{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:09:13Z","timestamp":1784610553530,"version":"3.55.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,26]]},"DOI":"10.7759\/cureus.49437","type":"journal-article","created":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T15:43:01Z","timestamp":1701013381000},"source":"Crossref","is-referenced-by-count":8,"title":["Implications of Gene Therapy in Dentistry and Periodontics: A Narrative Review"],"prefix":"10.7759","author":[{"given":"Arpit","family":"Barhate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unnati","family":"Shirbhate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Reche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Pahade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritiksha","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198011273032211","article-title":"Sounding boards. The potentials of inserting new genetic information","volume":"303","author":"Mercola KE","year":"1980","unstructured":"Mercola KE, Cline MJ. Sounding boards. The potentials of inserting new genetic information. N Engl J Med. 1980, 303:1297-300. 10.1056\/NEJM198011273032211","journal-title":"N Engl J Med"},{"key":"ref2","article-title":"Human gene therapy: a brief overview of the genetic revolution","volume":"61","author":"Sanjukta M","year":"2013","unstructured":"Sanjukta M. Human gene therapy: a brief overview of the genetic revolution. J Assoc Physicians India. 2013, 61:127-33.","journal-title":"J Assoc Physicians India"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-409x(00)00057-0","article-title":"Gene therapy approaches for modulating bone regeneration","volume":"42","author":"Winn SR","year":"2000","unstructured":"Winn SR, Hu Y, Sfeir C, Hollinger JO. Gene therapy approaches for modulating bone regeneration. Adv Drug Deliv Rev. 2000, 42:121-38. 10.1016\/s0169-409x(00)00057-0","journal-title":"Adv Drug Deliv Rev"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2002.0019","article-title":"The impact of gene therapy on dentistry: a revisiting after six years","volume":"133","author":"Baum BJ","year":"2002","unstructured":"Baum BJ, Kok M, Tran SD, Yamano S. The impact of gene therapy on dentistry: a revisiting after six years. J Am Dent Assoc. 2002, 133:35-44. 10.14219\/jada.archive.2002.0019","journal-title":"J Am Dent Assoc"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5005\/jcdp-7-3-83","article-title":"Gene therapy in periodontics: a review and future implications","volume":"7","author":"Karthikeyan BV","year":"2006","unstructured":"Karthikeyan BV, Pradeep AR. Gene therapy in periodontics: a review and future implications. J Contemp Dent Pract. 2006, 7:83-91. 10.5005\/jcdp-7-3-83","journal-title":"J Contemp Dent Pract"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1994.tb00020.x","article-title":"Microbial etiological agents of destructive periodontal diseases","volume":"5","author":"Haffajee AD","year":"1994","unstructured":"Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000. 1994, 5:78-111. 10.1111\/j.1600-0757.1994.tb00020.x","journal-title":"Periodontol 2000"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00189.x","article-title":"The pathogenesis of human periodontitis: an introduction","volume":"14","author":"Page RC","year":"1997","unstructured":"Page RC, Kornman KS. The pathogenesis of human periodontitis: an introduction. Periodontol 2000. 1997, 14:9-11. 10.1111\/j.1600-0757.1997.tb00189.x","journal-title":"Periodontol 2000"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/003591576505800503","article-title":"The environment and disease: association or causation?","volume":"58","author":"HI AB","year":"1965","unstructured":"HI AB. The environment and disease: association or causation?. Proc R Soc Med. 1965, 58:295-300. 