{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:16:14Z","timestamp":1777619774193,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,8]]},"DOI":"10.7759\/cureus.43156","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T17:50:26Z","timestamp":1691517026000},"source":"Crossref","is-referenced-by-count":10,"title":["A Review of the Dietary Intake, Bioavailability and Health Benefits of Ellagic Acid (EA) with a Primary Focus on Its Anti-Cancer Properties"],"prefix":"10.7759","author":[{"given":"Philip","family":"Harper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Pomegranate phytochemicals: nutraceutical and therapeutic values","volume":"4","author":"Sharma J","year":"2010","unstructured":"Sharma J, Maity A. Pomegranate phytochemicals: nutraceutical and therapeutic values. Fruit Vegetable Cereal Sci Biotechnol. 2010, 4:56-76.","journal-title":"Fruit Vegetable Cereal Sci Biotechnol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.02.006","article-title":"Intake and bioaccessibility of total polyphenols in a whole diet","volume":"101","author":"Saura-Calixto F","year":"2007","unstructured":"Saura-Calixto F, Serrano J, Goni I. Intake and bioaccessibility of total polyphenols in a whole diet. Food Chem. 2007, 101:492-501. 10.1016\/j.foodchem.2006.02.006","journal-title":"Food Chem"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.3.562","article-title":"Dietary intake and major food sources of polyphenols in Finnish adults","volume":"138","author":"Ovaskainen ML","year":"2008","unstructured":"Ovaskainen ML, T\u00f6rr\u00f6nen R, Koponen JM, Sinkko H, Hellstr\u00f6m J, Reinivuo H, Mattila P. Dietary intake and major food sources of polyphenols in Finnish adults. J Nutr. 2008, 138:562-6. 10.1093\/jn\/138.3.562","journal-title":"J Nutr"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0010(20000515)80:7<1118::AID-JSFA570>3.0.CO;2-9","article-title":"Ellagitannins-nature, occurrence and dietary burden","volume":"80","author":"Clifford MN","year":"2000","unstructured":"Clifford MN, Scalbert A. Ellagitannins-nature, occurrence and dietary burden. J Sci Food Agriculture. 2000, 80:1118-25. 10.1002\/(SICI)1097-0010(20000515)80:7&lt;1118::AID-JSFA570&gt;3.0.CO;2-9","journal-title":"J Sci Food Agriculture"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-2952(03)00413-1","article-title":"Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid\u2014extensive binding to protein and DNA","volume":"66","author":"Whitley AC","year":"2003","unstructured":"Whitley AC, Stoner GD, Darby MV, Walle T. Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid\u2014extensive binding to protein and DNA. Biochem Pharmacol. 2003, 66:907-15. 10.1016\/s0006-2952(03)00413-1","journal-title":"Biochem Pharmacol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/7.10.1663","article-title":"Disposition of the naturally occurring antimutagenic plant phenol, ellagic acid, and its synthetic derivatives, 3-O-decylellagic acid and 3,3'-di-O-methylellagic acid in mice","volume":"7","author":"Smart RC","year":"1986","unstructured":"Smart RC, Huang MT, Chang RL, Sayer JM, Jerina DM, Conney AH. Disposition of the naturally occurring antimutagenic plant phenol, ellagic acid, and its synthetic derivatives, 3-O-decylellagic acid and 3,3'-di-O-methylellagic acid in mice. Carcinogenesis. 1986, 7:1663-7. 10.1093\/carcin\/7.10.1663","journal-title":"Carcinogenesis"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.04.029","article-title":"Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice","volume":"348","author":"Seeram NP","year":"2004","unstructured":"Seeram NP, Lee R, Heber D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clin Chim Acta. 2004, 348:63-8. 10.1016\/j.cccn.2004.04.029","journal-title":"Clin Chim Acta"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.86420","article-title":"Food ellagitannins: structure, metabolomic fate, and biological properties","author":"Villalba KJ","year":"2019","unstructured":"Villalba KJ, Barka FV, Pasos CV, Rodr\u00edguez PE. Food ellagitannins: structure, metabolomic fate, and biological properties. Tannins: Structural Properties, Biological Properties and Current Knowledge. IntechOpen, 2019. 