{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T09:07:15Z","timestamp":1744967235114},"reference-count":31,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"DOI":"10.7759\/cureus.46341","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:22:40Z","timestamp":1696227760000},"source":"Crossref","is-referenced-by-count":3,"title":["Pioneering Periapical Healing: The Novel Synergy of Mineral Trioxide Aggregate and Injectable Platelet-Rich Fibrin"],"prefix":"10.7759","author":[{"given":"Paridhi","family":"Agrawal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradnya","family":"Nikhade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Bhopatkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tejas","family":"Suryawanshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01109.x","article-title":"Nonsurgical treatment of extensive cyst-like periapical lesion of endodontic origin","volume":"39","author":"Soares J","year":"2006","unstructured":"Soares J, Santos S, Silveira F, Nunes E. Nonsurgical treatment of extensive cyst-like periapical lesion of endodontic origin. Int Endod J. 2006, 39:566-75. 10.1111\/j.1365-2591.2006.01109.x","journal-title":"Int Endod J"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1998.00146.x","article-title":"New perspectives on radicular cysts: do they heal?","volume":"31","author":"Nair PN","year":"1998","unstructured":"Nair PN. New perspectives on radicular cysts: do they heal?. Int Endod J. 1998, 31:155-60. 10.1046\/j.1365-2591.1998.00146.x","journal-title":"Int Endod J"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.02.012","article-title":"Nonsurgical root canal therapy of large cyst-like inflammatory periapical lesions and inflammatory apical cysts","volume":"35","author":"Lin LM","year":"2009","unstructured":"Lin LM, Ricucci D, Lin J, Rosenberg PA. Nonsurgical root canal therapy of large cyst-like inflammatory periapical lesions and inflammatory apical cysts. J Endod. 2009, 35:607-15. 10.1016\/j.joen.2009.02.012","journal-title":"J Endod"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(86)90107-6","article-title":"Nonsurgical treatment of extraoral lesions caused by necrotic nonvital tooth","volume":"61","author":"Salamat K","year":"1986","unstructured":"Salamat K, Rezai RF. Nonsurgical treatment of extraoral lesions caused by necrotic nonvital tooth. Oral Surg Oral Med Oral Pathol. 1986, 61:618-23. 10.1016\/0030-4220(86)90107-6","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/0972-0707.212232","article-title":"Nonsurgical endodontic treatment of teeth associated with large periapical lesion using triple antibiotic paste and mineral trioxide aggregate apical plug: a case series","volume":"20","author":"Kunhappan S","year":"2017","unstructured":"Kunhappan S, Kunhappan N, Saraf KK, Kridutt V. Nonsurgical endodontic treatment of teeth associated with large periapical lesion using triple antibiotic paste and mineral trioxide aggregate apical plug: a case series. J Conserv Dent. 2017, 20:141-5. 10.4103\/0972-0707.212232","journal-title":"J Conserv Dent"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.02.006","article-title":"Proliferation of epithelial cell rests, formation of apical cysts, and regression of apical cysts after periapical wound healing","volume":"33","author":"Lin LM","year":"2007","unstructured":"Lin LM, Huang GT, Rosenberg PA. Proliferation of epithelial cell rests, formation of apical cysts, and regression of apical cysts after periapical wound healing. J Endod. 2007, 33:908-16. 10.1016\/j.joen.2007.02.006","journal-title":"J Endod"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.22037\/iej.2017.24","article-title":"Nonsurgical management of an extensive endodontic periapical lesion: a case report","volume":"12","author":"Moshari A","year":"2017","unstructured":"Moshari A, Vatanpour M, EsnaAshari E, Zakershahrak M, Jalali Ara A. Nonsurgical management of an extensive endodontic periapical lesion: a case report. Iran Endod J. 2017, 12:116-9. 10.22037\/iej.2017.24","journal-title":"Iran Endod J"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(84)80086-2","article-title":"Treatment of large periapical lesions using cannalization through involved teeth","volume":"10","author":"Walker TL","year":"1984","unstructured":"Walker TL, Davis MS. Treatment of large periapical lesions using cannalization through involved teeth. J Endod. 1984, 10:215-20. 10.1016\/S0099-2399(84)80086-2","journal-title":"J Endod"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1996.tb00518.x","article-title":"Endodontic treatment of teeth with apical periodontitis using calcium hydroxide: a long-term study","volume":"12","author":"Cali\u015fkan MK","year":"1996","unstructured":"Cali\u015fkan MK, Sen BH. Endodontic treatment of teeth with apical periodontitis using calcium hydroxide: a long-term study. Endod Dent Traumatol. 1996, 12:215-21. 10.1111\/j.1600-9657.1996.tb00518.x","journal-title":"Endod Dent Traumatol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(91)90374-l","article-title":"Healing of periapical radiolucencies after nonsurgical endodontic therapy","volume":"71","author":"Murphy WK","year":"1991","unstructured":"Murphy WK, Kaugars GE, Collett WK, Dodds RN. Healing of periapical radiolucencies after nonsurgical endodontic therapy. Oral Surg Oral Med Oral Pathol. 