10.1177\/003591576505800503","journal-title":"Proc R Soc Med"},{"key":"ref9","article-title":"Risk factors and risk indicators of destructive periodontitis. II. Genetic risk factors (literature review) [Article in Hungarian]","volume":"97","author":"Gera I","year":"2004","unstructured":"Gera I. Risk factors and risk indicators of destructive periodontitis. II. Genetic risk factors (literature review) [Article in Hungarian]. Fogorv Sz. 2004, 97:59-67.","journal-title":"Fogorv Sz"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.03.137","article-title":"History of gene therapy","volume":"525","author":"Wirth T","year":"2013","unstructured":"Wirth T, Parker N, Yl\u00e4-Herttuala S. History of gene therapy. Gene. 2013, 525:162-9. 10.1016\/j.gene.2013.03.137","journal-title":"Gene"},{"key":"ref11","unstructured":"Science history institute. (2023). Accessed. 10 Nov, 2023: https:\/\/www.sciencehistory.org\/education\/scientific-biographies\/james-watson-francis-crick-maurice-wilkins-and-rosali...."},{"key":"ref12","unstructured":"Science History Institute. Herbert W Boyer and Stanley N Cohen. (2023). Accessed. 10 Nov, 2023: https:\/\/www.sciencehistory.org\/education\/scientific-biographies\/herbert-w-boyer-and-stanley-n-cohen\/."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1126\/science.7302590","article-title":"Cline loses two NIH grants","volume":"214","author":"Sun M","year":"1981","unstructured":"Sun M. Cline loses two NIH grants. Science. 1981, 214:1220. 10.1126\/science.7302590","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2013.2524","article-title":"Historical perspectives pertaining to the NIH Recombinant DNA Advisory Committee","volume":"25","author":"Wivel NA","year":"2014","unstructured":"Wivel NA. Historical perspectives pertaining to the NIH Recombinant DNA Advisory Committee. Hum Gene Ther. 2014, 25:19-24. 10.1089\/hum.2013.2524","journal-title":"Hum Gene Ther"},{"key":"ref15","unstructured":"Results from the first human gene therapy clinical trial. (1995). https.\/\/www.genome.gov\/10000521\/1995-release-first-human-gene-therapy-results."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5259.263","article-title":"In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector","volume":"272","author":"Naldini L","year":"1996","unstructured":"Naldini L, Bl\u00f6mer U, Gallay P, et al.. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 1996, 272:263-7. 10.1126\/science.272.5259.263","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0106-0","article-title":"Clinical use of lentiviral vectors","volume":"32","author":"Milone MC","year":"2018","unstructured":"Milone MC, O'Doherty U. Clinical use of lentiviral vectors. Leukemia. 2018, 32:1529-41. 10.1038\/s41375-018-0106-0","journal-title":"Leukemia"},{"key":"ref18","article-title":"Death but one unintended consequence of gene-therapy trial","volume":"164","author":"Sibbald B","year":"2001","unstructured":"Sibbald B. Death but one unintended consequence of gene-therapy trial. Can Med Assoc J. 2001, 164:1612.","journal-title":"Can Med Assoc J"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35700DS1","article-title":"Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1","volume":"118","author":"Hacein-Bey-Abina S","year":"2008","unstructured":"Hacein-Bey-Abina S, Garrigue A, Wang GP, et al.. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest. 2008, 118:3132-42. 10.1172\/JCI35700DS1","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-019-03716-9","article-title":"Gene therapy arrives: after false starts, drugs that manipulate the code of life are finally changing lives","volume":"576","author":"Daley J","year":"2019","unstructured":"Daley J. Gene therapy arrives: after false starts, drugs that manipulate the code of life are finally changing lives\r\n. Nature. 2019, 576:12-3. 10.1038\/d41586-019-03716-9","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0339-9","article-title":"Alipogene tiparvovec: a review of its use in adults with familial lipoprotein lipase deficiency","volume":"75","author":"Scott LJ","year":"2015","unstructured":"Scott LJ. Alipogene tiparvovec: a review of its use in adults with familial lipoprotein lipase deficiency. Drugs. 2015, 75:175-82. 