{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:35:57Z","timestamp":1707525357477},"reference-count":42,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,7]]},"DOI":"10.7759\/cureus.46638","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T14:59:17Z","timestamp":1696690757000},"source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous Rupture of Hepatocellular Carcinoma With Fatal Outcome in a Patient Taking Direct-Acting Antivirals"],"prefix":"10.7759","author":[{"given":"Youness","family":"Dendane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghizlane","family":"Kharrasse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelkrim","family":"Zazour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajar","family":"Koulali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahi","family":"Ismaili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay J","year":"2010","unstructured":"Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010, 127:2893-917. 10.1002\/ijc.25516","journal-title":"Int J Cancer"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.014","article-title":"Hepatocellular carcinoma in cirrhosis: incidence and risk factors","volume":"127","author":"Fattovich G","year":"2004","unstructured":"Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology. 2004, 127:S35-50. 10.1053\/j.gastro.2004.09.014","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-001-8030-z","article-title":"Treatment of ruptured hepatocellular carcinoma","volume":"6","author":"Tanaka A","year":"2001","unstructured":"Tanaka A, Takeda R, Mukaihara S, et al.. Treatment of ruptured hepatocellular carcinoma. Int J Clin Oncol. 2001, 6:291-5. 10.1007\/s10147-001-8030-z","journal-title":"Int J Clin Oncol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.2.191","article-title":"Spontaneous rupture of hepatocellular carcinoma: a systematic review","volume":"141","author":"Lai EC","year":"2006","unstructured":"Lai EC, Lau WY. Spontaneous rupture of hepatocellular carcinoma: a systematic review. Arch Surg. 2006, 141:191-8. 10.1001\/archsurg.141.2.191","journal-title":"Arch Surg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.061","article-title":"Epidemiology of viral hepatitis and hepatocellular carcinoma","volume":"142","author":"El-Serag HB","year":"2012","unstructured":"El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 2012, 142:1264-73.e1. 10.1053\/j.gastro.2011.12.061","journal-title":"Gastroenterology"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung H","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021, 71:209-49. 10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i10.1221","article-title":"Management of ruptured hepatocellular carcinoma: implications for therapy","volume":"16","author":"Bassi N","year":"2010","unstructured":"Bassi N, Caratozzolo E, Bonariol L, et al.. Management of ruptured hepatocellular carcinoma: implications for therapy. World J Gastroenterol. 2010, 16:1221-5. 10.3748\/wjg.v16.i10.1221","journal-title":"World J Gastroenterol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2004.12.009","article-title":"Epidemiology of hepatocellular carcinoma","volume":"9","author":"Bosch FX","year":"2005","unstructured":"Bosch FX, Ribes J, Cl\u00e9ries R, D\u00edaz M. Epidemiology of hepatocellular carcinoma. Clin Liver Dis. 2005, 9:191-211, v. 10.1016\/j.cld.2004.12.009","journal-title":"Clin Liver Dis"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal A","year":"2011","unstructured":"Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011, 61:69-90. 10.3322\/caac.20107","journal-title":"CA Cancer J Clin"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2000.1001","article-title":"Spontaneous rupture of hepatocelluar carcinoma: surgical resection and long-term survival","volume":"26","author":"Vergara V","year":"2000","unstructured":"Vergara V, Muratore A, Bouzari H, Polastri R, Ferrero A, Galatola G, Capussotti L. Spontaneous rupture of hepatocelluar carcinoma: surgical resection and long-term survival. Eur J Surg Oncol. 2000, 26:770-2. 10.1053\/ejso.2000.1001","journal-title":"Eur J Surg Oncol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.02.033","article-title":"Spontaneous rupture of hepatocellular carcinoma: optimal timing of partial hepatectomy","volume":"45","author":"Wu JJ","year":"2019","unstructured":"Wu JJ, Zhu P, Zhang ZG, et al.. Spontaneous rupture of hepatocellular carcinoma: optimal timing of partial hepatectomy. Eur J Surg Oncol. 2019, 45:1887-94. 10.1016\/j.ejso.2019.02.033","journal-title":"Eur J Surg Oncol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001115","article-title":"Recurrence rate and overall survival of operated ruptured hepatocellular carcinomas","volume":"30","author":"Joliat GR","year":"2018","unstructured":"Joliat GR, Labgaa I, Uldry E, Demartines N, Halkic N. Recurrence rate and overall survival of operated ruptured hepatocellular carcinomas. Eur J Gastroenterol Hepatol. 