{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:22:35Z","timestamp":1785288155992,"version":"3.55.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,23]]},"DOI":"10.7759\/cureus.49297","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T14:55:21Z","timestamp":1700751321000},"source":"Crossref","is-referenced-by-count":3,"title":["Impact of miR-155 rs767649 Polymorphism on Rheumatoid Arthritis Activity in Egyptian Patients"],"prefix":"10.7759","author":[{"given":"Mohamed  A","family":"Elghouneimy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa A","family":"Ramadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enas A","family":"Farrag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan F","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seham K","family":"Khirala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Seliem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammar A","family":"Kasim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman M","family":"Moazen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa A","family":"Attia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten I","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya A","family":"Ghamry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.12.009","article-title":"The environment, geo-epidemiology, and autoimmune disease: rheumatoid arthritis","volume":"35","author":"Tob\u00f3n GJ","year":"2010","unstructured":"Tob\u00f3n GJ, Youinou P, Saraux A. The environment, geo-epidemiology, and autoimmune disease: rheumatoid arthritis. J Autoimmun. 2010, 35:10-4. 10.1016\/j.jaut.2009.12.009","journal-title":"J Autoimmun"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3204","article-title":"PTPN22 gene polymorphism and susceptibility to rheumatoid arthritis (RA): updated systematic review and meta-analysis","volume":"22","author":"Abbasifard M","year":"2020","unstructured":"Abbasifard M, Imani D, Bagheri-Hosseinabadi Z. PTPN22 gene polymorphism and susceptibility to rheumatoid arthritis (RA): updated systematic review and meta-analysis. J Gene Med. 2020, 22:e3204. 10.1002\/jgm.3204","journal-title":"J Gene Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha D","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, et al.. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010, 62:2569-81. 10.1002\/art.27584","journal-title":"Arthritis Rheum"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.669382","article-title":"Implications the role of miR-155 in the pathogenesis of autoimmune diseases","volume":"12","author":"Pashangzadeh S","year":"2021","unstructured":"Pashangzadeh S, Motallebnezhad M, Vafashoar F, Khalvandi A, Mojtabavi N. Implications the role of miR-155 in the pathogenesis of autoimmune diseases. Front Immunol. 2021, 12:10.3389\/fimmu.2021.669382","journal-title":"Front Immunol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.05.020","article-title":"MiRNAs: dynamic regulators of immune cell functions in inflammation and cancer","volume":"431","author":"Hirschberger S","year":"2018","unstructured":"Hirschberger S, Hinske LC, Kreth S. MiRNAs: dynamic regulators of immune cell functions in inflammation and cancer. Cancer Lett. 2018, 431:11-21. 10.1016\/j.canlet.2018.05.020","journal-title":"Cancer Lett"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2019.1599716","article-title":"MicroRNAs in rheumatoid arthritis: what is the latest with regards to diagnostics?","volume":"19","author":"Huang RY","year":"2019","unstructured":"Huang RY, Wu JQ, Liu ZH, Sun SL. MicroRNAs in rheumatoid arthritis: what is the latest with regards to diagnostics?. Expert Rev Mol Diagn. 2019, 19:363-6. 10.1080\/14737159.2019.1599716","journal-title":"Expert Rev Mol Diagn"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.32.4.324","article-title":"Plasma MicroRNAs (miR-146a, miR-103a, and miR-155) as potential biomarkers for rheumatoid arthritis (RA) and disease activity in Iranian patients","volume":"32","author":"Bagheri-Hosseinabadi Z","year":"2021","unstructured":"Bagheri-Hosseinabadi Z, Mirzaei MR, Hajizadeh MR, Asadi F, Rezaeian M, Abbasifard M. Plasma MicroRNAs (miR-146a, miR-103a, and miR-155) as potential biomarkers for rheumatoid arthritis (RA) and disease activity in Iranian patients. Mediterr J Rheumatol. 2021, 32:324-30. 10.31138\/mjr.32.4.324","journal-title":"Mediterr J Rheumatol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2005.01.005","article-title":"SNP discovery in associating genetic variation with human disease phenotypes","volume":"573","author":"Suh Y","year":"2005","unstructured":"Suh Y, Vijg J. SNP discovery in associating genetic variation with human disease phenotypes. Mutat Res. 2005, 573:41-53. 10.1016\/j.mrfmmm.2005.01.005","journal-title":"Mutat Res"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33236","article-title":"Single nucleotide polymorphism associated with nonsyndromic cleft palate influences the processing of miR-140","volume":"152A","author":"Li L","year":"2010","unstructured":"Li L, Meng T, Jia Z, Zhu G, Shi B. Single nucleotide polymorphism associated with nonsyndromic cleft palate influences the processing of miR-140. Am J Med Genet A. 2010, 152A:856-62. 10.1002\/ajmg.a.33236","journal-title":"Am J Med Genet A"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm062","article-title":"Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA","volume":"16","author":"Duan R","year":"2007","unstructured":"Duan R, Pak C, Jin P. Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA. Hum Mol Genet. 2007, 16:1124-31. 