10.1007\/s40265-014-0339-9","journal-title":"Drugs"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1126\/science.1225829","article-title":"A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity","volume":"337","author":"Jinek M","year":"2012","unstructured":"Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science. 2012, 337:816-21. 10.1126\/science.1225829","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201707573","article-title":"Gene therapy for ADA-SCID, the first marketing approval of an ex\u00a0vivo gene therapy in Europe: paving the road for the next generation of advanced therapy medicinal products","volume":"9","author":"Aiuti A","year":"2017","unstructured":"Aiuti A, Roncarolo MG, Naldini L. Gene therapy for ADA-SCID, the first marketing approval of an ex\u00a0vivo gene therapy in Europe: paving the road for the next generation of advanced therapy medicinal products. EMBO Mol Med. 2017, 9:737-40. 10.15252\/emmm.201707573","journal-title":"EMBO Mol Med"},{"key":"ref24","unstructured":"US food and drug administration. FDA approves novel gene therapy to treat patients with a rare. (2017). Accessed: 10 November 2023: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-novel-gene-therapy-treat-patients-rare-form-inherite...."},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1021\/cen-09602-bus2","article-title":"CRISPR is coming to the clinic this year","volume":"96","author":"Cross R","year":"20118","unstructured":"Cross R. CRISPR is coming to the clinic this year. Chem Eng News. 20118, 96:18-9. 10.1021\/cen-09602-bus2","journal-title":"Chem Eng News"},{"key":"ref26","unstructured":"US food and drug administration. FDA continues strong support of innovation in development of of gene therapy products. (2020). Accessed: 10 Nov, 2023: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-continues-strong-support-innovation-development-gene-therapy-...."},{"key":"ref27","unstructured":"Human genome project information. (2023). Accessed. 10 Nov, 2023: http:\/\/http\/\/www.genomics.energy.gov."},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb13908.x","article-title":"The maturation of human gene therapy","volume":"85","author":"Friedmann T","year":"1996","unstructured":"Friedmann T. The maturation of human gene therapy. Acta Paediatr. 1996, 85:1261-5. 10.1111\/j.1651-2227.1996.tb13908.x","journal-title":"Acta Paediatr"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.113062","article-title":"Gene therapy in periodontics","volume":"17","author":"Chatterjee A","year":"2013","unstructured":"Chatterjee A, Singh N, Saluja M. Gene therapy in periodontics. J Indian Soc Periodontol. 2013, 17:156-61. 10.4103\/0972-124X.113062","journal-title":"J Indian Soc Periodontol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1995.0143","article-title":"The impact of gene therapy on dentistry","volume":"126","author":"Baum BJ","year":"1995","unstructured":"Baum BJ, O'Connell BC. The impact of gene therapy on dentistry. J Am Dent Assoc. 1995, 126:179-89. 10.14219\/jada.archive.1995.0143","journal-title":"J Am Dent Assoc"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302511","article-title":"Gene therapy progress and prospects: targeted gene repair","volume":"12","author":"Parekh-Olmedo H","year":"2005","unstructured":"Parekh-Olmedo H, Ferrara L, Brachman E, Kmiec EB. Gene therapy progress and prospects: targeted gene repair. Gene Ther. 2005, 12:639-46. 10.1038\/sj.gt.3302511","journal-title":"Gene Ther"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.5.5.663","article-title":"Gene therapy for Parkinson's disease using recombinant adeno-associated viral vectors","volume":"5","author":"Muramatsu S","year":"2005","unstructured":"Muramatsu S, Tsukada H, Nakano I, Ozawa K. Gene therapy for Parkinson's disease using recombinant adeno-associated viral vectors. Expert Opin Biol Ther. 2005, 5:663-71. 10.1517\/14712598.5.5.663","journal-title":"Expert Opin Biol Ther"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1126\/science.1129003","article-title":"Cancer regression in patients after transfer of genetically engineered lymphocytes","volume":"314","author":"Morgan RA","year":"2006","unstructured":"Morgan RA, Dudley ME, Wunderlich JR, et al.. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science. 2006, 314:126-9. 10.1126\/science.1129003","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1088","article-title":"Gene therapy and its implications in dentistry","volume":"4","author":"Prabhakar AR","year":"2011","unstructured":"Prabhakar AR, Paul JM, Basappa N. Gene therapy and its implications in dentistry. Int J Clin Pediatr Dent. 2011, 4:85-92. 10.5005\/jp-journals-10005-1088","journal-title":"Int J Clin Pediatr Dent"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2006.tb00287.x","article-title":"Tissue engineering of bone: the reconstructive surgeon's point of view","volume":"10","author":"Kneser U","year":"2006","unstructured":"Kneser U, Schaefer DJ, Polykandriotis E, Horch RE. Tissue engineering of bone: the reconstructive surgeon's point of view. J Cell Mol Med. 2006, 10:7-19. 10.1111\/j.1582-4934.2006.tb00287.x","journal-title":"J Cell Mol Med"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-015-0030-6","article-title":"Oral tissue engineering progress and challenges","volume":"12","author":"Zafar MS","year":"2015","unstructured":"Zafar MS, Khurshid Z, Almas K . Oral tissue engineering progress and challenges. Tissue Eng Reg Med. 2015, 12:387-97. 10.1007\/s13770-015-0030-6","journal-title":"Tissue Eng Reg Med"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4644(20000901)78:3<476::aid-jcb12>3.0.co;2-5","article-title":"Gene therapy for bone formation: in vitro and in vivo osteogenic activity of an adenovirus expressing BMP7","volume":"78","author":"Franceschi RT","year":"2000","unstructured":"Franceschi RT, Wang D, Krebsbach PH, Rutherford RB. Gene therapy for bone formation: in vitro and in vivo osteogenic activity of an adenovirus expressing BMP7. J Cell Biochem. 2000, 78:476-86. 10.1002\/1097-4644(20000901)78:3&lt;476::aid-jcb12&gt;3.0.co;2-5","journal-title":"J Cell Biochem"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2007.061994","article-title":"Gene therapy in head and neck cancer: a review","volume":"83","author":"Chisholm E","year":"2007","unstructured":"Chisholm E, Bapat U, Chisholm C, Alusi G, Vassaux G. Gene therapy in head and neck cancer: a review. Postgrad Med J. 2007, 83:731-7. 10.1136\/pgmj.2007.061994","journal-title":"Postgrad Med J"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.2174\/1566523053544218","article-title":"Gene therapy for bone regeneration","volume":"5","author":"Luo J","year":"2005","unstructured":"Luo J, Sun MH, Kang Q, et al.. Gene therapy for bone regeneration. Curr Gene Ther. 2005, 5:167-79. 10.2174\/1566523053544218","journal-title":"Curr Gene Ther"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(97)00036-1","article-title":"Signal transduction by bone morphogenetic proteins","volume":"9","author":"Kawabata M","year":"1998","unstructured":"Kawabata M, Imamura T, Miyazono K. Signal transduction by bone morphogenetic proteins. Cytokine Growth Factor Rev. 1998, 9:49-61. 10.1016\/S1359-6101(97)00036-1","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2004.01.016","article-title":"Engineering of tooth-supporting structures by delivery of PDGF gene therapy vectors","volume":"9","author":"Jin Q","year":"2004","unstructured":"Jin Q, Anusaksathien O, Webb SA, Printz MA, Giannobile WV. Engineering of tooth-supporting structures by delivery of PDGF gene therapy vectors. Mol Ther. 2004, 9:519-26. 10.1016\/j.ymthe.2004.01.016","journal-title":"Mol Ther"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.12.011","article-title":"The role of the SIBLING, Bone Sialoprotein in skeletal biology - contribution of mouse experimental genetics","volume":"52-54","author":"Bouleftour W","year":"2016","unstructured":"Bouleftour W, Juignet L, Bouet G, et al.. The role of the SIBLING, Bone Sialoprotein in skeletal biology - contribution of mouse experimental genetics. Matrix Biol. 2016, 52-54:60-77. 