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J Clin Anesth. 2022, 80:110786. 10.1016\/j.jclinane.2022.110786","journal-title":"J Clin Anesth"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000564","article-title":"Investigating the efficacy of dexmedetomidine as an adjuvant to local anesthesia in brachial plexus block: a systematic review and meta-analysis of 18 randomized controlled trials","volume":"42","author":"Hussain N","year":"2017","unstructured":"Hussain N, Grzywacz VP, Ferreri CA, Atrey A, Banfield L, Shaparin N, Vydyanathan A. Investigating the efficacy of dexmedetomidine as an adjuvant to local anesthesia in brachial plexus block: a systematic review and meta-analysis of 18 randomized controlled trials. Reg Anesth Pain Med. 2017, 42:184-96. 10.1097\/AAP.0000000000000564","journal-title":"Reg Anesth Pain Med"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S146092","article-title":"Comparison of dexmedetomidine and fentanyl as local anesthetic adjuvants in spinal anesthesia: a systematic review and meta-analysis of randomized controlled trials","volume":"11","author":"Sun S","year":"2017","unstructured":"Sun S, Wang J, Bao N, Chen Y, Wang J. Comparison of dexmedetomidine and fentanyl as local anesthetic adjuvants in spinal anesthesia: a systematic review and meta-analysis of randomized controlled trials. Drug Des Devel Ther. 2017, 11:3413-24. 10.2147\/DDDT.S146092","journal-title":"Drug Des Devel Ther"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.13527","article-title":"The effect of dexmedetomidine on renal function after surgery: a systematic review and meta-analysis","volume":"47","author":"Loomba RS","year":"2022","unstructured":"Loomba RS, Villarreal EG, Dhargalkar J, Rausa J, Dorsey V, Farias JS, Flores S. The effect of dexmedetomidine on renal function after surgery: a systematic review and meta-analysis. J Clin Pharm Ther. 2022, 47:287-97. 10.1111\/jcpt.13527","journal-title":"J Clin Pharm Ther"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000426","article-title":"Supplementation with dexmedetomidine for transsphenoidal resection of pituitary adenoma: a meta-analysis of randomized controlled trials","volume":"44","author":"Liu Z","year":"2021","unstructured":"Liu Z, Gao C, Liu C, et al.. 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