{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:45:34Z","timestamp":1792057534555,"version":"4.4.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,26]]},"DOI":"10.7759\/cureus.47696","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T07:09:07Z","timestamp":1698304147000},"source":"Crossref","is-referenced-by-count":4,"title":["The Potential Gastro-Protective Effect of Qaysum (Achillea fragrantissima) Against Ethanol-Induced Gastric Ulcer in Wistar Albino Rats"],"prefix":"10.7759","author":[{"given":"Thekra  B","family":"Alhejaily","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaenah  Z","family":"Alamri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima  S","family":"ALaryani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhayla H","family":"Shareef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-0949-z","article-title":"The gastro protective effects of Cibotium barometz hair on ethanol-induced gastric ulcer in Sprague-Dawley rats","volume":"13","author":"Al-Wajeeh NS","year":"2017","unstructured":"Al-Wajeeh NS, Hajerezaie M, Noor SM, et al.. The gastro protective effects of Cibotium barometz hair on ethanol-induced gastric ulcer in Sprague-Dawley rats. BMC Vet Res. 2017, 13:27. 10.1186\/s12917-017-0949-z","journal-title":"BMC Vet Res"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2019.1691584","article-title":"Protective effect of the solvent extracts of Portulacca oleracea against acidified ethanol induced gastric ulcer in rabbits","volume":"45","author":"Jan MS","year":"2022","unstructured":"Jan MS, Ahmad W, Abdullah, et al.. Protective effect of the solvent extracts of Portulacca oleracea against acidified ethanol induced gastric ulcer in rabbits. Drug Chem Toxicol. 2022, 45:301-10. 10.1080\/01480545.2019.1691584","journal-title":"Drug Chem Toxicol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1085580","article-title":"Gastroprotective activity of chloroform extract of Muntingia calabura and Melastoma malabathricum leaves","volume":"54","author":"Zakaria ZA","year":"2016","unstructured":"Zakaria ZA, Zainol AS, Sahmat A, et al.. Gastroprotective activity of chloroform extract of Muntingia calabura and Melastoma malabathricum leaves. Pharm Biol. 2016, 54:812-26. 10.3109\/13880209.2015.1085580","journal-title":"Pharm Biol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S107018","article-title":"The antiulcer effect of Cibotium barometz leaves in rats with experimentally induced acute gastric ulcer","volume":"11","author":"Al-Wajeeh NS","year":"2017","unstructured":"Al-Wajeeh NS, Hajrezaie M, Al-Henhena N, et al.. The antiulcer effect of Cibotium barometz leaves in rats with experimentally induced acute gastric ulcer. Drug Des Devel Ther. 2017, 11:995-1009. 10.2147\/DDDT.S107018","journal-title":"Drug Des Devel Ther"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/pr10071314","article-title":"Gastroprophylactic effects of p-cymene in ethanol-induced gastric ulcer in rats","volume":"10","author":"Shareef SH","year":"2022","unstructured":"Shareef SH, Al-Medhtiy MH, Ibrahim IAA, et al.. Gastroprophylactic effects of p-cymene in ethanol-induced gastric ulcer in rats. Processes. 2022, 10:1314. 10.3390\/pr10071314","journal-title":"Processes"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2020.03.004","article-title":"Characterization of secondary metabolites of leaf and stem essential oils of Achillea fragrantissima from central region of Saudi Arabia","volume":"13","author":"Khan M","year":"2020","unstructured":"Khan M, Khan M, Abdullah MM, Al-Wahaibi LH, Alkhathlan HZ. Characterization of secondary metabolites of leaf and stem essential oils of Achillea fragrantissima from central region of Saudi Arabia. Arab J Chem. 2020, 13:5254-61. 10.1016\/j.arabjc.2020.03.004","journal-title":"Arab J Chem"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2020.e00581","article-title":"Effect of habitat variations on the chemical composition, antioxidant, and antimicrobial activities of Achillea fragrantissima (Forssk) Sch. Bip","volume":"29","author":"Elsharkawy ER","year":"2021","unstructured":"Elsharkawy ER, Alghanem SM, Elmorsy E. Effect of habitat variations on the chemical composition, antioxidant, and antimicrobial activities of Achillea fragrantissima (Forssk) Sch. Bip. Biotechnol Rep (Amst). 