{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:16:02Z","timestamp":1771035362372,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,18]]},"DOI":"10.7759\/cureus.43731","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T06:30:30Z","timestamp":1692426630000},"source":"Crossref","is-referenced-by-count":3,"title":["Early Trends to Show the Efficacy of Cordyceps militaris in Mild to Moderate COVID Inflammation"],"prefix":"10.7759","author":[{"given":"Siddharth","family":"Dubhashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagar","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sankalp","family":"Dwivedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaishree","family":"Ghanekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Kadam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parineeta","family":"Samant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibha","family":"Datta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarman","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irshad H","family":"Chaudry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padma","family":"Gurmet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshawardhan","family":"Kelkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagar","family":"Galwankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14462","article-title":"Changes of serum IL-10, IL-1\u03b2, IL-6, MCP-1, TNF-\u03b1, IP-10 and IL-4 in COVID-19 patients","volume":"75","author":"Lu Q","year":"2021","unstructured":"Lu Q, Zhu Z, Tan C, et al.. Changes of serum IL-10, IL-1\u03b2, IL-6, MCP-1, TNF-\u03b1, IP-10 and IL-4 in COVID-19 patients. Int J Clin Pract. 2021, 75:e14462. 10.1111\/ijcp.14462","journal-title":"Int J Clin Pract"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12024-021-00414-9","article-title":"Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players IL-1\u03b2, IL-6, IL-15 and TNF-\u03b1","volume":"18","author":"Frisoni P","year":"2022","unstructured":"Frisoni P, Neri M, D'Errico S, et al.. Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players IL-1\u03b2, IL-6, IL-15 and TNF-\u03b1. Forensic Sci Med Pathol. 2022, 18:4-19. 10.1007\/s12024-021-00414-9","journal-title":"Forensic Sci Med Pathol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06457-1","article-title":"Associations of immunological features with COVID-19 severity: a systematic review and meta-analysis","volume":"21","author":"Zhang Z","year":"2021","unstructured":"Zhang Z, Ai G, Chen L, et al.. Associations of immunological features with COVID-19 severity: a systematic review and meta-analysis. BMC Infect Dis. 2021, 21:738. 10.1186\/s12879-021-06457-1","journal-title":"BMC Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2021.1925906","article-title":"Anti-IgE monoclonal antibodies as potential treatment in COVID-19","volume":"43","author":"Farmani AR","year":"2021","unstructured":"Farmani AR, Mahdavinezhad F, Moslemi R, et al.. Anti-IgE monoclonal antibodies as potential treatment in COVID-19. Immunopharmacol Immunotoxicol. 2021, 43:259-64. 10.1080\/08923973.2021.1925906","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2021.05.004","article-title":"Engineering mesenchymal stromal cells with neutralizing and anti-inflammatory capability against SARS-CoV-2 infection","volume":"21","author":"Zhang X","year":"2021","unstructured":"Zhang X, Han P, Wang H, et al.. Engineering mesenchymal stromal cells with neutralizing and anti-inflammatory capability against SARS-CoV-2 infection. Mol Ther Methods Clin Dev. 2021, 21:754-64. 10.1016\/j.omtm.2021.05.004","journal-title":"Mol Ther Methods Clin Dev"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.675678","article-title":"Respiratory impairment predicts response to IL-1 and IL-6 blockade in COVID-19 patients with severe pneumonia and hyper-inflammation","volume":"12","author":"Della-Torre E","year":"2021","unstructured":"Della-Torre E, Lanzillotta M, Campochiaro C, et al.. Respiratory impairment predicts response to IL-1 and IL-6 blockade in COVID-19 patients with severe pneumonia and hyper-inflammation. Front Immunol. 2021, 12:675678. 