{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:02:38Z","timestamp":1784955758900,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,24]]},"DOI":"10.7759\/cureus.44044","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T15:51:14Z","timestamp":1692892274000},"source":"Crossref","is-referenced-by-count":3,"title":["Once Forgotten Now Re-emerging: Scrub Typhus Infection in Pediatric Patients From North West India"],"prefix":"10.7759","author":[{"given":"Sujaya","family":"Mukhopadhyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasun","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchika","family":"Bhatnagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanju","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahabzada Faisal","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arashdeep","family":"Virk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazmeen","family":"Imran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhar","family":"Liyakath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-9062.342357","article-title":"Emerging trends of scrub typhus disease in southern Rajasthan, India: a neglected public health problem","volume":"59","author":"Kumar D","year":"2022","unstructured":"Kumar D, Jakhar SD. Emerging trends of scrub typhus disease in southern Rajasthan, India: a neglected public health problem. J Vector Borne Dis. 2022, 59:303-11. 10.4103\/0972-9062.342357","journal-title":"J Vector Borne Dis"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-008-0198-z","article-title":"Pediatric scrub typhus in Indian Himalayas","volume":"75","author":"Mahajan SK","year":"2008","unstructured":"Mahajan SK, Rolain JM, Sankhyan N, Kaushal RK, Raoult D. Pediatric scrub typhus in Indian Himalayas. Indian J Pediatr. 2008, 75:947-9. 10.1007\/s12098-008-0198-z","journal-title":"Indian J Pediatr"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006062","article-title":"A review of the global epidemiology of scrub typhus","volume":"11","author":"Xu G","year":"2017","unstructured":"Xu G, Walker DH, Jupiter D, Melby PC, Arcari CM. A review of the global epidemiology of scrub typhus. PLoS Negl Trop Dis. 2017, 11:e0006062. 10.1371\/journal.pntd.0006062","journal-title":"PLoS Negl Trop Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5916.159279","article-title":"DHR-ICMR Guidelines for diagnosis & management of Rickettsial diseases in India","volume":"141","author":"Rahi M","year":"2015","unstructured":"Rahi M, Gupte MD, Bhargava A, Varghese GM, Arora R. DHR-ICMR Guidelines for diagnosis & management of Rickettsial diseases in India. Indian J Med Res. 2015, 141:417-22. 10.4103\/0971-5916.159279","journal-title":"Indian J Med Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.22207\/JPAM.14.2.57","article-title":"Scrub typhus: a neglected tropical disease and a potential threat in North India","volume":"14","author":"Yaqoob S","year":"2020","unstructured":"Yaqoob S, Siddiqui AH, Shukla P. Scrub typhus: a neglected tropical disease and a potential threat in North India. J Pure Appl Microbiol. 2020, 14:1589-93. 10.22207\/JPAM.14.2.57","journal-title":"J Pure Appl Microbiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.136552","article-title":"Recent outbreak of scrub typhus in North Western part of India","volume":"32","author":"Sinha P","year":"2014","unstructured":"Sinha P, Gupta S, Dawra R, Rijhawan P. Recent outbreak of scrub typhus in North Western part of India. Indian J Med Microbiol. 2014, 32:247-50. 10.4103\/0255-0857.136552","journal-title":"Indian J Med Microbiol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199103000-00006","article-title":"Scrub and murine typhus in children with obscure fever in the tropics","volume":"10","author":"Silpapojakul K","year":"1991","unstructured":"Silpapojakul K, Chupuppakarn S, Yuthasompob S, Varachit B, Chaipak D, Borkerd T, Silpapojakul K. Scrub and murine typhus in children with obscure fever in the tropics. Pediatr Infect Dis J. 1991, 10:200-3. 10.1097\/00006454-199103000-00006","journal-title":"Pediatr Infect Dis J"},{"key":"ref8","article-title":"Scrub Typhus","author":"Singh OB","year":"2022","unstructured":"Singh OB, Panda PK. Scrub Typhus. StatPearls Publishing, Treasure Island, FL; 2022."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1086\/425365","article-title":"Rickettsioses and the international traveler","volume":"39","author":"Jensenius M","year":"2004","unstructured":"Jensenius M, Fournier PE, Raoult D. Rickettsioses and the international traveler. Clin Infect Dis. 2004, 39:1493-9. 10.1086\/425365","journal-title":"Clin Infect Dis"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-020-02389-w","article-title":"Diagnosis of scrub typhus: recent advancements and challenges","volume":"10","author":"Kala D","year":"2020","unstructured":"Kala D, Gupta S, Nagraik R, Verma V, Thakur A, Kaushal A. Diagnosis of scrub typhus: recent advancements and challenges. 3 Biotech. 2020, 10:396. 10.1007\/s13205-020-02389-w","journal-title":"3 Biotech"},{"key":"ref11","article-title":"Nelson Textbook of Pediatrics","author":"Kliegman RM","year":"2020","unstructured":"Kliegman RM, Stanton BF, St. Geme III JW, Schor NF, Behrman RE. Nelson Textbook of Pediatrics. Kliegman RM (ed): Elsevier Health Sciences, Philadelphia, Pennsylvania; 2020."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072-1439.2013.04.05","article-title":"Acute respiratory distress syndrome: new definition, current and future therapeutic options","volume":"5","author":"Fanelli V","year":"2013","unstructured":"Fanelli V, Vlachou A, Ghannadian S, Simonetti U, Slutsky AS, Zhang H. Acute respiratory distress syndrome: new definition, current and future therapeutic options. J Thorac Dis. 2013, 5:326-34. 