2021, 29:e00581. 10.1016\/j.btre.2020.e00581","journal-title":"Biotechnol Rep (Amst)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5269074","article-title":"Potential protective effect of Achillea fragrantissima against adriamycin-induced cardiotoxicity in rats via an antioxidant and anti-inflammatory pathway","volume":"2019","author":"Hijazi MA","year":"2019","unstructured":"Hijazi MA, Jambi HA, Aljehany BM, Althaiban MA. Potential protective effect of Achillea fragrantissima against adriamycin-induced cardiotoxicity in rats via an antioxidant and anti-inflammatory pathway. Biomed Res Int. 2019, 2019:5269074. 10.1155\/2019\/5269074","journal-title":"Biomed Res Int"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6326452","article-title":"The efficacy of processing strategies on the gastroprotective potentiality of Chenopodium quinoa seeds","volume":"2020","author":"Mariod AA","year":"2020","unstructured":"Mariod AA, Salama SM. The efficacy of processing strategies on the gastroprotective potentiality of Chenopodium quinoa seeds. Sci World J. 2020, 2020:6326452. 10.1155\/2020\/6326452","journal-title":"Sci World J"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12060","article-title":"Animal models of acute gastric mucosal injury: macroscopic and microscopic evaluation","volume":"2","author":"Sim\u00f5es S","year":"2019","unstructured":"Sim\u00f5es S, Lopes R, Campos MC, Marruz MJ, da Cruz ME, Corvo L. Animal models of acute gastric mucosal injury: macroscopic and microscopic evaluation. Animal Model Exp Med. 2019, 2:121-6. 10.1002\/ame2.12060","journal-title":"Animal Model Exp Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121529","article-title":"Biochanin a gastroprotective effects in ethanol-induced gastric mucosal ulceration in rats","volume":"10","author":"Hajrezaie M","year":"2015","unstructured":"Hajrezaie M, Salehen N, Karimian H, et al.. Biochanin a gastroprotective effects in ethanol-induced gastric mucosal ulceration in rats. PLoS One. 2015, 10: e0145686. 10.1371\/journal.pone.0121529","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7656127","article-title":"Flavonoid-rich extract of Dissotis rotundifolia whole plant protects against ethanol-induced gastric mucosal damage","volume":"2020","author":"Adinortey MB","year":"2020","unstructured":"Adinortey MB, Ansah C, Aboagye B, Sarfo JK, Martey O, Nyarko AK. Flavonoid-rich extract of Dissotis rotundifolia whole plant protects against ethanol-induced gastric mucosal damage. Biochem Res Int. 2020, 2020:7656127. 10.1155\/2020\/7656127","journal-title":"Biochem Res Int"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2022.103506","article-title":"Hepatoprotective effect of pinostrobin against thioacetamide-induced liver cirrhosis in rats","volume":"30","author":"Shareef SH","year":"2023","unstructured":"Shareef SH, Al-Medhtiy MH, Al Rashdi AS, Aziz PY, Abdulla MA. Hepatoprotective effect of pinostrobin against thioacetamide-induced liver cirrhosis in rats. Saudi J Biol Sci. 2023, 30:103506. 10.1016\/j.sjbs.2022.103506","journal-title":"Saudi J Biol Sci"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-021-03189-z","article-title":"The global prevalence of peptic ulcer in the world: a systematic review and meta-analysis","volume":"84","author":"Salari N","year":"2022","unstructured":"Salari N, Darvishi N, Shohaimi S, Bartina Y, Ahmadipanah M, Salari HR, Mohammadi M. The global prevalence of peptic ulcer in the world: a systematic review and meta-analysis. Indian J Surg. 2022, 84:913-21. 10.1007\/s12262-021-03189-z","journal-title":"Indian J Surg"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750422585","article-title":"Long-term omeprazole treatment suppresses body weight gain and bone mineralization in young male rats","volume":"36","author":"Cui GL","year":"2001","unstructured":"Cui GL, Syversen U, Zhao CM, Chen D, Waldum HL. Long-term omeprazole treatment suppresses body weight gain and bone mineralization in young male rats. Scand J Gastroenterol. 2001, 36:1011-5. 