{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:53:24Z","timestamp":1771026804497,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,28]]},"DOI":"10.7759\/cureus.46169","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T06:33:10Z","timestamp":1695969190000},"source":"Crossref","is-referenced-by-count":3,"title":["Exploring the Impact of Prior Beta-Blocker and Calcium Channel Blocker Usage on Clinical Outcomes in Critically Ill Patients With Sepsis: An Observational Study"],"prefix":"10.7759","author":[{"given":"Sachin","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Malviya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujeet","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumya S","family":"Nath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiv Shanker","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smarika","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations","volume":"193","author":"Fleischmann C","year":"2016","unstructured":"Fleischmann C, Scherag A, Adhikari NK, et al.. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016, 193:259-72. 10.1164\/rccm.201504-0781OC","journal-title":"Am J Respir Crit Care Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.5804","article-title":"Hospital deaths in patients with sepsis from 2 independent cohorts","volume":"312","author":"Liu V","year":"2014","unstructured":"Liu V, Escobar GJ, Greene JD, Soule J, Whippy A, Angus DC, Iwashyna TJ. Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA. 2014, 312:90-2. 10.1001\/jama.2014.5804","journal-title":"JAMA"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1004-z","article-title":"Elucidating the impact of the pneumococcal conjugate vaccine programme on pneumonia, sepsis and otitis media hospital admissions in England using a composite control","volume":"16","author":"Thorrington D","year":"2018","unstructured":"Thorrington D, Andrews N, Stowe J, Miller E, van Hoek AJ. Elucidating the impact of the pneumococcal conjugate vaccine programme on pneumonia, sepsis and otitis media hospital admissions in England using a composite control. BMC Med. 2018, 16:13. 10.1186\/s12916-018-1004-z","journal-title":"BMC Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2011-3","article-title":"Promoting and sustaining a historical and global effort to prevent sepsis: the 2018 World Health Organization SAVE LIVES: Clean Your Hands campaign","volume":"22","author":"Martischang R","year":"2018","unstructured":"Martischang R, Pires D, Masson-Roy S, Saito H, Pittet D. Promoting and sustaining a historical and global effort to prevent sepsis: the 2018 World Health Organization SAVE LIVES: Clean Your Hands campaign. Crit Care. 2018, 22:92. 10.1186\/s13054-018-2011-3","journal-title":"Crit Care"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer M","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, et al.. The Third International Consensus Definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016, 315:801-10. 10.1001\/jama.2016.0287","journal-title":"JAMA"},{"key":"ref6","article-title":"Calcium: a regulator of the inflammatory response in endotoxemia and sepsis","volume":"4","author":"Hotchkiss RS","year":"1996","unstructured":"Hotchkiss RS, Karl IE. Calcium: a regulator of the inflammatory response in endotoxemia and sepsis. New Horiz. 1996, 4:58-71.","journal-title":"New Horiz"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.1.110304.100218","article-title":"Calcium in cell injury and death","volume":"1","author":"Dong Z","year":"2006","unstructured":"Dong Z, Saikumar P, Weinberg JM, Venkatachalam MA. Calcium in cell injury and death. Annu Rev Pathol. 2006, 1:405-34. 10.1146\/annurev.pathol.1.110304.100218","journal-title":"Annu Rev Pathol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium signaling","volume":"131","author":"Clapham DE","year":"2007","unstructured":"Clapham DE. Calcium signaling. Cell. 2007, 131:1047-58. 10.1016\/j.cell.2007.11.028","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-2952(98)00070-7","article-title":"Antioxidant and cytoprotective activities of the calcium channel blocker mibefradil","volume":"55","author":"Mason RP","year":"1998","unstructured":"Mason RP, Mak IT, Walter MF, et al.. Antioxidant and cytoprotective activities of the calcium channel blocker mibefradil. Biochem Pharmacol. 1998, 55:1843-52. 10.1016\/s0006-2952(98)00070-7","journal-title":"Biochem Pharmacol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.200311","article-title":"L-type calcium channel blockers exert an antiinflammatory effect by suppressing expression of plasminogen receptors on macrophages","volume":"105","author":"Das R","year":"2009","unstructured":"Das R, Burke T, Van Wagoner DR, Plow EF. L-type calcium channel blockers exert an antiinflammatory effect by suppressing expression of plasminogen receptors on macrophages. Circ Res. 2009, 105:167-75. 10.1161\/CIRCRESAHA.109.200311","journal-title":"Circ Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2015.1062357","article-title":"Beta-blocker use in severe sepsis and septic shock: a systematic review","volume":"31","author":"Sanfilippo F","year":"2015","unstructured":"Sanfilippo F, Santonocito C, Morelli A, Foex P. Beta-blocker use in severe sepsis and septic shock: a systematic review. Curr Med Res Opin. 2015, 31:1817-25. 