{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:33:08Z","timestamp":1707525188062},"reference-count":24,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,9]]},"DOI":"10.7759\/cureus.43180","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T08:46:02Z","timestamp":1691570762000},"source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Hyperandrogenism Due to Fibrothecoma and Leydig Cell Tumor in a Postmenopausal Woman With Adrenal Adenoma: A Case Report and Literature Review"],"prefix":"10.7759","author":[{"given":"Akbar","family":"Hussain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edilfavia","family":"Uy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Marlowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Piercy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aelia","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Ovarian hyperthecosis","volume":"165","author":"Van Beek AP","year":"2011","unstructured":"Van Beek AP, Cantineau AEP. Ovarian hyperthecosis. Eur J Endocrinol. 2011, 165:779-88.","journal-title":"Eur J Endocrinol"},{"key":"ref2","unstructured":"Hyperandrogenism. (2023). Accessed. July, 2023: https:\/\/my.clevelandclinic.org\/health\/diseases\/24639-hyperandrogenism."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0111","article-title":"Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies","volume":"177","author":"Yance VR","year":"2017","unstructured":"Yance VR, Marcondes JA, Rocha MP, et al.. Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies. Eur J Endocrinol. 2017, 177:93-102. 10.1530\/EJE-17-0111","journal-title":"Eur J Endocrinol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2021.1903419","article-title":"Hyperthecosis: an underestimated nontumorous cause of hyperandrogenism","volume":"37","author":"Meczekalski B","year":"2021","unstructured":"Meczekalski B, Szeliga A, Maciejewska-Jeske M, Podfigurna A, Cornetti P, Bala G, Adashi EY. Hyperthecosis: an underestimated nontumorous cause of hyperandrogenism. Gynecol Endocrinol. 2021, 37:677-82. 10.1080\/09513590.2021.1903419","journal-title":"Gynecol Endocrinol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0029-7844(01)01588-5","article-title":"Postmenopausal hyperthecosis: functional dysregulation of androgenesis in climacteric ovary","volume":"99","author":"Krug E","year":"2002","unstructured":"Krug E, Berga SL. Postmenopausal hyperthecosis: functional dysregulation of androgenesis in climacteric ovary. Obstet Gynecol. 2002, 99:893-7. 10.1016\/s0029-7844(01)01588-5","journal-title":"Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90676-9","article-title":"Hyperinsulinemia in hyperthecosis of the ovaries","volume":"154","author":"Nagamani M","year":"1986","unstructured":"Nagamani M, Van Dinh T, Kelver ME. Hyperinsulinemia in hyperthecosis of the ovaries. Am J Obstet Gynecol. 1986, 154:384-9. 10.1016\/0002-9378(86)90676-9","journal-title":"Am J Obstet Gynecol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.1050916.x","article-title":"Ovarian hyperthecosis, diabetes and hirsuties in post-menopausal women","volume":"46","author":"Barth JH","year":"1997","unstructured":"Barth JH, Jenkins M, Belchetz PE. Ovarian hyperthecosis, diabetes and hirsuties in post-menopausal women. Clin Endocrinol (Oxf). 1997, 46:123-8. 10.1046\/j.1365-2265.1997.1050916.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04040.x","article-title":"How should postmenopausal androgen excess be evaluated?","volume":"75","author":"Rothman MS","year":"2011","unstructured":"Rothman MS, Wierman ME. How should postmenopausal androgen excess be evaluated?. Clin Endocrinol (Oxf). 2011, 75:160-4. 10.1111\/j.1365-2265.2011.04040.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0581","article-title":"Ovarian androgen production in postmenopausal women","volume":"92","author":"Fogle RH","year":"2007","unstructured":"Fogle RH, Stanczyk FZ, Zhang X, Paulson RJ. Ovarian androgen production in postmenopausal women. J Clin Endocrinol Metab. 2007, 92:3040-3. 10.1210\/jc.2007-0581","journal-title":"J Clin Endocrinol Metab"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.7314\/apjcp.2014.15.3.1351","article-title":"Ovarian sex cord stromal tumours in children and young girls - a more than two decade clinicopathological experience in a developing country, Pakistan","volume":"15","author":"Haroon S","year":"2014","unstructured":"Haroon S, Idrees R, Zia A, Memon A, Fatima S, Kayani N. Ovarian sex cord stromal tumours in children and young girls - a more than two decade clinicopathological experience in a developing country, Pakistan. Asian Pac J Cancer Prev. 2014, 15:1351-5. 10.7314\/apjcp.2014.15.3.1351","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref11","article-title":"Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature","volume":"7","author":"Chen L","year":"2014","unstructured":"Chen L, Tunnell CD, Petris GD. Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature. Int J Clin Exp Pathol. 2014, 7:1176-81.","journal-title":"Int J Clin Exp Pathol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.01.011","article-title":"The activity of taxanes compared with bleomycin, etoposide, and cisplatin in the treatment of sex cord-stromal ovarian tumors","volume":"97","author":"Brown J","year":"2005","unstructured":"Brown J, Shvartsman HS, Deavers MT, Ramondetta LM, Burke TW, Munsell MF, Gershenson DM. The activity of taxanes compared with bleomycin, etoposide, and cisplatin in the treatment of sex cord-stromal ovarian tumors. Gynecol Oncol. 2005, 97:489-96. 10.1016\/j.ygyno.2005.01.011","journal-title":"Gynecol Oncol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2012.705375","article-title":"Leydig cell hyperplasia and Leydig cell tumour in postmenopausal women: report of two cases","volume":"29","author":"Hofland M","year":"2013","unstructured":"Hofland M, Cosyns S, De Sutter P, Bourgain C, Velkeniers B. Leydig cell hyperplasia and Leydig cell tumour in postmenopausal women: report of two cases. Gynecol Endocrinol. 