26-46. 10.5772\/intechopen.86420"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201000044","article-title":"Plant polyphenols: chemical properties, biological activities, and synthesis","volume":"50","author":"Quideau S","year":"2011","unstructured":"Quideau S, Deffieux D, Douat-Casassus C, Pouys\u00e9gu L. Plant polyphenols: chemical properties, biological activities, and synthesis. Angew Chem Int Ed Engl. 2011, 50:586-621. 10.1002\/anie.201000044","journal-title":"Angew Chem Int Ed Engl"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.10.043","article-title":"Safety assessment of ellagic acid, a food additive, in a subchronic toxicity study using F344 rats","volume":"46","author":"Tasaki M","year":"2008","unstructured":"Tasaki M, Umemura T, Maeda M, et al.. Safety assessment of ellagic acid, a food additive, in a subchronic toxicity study using F344 rats. Food Chem Toxicol. 2008, 46:1119-24. 10.1016\/j.fct.2007.10.043","journal-title":"Food Chem Toxicol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.685364","article-title":"Role of flavonoids in the treatment of iron overload","volume":"9","author":"Wang X","year":"2021","unstructured":"Wang X, Li Y, Han L, Li J, Liu C, Sun C. Role of flavonoids in the treatment of iron overload. Front Cell Dev Biol. 2021, 9:685364. 10.3389\/fcell.2021.685364","journal-title":"Front Cell Dev Biol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2147\/cia.s9664","article-title":"Assessment and management of nutrition in older people and its importance to health","volume":"5","author":"Ahmed T","year":"2010","unstructured":"Ahmed T, Haboubi N. Assessment and management of nutrition in older people and its importance to health. Clin Interv Aging. 2010, 5:207-16. 10.2147\/cia.s9664","journal-title":"Clin Interv Aging"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9351-2_19","article-title":"Recent trends in food applications of antioxidants","author":"Porter WL","year":"1980","unstructured":"Porter WL. Recent trends in food applications of antioxidants. Autoxidation in Food and Biological Systems.  Simic MG, Karel M  (ed): Springer, Boston, USA; 1980. 295-365. 10.1007\/978-1-4757-9351-2_19"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-food-041715-033206","article-title":"Food antioxidants: chemical insights at the molecular level","volume":"7","author":"Galano A","year":"2016","unstructured":"Galano A, Mazzone G, Alvarez-Diduk R, Marino T, Alvarez-Idaboy JR, Russo N. Food antioxidants: chemical insights at the molecular level. Annu Rev Food Sci Technol. 2016, 7:335-52. 10.1146\/annurev-food-041715-033206","journal-title":"Annu Rev Food Sci Technol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9020177","article-title":"The metabolite urolithin-A ameliorates oxidative stress in neuro-2a cells, becoming a potential neuroprotective agent","volume":"9","author":"C\u00e1sedas G","year":"2020","unstructured":"C\u00e1sedas G, Les F, Choya-Foces C, Hugo M, L\u00f3pez V. The metabolite urolithin-A ameliorates oxidative stress in neuro-2a cells, becoming a potential neuroprotective agent. Antioxidants (Basel). 2020, 9:177. 10.3390\/antiox9020177","journal-title":"Antioxidants (Basel)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1021\/jf9025794","article-title":"Urolithins, intestinal microbial metabolites of pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay","volume":"57","author":"Bialonska D","year":"2009","unstructured":"Bialonska D, Kasimsetty SG, Khan SI, Ferreira D. Urolithins, intestinal microbial metabolites of pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay. J Agric Food Chem. 2009, 57:10181-6. 10.1021\/jf9025794","journal-title":"J Agric Food Chem"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.03.013","article-title":"Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis","volume":"24","author":"Shukla M","year":"2008","unstructured":"Shukla M, Gupta K, Rasheed Z, Khan KA, Haqqi TM. Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis. Nutrition. 2008, 24:733-43. 