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Pain. 1987, 31:199-209. 10.1016\/0304-3959(87)90036-4","journal-title":"Pain"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.08.029","article-title":"Clinical anesthetic effectiveness of intraoral mucoadhesive tablets of amitriptyline in healthy volunteers","volume":"71","author":"Movassaghian S","year":"2013","unstructured":"Movassaghian S, Afzalifar R, Alaeddini M. Clinical anesthetic effectiveness of intraoral mucoadhesive tablets of amitriptyline in healthy volunteers. 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