","volume":"20","author":"Powers SK","year":"2010","unstructured":"Powers SK, Smuder AJ, Kavazis AN, Hudson MB. Experimental guidelines for studies designed to investigate the impact of antioxidant supplementation on exercise performance. Int J Sport Nutr Exerc Metab. 2010, 20:2-14. 10.1123\/ijsnem.20.1.2","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0280-6","article-title":"A multi-faceted approach to understanding male infertility: gene mutations, molecular defects and assisted reproductive techniques (ART)","volume":"31","author":"Tahmasbpour E","year":"2014","unstructured":"Tahmasbpour E, Balasubramanian D, Agarwal A. A multi-faceted approach to understanding male infertility: gene mutations, molecular defects and assisted reproductive techniques (ART). J Assist Reprod Genet. 2014, 31:1115-37. 10.1007\/s10815-014-0280-6","journal-title":"J Assist Reprod Genet"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.2217\/epi.11.22","article-title":"Epigenetics and lifestyle","volume":"3","author":"Alegr\u00eda-Torres JA","year":"2011","unstructured":"Alegr\u00eda-Torres JA, Baccarelli A, Bollati V. Epigenetics and lifestyle. Epigenomics. 2011, 3:267-77. 10.2217\/epi.11.22","journal-title":"Epigenomics"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153254","article-title":"Oral antioxidant treatment of men significantly improves the reproductive outcome of IVF cycles","volume":"10","author":"Scaruffi P","year":"2021","unstructured":"Scaruffi P, Licata E, Maccarini E, et al.. Oral antioxidant treatment of men significantly improves the reproductive outcome of IVF cycles. J Clin Med. 2021, 10:10.3390\/jcm10153254","journal-title":"J Clin Med"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx021","article-title":"The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance\u2014challenges and future research opportunities","volume":"23","author":"Barratt CL","year":"2017","unstructured":"Barratt CL, Bj\u00f6rndahl L, De Jonge CJ, et al.. The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance\u2014challenges and future research opportunities. Hum Reprod Update. 2017, 23:660-80. 10.1093\/humupd\/dmx021","journal-title":"Hum Reprod Update"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2010.183","article-title":"The role of antioxidant therapy in the treatment of male infertility: an overview","volume":"13","author":"Lombardo F","year":"2011","unstructured":"Lombardo F, Sansone A, Romanelli F, Paoli D, Gandini L, Lenzi A. The role of antioxidant therapy in the treatment of male infertility: an overview. Asian J Androl. 2011, 13:690-7. 10.1038\/aja.2010.183","journal-title":"Asian J Androl"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.2147\/cia.S12159918","article-title":"Effects of antioxidant supplementation on the aging process","volume":"2","author":"Fusco D","year":"2007","unstructured":"Fusco D, Colloca G, Monaco MRL, Cesari M. Effects of antioxidant supplementation on the aging process. Clin Interv Aging. 2007, 2:377-87. 10.2147\/cia.S12159918","journal-title":"Clin Interv Aging"},{"key":"ref63","article-title":"Lifestyle Changes: Effect of Diet, Exercise, Functional Food, and Obesity Treatment on Lipids and Lipoproteins","author":"Enkhmaa B","year":"2000","unstructured":"Enkhmaa B, Surampudi P, Anuurad E, Berglund L. Lifestyle Changes: Effect of Diet, Exercise, Functional Food, and Obesity Treatment on Lipids and Lipoproteins. Feingold KR, Anawalt B, Blackman MR (ed): MDText.com, South Dartmouth, MA, USA; 2000."},{"key":"ref64","unstructured":"Antioxidants. In Depth. (2023). Accessed: June 30, 2023: https:\/\/www.nccih.nih.gov\/health\/antioxidants-in-depth."},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1177\/1534735415610427","article-title":"Efficacy and interaction of antioxidant supplements as adjuvant therapy in cancer treatment: a systematic review","volume":"15","author":"Yasueda A","year":"2016","unstructured":"Yasueda A, Urushima H, Ito T. Efficacy and interaction of antioxidant supplements as adjuvant therapy in cancer treatment: a systematic review. Integr Cancer Ther. 2016, 15:17-39. 