10.1016\/j.nut.2008.03.013","journal-title":"Nutrition"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507837421","article-title":"Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483","volume":"99","author":"Papoutsi Z","year":"2008","unstructured":"Papoutsi Z, Kassi E, Chinou I, Halabalaki M, Skaltsounis LA, Moutsatsou P. Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483. Br J Nutr. 2008, 99:715-22. 10.1017\/S0007114507837421","journal-title":"Br J Nutr"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2021.20344","article-title":"Improving effect of ellagic acid on sleep quality and gastrointestinal symptoms in patient with irritable bowel syndrome: randomized double-blind clinical trial","volume":"32","author":"Mirzaie Z","year":"2021","unstructured":"Mirzaie Z, Bastani A, Hesami S, Pouryousefi E, Kavianpour M, Haghighian HK. Improving effect of ellagic acid on sleep quality and gastrointestinal symptoms in patient with irritable bowel syndrome: randomized double-blind clinical trial. Turk J Gastroenterol. 2021, 32:937-44. 10.5152\/tjg.2021.20344","journal-title":"Turk J Gastroenterol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2010.03.038","article-title":"The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota","volume":"140","author":"Bialonska D","year":"2010","unstructured":"Bialonska D, Ramnani P, Kasimsetty SG, Muntha KR, Gibson GR, Ferreira D. The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota. Int J Food Microbiol. 2010, 140:175-82. 10.1016\/j.ijfoodmicro.2010.03.038","journal-title":"Int J Food Microbiol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-967167","article-title":"Antioxidant, antimalarial and antimicrobial activities of tannin-rich fractions, ellagitannins and phenolic acids from Punica granatum L","volume":"73","author":"Reddy MK","year":"2007","unstructured":"Reddy MK, Gupta SK, Jacob MR, Khan SI, Ferreira D. Antioxidant, antimalarial and antimicrobial activities of tannin-rich fractions, ellagitannins and phenolic acids from Punica granatum L. Planta Med\r\n. 2007, 73:461-7. 10.1055\/s-2007-967167","journal-title":"Planta Med"},{"key":"ref22","article-title":"Inhibitory actions of ellagic acid on growth and arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients","volume":"93","author":"Chung JG","year":"1998","unstructured":"Chung JG. Inhibitory actions of ellagic acid on growth and arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients. Microbios. 1998, 93:115-27.","journal-title":"Microbios"},{"key":"ref23","article-title":"Ellagic acid inhibits growth and arylamine N-acetyltransferase activity and gene expression in Staphylococcus aureus","volume":"19","author":"Lu HF","year":"2005","unstructured":"Lu HF, Tsou MF, Lin JG,  Ho CC, Liu JY, Chuang JY, Chung JG. Ellagic acid inhibits growth and arylamine N-acetyltransferase activity and gene expression in Staphylococcus aureus. In Vivo. 2005, 19:195-9.","journal-title":"In Vivo"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-003-0284-0","article-title":"Different susceptibilities of Staphylococcus and Gram-negative rods to epigallocatechin gallate","volume":"10","author":"Yoda Y","year":"2004","unstructured":"Yoda Y, Hu ZQ, Zhao WH, Shimamura T. Different susceptibilities of Staphylococcus and Gram-negative rods to epigallocatechin gallate. J Infect Chemother. 2004, 10:55-8. 10.1007\/s10156-003-0284-0","journal-title":"J Infect Chemother"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11060817","article-title":"Ethyl acetate fraction of Bixa orellana and its component ellagic acid exert antibacterial and anti-inflammatory properties against Mycobacterium abscessus subsp. massiliense","volume":"11","author":"Moraes-Neto RN","year":"2022","unstructured":"Moraes-Neto RN, Coutinho GG, Ata\u00edde AC, et al.. Ethyl acetate fraction of Bixa orellana and its component ellagic acid exert antibacterial and anti-inflammatory properties against Mycobacterium abscessus subsp. massiliense. Antibiotics (Basel). 2022, 11:87. 