2018, 30:792-6. 10.1097\/MEG.0000000000001115","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2018.19.12.3629","article-title":"Risk factors and prognosis of spontaneously ruptured hepatocellular carcinoma in Thailand","volume":"19","author":"Kerdsuknirun J","year":"2018","unstructured":"Kerdsuknirun J, Vilaichone V, Vilaichone RK. Risk factors and prognosis of spontaneously ruptured hepatocellular carcinoma in Thailand. Asian Pac J Cancer Prev. 2018, 19:3629-34. 10.31557\/APJCP.2018.19.12.3629","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.848903","article-title":"Ruptured hepatocellular carcinoma: current status of research","volume":"12","author":"Xia F","year":"2022","unstructured":"Xia F, Ndhlovu E, Zhang M, Chen X, Zhang B, Zhu P. Ruptured hepatocellular carcinoma: current status of research. Front Oncol. 2022, 12:848903. 10.3389\/fonc.2022.848903","journal-title":"Front Oncol"},{"key":"ref15","article-title":"Spontaneous rupture of hepatocellular carcinoma: a review of 172 Japanese cases","volume":"86","author":"Miyamoto M","year":"1991","unstructured":"Miyamoto M, Sudo T, Kuyama T. Spontaneous rupture of hepatocellular carcinoma: a review of 172 Japanese cases. Am J Gastroenterol. 1991, 86:67-71.","journal-title":"Am J Gastroenterol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800780424","article-title":"Management of bleeding liver tumours in Hong Kong","volume":"78","author":"Dewar GA","year":"1991","unstructured":"Dewar GA, Griffin SM, Ku KW, Lau WY, Li AK. Management of bleeding liver tumours in Hong Kong. Br J Surg. 1991, 78:463-6. 10.1002\/bjs.1800780424","journal-title":"Br J Surg"},{"key":"ref17","article-title":"Conservative management of spontaneous ruptured hepatocellular carcinoma","volume":"60","author":"Xu HS","year":"1994","unstructured":"Xu HS, Yan JB. Conservative management of spontaneous ruptured hepatocellular carcinoma. Am Surg. 1994, 60:629-33.","journal-title":"Am Surg"},{"key":"ref18","article-title":"Spontaneous rupture of primary hepatocellular carcinoma in Zaria, Nigeria","volume":"36","author":"Muhammad I","year":"1991","unstructured":"Muhammad I, Mabogunje O. Spontaneous rupture of primary hepatocellular carcinoma in Zaria, Nigeria. J R Coll Surg Edinb. 1991, 36:117-20.","journal-title":"J R Coll Surg Edinb"},{"key":"ref19","article-title":"Management of hepatocellular carcinoma","volume":"47","author":"Lau WY","year":"2002","unstructured":"Lau WY. Management of hepatocellular carcinoma. J R Coll Surg Edinb. 2002, 47:389-99.","journal-title":"J R Coll Surg Edinb"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198804000-00025","article-title":"Acute hemoperitoneum from rupture of a hepatocellular carcinoma","volume":"10","author":"Clarkston W","year":"1988","unstructured":"Clarkston W, Inciardi M, Kirkpatrick S, McEwen G, Ediger S, Schubert T. Acute hemoperitoneum from rupture of a hepatocellular carcinoma. J Clin Gastroenterol. 1988, 10:221-5. 10.1097\/00004836-198804000-00025","journal-title":"J Clin Gastroenterol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/s0009-9260(05)80129-1","article-title":"The role of hepatic arterial embolization in the management of ruptured hepatocellular carcinoma","volume":"48","author":"Corr P.","year":"1993","unstructured":"Corr P., Chan M., Lau W.Y., Metreweli C. The role of hepatic arterial embolization in the management of ruptured hepatocellular carcinoma. Clin Radiol. 1993, 48:163-5. 10.1016\/s0009-9260(05)80129-1","journal-title":"Clin Radiol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.17.3725","article-title":"Management of spontaneous rupture of hepatocellular carcinoma: single-center experience","volume":"19","author":"Liu CL","year":"2001","unstructured":"Liu CL, Fan ST, Lo CM, Tso WK, Poon RT, Lam CM, Wong J. Management of spontaneous rupture of hepatocellular carcinoma: single-center experience. J Clin Oncol. 2001, 19:3725-32. 10.1200\/JCO.2001.19.17.3725","journal-title":"J Clin Oncol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1023\/a:1005699132142","article-title":"Hemoperitoneum as a first manifestation of hepatocellular carcinoma in western patients with liver cirrhosis: effectiveness of emergency treatment with transcatheter arterial embolization","volume":"46","author":"Castells L","year":"2001","unstructured":"Castells L, Moreiras M, Quiroga S, Alvarez-Castells A, Segarra A, Esteban R, Guardia J. Hemoperitoneum as a first manifestation of hepatocellular carcinoma in western patients with liver cirrhosis: effectiveness of emergency treatment with transcatheter arterial embolization. Dig Dis Sci. 2001, 46:555-62. 