{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:00:21Z","timestamp":1786413621090,"version":"build-2736575974"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,28]]},"DOI":"10.7759\/cureus.44278","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T20:24:36Z","timestamp":1693254276000},"source":"Crossref","is-referenced-by-count":3,"title":["Cancer Stem Cells' Biomarker ALDH1&amp;2 Increased Expression in Erosive Oral Lichen Planus Compared to Oral Leukoplakia"],"prefix":"10.7759","author":[{"given":"Vasileios","family":"Zisis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos N","family":"Giannakopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schmitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Poulopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Andreadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.016","article-title":"Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management","volume":"45","author":"van der Waal I","year":"2009","unstructured":"van der Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol. 2009, 45:317-23. 10.1016\/j.oraloncology.2008.05.016","journal-title":"Oral Oncol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.20205","article-title":"Oral potentially malignant disorders: is malignant transformation predictable and preventable?","volume":"19","author":"van der Waal I","year":"2014","unstructured":"van der Waal I. Oral potentially malignant disorders: is malignant transformation predictable and preventable?. Med Oral Patol Oral Cir Bucal. 2014, 19:e386-90. 10.4317\/medoral.20205","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3290\/j.qi.a43868","article-title":"Oral lichen planus and lichenoid lesions: what's new?","volume":"51","author":"Schmidt-Westhausen AM","year":"2020","unstructured":"Schmidt-Westhausen AM. Oral lichen planus and lichenoid lesions: what's new?. Quintessence Int. 2020, 51:156-61. 10.3290\/j.qi.a43868","journal-title":"Quintessence Int"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s41048-018-0062-2","article-title":"Cancer stem cells and tumorigenesis","volume":"4","author":"Zhu P","year":"2018","unstructured":"Zhu P, Fan Z. Cancer stem cells and tumorigenesis. Biophys Rep. 2018, 4:178-88. 10.1007\/s41048-018-0062-2","journal-title":"Biophys Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/bies.200900058","article-title":"Identification and targeting of cancer stem cells","volume":"31","author":"Schatton T","year":"2009","unstructured":"Schatton T, Frank NY, Frank MH. Identification and targeting of cancer stem cells. Bioessays. 2009, 31:1038-49. 10.1002\/bies.200900058","journal-title":"Bioessays"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.3892\/mco.2020.2112","article-title":"Biomarkers of progression to oral cancer in patients with dysplasia: a systematic review","volume":"13","author":"Rivera C","year":"2020","unstructured":"Rivera C, Gallegos R, Figueroa C. Biomarkers of progression to oral cancer in patients with dysplasia: a systematic review. Mol Clin Oncol. 2020, 13:42.","journal-title":"Mol Clin Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2007.057","article-title":"Oral lichenoid lesions and allergy to dental materials","volume":"151","author":"Ditrichova D","year":"2007","unstructured":"Ditrichova D, Kapralova S, Tichy M, et al.. Oral lichenoid lesions and allergy to dental materials. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007, 151:333-9. 10.5507\/bp.2007.057","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1987.tb01826.x","article-title":"Activation marker analysis of mononuclear cell infiltrates of oral lichen planus in situ","volume":"95","author":"Kilpi AM","year":"1987","unstructured":"Kilpi AM. Activation marker analysis of mononuclear cell infiltrates of oral lichen planus in situ. Scand J Dent Res. 1987, 95:174-80. 