10.1080\/003655201750422585","journal-title":"Scand J Gastroenterol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-014-0544-9","article-title":"Phytochemical composition, protective and therapeutic effect on gastric ulcer and \u03b1-amylase inhibitory activity of Achillea biebersteinii Afan","volume":"39","author":"Abd-Alla HI","year":"2016","unstructured":"Abd-Alla HI, Shalaby NM, Hamed MA, El-Rigal NS, Al-Ghamdi SN, Bouajila J. Phytochemical composition, protective and therapeutic effect on gastric ulcer and \u03b1-amylase inhibitory activity of Achillea biebersteinii Afan. Arch Pharm Res. 2016, 39:10-20. 10.1007\/s12272-014-0544-9","journal-title":"Arch Pharm Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(14)60065-1","article-title":"Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats","volume":"7","author":"Gao W","year":"2014","unstructured":"Gao W, Li HY, Wang LX, et al.. Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats. Asian Pac J Trop Med. 2014, 7:402-6. 10.1016\/S1995-7645(14)60065-1","journal-title":"Asian Pac J Trop Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2015.02.009","article-title":"Evaluation of the anti-inflammatory, analgesic and anti-ulcerogenic potentials of Achillea fragrantissima (Forssk.)","volume":"98","author":"Abdel-Rahman R","year":"2015","unstructured":"Abdel-Rahman R, Alqasoumi S, El-Desoky A, Soliman GA, Par\u00e9 PW, Hegazy ME. Evaluation of the anti-inflammatory, analgesic and anti-ulcerogenic potentials of Achillea fragrantissima (Forssk.). S Afr J Bot. 2015, 98:122-7. 10.1016\/j.sajb.2015.02.009","journal-title":"S Afr J Bot"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060763","article-title":"Amelioration of ethanol-induced gastric ulcers in rats pretreated with phycobiliproteins of Arthrospira (Spirulina) maxima","volume":"10","author":"Guzm\u00e1n-G\u00f3mez O","year":"2018","unstructured":"Guzm\u00e1n-G\u00f3mez O, Garc\u00eda-Rodr\u00edguez RV, Quevedo-Corona L, et al.. Amelioration of ethanol-induced gastric ulcers in rats pretreated with phycobiliproteins of Arthrospira (Spirulina) maxima. Nutrients. 2018, 10:763. 10.3390\/nu10060763","journal-title":"Nutrients"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.18502\/pbr.v5i1.761","article-title":"The protective effect of curcumin against aluminum chloride-induced oxidative stress and hepatotoxicity in rats","volume":"5","author":"Cheraghi E","year":"2019","unstructured":"Cheraghi E, Roshanaei K. The protective effect of curcumin against aluminum chloride-induced oxidative stress and hepatotoxicity in rats. Pharm Biomed Res. 2019, 5:10.18502\/pbr.v5i1.761","journal-title":"Pharm Biomed Res"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.12944\/CRNFSJ.10.2.27","article-title":"In vivo immune study of Achillea fragrantissima extract versus Echinaid and Endoxan in Wistar rats","volume":"10","author":"Alhomaid RM","year":"2022","unstructured":"Alhomaid RM, Alharbi YM, Algheshairy RM, Almujaydil MS, Alharbi HS, Ali, HA. In vivo immune study of Achillea fragrantissima extract versus Echinaid and Endoxan in Wistar rats. Curr Res Nutr Food Sci. 2022, 10:733-48. 10.12944\/CRNFSJ.10.2.27","journal-title":"Curr Res Nutr Food Sci"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216737","article-title":"Prodigiosins from a marine sponge-associated actinomycete attenuate HCl\/ethanol-induced gastric lesion via antioxidant and anti-inflammatory mechanisms","volume":"14","author":"Abdelfattah MS","year":"2019","unstructured":"Abdelfattah MS, Elmallah MI, Ebrahim HY, Almeer RS, Eltanany RM, Abdel Moneim AE. Prodigiosins from a marine sponge-associated actinomycete attenuate HCl\/ethanol-induced gastric lesion via antioxidant and anti-inflammatory mechanisms. PLoS One. 2019, 14:e0216737. 10.1371\/journal.pone.0216737","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3390\/ph15070782","article-title":"Omeprazole prevents colistin-induced nephrotoxicity in rats: emphasis on oxidative stress, inflammation, apoptosis and colistin accumulation in kidneys","volume":"15","author":"Nasrullah MZ","year":"2022","unstructured":"Nasrullah MZ, Eljaaly K, Neamatallah T, Fahmy UA, Alamoudi AJ, Bakhsh HT, Abdel-Naim AB. Omeprazole prevents colistin-induced nephrotoxicity in rats: emphasis on oxidative stress, inflammation, apoptosis and colistin accumulation in kidneys. Pharmaceuticals (Basel). 