1991, 71:620-4. 10.1016\/0030-4220(91)90374-l","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"ref11","article-title":"Oral radiology: principles and interpretation","author":"White S","year":"2014","unstructured":"White S, Pharoah M. Oral radiology: principles and interpretation. Elsevier Health Science, Amsterdam; 2014."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(72)90325-8","article-title":"Nonsurgical resolution of radicular cysts","volume":"34","author":"Bhaskar SN","year":"1972","unstructured":"Bhaskar SN. Nonsurgical resolution of radicular cysts. Oral Surg Oral Med Oral Pathol. 1972, 34:458-68. 10.1016\/0030-4220(72)90325-8","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2063-9","article-title":"Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry?","volume":"21","author":"Miron RJ","year":"2017","unstructured":"Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, Choukroun J. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry?. Clin Oral Investig. 2017, 21:2619-27. 10.1007\/s00784-017-2063-9","journal-title":"Clin Oral Investig"},{"key":"ref14","article-title":"Reparative calcified barrier characterization after mixing injectable-platelet rich fibrin with bioactive direct pulp capping agents; an exp. study","volume":"2","author":"Mansour NK","year":"2023","unstructured":"Mansour NK, Fayyad DM, Farghaly AM. Reparative calcified barrier characterization after mixing injectable-platelet rich fibrin with bioactive direct pulp capping agents; an exp. study. Study Insights Herb Med. 2023, 2:07-16.","journal-title":"Study Insights Herb Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(68)90163-1","article-title":"The frequency and distribution of periapical cysts and granulomas. an evaluation of 800 specimens","volume":"25","author":"Lalonde ER","year":"1986","unstructured":"Lalonde ER, Luebke RG. The frequency and distribution of periapical cysts and granulomas. an evaluation of 800 specimens. Oral Surg Oral Med Oral Pathol. 1986, 25:861-8. 10.1016\/0030-4220(68)90163-1","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s1079-2104(96)80156-9","article-title":"Types and incidence of human periapical lesions obtained with extracted teeth","volume":"81","author":"Nair PNR","year":"1996","unstructured":"Nair PNR, Pajarola G, Schroeder HE. Types and incidence of human periapical lesions obtained with extracted teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996, 81:93-102. 10.1016\/s1079-2104(96)80156-9","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.01.024","article-title":"Histology of periapical lesions obtained during apical surgery","volume":"35","author":"Schulz M","year":"2009","unstructured":"Schulz M, von Arx T, Altermatt HJ, Bosshardt D. Histology of periapical lesions obtained during apical surgery. J Endod. 2009, 35:634-42. 10.1016\/j.joen.2009.01.024","journal-title":"J Endod"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(84)90267-6","article-title":"The relationship of lesion size to diagnosis, incidence, and treatment of periapical cysts and granulomas","volume":"57","author":"Natkin E","year":"1984","unstructured":"Natkin E, Oswald RJ, Carnes LI. The relationship of lesion size to diagnosis, incidence, and treatment of periapical cysts and granulomas. Oral Surg Oral Med Oral Pathol. 1984, 57:82-94. 10.1016\/0030-4220(84)90267-6","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"ref19","article-title":"Clinical outline of oral pathology: diagnosis and treatment","author":"Eversole LR","year":"1984","unstructured":"Eversole LR. Clinical outline of oral pathology: diagnosis and treatment. Lea and Febiger, Philadelphia, PA; 1984."},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1970.0236","article-title":"A new rationale for the management of periapical granulomas and cysts: an evaluation of histopathological and radiographic findings","volume":"80","author":"Lalonde ER","year":"1970","unstructured":"Lalonde ER. A new rationale for the management of periapical granulomas and cysts: an evaluation of histopathological and radiographic findings. J Am Dent Assoc. 1970, 80:1056-9. 10.14219\/jada.archive.1970.0236","journal-title":"J Am Dent Assoc"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(73)90292-2","article-title":"Electrophoretic differentiation of radicular cysts and granulomas","volume":"35","author":"Morse DR","year":"1973","unstructured":"Morse DR, Patnik JW, Schacterle GR. Electrophoretic differentiation of radicular cysts and granulomas. Oral Surg Oral Med Oral Pathol. 1973, 35:249-64. 10.1016\/0030-4220(73)90292-2","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.10.046","article-title":"Binary decision trees for preoperative periapical cyst screening using cone-beam computed tomography","volume":"43","author":"Pitcher B","year":"2017","unstructured":"Pitcher B, Alaqla A, Noujeim M, Wealleans JA, Kotsakis G, Chrepa V. Binary decision trees for preoperative periapical cyst screening using cone-beam computed tomography. J Endod. 