10.1023\/a:1005699132142","journal-title":"Dig Dis Sci"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.158.6.1317090","article-title":"Rupture of hepatocellular carcinoma: predictive value of CT findings","volume":"158","author":"Kanematsu M","year":"1992","unstructured":"Kanematsu M, Imaeda T, Yamawaki Y, et al.. Rupture of hepatocellular carcinoma: predictive value of CT findings. AJR Am J Roentgenol. 1992, 158:1247-50. 10.2214\/ajr.158.6.1317090","journal-title":"AJR Am J Roentgenol"},{"key":"ref25","article-title":"Transcatheter arterial embolization for spontaneous rupture of hepatocellular carcinoma","volume":"81","author":"Hirai K","year":"1986","unstructured":"Hirai K, Kawazoe Y, Yamashita K, et al.. Transcatheter arterial embolization for spontaneous rupture of hepatocellular carcinoma. Am J Gastroenterol. 1986, 81:275-9.","journal-title":"Am J Gastroenterol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12498","article-title":"Spontaneous ruptured hepatocellular carcinoma","volume":"46","author":"Yoshida H","year":"2016","unstructured":"Yoshida H, Mamada Y, Taniai N, Uchida E. Spontaneous ruptured hepatocellular carcinoma. Hepatol Res. 2016, 46:13-21. 10.1111\/hepr.12498","journal-title":"Hepatol Res"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3983","article-title":"Transcatheter arterial embolization in the emergency department for hemodynamic instability due to ruptured hepatocellular carcinoma: analysis of 167 cases","volume":"191","author":"Kung CT","year":"2008","unstructured":"Kung CT, Liu BM, Ng SH, Lee TY, Cheng YF, Chen MC, Ko SF. Transcatheter arterial embolization in the emergency department for hemodynamic instability due to ruptured hepatocellular carcinoma: analysis of 167 cases. AJR Am J Roentgenol. 2008, 191:W231-9. 10.2214\/AJR.07.3983","journal-title":"AJR Am J Roentgenol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i28.4537","article-title":"Survival outcome of patients with spontaneously ruptured hepatocellular carcinoma treated surgically or by transarterial embolization","volume":"19","author":"Jin YJ","year":"2013","unstructured":"Jin YJ, Lee JW, Park SW, et al.. Survival outcome of patients with spontaneously ruptured hepatocellular carcinoma treated surgically or by transarterial embolization. World J Gastroenterol. 2013, 19:4537-44. 10.3748\/wjg.v19.i28.4537","journal-title":"World J Gastroenterol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1258\/ar.2010.100369","article-title":"Outcome and prognostic factors of spontaneous ruptured hepatocellular carcinoma treated with transarterial embolization","volume":"52","author":"Shin BS","year":"2011","unstructured":"Shin BS, Park MH, Jeon GS. Outcome and prognostic factors of spontaneous ruptured hepatocellular carcinoma treated with transarterial embolization. Acta Radiol. 2011, 52:331-5. 10.1258\/ar.2010.100369","journal-title":"Acta Radiol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.180.3.1651524","article-title":"Intraperitoneal hemorrhage from hepatocellular carcinoma: emergency chemoembolization or embolization","volume":"180","author":"Okazaki M","year":"1991","unstructured":"Okazaki M, Higashihara H, Koganemaru F, Nakamura T, Kitsuki H, Hoashi T, Makuuchi M. Intraperitoneal hemorrhage from hepatocellular carcinoma: emergency chemoembolization or embolization. Radiology. 1991, 180:647-51. 10.1148\/radiology.180.3.1651524","journal-title":"Radiology"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2014.04.003","article-title":"The Indian National Association for Study of the Liver (INASL) consensus on prevention, diagnosis and management of hepatocellular carcinoma in India: the Puri recommendations","volume":"4","author":"Kumar A","year":"2014","unstructured":"Kumar A, Acharya SK, Singh SP, et al.. The Indian National Association for Study of the Liver (INASL) consensus on prevention, diagnosis and management of hepatocellular carcinoma in India: the Puri recommendations. J Clin Exp Hepatol. 2014, 4:S3-S26. 10.1016\/j.jceh.2014.04.003","journal-title":"J Clin Exp Hepatol"},{"key":"ref32","article-title":"Radiofrequency ablation as a salvage procedure for ruptured hepatocellular carcinoma","volume":"50","author":"Ng KK","year":"2003","unstructured":"Ng KK, Lam CM, Poon RT, Law WL, Seto CL, Fan ST. Radiofrequency ablation as a salvage procedure for ruptured hepatocellular carcinoma. Hepatogastroenterology. 2003, 50:1641-3.","journal-title":"Hepatogastroenterology"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0337","article-title":"Radiofrequency ablation and microwave ablation in liver tumors: an update","volume":"24","author":"Izzo F","year":"2019","unstructured":"Izzo F, Granata V, Grassi R, et al.. Radiofrequency ablation and microwave ablation in liver tumors: an update. Oncologist. 2019, 24:e990-e1005. 