10.3390\/antibiotics11060817","journal-title":"Antibiotics (Basel)"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.2001.01271.x","article-title":"Antimicrobial properties of phenolic compounds from berries","volume":"90","author":"Puupponen-Pimi\u00e4 R","year":"2001","unstructured":"Puupponen-Pimi\u00e4 R, Nohynek L, Meier C, K\u00e4hk\u00f6nen M, Heinonen M, Hopia A, Oksman-Caldentey KM. Antimicrobial properties of phenolic compounds from berries. J Appl Microbiol. 2001, 90:494-507. 10.1046\/j.1365-2672.2001.01271.x","journal-title":"J Appl Microbiol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2004.06.024","article-title":"Cranberry synergies for dietary management of Helicobacter pylori infections","volume":"40","author":"Vattem DA","year":"2005","unstructured":"Vattem DA, Lin Y-T, Ghaedian R, Shetty K. Cranberry synergies for dietary management of Helicobacter pylori infections. Process Biochem. 2005, 40:1583-92. 10.1016\/j.procbio.2004.06.024","journal-title":"Process Biochem"},{"key":"ref28","article-title":"The inhibitory effect of polyphenols on human gut microbiota","volume":"63","author":"Duda-Chodak A","year":"2012","unstructured":"Duda-Chodak A. The inhibitory effect of polyphenols on human gut microbiota. J Physiol Pharmacol. 2012, 63:497-503.","journal-title":"J Physiol Pharmacol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.165873","article-title":"Evaluating the effects of ellagic acid on pSTAT3, pAKT, and pERK1\/2 signaling pathways in prostate cancer PC3 cells","volume":"12","author":"Eskandari E","year":"2016","unstructured":"Eskandari E, Heidarian E, Amini SA, Saffari-Chaleshtori J. Evaluating the effects of ellagic acid on pSTAT3, pAKT, and pERK1\/2 signaling pathways in prostate cancer PC3 cells. J Cancer Res Ther. 2016, 12:1266-71. 10.4103\/0973-1482.165873","journal-title":"J Cancer Res Ther"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1023\/B:DRUG.0000047101.02178.07","article-title":"Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions","volume":"23","author":"Lansky EP","year":"2005","unstructured":"Lansky EP, Jiang W, Mo H, et al.. Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions. Invest New Drugs. 2005, 23:11-20. 10.1023\/B:DRUG.0000047101.02178.07","journal-title":"Invest New Drugs"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2004.7.274","article-title":"Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells","volume":"7","author":"Albrecht M","year":"2004","unstructured":"Albrecht M, Jiang W, Kumi-Diaka J, et al.. Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells. J Med Food. 2004, 7:274-83. 10.1089\/jmf.2004.7.274","journal-title":"J Med Food"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.03.043","article-title":"Multitargeted therapy of cancer by ellagitannins","volume":"269","author":"Heber D","year":"2008","unstructured":"Heber D. Multitargeted therapy of cancer by ellagitannins. Cancer Lett. 2008, 269:262-8. 10.1016\/j.canlet.2008.03.043","journal-title":"Cancer Lett"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.32.2.475","article-title":"Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo","volume":"32","author":"Sartippour MR","year":"2008","unstructured":"Sartippour MR, Seeram NP, Rao JY, et al.. Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo. Int J Oncol. 2008, 32:475-80. 10.3892\/ijo.32.2.475","journal-title":"Int J Oncol"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2290","article-title":"Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer","volume":"12","author":"Pantuck AJ","year":"2006","unstructured":"Pantuck AJ, Leppert JT, Zomorodian N, et al.. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res. 2006, 12:4018-26. 10.1158\/1078-0432.CCR-05-2290","journal-title":"Clin Cancer Res"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0226","article-title":"Foodstuffs for preventing cancer: the preclinical and clinical development of berries","volume":"2","author":"Stoner GD","year":"2009","unstructured":"Stoner GD. Foodstuffs for preventing cancer: the preclinical and clinical development of berries. Cancer Prev Res (Phila). 2009, 2:187-94. 