2017, 43:383-8. 10.1016\/j.joen.2016.10.046","journal-title":"J Endod"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1249","article-title":"Management of large periapical cystic lesion by aspiration and nonsurgical endodontic therapy using calcium hydroxide paste","volume":"13","author":"Thomas K","year":"2012","unstructured":"Thomas K, T PD, Simon EP. Management of large periapical cystic lesion by aspiration and nonsurgical endodontic therapy using calcium hydroxide paste. J Contemp Dent Pract. 2012, 13:897-901. 10.5005\/jp-journals-10024-1249","journal-title":"J Contemp Dent Pract"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4477.2002.tb00399.x","article-title":"The periapical space--a dynamic interface","volume":"28","author":"Abbott PV","year":"2002","unstructured":"Abbott PV. The periapical space--a dynamic interface. Aust Endod J. 2002, 28:96-107. 10.1111\/j.1747-4477.2002.tb00399.x","journal-title":"Aust Endod J"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1991.tb00117.x","article-title":"The antimicrobial effect of calcium hydroxide as a short-term intracanal dressing","volume":"24","author":"Sj\u00f6gren U","year":"1991","unstructured":"Sj\u00f6gren U, Figdor D, Sp\u00e5ngberg L, Sundqvist G. The antimicrobial effect of calcium hydroxide as a short-term intracanal dressing. Int Endod J. 1991, 24:119-25. 10.1111\/j.1365-2591.1991.tb00117.x","journal-title":"Int Endod J"},{"key":"ref26","article-title":"An in vitro evaluation of environmental pH changes after root canal therapy with three different types of calcium hydroxide","volume":"7","author":"Javidi M","year":"2013","unstructured":"Javidi M, Zarei M, Afkhami F, Majdi LM. An in vitro evaluation of environmental pH changes after root canal therapy with three different types of calcium hydroxide. Eur J Dent. 2013, 7:69-73.","journal-title":"Eur J Dent"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.011","article-title":"Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing","volume":"101","author":"Choukroun J","year":"2006","unstructured":"Choukroun J, Diss A, Simonpieri A, et al.. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006, 101:e56-60. 10.1016\/j.tripleo.2005.07.011","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.10.016","article-title":"Second-generation platelet concentrate (platelet-rich fibrin) as a scaffold in regenerative endodontics: a case series","volume":"43","author":"Bakhtiar H","year":"2017","unstructured":"Bakhtiar H, Esmaeili S, Fakhr Tabatabayi S, Ellini MR, Nekoofar MH, Dummer PM. Second-generation platelet concentrate (platelet-rich fibrin) as a scaffold in regenerative endodontics: a case series. J Endod. 2017, 43:401-8. 10.1016\/j.joen.2016.10.016","journal-title":"J Endod"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_201_17","article-title":"Comparative evaluation of platelet count and antimicrobial efficacy of injectable platelet-rich fibrin with other platelet concentrates: an in vitro study","volume":"21","author":"Karde PA","year":"2017","unstructured":"Karde PA, Sethi KS, Mahale SA, Khedkar SU, Patil AG, Joshi CP. Comparative evaluation of platelet count and antimicrobial efficacy of injectable platelet-rich fibrin with other platelet concentrates: an in vitro study. J Indian Soc Periodontol. 2017, 21:97-101. 10.4103\/jisp.jisp_201_17","journal-title":"J Indian Soc Periodontol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246243","article-title":"Systematic comparison of the effect of four clinical-grade platelet rich hemoderivatives on osteoblast behaviour","volume":"20","author":"Fern\u00e1ndez-Medina T","year":"2019","unstructured":"Fern\u00e1ndez-Medina T, Vaquette C, Ivanovski S. Systematic comparison of the effect of four clinical-grade platelet rich hemoderivatives on osteoblast behaviour. Int J Mol Sci. 2019, 20:6243. 10.3390\/ijms20246243","journal-title":"Int J Mol Sci"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.21608\/dsu.2021.64004.1066","article-title":"Effect of injectable-platelet rich fibrin on marginal adaptation of bioactive materials used as direct pulp capping; an experimental animal study","volume":"2","author":"Mansour NK","year":"2021","unstructured":"Mansour NK, Sharraan M, Fayad D, Abdullah Hashem M. Effect of injectable-platelet rich fibrin on marginal adaptation of bioactive materials used as direct pulp capping; an experimental animal study. Dent Sci Updat. 2021, 2:185-95. 10.21608\/dsu.2021.64004.1066","journal-title":"Dent Sci Updat"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/191114-pioneering-periapical-healing-the-novel-synergy-of-mineral-trioxide-aggregate-and-injectable-platelet-rich-fibrin","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:09:08Z","timestamp":1707509348000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/191114-pioneering-periapical-healing-the-novel-synergy-of-mineral-trioxide-aggregate-and-injectable-platelet-rich-fibrin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,1]]},"references-count":31,"URL":"https:\/\/doi.org\/10.7759\/cureus.46341","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10,1]]}}}