10.3389\/fimmu.2021.675678","journal-title":"Front Immunol"},{"key":"ref7","article-title":"Therapeutic effect of Fuzheng Huayu recipe on bleomycin-induced pulmonary interstitial fibrosis in rats","volume":"7","author":"Xiong L","year":"2006","unstructured":"Xiong L, Weicheng Y, Ping L. Therapeutic effect of Fuzheng Huayu recipe on bleomycin-induced pulmonary interstitial fibrosis in rats. J Traditional Chin Med. 2006, 7:538-40.","journal-title":"J Traditional Chin Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-37422\/v1","article-title":"The efficacy of treating pulmonary fibrosis and pulmonary function injury in COVID-19 with the Fuzheng Huayu tablets: study protocol for a multicenter randomized controlled trial","volume":"10","author":"Jing F","year":"2021","unstructured":"Jing F, Fan H, Zhao Z, Xing F, He Y, Liu C. The efficacy of treating pulmonary fibrosis and pulmonary function injury in COVID-19 with the Fuzheng Huayu tablets: study protocol for a multicenter randomized controlled trial. J Dev Drugs. 2021, 10:1-9. 10.21203\/rs.3.rs-37422\/v1","journal-title":"J Dev Drugs"},{"key":"ref9","article-title":"Cordyceps as an herbal drug","author":"Lin B-q","year":"2011","unstructured":"Lin B-q, Li S-p. Cordyceps as an herbal drug. Herbal Medicine: Biomolecular and Clinical Aspects. Benzie IF, Wachtel-Galor S (ed): CRC Press\/Taylor &amp; Francis, Boca Raton (FL); 2011."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.06.047","article-title":"Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells","volume":"545","author":"Kim HG","year":"2006","unstructured":"Kim HG, Shrestha B, Lim SY, et al.. Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur J Pharmacol. 2006, 545:192-9. 10.1016\/j.ejphar.2006.06.047","journal-title":"Eur J Pharmacol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4110\/in.2009.9.6.255","article-title":"Role of cordycepin and adenosine on the phenotypic switch of macrophages via induced anti-inflammatory cytokines","volume":"9","author":"Shin S","year":"2009","unstructured":"Shin S, Moon S, Park Y, et al.. Role of cordycepin and adenosine on the phenotypic switch of macrophages via induced anti-inflammatory cytokines. Immune Netw. 2009, 9:255-64. 10.4110\/in.2009.9.6.255","journal-title":"Immune Netw"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.25.1.124-128.1978","article-title":"Effect of cordycepin triphosphate on in vitro RNA synthesis by picornavirus polymerase complexes","volume":"25","author":"Panicali DL","year":"1978","unstructured":"Panicali DL, Nair CN. Effect of cordycepin triphosphate on in vitro RNA synthesis by picornavirus polymerase complexes. J Virol. 1978, 25:124-8. 10.1128\/JVI.25.1.124-128.1978","journal-title":"J Virol"},{"key":"ref13","article-title":"Inhibitors of RNA and DNA biosynthesis","author":"Sung S-c","unstructured":"Sung S-c. Inhibitors of RNA and DNA biosynthesis. Metabolic Inhibitors V3: A Comprehensive Treatise. 2012 (ed): Elsevier, New York; 175."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.06.033","article-title":"Protective roles of Cordyceps on lung fibrosis in cellular and rat models","volume":"143","author":"Chen M","year":"2012","unstructured":"Chen M, Cheung FW, Chan MH, et al.. Protective roles of Cordyceps on lung fibrosis in cellular and rat models. J Ethnopharmacol. 2012, 143:448-54. 10.1016\/j.jep.2012.06.033","journal-title":"J Ethnopharmacol"},{"key":"ref15","article-title":"Cordyceps sinensis improved post-SARS pulmonary fibrosis","volume":"3","author":"Hui P","year":"2006","unstructured":"Hui P, Chan M. Cordyceps sinensis improved post-SARS pulmonary fibrosis. Hua Xia Med J (Hong Kong). 2006, 3:172-176.","journal-title":"Hua Xia Med J (Hong Kong)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2005.11254","article-title":"Virtual Screening of Plant Metabolites against Main protease, RNA-dependent RNA polymerase and Spike protein of SARS-CoV- 2: Therapeutics option of COVID-19 [PREPRINT]","author":"Parvez MSA","year":"2020","unstructured":"Parvez MSA, Azim KF, Imran AS, et al.. Virtual Screening of Plant Metabolites against Main protease, RNA-dependent RNA polymerase and Spike protein of SARS-CoV- 2: Therapeutics option of COVID-19 [PREPRINT]. 2020. 10.48550\/arXiv.2005.11254"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6134593","article-title":"Herbal medicine Cordyceps sinensis improves health-related quality of life in moderate-to-severe asthma","volume":"2016","author":"Wang N","year":"2016","unstructured":"Wang N, Li J, Huang X, Chen W, Chen Y. Herbal medicine Cordyceps sinensis improves health-related quality of life in moderate-to-severe asthma. Evid Based Complement Alternat Med. 2016, 2016:6134593. 