10.1111\/j.1600-0722.1987.tb01826.x","journal-title":"Scand J Dent Res"},{"key":"ref9","article-title":"Characterization of mononuclear cells of inflammatory infiltrates in oral tissues. A histochemical and immunohistochemical study of labial salivary glands in Sj\u00f6gren's syndrome and of oral lesions in systemic lupus erythematosus and in lichen planus","volume":"84 Suppl 3","author":"Kilpi A","year":"1988","unstructured":"Kilpi A. Characterization of mononuclear cells of inflammatory infiltrates in oral tissues. A histochemical and immunohistochemical study of labial salivary glands in Sj\u00f6gren's syndrome and of oral lesions in systemic lupus erythematosus and in lichen planus. Proc Finn Dent Soc. 1988, 84 Suppl 3:1-93.","journal-title":"Proc Finn Dent Soc"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(00)00142-5","article-title":"Oral lichen planus","volume":"18","author":"Sugerman PB","year":"2000","unstructured":"Sugerman PB, Savage NW, Zhou X, Walsh LJ, Bigby M. Oral lichen planus. Clin Dermatol. 2000, 18:533-9. 10.1016\/S0738-081X(00)00142-5","journal-title":"Clin Dermatol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.40836","article-title":"Altered presence of cancer stem cell ALDH1\/2 in oral leukoplakias and squamous cell carcinomas","volume":"15","author":"Zisis V","year":"2023","unstructured":"Zisis V, Paraskeuopoulos K, Athanasios P, Panta P, Dimitrios A. Altered presence of cancer stem cell ALDH1\/2 in oral leukoplakias and squamous cell carcinomas. Cureus. 2023, 15:e40836. 10.7759\/cureus.40836","journal-title":"Cureus"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-18-0672","article-title":"Prognostic value of cancer stem cell markers in potentially malignant disorders of oral mucosa: a meta-analysis","volume":"28","author":"Saluja TS","year":"2019","unstructured":"Saluja TS, Ali M, Mishra P, Kumar V, Singh SK. Prognostic value of cancer stem cell markers in potentially malignant disorders of oral mucosa: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2019, 28:144-53. 10.1158\/1055-9965.EPI-18-0672","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00112","article-title":"Cancer stem cells in oral cavity squamous cell carcinoma: a review","volume":"7","author":"Baillie R","year":"2017","unstructured":"Baillie R, Tan ST, Itinteang T. Cancer stem cells in oral cavity squamous cell carcinoma: a review. Front Oncol. 2017, 7:112. 10.3389\/fonc.2017.00112","journal-title":"Front Oncol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.781","article-title":"Aldehyde dehydrogenase activity is a cancer stem cell marker of tongue squamous cell carcinoma","volume":"5","author":"Zou B","year":"2012","unstructured":"Zou B, Sun S, Qi X, Ji P. Aldehyde dehydrogenase activity is a cancer stem cell marker of tongue squamous cell carcinoma. Mol Med Rep. 2012, 5:1116-20. 10.3892\/mmr.2012.781","journal-title":"Mol Med Rep"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.9.15486","article-title":"Aldehyde dehydrogenase: its role as a cancer stem cell marker comes down to the specific isoform","volume":"10","author":"Marcato P","year":"2011","unstructured":"Marcato P, Dean CA, Giacomantonio CA, Lee PW. Aldehyde dehydrogenase: its role as a cancer stem cell marker comes down to the specific isoform. Cell Cycle. 2011, 10:1378-84. 10.4161\/cc.10.9.15486","journal-title":"Cell Cycle"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27720","article-title":"Expression patterns of cancer stem cell markers ALDH1 and CD133 correlate with a high risk of malignant transformation of oral leukoplakia","volume":"132","author":"Liu W","year":"2013","unstructured":"Liu W, Wu L, Shen XM, Shi LJ, Zhang CP, Xu LQ, Zhou ZT. Expression patterns of cancer stem cell markers ALDH1 and CD133 correlate with a high risk of malignant transformation of oral leukoplakia. Int J Cancer. 2013, 132:868-74. 10.1002\/ijc.27720","journal-title":"Int J Cancer"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2012.02851.x","article-title":"High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis","volume":"62","author":"Michifuri Y","year":"2012","unstructured":"Michifuri Y, Hirohashi Y, Torigoe T, et al.. High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis. Pathol Int. 2012, 62:684-9. 