{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:09:40Z","timestamp":1770332980407,"version":"3.49.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,6]]},"DOI":"10.7759\/cureus.44757","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T07:47:41Z","timestamp":1693986461000},"source":"Crossref","is-referenced-by-count":1,"title":["Effect of Non-Surgical Periodontal Therapy on Systemic Inflammatory Markers, Glycemic Status and Levels of Proteinuria in Type 2 Diabetic and Non-Diabetic Patients With Chronic Periodontitis"],"prefix":"10.7759","author":[{"given":"S Gopalakrishnan","family":"Sundaram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sneha G","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keerthi V","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siva","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Kanimozhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050459","article-title":"Diabetes mellitus and periodontal diseases","volume":"77","author":"Mealey BL","year":"2006","unstructured":"Mealey BL, Oates TW. Diabetes mellitus and periodontal diseases. J Periodontol. 2006, 77:1289-303. 10.1902\/jop.2006.050459","journal-title":"J Periodontol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01282.x","article-title":"Effects of diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks","volume":"35","author":"Salvi GE","year":"2008","unstructured":"Salvi GE, Carollo-Bittel B, Lang NP. Effects of diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks. J Clin Periodontol. 2008, 35:398-409. 10.1111\/j.1600-051X.2008.01282.x","journal-title":"J Clin Periodontol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/BF03405434","article-title":"Incidence and prevalence of type 2 diabetes in the First Nation community of Kahnaw\u00e1:ke, Quebec, Canada, 1986-2003","volume":"98","author":"Horn OK","year":"2007","unstructured":"Horn OK, Jacobs-Whyte H, Ing A, Bruegl A, Paradis G, Macaulay AC. Incidence and prevalence of type 2 diabetes in the First Nation community of Kahnaw\u00e1:ke, Quebec, Canada, 1986-2003. Can J Public Health. 2007, 98:438-43. 10.1007\/BF03405434","journal-title":"Can J Public Health"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane DF","year":"2017","unstructured":"Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017, 3:17038. 10.1038\/nrdp.2017.38","journal-title":"Nat Rev Dis Primers"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-013-0367-y","article-title":"Diabetes mellitus and periodontal diseases","volume":"13","author":"Sima C","year":"2013","unstructured":"Sima C, Glogauer M. Diabetes mellitus and periodontal diseases. Curr Diab Rep. 2013, 13:445-52. 10.1007\/s11892-013-0367-y","journal-title":"Curr Diab Rep"},{"key":"ref6","article-title":"Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links","volume":"11","author":"Oguntibeju OO","year":"2019","unstructured":"Oguntibeju OO. Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links. International journal of physiology, pathophysiology and pharmacology. 2019, 11:45.","journal-title":"International journal of physiology, pathophysiology and pharmacology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.3.812","article-title":"Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study","volume":"52","author":"Spranger J","year":"2003","unstructured":"Spranger J, Kroke A, M\u00f6hlig M, et al.. Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes. 2003, 52:812-7. 10.2337\/diabetes.52.3.812","journal-title":"Diabetes"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2004110961","article-title":"Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes","volume":"16 Suppl 1","author":"Dalla Vestra M","year":"2005","unstructured":"Dalla Vestra M, Mussap M, Gallina P, et al.. Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes. J Am Soc Nephrol. 2005, 16 Suppl 1:S78-82. 10.1681\/asn.2004110961","journal-title":"J Am Soc Nephrol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300214","article-title":"Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers","volume":"83","author":"D'Aiuto F","year":"2004","unstructured":"D'Aiuto F, Parkar M, Andreou G, Suvan J, Brett PM, Ready D, Tonetti MS. Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. J Dent Res. 2004, 83:156-60. 10.1177\/154405910408300214","journal-title":"J Dent Res"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2004.01019.x","article-title":"Update on diabetes mellitus and related oral diseases","volume":"10","author":"Manfredi M","year":"2004","unstructured":"Manfredi M, McCullough MJ, Vescovi P, Al-Kaarawi ZM, Porter SR. Update on diabetes mellitus and related oral diseases. Oral Dis. 2004, 10:187-200. 10.1111\/j.1601-0825.2004.01019.x","journal-title":"Oral Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.9","article-title":"The association between periodontal diseases and cardiovascular diseases: a state-of-the-science review","volume":"6","author":"Beck JD","year":"2001","unstructured":"Beck JD, Offenbacher S. The association between periodontal diseases and cardiovascular diseases: a state-of-the-science review. Ann Periodontol. 2001, 6:9-15. 