10.1177\/1534735415610427","journal-title":"Integr Cancer Ther"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03413.x","article-title":"Antioxidants and allergic disease: a case of too little or too much?","volume":"40","author":"Allan K","year":"2010","unstructured":"Allan K, Kelly FJ, Devereux G. Antioxidants and allergic disease: a case of too little or too much?. Clin Exp Allergy. 2010, 40:370-80. 10.1111\/j.1365-2222.2009.03413.x","journal-title":"Clin Exp Allergy"},{"key":"ref67","unstructured":"How to Choose High Quality Vitamins and Supplements. (2023). Accessed. June 30, 2023: https:\/\/www.healthline.com\/nutrition\/how-to-choose-high-quality-vitamins-and-supplements."},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20175697","article-title":"Antioxidants in dermatology","volume":"92","author":"Addor FA","year":"2017","unstructured":"Addor FA. Antioxidants in dermatology. An Bras Dermatol. 2017, 92:356-62. 10.1590\/abd1806-4841.20175697","journal-title":"An Bras Dermatol"},{"key":"ref69","unstructured":"Office of Dietary Supplements - Vitamin C. (2023). Accessed. June 30, 2023: https:\/\/ods.od.nih.gov\/factsheets\/VitaminC-HealthProfessional\/."},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17228452","article-title":"Antioxidants and exercise performance: with a focus on vitamin E and C supplementation","volume":"17","author":"Higgins MR","year":"2020","unstructured":"Higgins MR, Izadi A, Kaviani M. Antioxidants and exercise performance: with a focus on vitamin E and C supplementation. Int J Environ Res Public Health. 2020, 17:10.3390\/ijerph17228452","journal-title":"Int J Environ Res Public Health"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.12793\/tcp.2023.31.e6","article-title":"Impact of antioxidants in improving semen parameters like count, motility and DNA fragmentation in sub-fertile males: a randomized, double-blind, placebo-controlled clinical trial","volume":"31","author":"Patki A","year":"2023","unstructured":"Patki A, Shelatkar R, Singh M, et al.. Impact of antioxidants in improving semen parameters like count, motility and DNA fragmentation in sub-fertile males: a randomized, double-blind, placebo-controlled clinical trial. Transl Clin Pharmacol. 2023, 31:28-39. 10.12793\/tcp.2023.31.e6","journal-title":"Transl Clin Pharmacol"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00477\/full","article-title":"Role of ROS and nutritional antioxidants in human diseases","volume":"9","author":"Liu Z","year":"2018","unstructured":"Liu Z, Ren Z, Zhang J, Chuang C-C, Kandaswamy E, Zhou T, Zuo L. Role of ROS and nutritional antioxidants in human diseases. Front Physiol. 2018, 9:477. 10.3389\/fphys.2018.00477\/full","journal-title":"Front Physiol"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24729","article-title":"Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging","volume":"9","author":"Simioni C","year":"2018","unstructured":"Simioni C, Zauli G, Martelli AM, Vitale M, Sacchetti G, Gonelli A, Neri LM. Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget. 2018, 9:17181-98. 10.18632\/oncotarget.24729","journal-title":"Oncotarget"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091439","article-title":"Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer\u2019s disease: the role of antioxidants in prevention and treatment","volume":"10","author":"Juszczyk G","year":"2021","unstructured":"Juszczyk G, Mikulska J, Kasperek K, Pietrzak D, Mrozek W, Herbet M. Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer\u2019s disease: the role of antioxidants in prevention and treatment. Antioxidants (Basel). 2021, 10:10.3390\/antiox10091439","journal-title":"Antioxidants (Basel)"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123908","article-title":"The role of vitamin C in two distinct physiological states: physical activity and sleep","volume":"12","author":"Otocka-Kmiecik A","year":"2020","unstructured":"Otocka-Kmiecik A, Kr\u00f3l A. The role of vitamin C in two distinct physiological states: physical activity and sleep. Nutrients. 