10.1111\/j.1440-1827.2012.02851.x","journal-title":"Pathol Int"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.05.048","article-title":"Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer","volume":"385","author":"Chen YC","year":"2009","unstructured":"Chen YC, Chen YW, Hsu HS, et al.. Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer. Biochem Biophys Res Commun. 2009, 385:307-13. 10.1016\/j.bbrc.2009.05.048","journal-title":"Biochem Biophys Res Commun"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000612","article-title":"Different expression of aldehyde dehydrogenases 1A1 and 2 in oral leukoplakia with epithelial dysplasia and in oral squamous cell carcinoma","volume":"27","author":"Herrera Costa F","year":"2019","unstructured":"Herrera Costa F, Narana Ribeiro El Achkar V, Costa V, Paladini I, Kowalski LP, Rodarte Carvalho Y, Kaminagakura E. Different expression of aldehyde dehydrogenases 1A1 and 2 in oral leukoplakia with epithelial dysplasia and in oral squamous cell carcinoma. Appl Immunohistochem Mol Morphol. 2019, 27:537-42. 10.1097\/PAI.0000000000000612","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01191.x","article-title":"Expression of cancer stem cell markers ALDH1 and Bmi1 in oral erythroplakia and the risk of oral cancer","volume":"42","author":"Feng JQ","year":"2013","unstructured":"Feng JQ, Xu ZY, Shi LJ, Wu L, Liu W, Zhou ZT. Expression of cancer stem cell markers ALDH1 and Bmi1 in oral erythroplakia and the risk of oral cancer. J Oral Pathol Med. 2013, 42:148-53. 10.1111\/j.1600-0714.2012.01191.x","journal-title":"J Oral Pathol Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20174964","article-title":"Increased salivary aldehyde dehydrogenase 1 in non-reticular oral lichen planus","volume":"92","author":"Mansourian A","year":"2017","unstructured":"Mansourian A, Shanbehzadeh N, Kia SJ, Moosavi MS. Increased salivary aldehyde dehydrogenase 1 in non-reticular oral lichen planus. An Bras Dermatol. 2017, 92:168-71. 10.1590\/abd1806-4841.20174964","journal-title":"An Bras Dermatol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05557-x","article-title":"Aldehyde dehydrogenase 2 alleviates mitochondrial dysfunction by promoting PGC-1\u03b1-mediated biogenesis in acute kidney injury","volume":"14","author":"Li J","year":"2023","unstructured":"Li J, Shi X, Chen Z, et al.. Aldehyde dehydrogenase 2 alleviates mitochondrial dysfunction by promoting PGC-1\u03b1-mediated biogenesis in acute kidney injury. Cell Death Dis. 2023, 14:45. 10.1038\/s41419-023-05557-x","journal-title":"Cell Death Dis"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12142","article-title":"Inflammation-related cytokines in oral lichen planus: an overview","volume":"44","author":"Lu R","year":"2015","unstructured":"Lu R, Zhang J, Sun W, Du G, Zhou G. Inflammation-related cytokines in oral lichen planus: an overview. J Oral Pathol Med. 2015, 44:1-14. 10.1111\/jop.12142","journal-title":"J Oral Pathol Med"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.38807","article-title":"Preliminary study of the cancer stem cells' biomarker CD147 in leukoplakia: dysplasia and squamous cell carcinoma of oral epithelial origin","volume":"15","author":"Zisis V","year":"2023","unstructured":"Zisis V, Andreadis D, Anastasiadou P, Vahtsevanos K, Akrivou M, Vizirianakis IS, Poulopoulos A. Preliminary study of the cancer stem cells' biomarker CD147 in leukoplakia: dysplasia and squamous cell carcinoma of oral epithelial origin. Cureus. 2023, 15:e38807. 10.7759\/cureus.38807","journal-title":"Cureus"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/185317-cancer-stem-cells-biomarker-aldh12-increased-expression-in-erosive-oral-lichen-planus-compared-to-oral-leukoplakia","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:55:26Z","timestamp":1707508526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/185317-cancer-stem-cells-biomarker-aldh12-increased-expression-in-erosive-oral-lichen-planus-compared-to-oral-leukoplakia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":24,"URL":"https:\/\/doi.org\/10.7759\/cureus.44278","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,28]]}}}