10.1634\/theoncologist.2018-0337","journal-title":"Oncologist"},{"key":"ref34","unstructured":"Protocols and guidelines for adults undergoing deceased donor liver transplantation in the UK. (2017). Accessed. October 29, 2017: https:\/\/www.uptodate.com\/contents\/liver-transplantation-in-adults-deceased-donor-evaluation-and-selection#!."},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.008","article-title":"Unexpected high rate of early tumor recurrence in patients with HCV-related HCC undergoing interferon-free therapy","volume":"65","author":"Reig M","year":"2016","unstructured":"Reig M, Mari\u00f1o Z, Perell\u00f3 C, et al.. Unexpected high rate of early tumor recurrence in patients with HCV-related HCC undergoing interferon-free therapy. J Hepatol. 2016, 65:719-26. 10.1016\/j.jhep.2016.04.008","journal-title":"J Hepatol"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.06.015","article-title":"Early occurrence and recurrence of hepatocellular carcinoma in HCV-related cirrhosis treated with direct-acting antivirals","volume":"65","author":"Conti F","year":"2016","unstructured":"Conti F, Buonfiglioli F, Scuteri A, et al.. Early occurrence and recurrence of hepatocellular carcinoma in HCV-related cirrhosis treated with direct-acting antivirals. J Hepatol. 2016, 65:727-33. 10.1016\/j.jhep.2016.06.015","journal-title":"J Hepatol"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.045","article-title":"Lack of evidence of an effect of direct-acting antivirals on the recurrence of hepatocellular carcinoma: data from three ANRS cohorts","volume":"65","author":"ANRS collaborative study group on hepatocellular carcinoma (ANRS CO22 HEPATHER COCaCCcEaspaf","year":"2016","unstructured":"ANRS collaborative study group on hepatocellular carcinoma (ANRS CO22 HEPATHER COCaCCcEaspaf. Lack of evidence of an effect of direct-acting antivirals on the recurrence of hepatocellular carcinoma: data from three ANRS cohorts. J Hepatol. 2016, 65:734-40. 10.1016\/j.jhep.2016.05.045","journal-title":"J Hepatol"},{"key":"ref38","article-title":"Effect of interferonbased and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C","volume":"67","author":"Nagata H","year":"2017","unstructured":"Nagata H, Nakagawa M, Asahina Y, et al.. Effect of interferonbased and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C. C J Hepatol. 2017, 67:933-9.","journal-title":"C J Hepatol"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167934","article-title":"DAAs rapidly reduce infammation but increase serum VEGF level: a rationale for tumor risk during anti-HCV treatment","volume":"11","author":"Villani R","year":"2016","unstructured":"Villani R, Facciorusso A, Bellanti F, et al.. DAAs rapidly reduce infammation but increase serum VEGF level: a rationale for tumor risk during anti-HCV treatment. PLoS One. 2016, 11:e0167934. 10.1371\/journal.pone.0167934","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280111","article-title":"Expression of vascular endothelial growth factor in human hepatocellular carcinoma","volume":"28","author":"Yamaguchi R","year":"1998","unstructured":"Yamaguchi R, Yano H, Iemura A, Ogasawara S, Haramaki M, Kojiro M. Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatology. 1998, 28:68-77. 10.1002\/hep.510280111","journal-title":"Hepatology"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.03.004","article-title":"Successful interferon-free therapy of chronic hepatitis C virus infection normalizes natural killer cell function","volume":"149","author":"Serti E","year":"2015","unstructured":"Serti E, Chepa-Lotrea X, Kim YJ, et al.. Successful interferon-free therapy of chronic hepatitis C virus infection normalizes natural killer cell function. Gastroenterology. 2015, 149:190-200.e2. 10.1053\/j.gastro.2015.03.004","journal-title":"Gastroenterology"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv391","article-title":"Immunological analysis during interferon-free therapy for chronic hepatitis C virus infection reveals modulation of the natural killer cell compartment","volume":"213","author":"Spaan M","year":"2016","unstructured":"Spaan M, van Oord G, Kreefft K, et al.. Immunological analysis during interferon-free therapy for chronic hepatitis C virus infection reveals modulation of the natural killer cell compartment. J Infect Dis. 2016, 213:216-23. 10.1093\/infdis\/jiv391","journal-title":"J Infect Dis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/177905-spontaneous-rupture-of-hepatocellular-carcinoma-with-fatal-outcome-in-a-patient-taking-direct-acting-antivirals","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:07:52Z","timestamp":1707509272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/177905-spontaneous-rupture-of-hepatocellular-carcinoma-with-fatal-outcome-in-a-patient-taking-direct-acting-antivirals"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,7]]},"references-count":42,"URL":"https:\/\/doi.org\/10.7759\/cureus.46638","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10,7]]}}}