10.1093\/hmg\/ddm062","journal-title":"Hum Mol Genet"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes279","article-title":"ACR\/EULAR 2010 rheumatoid arthritis classification criteria","volume":"51 Suppl 6","author":"Kay J","year":"2012","unstructured":"Kay J, Upchurch KS. ACR\/EULAR 2010 rheumatoid arthritis classification criteria. Rheumatology (Oxford). 2012, 51 Suppl 6:vi5-9. 10.1093\/rheumatology\/kes279","journal-title":"Rheumatology (Oxford)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2174\/187221511794839264","article-title":"Human DNA extraction methods: patents and applications","volume":"5","author":"Carpi FM","year":"2011","unstructured":"Carpi FM, Di Pietro F, Vincenzetti S, Mignini F, Napolioni V. Human DNA extraction methods: patents and applications. Recent Pat DNA Gene Seq. 2011, 5:1-7. 10.2174\/187221511794839264","journal-title":"Recent Pat DNA Gene Seq"},{"key":"ref13","article-title":"The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression","volume":"14","author":"Overbergh L","year":"2003","unstructured":"Overbergh L, Giulietti A, Valckx D, Decallonne R, Bouillon R, Mathieu C. The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression. J Biomol Tech. 2003, 14:33-43.","journal-title":"J Biomol Tech"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102400","article-title":"The etiology of rheumatoid arthritis","volume":"110","author":"Scherer HU","year":"2020","unstructured":"Scherer HU, H\u00e4upl T, Burmester GR. The etiology of rheumatoid arthritis. J Autoimmun. 2020, 110:102400. 10.1016\/j.jaut.2019.102400","journal-title":"J Autoimmun"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.02.005","article-title":"The role of microRNA in rheumatoid arthritis and other autoimmune diseases","volume":"136","author":"Furer V","year":"2010","unstructured":"Furer V, Greenberg JD, Attur M, Abramson SB, Pillinger MH. The role of microRNA in rheumatoid arthritis and other autoimmune diseases. Clin Immunol. 2010, 136:1-15. 10.1016\/j.clim.2010.02.005","journal-title":"Clin Immunol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4103\/jrms.jrms_960_21","article-title":"miR-155 rs767649 T>A gene polymorphism is associated with downregulation of miR-155 expression, suppressor of cytokine signaling-1 overexpression, and low probability of metastatic tumor at the time of breast cancer diagnosis","volume":"28","author":"Iranparast S","year":"2023","unstructured":"Iranparast S, Tahmasebi-Birgani M, Motamedfar A, Amari A, Ghafourian M. miR-155 rs767649 T>A gene polymorphism is associated with downregulation of miR-155 expression, suppressor of cytokine signaling-1 overexpression, and low probability of metastatic tumor at the time of breast cancer diagnosis. J Res Med Sci. 2023, 28:32. 10.4103\/jrms.jrms_960_21","journal-title":"J Res Med Sci"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/biology12030458","article-title":"Potential impact of polymorphisms in toll-like receptors 2, 3, 4, 7, 9, miR-146a, miR-155, and miR-196a genes on osteoarthritis susceptibility","volume":"12","author":"Stefik D","year":"2023","unstructured":"Stefik D, Vranic V, Ivkovic N, et al.. Potential impact of polymorphisms in toll-like receptors 2, 3, 4, 7, 9, miR-146a, miR-155, and miR-196a genes on osteoarthritis susceptibility. Biology (Basel). 2023, 12:10.3390\/biology12030458","journal-title":"Biology (Basel)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2022.06.030","article-title":"Serum sulfatide as a biomarker of carotid atherosclerosis in patients with rheumatoid arthritis","volume":"534","author":"Li J","year":"2022","unstructured":"Li J, Yin L, Qi X, Huang Y. Serum sulfatide as a biomarker of carotid atherosclerosis in patients with rheumatoid arthritis. Clin Chim Acta. 2022, 534:6-13. 10.1016\/j.cca.2022.06.030","journal-title":"Clin Chim Acta"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1303006","article-title":"Therapies for active rheumatoid arthritis after methotrexate failure","volume":"369","author":"O'Dell JR","year":"2013","unstructured":"O'Dell JR, Mikuls TR, Taylor TH, et al.. Therapies for active rheumatoid arthritis after methotrexate failure. N Engl J Med. 2013, 369:307-18. 10.1056\/NEJMoa1303006","journal-title":"N Engl J Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31491-5","article-title":"Novel treatment strategies in rheumatoid arthritis","volume":"389","author":"Burmester G","year":"2017","unstructured":"Burmester G, Pope J. Novel treatment strategies in rheumatoid arthritis. Lancet. 2017, 389:2338-48. 10.1016\/S0140-6736(17)31491-5","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210708","article-title":"Safety of synthetic and biological DMARDs: a systematic literature review informing the 2016 update of the EULAR recommendations for management of rheumatoid arthritis","volume":"76","author":"Ramiro S","year":"2017","unstructured":"Ramiro S, Sepriano A, Chatzidionysiou K, et al.. Safety of synthetic and biological DMARDs: a systematic literature review informing the 2016 update of the EULAR recommendations for management of rheumatoid arthritis. Ann Rheum Dis. 2017, 76:1101-36. 10.1136\/annrheumdis-2016-210708","journal-title":"Ann Rheum Dis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/207625-impact-of-mir-155-rs767649-polymorphism-on-rheumatoid-arthritis-activity-in-egyptian-patients","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:10:43Z","timestamp":1707509443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/207625-impact-of-mir-155-rs767649-polymorphism-on-rheumatoid-arthritis-activity-in-egyptian-patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"references-count":21,"URL":"https:\/\/doi.org\/10.7759\/cureus.49297","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,23]]}}}