10.3978\/j.issn.2072-1439.2013.04.05","journal-title":"J Thorac Dis"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-016-0144-6","article-title":"Multiple organ dysfunction syndrome in critically ill children: clinical value of two lists of diagnostic criteria","volume":"6","author":"Villeneuve A","year":"2016","unstructured":"Villeneuve A, Joyal JS, Proulx F, Ducruet T, Poitras N, Lacroix J. Multiple organ dysfunction syndrome in critically ill children: clinical value of two lists of diagnostic criteria. Ann Intensive Care. 2016, 6:40. 10.1186\/s13613-016-0144-6","journal-title":"Ann Intensive Care"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2147\/PHMT.S253106","article-title":"Scrub typhus in children at Tribhuvan University Teaching Hospital in Nepal","volume":"11","author":"Bajracharya L","year":"2020","unstructured":"Bajracharya L. Scrub typhus in children at Tribhuvan University Teaching Hospital in Nepal. Pediatric Health Med Ther. 2020, 11:193-202. 10.2147\/PHMT.S253106","journal-title":"Pediatric Health Med Ther"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-82","article-title":"Clinical characteristics of the autumn-winter type scrub typhus cases in south of Shandong province, northern China","volume":"9","author":"Liu YX","year":"2009","unstructured":"Liu YX, Feng D, Suo JJ, et al.. Clinical characteristics of the autumn-winter type scrub typhus cases in south of Shandong province, northern China. BMC Infect Dis. 2009, 9:82. 10.1186\/1471-2334-9-82","journal-title":"BMC Infect Dis"},{"key":"ref16","article-title":"Scrub typhus in children at a tertiary hospital in North India: clinical profile and complications","volume":"24","author":"Kumar BN","year":"2014","unstructured":"Kumar BN, Dhar M, Mittal G, et al.. Scrub typhus in children at a tertiary hospital in North India: clinical profile and complications. Iran J Pediatr. 2014, 24:387-92.","journal-title":"Iran J Pediatr"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3201\/eid1210.051697","article-title":"Scrub typhus in Himalayas","volume":"12","author":"Mahajan SK","year":"2006","unstructured":"Mahajan SK, Rolain JM, Kashyap R, et al.. Scrub typhus in Himalayas. Emerg Infect Dis. 2006, 12:1590-2. 10.3201\/eid1210.051697","journal-title":"Emerg Infect Dis"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220905","article-title":"Clinical profile, complications and outcome of scrub typhus in children: a hospital based observational study in central Nepal","volume":"14","author":"Pathak S","year":"2019","unstructured":"Pathak S, Chaudhary N, Dhakal P, et al.. Clinical profile, complications and outcome of scrub typhus in children: a hospital based observational study in central Nepal. PLoS One. 2019, 14:e0220905. 10.1371\/journal.pone.0220905","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1613-0","article-title":"The clinical characteristics of pleural effusion in scrub typhus","volume":"16","author":"Kim HH","year":"2016","unstructured":"Kim HH, Chung JH, Kim DM, et al.. The clinical characteristics of pleural effusion in scrub typhus. BMC Infect Dis. 2016, 16:278. 10.1186\/s12879-016-1613-0","journal-title":"BMC Infect Dis"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.18535\/jmscr\/v8i5.50","article-title":"Empyema thoracis: an unusual presentation of a child with scrub typhus","volume":"8","author":"Agarwalla SK","year":"2020","unstructured":"Agarwalla SK, Tudu L. Empyema thoracis: an unusual presentation of a child with scrub typhus. J Med Sci Res. 2020, 8:267-9. 10.18535\/jmscr\/v8i5.50","journal-title":"J Med Sci Res"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-021-2101-1","article-title":"Takotsubo cardiomyopathy in pediatric scrub typhus","volume":"58","author":"Mohanty S","year":"2021","unstructured":"Mohanty S, Harsha KN, Kalale N. Takotsubo cardiomyopathy in pediatric scrub typhus. Indian Pediatr. 2021, 58:78-9. 10.1007\/s13312-021-2101-1","journal-title":"Indian Pediatr"},{"key":"ref22","article-title":"Tsutsugamushi disease presenting with aortic valve endocarditis: a case report and literature review","volume":"6","author":"Yu S","year":"2016","unstructured":"Yu S, Yu X, Zhou B, Liu D, Wang M, Zhang H, Qian X. Tsutsugamushi disease presenting with aortic valve endocarditis: a case report and literature review. Am J Cardiovasc Dis. 2016, 6:185-90.","journal-title":"Am J Cardiovasc Dis"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.5492\/wjccm.v4.i3.244","article-title":"Severe scrub typhus infection: clinical features, diagnostic challenges and management","volume":"4","author":"Peter JV","year":"2015","unstructured":"Peter JV, Sudarsan TI, Prakash JA, Varghese GM. Severe scrub typhus infection: clinical features, diagnostic challenges and management. World J Crit Care Med. 2015, 4:244-50. 10.5492\/wjccm.v4.i3.244","journal-title":"World J Crit Care Med"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02065","article-title":"Scrub typhus pathogenesis: innate immune response and lung injury during Orientia tsutsugamushi infection","volume":"10","author":"Trent B","year":"2019","unstructured":"Trent B, Fisher J, Soong L. Scrub typhus pathogenesis: innate immune response and lung injury during Orientia tsutsugamushi infection. Front Microbiol. 2019, 10:2065. 10.3389\/fmicb.2019.02065","journal-title":"Front Microbiol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/154323-once-forgotten-now-re-emerging-scrub-typhus-infection-in-pediatric-patients-from-north-west-india","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:55:30Z","timestamp":1707508530000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/154323-once-forgotten-now-re-emerging-scrub-typhus-infection-in-pediatric-patients-from-north-west-india"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,24]]},"references-count":24,"URL":"https:\/\/doi.org\/10.7759\/cureus.44044","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,24]]}}}