10.1155\/2016\/6134593","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.5777","article-title":"Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease","volume":"15","author":"Yang L","year":"2018","unstructured":"Yang L, Jiao X, Wu J, et al.. Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease. Exp Ther Med. 2018, 15:2731-8. 10.3892\/etm.2018.5777","journal-title":"Exp Ther Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190331","article-title":"Ergosterol attenuates cigarette smoke extract-induced COPD by modulating inflammation, oxidative stress and apoptosis in vitro and in vivo","volume":"133","author":"Sun X","year":"2019","unstructured":"Sun X, Feng X, Zheng D, Li A, Li C, Li S, Zhao Z. Ergosterol attenuates cigarette smoke extract-induced COPD by modulating inflammation, oxidative stress and apoptosis in vitro and in vivo. Clin Sci (Lond). 2019, 133:1523-36. 10.1042\/CS20190331","journal-title":"Clin Sci (Lond)"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1039\/c4fo00294f","article-title":"Anti-inflammatory effect of a novel food Cordyceps guangdongensis on experimental rats with chronic bronchitis induced by tobacco smoking","volume":"5","author":"Yan W","year":"2014","unstructured":"Yan W, Li T, Zhong Z. Anti-inflammatory effect of a novel food Cordyceps guangdongensis on experimental rats with chronic bronchitis induced by tobacco smoking. Food Funct. 2014, 5:2552-7. 10.1039\/c4fo00294f","journal-title":"Food Funct"},{"key":"ref21","article-title":"[Effects of Fuzheng Huayu recipe on MMP-2 activity and type IV collagen expression at fibrotic lung]","volume":"32","author":"Tan SZ","year":"2007","unstructured":"Tan SZ, Liu CH, Zhang W, Lu X, Ye WC, Cai ZZ, Liu P. [Effects of Fuzheng Huayu recipe on MMP-2 activity and type IV collagen expression at fibrotic lung]. Zhongguo Zhong Yao Za Zhi. 2007, 32:835-9.","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref22","article-title":"Herbal compatibility of Fuzheng Huayu recipe against pulmonary fibrosis","volume":"8","author":"Yang K","year":"2009","unstructured":"Yang K, Tan SZ, Zhang W, Tao YY, Chen Y, Cai ZZ, Liu CH. Herbal compatibility of Fuzheng Huayu recipe against pulmonary fibrosis. J Traditional Chin Med. 2009, 8:732-6.","journal-title":"J Traditional Chin Med"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.602364","article-title":"Cordyceps spp.: A review on its immune-stimulatory and other biological potentials","volume":"11","author":"Das G","year":"2020","unstructured":"Das G, Shin HS, Leyva-G\u00f3mez G, et al.. Cordyceps spp.: A review on its immune-stimulatory and other biological potentials. Front Pharmacol. 2020, 11:602364. 10.3389\/fphar.2020.602364","journal-title":"Front Pharmacol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2483-y","article-title":"Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial","volume":"19","author":"Jung SJ","year":"2019","unstructured":"Jung SJ, Jung ES, Choi EK, Sin HS, Ha KC, Chae SW. Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial. BMC Complement Altern Med. 2019, 19:77. 10.1186\/s12906-019-2483-y","journal-title":"BMC Complement Altern Med"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.18.7191","article-title":"Phosphorothioate and cordycepin analogues of 2',5'-oligoadenylate: inhibition of human immunodeficiency virus type 1 reverse transcriptase and infection in vitro","volume":"86","author":"Montefiori DC","year":"1989","unstructured":"Montefiori DC, Sobol RW Jr, Li SW, et al.. Phosphorothioate and cordycepin analogues of 2',5'-oligoadenylate: inhibition of human immunodeficiency virus type 1 reverse transcriptase and infection in vitro. Proc Natl Acad Sci U S A. 1989, 86:7191-4. 10.1073\/pnas.86.18.7191","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.18632\/oncoscience.110","article-title":"Cordycepin is a novel chemical suppressor of Epstein-Barr virus replication","volume":"1","author":"Ryu E","year":"2014","unstructured":"Ryu E, Son M, Lee M, et al.. Cordycepin is a novel chemical suppressor of Epstein-Barr virus replication. Oncoscience. 2014, 1:866-81. 10.18632\/oncoscience.110","journal-title":"Oncoscience"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-014-4300-0","article-title":"Anti-influenza effect of Cordyceps militaris through immunomodulation in a DBA\/2 mouse model","volume":"52","author":"Lee HH","year":"2014","unstructured":"Lee HH, Park H, Sung GH, et al.. Anti-influenza effect of Cordyceps militaris through immunomodulation in a DBA\/2 mouse model. J Microbiol. 