10.1016\/j.matbio.2015.12.011","journal-title":"Matrix Biol"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1996.7.5-613","article-title":"Retrovirus-mediated gene transfer into salivary glands in vivo","volume":"7","author":"Barka T","year":"1996","unstructured":"Barka T, Van der Noen HM. Retrovirus-mediated gene transfer into salivary glands in vivo. Hum Gene Ther. 1996, 7:613-8. 10.1089\/hum.1996.7.5-613","journal-title":"Hum Gene Ther"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.038232","article-title":"Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjogren's syndrome","volume":"65","author":"Lodde BM","year":"2006","unstructured":"Lodde BM, Mineshiba F, Wang J, Cotrim AP, Afione S, Tak PP, Baum BJ. Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjogren's syndrome. Ann Rheum Dis. 2006, 65:195-200. 10.1136\/ard.2005.038232","journal-title":"Ann Rheum Dis"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.2.289","article-title":"Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer","volume":"19","author":"Nemunaitis J","year":"2001","unstructured":"Nemunaitis J, Khuri F, Ganly I, et al.. Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer. J Clin Oncol. 2001, 19:289-98. 10.1200\/JCO.2001.19.2.289","journal-title":"J Clin Oncol"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2014.14","article-title":"Gene therapy for trigeminal pain in mice","volume":"21","author":"Tzabazis AZ","year":"2014","unstructured":"Tzabazis AZ, Klukinov M, Feliciano DP, Wilson SP, Yeomans DC. Gene therapy for trigeminal pain in mice. Gene Ther. 2014, 21:422-6. 10.1038\/gt.2014.14","journal-title":"Gene Ther"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-005-1115-7","article-title":"Dexamethasone stimulates differentiation of odontoblast-like cells in human dental pulp cultures","volume":"321","author":"Alliot-Licht B","year":"2005","unstructured":"Alliot-Licht B, Bluteau G, Magne D, Lopez-Cazaux S, Lieubeau B, Daculsi G, Guicheux J. Dexamethasone stimulates differentiation of odontoblast-like cells in human dental pulp cultures. Cell Tissue Res. 2005, 321:391-400. 10.1007\/s00441-005-1115-7","journal-title":"Cell Tissue Res"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.22203\/ecm.v018a07","article-title":"Human mandible bone defect repair by the grafting of dental pulp stem\/progenitor cells and collagen sponge biocomplexes","volume":"18","author":"d'Aquino R","year":"2009","unstructured":"d'Aquino R, De Rosa A, Lanza V, et al.. Human mandible bone defect repair by the grafting of dental pulp stem\/progenitor cells and collagen sponge biocomplexes. Eur Cell Mater. 2009, 18:75-83. 10.22203\/ecm.v018a07","journal-title":"Eur Cell Mater"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/nature02122","article-title":"A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance","volume":"426","author":"Mah TF","year":"2003","unstructured":"Mah TF, Pitts B, Pellock B, Walker GC, Stewart PS, O'Toole GA. A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance. Nature. 2003, 426:306-10. 10.1038\/nature02122","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1237223100","article-title":"Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model","volume":"100","author":"Schreiner HC","year":"2003","unstructured":"Schreiner HC, Sinatra K, Kaplan JB, et al.. Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model. Proc Natl Acad Sci U S A. 2003, 100:7295-300. 10.1073\/pnas.1237223100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref51","unstructured":"Cathy AJ. Teeth - we\u2019re going to grow them back. (2005). Accessed: 10 Nov, 2023: http:\/\/www.filipinodentist.com\/."}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/207520-implications-of-gene-therapy-in-dentistry-and-periodontics-a-narrative-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T19:51:49Z","timestamp":1707508309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/207520-implications-of-gene-therapy-in-dentistry-and-periodontics-a-narrative-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,26]]},"references-count":51,"URL":"https:\/\/doi.org\/10.7759\/cureus.49437","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,26]]}}}