2013, 29:213-5. 10.3109\/09513590.2012.705375","journal-title":"Gynecol Endocrinol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.11.1288","article-title":"Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis","volume":"295","author":"Ding EL","year":"2006","unstructured":"Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA. 2006, 295:1288-99. 10.1001\/jama.295.11.1288","journal-title":"JAMA"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004274","article-title":"Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes--a potential model for PCOS-related insulin resistance","volume":"4","author":"Allemand MC","year":"2009","unstructured":"Allemand MC, Irving BA, Asmann YW, Klaus KA, Tatpati L, Coddington CC, Nair KS. Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes--a potential model for PCOS-related insulin resistance. PLoS One. 2009, 4:e4274. 10.1371\/journal.pone.0004274","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1517\/14656560802559932","article-title":"Polycystic ovary syndrome: treatment strategies and management","volume":"9","author":"Escobar-Morreale HF","year":"2008","unstructured":"Escobar-Morreale HF. Polycystic ovary syndrome: treatment strategies and management. Expert Opin Pharmacother. 2008, 9:2995-3008. 10.1517\/14656560802559932","journal-title":"Expert Opin Pharmacother"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0130","article-title":"Hyperandrogenism in women with polycystic ovary syndrome persists after menopause","volume":"96","author":"Markopoulos MC","year":"2011","unstructured":"Markopoulos MC, Rizos D, Valsamakis G, et al.. Hyperandrogenism in women with polycystic ovary syndrome persists after menopause. J Clin Endocrinol Metab. 2011, 96:623-31. 10.1210\/jc.2010-0130","journal-title":"J Clin Endocrinol Metab"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1683","article-title":"Management of postmenopausal virilization","volume":"97","author":"Alpa\u00f1\u00e9s M","year":"2012","unstructured":"Alpa\u00f1\u00e9s M, Gonz\u00e1lez-Casbas JM, S\u00e1nchez J, Pi\u00e1n H, Escobar-Morreale HF. Management of postmenopausal virilization. J Clin Endocrinol Metab. 2012, 97:2584-8. 10.1210\/jc.2012-1683","journal-title":"J Clin Endocrinol Metab"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020922","article-title":"The value of the low-dose dexamethasone suppression test in the differential diagnosis of hyperandrogenism in women","volume":"88","author":"Kaltsas GA","year":"2003","unstructured":"Kaltsas GA, Isidori AM, Kola BP, et al.. The value of the low-dose dexamethasone suppression test in the differential diagnosis of hyperandrogenism in women. J Clin Endocrinol Metab. 2003, 88:2634-43. 10.1210\/jc.2002-020922","journal-title":"J Clin Endocrinol Metab"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01792.x","article-title":"Is ovarian and adrenal venous catheterization and sampling helpful in the investigation of hyperandrogenic women?","volume":"59","author":"Kaltsas GA","year":"2003","unstructured":"Kaltsas GA, Mukherjee JJ, Kola B, et al.. Is ovarian and adrenal venous catheterization and sampling helpful in the investigation of hyperandrogenic women?. Clin Endocrinol (Oxf). 2003, 59:34-43. 10.1046\/j.1365-2265.2003.01792.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3109\/09513599909167586","article-title":"Total testosterone and DHEAS levels as predictors of androgen-secreting neoplasms: a populational study","volume":"13","author":"Waggoner W","year":"1999","unstructured":"Waggoner W, Boots LR, Azziz R. Total testosterone and DHEAS levels as predictors of androgen-secreting neoplasms: a populational study. Gynecol Endocrinol. 1999, 13:394-400. 10.3109\/09513599909167586","journal-title":"Gynecol Endocrinol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13492","article-title":"Clinical case seminar: postmenopausal androgen excess-challenges in diagnostic work-up and management of ovarian thecosis","volume":"88","author":"Mamoojee Y","year":"2018","unstructured":"Mamoojee Y, Ganguri M, Taylor N, Quinton R. Clinical case seminar: postmenopausal androgen excess-challenges in diagnostic work-up and management of ovarian thecosis. Clin Endocrinol (Oxf). 2018, 88:13-20. 10.1111\/cen.13492","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1991","article-title":"Gonadotropin-releasing hormone agonist treatment in postmenopausal women with hyperandrogenism of ovarian origin","volume":"96","author":"Vollaard ES","year":"2011","unstructured":"Vollaard ES, van Beek AP, Verburg FA, Roos A, Land JA. Gonadotropin-releasing hormone agonist treatment in postmenopausal women with hyperandrogenism of ovarian origin. J Clin Endocrinol Metab. 2011, 96:1197-201. 10.1210\/jc.2010-1991","journal-title":"J Clin Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2020.1789591","article-title":"Tolerability considerations for gonadotropin-releasing hormone analogues for endometriosis","volume":"16","author":"Della Corte L","year":"2020","unstructured":"Della Corte L, Barra F, Mercorio A, et al.. Tolerability considerations for gonadotropin-releasing hormone analogues for endometriosis. Expert Opin Drug Metab Toxicol. 2020, 16:759-68. 10.1080\/17425255.2020.1789591","journal-title":"Expert Opin Drug Metab Toxicol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/176770-a-rare-case-of-hyperandrogenism-due-to-fibrothecoma-and-leydig-cell-tumor-in-a-postmenopausal-woman-with-adrenal-adenoma-a-case-report-and-literature-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:04:37Z","timestamp":1707509077000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/176770-a-rare-case-of-hyperandrogenism-due-to-fibrothecoma-and-leydig-cell-tumor-in-a-postmenopausal-woman-with-adrenal-adenoma-a-case-report-and-literature-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,9]]},"references-count":24,"URL":"https:\/\/doi.org\/10.7759\/cureus.43180","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,9]]}}}