10.1902\/annals.2001.6.1.9","journal-title":"Ann Periodontol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00171.x","article-title":"The periodontal host response with diabetes","volume":"43","author":"Nishimura F","year":"2007","unstructured":"Nishimura F, Iwamoto Y, Soga Y. The periodontal host response with diabetes. Periodontol 2000. 2007, 43:245-53. 10.1111\/j.1600-0757.2006.00171.x","journal-title":"Periodontol 2000"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2075","article-title":"A proposed model linking inflammation to obesity, diabetes, and periodontal infections","volume":"76 Suppl 11S","author":"Genco RJ","year":"2005","unstructured":"Genco RJ, Grossi SG, Ho A, Nishimura F, Murayama Y. A proposed model linking inflammation to obesity, diabetes, and periodontal infections. J Periodontol. 2005, 76 Suppl 11S:2075-84. 10.1902\/jop.2005.76.11-S.2075","journal-title":"J Periodontol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.6.774","article-title":"The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes","volume":"72","author":"Iwamoto Y","year":"2001","unstructured":"Iwamoto Y, Nishimura F, Nakagawa M, et al.. The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. J Periodontol. 2001, 72:774-8. 10.1902\/jop.2001.72.6.774","journal-title":"J Periodontol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12318","article-title":"The impact of diabetes on periodontal diseases","volume":"82","author":"Graves DT","year":"2020","unstructured":"Graves DT, Ding Z, Yang Y. The impact of diabetes on periodontal diseases. Periodontol 2000. 2020, 82:214-24. 10.1111\/prd.12318","journal-title":"Periodontol 2000"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93062-6","article-title":"Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies","volume":"11","author":"St\u00f6hr J","year":"2021","unstructured":"St\u00f6hr J, Barbaresko J, Neuenschwander M, Schlesinger S. Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies. Sci Rep. 2021, 11:13686. 10.1038\/s41598-021-93062-6","journal-title":"Sci Rep"},{"key":"ref17","article-title":"The relationship between diabetes and periodontal disease","volume":"68","author":"Matthews DC","year":"20021","unstructured":"Matthews DC. The relationship between diabetes and periodontal disease. Journal-Canadian Dental Association. 20021, 68:161-4.","journal-title":"Journal-Canadian Dental Association"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.9.1361","article-title":"Effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes mellitus","volume":"74","author":"Rodrigues DC","year":"2003","unstructured":"Rodrigues DC, Taba MJ, Novaes AB, Souza SL, Grisi MF. Effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes mellitus. J Periodontol. 2003, 74:1361-7. 10.1902\/jop.2003.74.9.1361","journal-title":"J Periodontol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e3282f824b7","article-title":"Diabetes mellitus and inflammatory periodontal diseases","volume":"15","author":"Mealey BL","year":"2008","unstructured":"Mealey BL, Rose LF. Diabetes mellitus and inflammatory periodontal diseases. Curr Opin Endocrinol Diabetes Obes. 2008, 15:135-41. 10.1097\/MED.0b013e3282f824b7","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508401212","article-title":"Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies","volume":"84","author":"Janket SJ","year":"2005","unstructured":"Janket SJ, Wightman A, Baird AE, Van Dyke TE, Jones JA. Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies. J Dent Res. 2005, 84:1154-9. 10.1177\/154405910508401212","journal-title":"J Dent Res"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00567-2","article-title":"Abnormalities of coagulation in hypertensive patients with reduced creatinine clearance","volume":"109","author":"Catena C","year":"20001","unstructured":"Catena C, Zingaro L, Casaccio D, Sechi LA. Abnormalities of coagulation in hypertensive patients with reduced creatinine clearance. Ame Jr Med. 20001, 109:556-61. 10.1016\/S0002-9343(00)00567-2","journal-title":"Ame Jr Med"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1184","article-title":"Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes","volume":"30","author":"Shultis WA","year":"2007","unstructured":"Shultis WA, Weil EJ, Looker HC, et al.. Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes. Diabetes Care. 2007, 30:306-11. 10.2337\/dc06-1184","journal-title":"Diabetes Care"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/181626-effect-of-non-surgical-periodontal-therapy-on-systemic-inflammatory-markers-glycemic-status-and-levels-of-proteinuria-in-type-2-diabetic-and-non-diabetic-patients-with-chronic-periodontitis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:04:43Z","timestamp":1707509083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/181626-effect-of-non-surgical-periodontal-therapy-on-systemic-inflammatory-markers-glycemic-status-and-levels-of-proteinuria-in-type-2-diabetic-and-non-diabetic-patients-with-chronic-periodontitis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,6]]},"references-count":22,"URL":"https:\/\/doi.org\/10.7759\/cureus.44757","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9,6]]}}}