2020, 12:10.3390\/nu12123908","journal-title":"Nutrients"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2020.1866597","article-title":"Antioxidant-rich natural fruit and vegetable products and human health","volume":"24","author":"Jideani AIO","year":"2021","unstructured":"Jideani AIO, Silungwe H, Takalani T, Omolola AO, Udeh HO, Anyasi TA. Antioxidant-rich natural fruit and vegetable products and human health. Int J Food Prop. 2021, 24:41-67. 10.1080\/10942912.2020.1866597","journal-title":"Int J Food Prop"},{"key":"ref77","unstructured":"Office of Dietary Supplements - Omega-3 Fatty Acids. (2023). Accessed. June 30, 2023: https:\/\/ods.od.nih.gov\/factsheets\/Omega3FattyAcids-HealthProfessional\/."},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.3390\/nu7115459","article-title":"Definition of the Mediterranean diet: a literature review","volume":"7","author":"Davis C","year":"2015","unstructured":"Davis C, Bryan J, Hodgson J, Murphy K. Definition of the Mediterranean diet: a literature review. Nutrients. 2015, 7:9139-53. 10.3390\/nu7115459","journal-title":"Nutrients"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.3390\/foods10102452","article-title":"The effect of trans fatty acids on human health: regulation and consumption patterns","volume":"10","author":"Pipoyan D","year":"2021","unstructured":"Pipoyan D, Stepanyan S, Stepanyan S, Beglaryan M, Costantini L, Molinari R, Merendino N. The effect of trans fatty acids on human health: regulation and consumption patterns. Foods. 2021, 10:10.3390\/foods10102452","journal-title":"Foods"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2010.00304.x","article-title":"Water, hydration, and health","volume":"68","author":"Popkin BM","year":"2010","unstructured":"Popkin BM, D'Anci KE, Rosenberg IH. Water, hydration, and health. Nutr Rev. 2010, 68:439-58. 10.1111\/j.1753-4887.2010.00304.x","journal-title":"Nutr Rev"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_110_18","article-title":"Heavy cigarette smoking and alcohol consumption are associated with impaired sperm parameters in primary infertile men","volume":"21","author":"Boeri L","year":"2019","unstructured":"Boeri L, Capogrosso P, Ventimiglia E, et al.. Heavy cigarette smoking and alcohol consumption are associated with impaired sperm parameters in primary infertile men. Asian J Androl. 2019, 21:478-85. 10.4103\/aja.aja_110_18","journal-title":"Asian J Androl"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5563759","article-title":"A common feature of pesticides: oxidative stress\u2014the role of oxidative stress in pesticide-induced toxicity","volume":"2022","author":"Sule RO","year":"2022","unstructured":"Sule RO, Condon L, Gomes AV. A common feature of pesticides: oxidative stress\u2014the role of oxidative stress in pesticide-induced toxicity. Oxid Med Cell Longev. 2022, 2022:5563759. 10.1155\/2022\/5563759","journal-title":"Oxid Med Cell Longev"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.18502\/ijph.v51i4.9232","article-title":"The impact of high ambient temperature on human sperm parameters: a meta-analysis","volume":"51","author":"Hoang-Thi AP","year":"2022","unstructured":"Hoang-Thi AP, Dang-Thi AT, Phan-Van S, et al.. The impact of high ambient temperature on human sperm parameters: a meta-analysis. Iran J Public Health. 2022, 51:710-23. 10.18502\/ijph.v51i4.9232","journal-title":"Iran J Public Health"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.5152\/jtgga.2015.15232","article-title":"Impact of obesity on infertility in women","volume":"16","author":"Da\u011f Z\u00d6","year":"2015","unstructured":"Da\u011f Z\u00d6, Dilbaz B. Impact of obesity on infertility in women. J Turk Ger Gynecol Assoc. 2015, 16:111-7. 10.5152\/jtgga.2015.15232","journal-title":"J Turk Ger Gynecol Assoc"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/169642-the-impact-of-oxidative-stress-on-male-reproductive-function-exploring-the-role-of-antioxidant-supplementation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T15:02:19Z","timestamp":1707490939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/169642-the-impact-of-oxidative-stress-on-male-reproductive-function-exploring-the-role-of-antioxidant-supplementation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,27]]},"references-count":84,"URL":"https:\/\/doi.org\/10.7759\/cureus.42583","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,27]]}}}