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Part II: guidance and recommendations","volume":"16","author":"Manchikanti L","year":"2013","unstructured":"Manchikanti L, Abdi S, Atluri S, et al.. An update of comprehensive evidence-based guidelines for interventional techniques in chronic spinal pain. Part II: guidance and recommendations. Pain Physician. 2013, 16:S49-283.","journal-title":"Pain Physician"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1979.tb01417.x","article-title":"Paresthesiae or no paresthesiae? Nerve lesions after axillary blocks","volume":"23","author":"Selander D","year":"1979","unstructured":"Selander D, Edshage S, Wolff T. Paresthesiae or no paresthesiae? Nerve lesions after axillary blocks. 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