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Eur J Biochem. 1997, 243:240-6. 10.1111\/j.1432-1033.1997.0240a.x","journal-title":"Eur J Biochem"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.1889","article-title":"3-Methyladenine: specific inhibitor of autophagic\/lysosomal protein degradation in isolated rat hepatocytes","volume":"79","author":"Seglen PO","year":"1982","unstructured":"Seglen PO, Gordon PB. 3-Methyladenine: specific inhibitor of autophagic\/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A. 1982, 79:1889-92. 10.1073\/pnas.79.6.1889","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204861200","article-title":"Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation","volume":"277","author":"Carmichael J","year":"2002","unstructured":"Carmichael J, Sugars KL, Bao YP, Rubinsztein DC. Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation. J Biol Chem. 2002, 277:33791-8. 10.1074\/jbc.M204861200","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4161\/auto.2387","article-title":"Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations","volume":"2","author":"Sarkar S","year":"2006","unstructured":"Sarkar S, Rubinsztein DC. Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. Autophagy. 2006, 2:132-4. 10.4161\/auto.2387","journal-title":"Autophagy"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm294","article-title":"A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin","volume":"17","author":"Sarkar S","year":"2008","unstructured":"Sarkar S, Krishna G, Imarisio S, Saiki S, O'Kane CJ, Rubinsztein DC. 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