2014, 52:696-701. 10.1007\/s12275-014-4300-0","journal-title":"J Microbiol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/newbio243172a0","article-title":"Multiplication of influenza virus in the presence of cordycepin, an inhibitor of cellular RNA synthesis","volume":"243","author":"Mahy BW","year":"1973","unstructured":"Mahy BW, Cox NJ, Armstrong SJ, Barry RD. Multiplication of influenza virus in the presence of cordycepin, an inhibitor of cellular RNA synthesis. Nat New Biol. 1973, 243:172-4. 10.1038\/newbio243172a0","journal-title":"Nat New Biol"},{"key":"ref29","article-title":"[Effect of dongchong xiacao capsule on airway inflammation of asthmatic patients]","volume":"32","author":"Wang NQ","year":"2007","unstructured":"Wang NQ, Jiang LD, Zhang XM, Li ZX. [Effect of dongchong xiacao capsule on airway inflammation of asthmatic patients]. Zhongguo Zhong Yao Za Zhi. 2007, 32:1566-8.","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1021\/jf0721287","article-title":"In vivo anti-influenza virus activity of an immunomodulatory acidic polysaccharide isolated from Cordyceps militaris grown on germinated soybeans","volume":"55","author":"Ohta Y","year":"2007","unstructured":"Ohta Y, Lee JB, Hayashi K, Fujita A, Park DK, Hayashi T. In vivo anti-influenza virus activity of an immunomodulatory acidic polysaccharide isolated from Cordyceps militaris grown on germinated soybeans. J Agric Food Chem. 2007, 55:10194-9. 10.1021\/jf0721287","journal-title":"J Agric Food Chem"},{"key":"ref31","article-title":"Sportsmen\u2019s energy package Cordyceps sinensis: Medicinal importance and responsible phytochemical constituents","volume":"5","author":"Joshi YC","year":"2017","unstructured":"Joshi YC, Joshi MC, Chopra V, Joshi RK, Sharma RK, Kumar V. Sportsmen\u2019s energy package Cordyceps sinensis: Medicinal importance and responsible phytochemical constituents. Am J Essential Oils Nat Products. 2017, 5:37-51.","journal-title":"Am J Essential Oils Nat Products"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1089\/107555301300328106","article-title":"CordyMax Cs-4 improves steady-state bioenergy status in mouse liver","volume":"7","author":"Dai G","year":"2001","unstructured":"Dai G, Bao T, Xu C, Cooper R, Zhu JS. CordyMax Cs-4 improves steady-state bioenergy status in mouse liver. J Altern Complement Med. 2001, 7:231-40. 10.1089\/107555301300328106","journal-title":"J Altern Complement Med"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001627","article-title":"Potential immunotherapeutic targets for hypoxia due to COVI-Flu","volume":"54","author":"Leyfman Y","year":"2020","unstructured":"Leyfman Y, Erick TK, Reddy SS, et al.. Potential immunotherapeutic targets for hypoxia due to COVI-Flu. Shock. 2020, 54:438-50. 10.1097\/SHK.0000000000001627","journal-title":"Shock"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001923","article-title":"Inflammasome-related markers upon ICU admission do not correlate with outcome in critically ill COVID-19 patients","volume":"57","author":"Adamik B","year":"2022","unstructured":"Adamik B, Ambro\u017cek-Latecka M, Dragan B, Jeznach A, \u015amiechowicz J, Go\u017cdzik W, Skirecki T. Inflammasome-related markers upon ICU admission do not correlate with outcome in critically ill COVID-19 patients. Shock. 2022, 57:672-9. 10.1097\/SHK.0000000000001923","journal-title":"Shock"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001769","article-title":"Cytokine drizzle-the rationale for abandoning \u201ccytokine storm\u201d","volume":"56","author":"Stolarski AE","year":"2021","unstructured":"Stolarski AE, Kim J, Zhang Q, Remick DG. Cytokine drizzle-the rationale for abandoning \u201ccytokine storm\u201d. Shock. 2021, 56:667-72. 10.1097\/SHK.0000000000001769","journal-title":"Shock"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/166304-early-trends-to-show-the-efficacy-of-cordyceps-militaris-in-mild-to-moderate-covid-inflammation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:02:43Z","timestamp":1707508963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/166304-early-trends-to-show-the-efficacy-of-cordyceps-militaris-in-mild-to-moderate-covid-inflammation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,18]]},"references-count":35,"URL":"https:\/\/doi.org\/10.7759\/cureus.43731","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,18]]}}}