10.1158\/1940-6207.CAPR-08-0226","journal-title":"Cancer Prev Res (Phila)"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1021\/jf902857v","article-title":"Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling","volume":"58","author":"Sharma M","year":"2010","unstructured":"Sharma M, Li L, Celver J, Killian C, Kovoor A, Seeram NP. Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling. J Agric Food Chem. 2010, 58:3965-9. 10.1021\/jf902857v","journal-title":"J Agric Food Chem"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1021\/jf903762h","article-title":"Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins","volume":"58","author":"Kasimsetty SG","year":"2010","unstructured":"Kasimsetty SG, Bialonska D, Reddy MK, Ma G, Khan SI, Ferreira D. Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins. J Agric Food Chem. 2010, 58:2180-7. 10.1021\/jf903762h","journal-title":"J Agric Food Chem"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1021\/jf900725e","article-title":"Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1","volume":"57","author":"Gonz\u00e1lez-Sarr\u00edas A","year":"2009","unstructured":"Gonz\u00e1lez-Sarr\u00edas A, Azor\u00edn-Ortu\u00f1o M, Y\u00e1\u00f1ez-Gasc\u00f3n MJ, Tom\u00e1s-Barber\u00e1n FA, Garc\u00eda-Conesa MT, Esp\u00edn JC. Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1. J Agric Food Chem. 2009, 57:5623-32. 10.1021\/jf900725e","journal-title":"J Agric Food Chem"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1039\/c5fo00120j","article-title":"The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells","volume":"6","author":"Gonz\u00e1lez-Sarr\u00edas A","year":"2015","unstructured":"Gonz\u00e1lez-Sarr\u00edas A, Tom\u00e9-Carneiro J, Bellesia A, Tom\u00e1s-Barber\u00e1n FA, Esp\u00edn JC. The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells. Food Funct. 2015, 6:1460-9. 10.1039\/c5fo00120j","journal-title":"Food Funct"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-1260","article-title":"Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study","volume":"17","author":"Wang LS","year":"2011","unstructured":"Wang LS, Arnold M, Huang YW, et al.. Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study. Clin Cancer Res. 2011, 17:598-610. 10.1158\/1078-0432.CCR-10-1260","journal-title":"Clin Cancer Res"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.570683","article-title":"Black raspberries suppress colorectal cancer by enhancing Smad4 expression in colonic epithelium and natural killer cells","volume":"11","author":"Huang YW","year":"2020","unstructured":"Huang YW, Lin CW, Pan P, et al.. Black raspberries suppress colorectal cancer by enhancing Smad4 expression in colonic epithelium and natural killer cells. Front Immunol. 2020, 11:570683. 10.3389\/fimmu.2020.570683","journal-title":"Front Immunol"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-1977-9","article-title":"Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer","volume":"134","author":"Wang N","year":"2012","unstructured":"Wang N, Wang ZY, Mo SL, et al.. Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer. Breast Cancer Res Treat. 2012, 134:943-55. 10.1007\/s10549-012-1977-9","journal-title":"Breast Cancer Res Treat"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2005.01.006","article-title":"In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice","volume":"16","author":"Seeram NP","year":"2005","unstructured":"Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem. 2005, 16:360-7. 10.1016\/j.jnutbio.2005.01.006","journal-title":"J Nutr Biochem"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/169573-a-review-of-the-dietary-intake-bioavailability-and-health-benefits-of-ellagic-acid-ea-with-a-primary-focus-on-its-anti-cancer-properties","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:00:53Z","timestamp":1707508853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/169573-a-review-of-the-dietary-intake-bioavailability-and-health-benefits-of-ellagic-acid-ea-with-a-primary-focus-on-its-anti-cancer-properties"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,8]]},"references-count":43,"URL":"https:\/\/doi.org\/10.7759\/cureus.43156","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,8]]}}}