{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T13:56:06Z","timestamp":1762782966466},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"DOI":"10.7759\/cureus.44547","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T05:01:18Z","timestamp":1693630878000},"source":"Crossref","is-referenced-by-count":1,"title":["The Concurrent Use of Phenytoin and Levetiracetam for Seizure Prophylaxis in ICU Patients: The \u201cArrowhead Rationale\u201d"],"prefix":"10.7759","author":[{"given":"Meghan","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javed","family":"Siddiqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001445","article-title":"Should levetiracetam or phenytoin be used for posttraumatic seizure prophylaxis? A systematic review of the literature and meta-analysis","volume":"79","author":"Khan NR","year":"2016","unstructured":"Khan NR, VanLandingham MA, Fierst TM, et al.. Should levetiracetam or phenytoin be used for posttraumatic seizure prophylaxis? A systematic review of the literature and meta-analysis. Neurosurgery. 2016, 79:775-82. 10.1227\/NEU.0000000000001445","journal-title":"Neurosurgery"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes027","article-title":"Anaesthesia and epilepsy","volume":"108","author":"Perks A","year":"2012","unstructured":"Perks A, Cheema S, Mohanraj R. Anaesthesia and epilepsy. Br J Anaesth. 2012, 108:562-71. 10.1093\/bja\/aes027","journal-title":"Br J Anaesth"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0640-5","article-title":"Treatment of refractory and super-refractory status epilepticus","volume":"15","author":"Rai S","year":"2018","unstructured":"Rai S, Drislane FW. Treatment of refractory and super-refractory status epilepticus. Neurotherapeutics. 2018, 15:697-712. 10.1007\/s13311-018-0640-5","journal-title":"Neurotherapeutics"},{"key":"ref4","doi-asserted-by":"crossref","DOI":"10.1002\/j.1552-4604.2000.tb05984.x","article-title":"Absence of pharmacokinetic drug interaction of levetiracetam with phenytoin in patients with epilepsy determined by new technique","volume":"40","author":"Browne TR","year":"2000","unstructured":"Browne TR, Szabo GK, Leppik IE, et al.. Absence of pharmacokinetic drug interaction of levetiracetam with phenytoin in patients with epilepsy determined by new technique. J Clin Pharmacol. 2000, 40:590-5.","journal-title":"J Clin Pharmacol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007503","article-title":"Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus","volume":"92","author":"S\u00e1nchez Fern\u00e1ndez I","year":"2019","unstructured":"S\u00e1nchez Fern\u00e1ndez I, Ga\u00ednza-Lein M, Lamb N, Loddenkemper T. Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus. Neurology. 2019, 92:e2339-48. 10.1212\/WNL.0000000000007503","journal-title":"Neurology"},{"key":"ref6","unstructured":"Dilantin\u00ae. (2009). Accessed. June 15, 2021: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2009\/084349s060lbl.pdf."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2174\/157015910792246254","article-title":"Antiepileptic drug interactions - principles and clinical implications","volume":"8","author":"Johannessen SI","year":"2010","unstructured":"Johannessen SI, Landmark CJ. Antiepileptic drug interactions - principles and clinical implications. Curr Neuropharmacol. 2010, 8:254-67. 10.2174\/157015910792246254","journal-title":"Curr Neuropharmacol"},{"key":"ref8","unstructured":"Keppra\u00ae. (2017). Accessed. June 15, 2021: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2009\/021035s078s080%2C021505s021s024lbl.pdf."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01713.x","article-title":"Benefit of combination therapy in epilepsy: a review of the preclinical evidence with levetiracetam","volume":"50","author":"Kaminski RM","year":"2009","unstructured":"Kaminski RM, Matagne A, Patsalos PN, Klitgaard H. Benefit of combination therapy in epilepsy: a review of the preclinical evidence with levetiracetam. Epilepsia. 2009, 50:387-97. 10.1111\/j.1528-1167.2008.01713.x","journal-title":"Epilepsia"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/ph3082362","article-title":"Rational polytherapy with antiepileptic drugs","volume":"3","author":"Lee JW","year":"2010","unstructured":"Lee JW, Dworetzky B. Rational polytherapy with antiepileptic drugs. Pharmaceuticals (Basel). 2010, 3:2362-79. 10.3390\/ph3082362","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1016\/0896-6974(96)00010-2","article-title":"Efficacy and tolerability study of ucb L059 in patients with refractory epilepsy","volume":"9","author":"Sharief MK","year":"1996","unstructured":"Sharief MK, Singh P, Sander JWAS, et al.. Efficacy and tolerability study of ucb L059 in patients with refractory epilepsy. J Epilepsy. 1996, 9:106-12.","journal-title":"J Epilepsy"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2014.12.013","article-title":"Levetiracetam versus phenytoin in management of status epilepticus","volume":"22","author":"Chakravarthi S","year":"2015","unstructured":"Chakravarthi S, Goyal MK, Modi M, Bhalla A, Singh P. Levetiracetam versus phenytoin in management of status epilepticus. J Clin Neurosci. 2015, 22:959-63. 10.1016\/j.jocn.2014.12.013","journal-title":"J Clin Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.14740\/jnr356w","article-title":"Evidence for efficacy of combination of antiepileptic drugs in treatment of epilepsy","volume":"5","author":"Sarhan EM","year":"2015","unstructured":"Sarhan EM, Walker MC, Selai C. Evidence for efficacy of combination of antiepileptic drugs in treatment of epilepsy. J Neurol Res. 2015, 5:267-76.","journal-title":"J Neurol Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666140-00004","article-title":"Combination therapy in epilepsy: when and what to use","volume":"66","author":"Kwan P","year":"2006","unstructured":"Kwan P, Brodie MJ. Combination therapy in epilepsy: when and what to use. Drugs. 2006, 66:1817-29. 10.2165\/00003495-200666140-00004","journal-title":"Drugs"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Levetiracetam Is No More Effective Than Phenytoin in Children with Convulsive Status Epilepticus. (2019). https.\/\/journals.lww.com\/neurotodayonline\/Fulltext\/2019\/07110\/Levetiracetam_Is_No_More_Effective_Than_Phenytoin.1.aspx.","DOI":"10.1097\/01.NT.0000576888.75697.ae"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/68901-the-concurrent-use-of-phenytoin-and-levetiracetam-for-seizure-prophylaxis-in-icu-patients-the-arrowhead-rationale","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:58:17Z","timestamp":1707508697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/68901-the-concurrent-use-of-phenytoin-and-levetiracetam-for-seizure-prophylaxis-in-icu-patients-the-arrowhead-rationale"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.44547","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9,1]]}}}