2022, 15:782. 10.3390\/ph15070782","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113550","article-title":"Effect of nano silver on gastroprotective activity against ethanol-induced stomach ulcer in rats","volume":"154","author":"Ibrahim IA","year":"2022","unstructured":"Ibrahim IA, Hussein AI, Muter MS, et al.. Effect of nano silver on gastroprotective activity against ethanol-induced stomach ulcer in rats. Biomed Pharmacother. 2022, 154:113550. 10.1016\/j.biopha.2022.113550","journal-title":"Biomed Pharmacother"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.05.035","article-title":"Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice","volume":"272","author":"Li W","year":"2013","unstructured":"Li W, Huang H, Niu X, Fan T, Mu Q, Li H. Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice. Toxicol Appl Pharmacol. 2013, 272:21-9. 10.1016\/j.taap.2013.05.035","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1021\/jf2003267","article-title":"Gastroprotective and ulcer-healing mechanisms of ellagic acid in experimental rats","volume":"59","author":"Beserra AM","year":"2011","unstructured":"Beserra AM, Calegari PI, Souza Mdo C, et al.. Gastroprotective and ulcer-healing mechanisms of ellagic acid in experimental rats. J Agric Food Chem. 2011, 59:6957-65. 10.1021\/jf2003267","journal-title":"J Agric Food Chem"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/pr10081613","article-title":"Histopathological evaluation of Annona muricata in TAA-induced liver injury in rats","volume":"10","author":"Al-Medhtiy MH","year":"2022","unstructured":"Al-Medhtiy MH, Jabbar AA, Shareef SH, Ibrahim IA, Alzahrani AR, Abdulla MA. Histopathological evaluation of Annona muricata in TAA-induced liver injury in rats. Processes. 2022, 10:1613. 10.3390\/pr10081613","journal-title":"Processes"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9968112","article-title":"Gastroprotective effect of myricetin on ethanol-induced acute gastric injury in rats","volume":"2021","author":"Park HS","year":"2021","unstructured":"Park HS, Seo CS, Baek EB, Rho JH, Won YS, Kwun HJ. Gastroprotective effect of myricetin on ethanol-induced acute gastric injury in rats. Evid Based Complement Alternat Med. 2021, 2021:9968112. 10.1155\/2021\/9968112","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.24086\/cuesj.v6n2y2022.pp68-75","article-title":"Green synthesis of gold nanoparticles using Zingiber officinale rhizomes aqueous extract and its gastroprotective activity against ethanol-produced stomach ulcer in rodents","volume":"6","author":"Shareef SH","year":"2022","unstructured":"Shareef SH, Hadi IN, Badeea MA, Abdulla MA. Green synthesis of gold nanoparticles using Zingiber officinale rhizomes aqueous extract and its gastroprotective activity against ethanol-produced stomach ulcer in rodents. CUESJ. 2022, 6:68-75. 10.24086\/cuesj.v6n2y2022.pp68-75","journal-title":"CUESJ"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.03.011","article-title":"Safety and antiulcer efficacy studies of Achillea millefolium L. after chronic treatment in Wistar rats","volume":"107","author":"Cavalcanti AM","year":"2006","unstructured":"Cavalcanti AM, Baggio CH, Freitas CS, et al.. Safety and antiulcer efficacy studies of Achillea millefolium L. after chronic treatment in Wistar rats. J Ethnopharmacol. 2006, 107:277-84. 10.1016\/j.jep.2006.03.011","journal-title":"J Ethnopharmacol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/194724-the-potential-gastro-protective-effect-of-qaysum-achillea-fragrantissima-against-ethanol-induced-gastric-ulcer-in-wistar-albino-rats","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:07:53Z","timestamp":1707509273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/194724-the-potential-gastro-protective-effect-of-qaysum-achillea-fragrantissima-against-ethanol-induced-gastric-ulcer-in-wistar-albino-rats"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,26]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.47696","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10,26]]}}}