10.1185\/03007995.2015.1062357","journal-title":"Curr Med Res Opin"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31825f757b","article-title":"\u03b2-blockers: more good news?","volume":"40","author":"Ginsberg F","year":"2012","unstructured":"Ginsberg F. \u03b2-blockers: more good news?. Crit Care Med. 2012, 40:2901-2. 10.1097\/CCM.0b013e31825f757b","journal-title":"Crit Care Med"},{"key":"ref13","article-title":"The role of beta-blockers in septic patients","volume":"81","author":"Hamzaoui O","year":"2015","unstructured":"Hamzaoui O, Teboul JL. The role of beta-blockers in septic patients. Minerva Anestesiol. 2015, 81:312-9.","journal-title":"Minerva Anestesiol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181f204ca","article-title":"Beta-block the septic heart","volume":"38","author":"Rudiger A","year":"2010","unstructured":"Rudiger A. Beta-block the septic heart. Crit Care Med. 2010, 38:S608-12. 10.1097\/CCM.0b013e3181f204ca","journal-title":"Crit Care Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e318180ffb6","article-title":"Beta-blockers in sepsis: reexamining the evidence","volume":"31","author":"Novotny NM","year":"2009","unstructured":"Novotny NM, Lahm T, Markel TA, et al.. Beta-blockers in sepsis: reexamining the evidence. Shock. 2009, 31:113-9. 10.1097\/SHK.0b013e318180ffb6","journal-title":"Shock"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002236","article-title":"Prior use of calcium channel blockers is associated with decreased mortality in critically ill patients with sepsis: a prospective observational study","volume":"45","author":"Wiewel MA","year":"2017","unstructured":"Wiewel MA, van Vught LA, Scicluna BP, et al.. Prior use of calcium channel blockers is associated with decreased mortality in critically ill patients with sepsis: a prospective observational study. Crit Care Med. 2017, 45:454-63. 10.1097\/CCM.0000000000002236","journal-title":"Crit Care Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278477","article-title":"Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial","volume":"310","author":"Morelli A","year":"2013","unstructured":"Morelli A, Ertmer C, Westphal M, et al.. Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA. 2013, 310:1683-91. 10.1001\/jama.2013.278477","journal-title":"JAMA"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000000312","article-title":"Preadmission use of calcium channel blockers and outcomes after hospitalization with pneumonia: a retrospective propensity-matched cohort study","volume":"24","author":"Zheng L","year":"2017","unstructured":"Zheng L, Hunter K, Gaughan J, Poddar S. Preadmission use of calcium channel blockers and outcomes after hospitalization with pneumonia: a retrospective propensity-matched cohort study. Am J Ther. 2017, 24:e30-8. 10.1097\/MJT.0000000000000312","journal-title":"Am J Ther"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31825b9509","article-title":"Previous prescription of \u03b2-blockers is associated with reduced mortality among patients hospitalized in intensive care units for sepsis","volume":"40","author":"Macchia A","year":"2012","unstructured":"Macchia A, Romero M, Comignani PD, et al.. Previous prescription of \u03b2-blockers is associated with reduced mortality among patients hospitalized in intensive care units for sepsis. Crit Care Med. 2012, 40:2768-72. 10.1097\/CCM.0b013e31825b9509","journal-title":"Crit Care Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex231","article-title":"Continuing chronic beta-blockade in the acute phase of severe sepsis and septic shock is associated with decreased mortality rates up to 90 days","volume":"119","author":"Fuchs C","year":"2017","unstructured":"Fuchs C, Wauschkuhn S, Scheer C, et al.. Continuing chronic beta-blockade in the acute phase of severe sepsis and septic shock is associated with decreased mortality rates up to 90 days. Br J Anaesth. 2017, 119:616-25. 10.1093\/bja\/aex231","journal-title":"Br J Anaesth"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2019.12.046","article-title":"Beta-blockers\u2019 effect on levels of lactate in patients with suspected sepsis - The BeLLa study","volume":"38","author":"Chan JZ","year":"2020","unstructured":"Chan JZ, Tan JH, Lather KS, et al.. Beta-blockers\u2019 effect on levels of lactate in patients with suspected sepsis - The BeLLa study. Am J Emerg Med. 2020, 38:2574-9. 10.1016\/j.ajem.2019.12.046","journal-title":"Am J Emerg Med"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001308","article-title":"Long-term \u03b2-blocker therapy decreases blood lactate concentration in severely septic patients","volume":"43","author":"Contenti J","year":"2015","unstructured":"Contenti J, Occelli C, Corraze H, Lemo\u00ebl F, Levraut J. Long-term \u03b2-blocker therapy decreases blood lactate concentration in severely septic patients. Crit Care Med. 2015, 43:2616-22. 10.1097\/CCM.0000000000001308","journal-title":"Crit Care Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/146641-exploring-the-impact-of-prior-beta-blocker-and-calcium-channel-blocker-usage-on-clinical-outcomes-in-critically-ill-patients-with-sepsis-an-observational-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:08:53Z","timestamp":1707509333000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/146641-exploring-the-impact-of-prior-beta-blocker-and-calcium-channel-blocker-usage-on-clinical-outcomes-in-critically-ill-patients-with-sepsis-an-observational-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":22,"URL":"https:\/\/doi.org\/10.7759\/cureus.46169","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9,28]]}}}