{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:41:35Z","timestamp":1790102495383,"version":"4.0.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,14]]},"DOI":"10.7759\/cureus.50513","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T14:15:41Z","timestamp":1702563341000},"source":"Crossref","is-referenced-by-count":10,"title":["Vitamin A-Mediated Birth Defects: A Narrative Review"],"prefix":"10.7759","author":[{"given":"Raegan  B","family":"Abadie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail  A","family":"Staples","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian  V","family":"Lauck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra  D","family":"Dautel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah J","family":"Spillers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J","family":"Klapper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon  D","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giustino","family":"Varrassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahab","family":"Ahmadzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Shekoohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051703","article-title":"Vitamin A update: forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity","volume":"18","author":"Carazo A","year":"2021","unstructured":"Carazo A, Mac\u00e1kov\u00e1 K, Matou\u0161ov\u00e1 K, Kr\u010dmov\u00e1 LK, Protti M, Mlad\u011bnka P. Vitamin A update: forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity. Nutrients. 2021, 18:1703. 10.3390\/nu13051703","journal-title":"Nutrients"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030681","article-title":"Vitamin A and pregnancy: a narrative review","volume":"11","author":"Bastos MS","year":"2019","unstructured":"Bastos MS, Rolland Souza AS, Costa Caminha MF, Lins da Silva S, Callou Cruz RS, Carvalho Dos SC, Batista FM. Vitamin A and pregnancy: a narrative review. Nutrients. 2019, 11:681. 10.3390\/nu11030681","journal-title":"Nutrients"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437597.44550.5d","article-title":"Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association","volume":"129","author":"Donofrio MT","year":"2014","unstructured":"Donofrio MT, Moon-Grady AJ, Hornberger LK, et al.. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association. Circulation. 2014, 129:2183-242. 10.1161\/01.cir.0000437597.44550.5d","journal-title":"Circulation"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2022.2124767","article-title":"Skin, hair, and nail supplements advertised on Instagram","volume":"36","author":"Zamil DH","year":"2023","unstructured":"Zamil DH, Ameri M, Fu S, Abughosh FM, Katta R. Skin, hair, and nail supplements advertised on Instagram. Proc (Bayl Univ Med Cent). 2023, 36:38-40. 10.1080\/08998280.2022.2124767","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/nu15133071","article-title":"An evaluation of food and nutrient intake among pregnant women in the netherlands: a systematic review","volume":"15","author":"Ter Borg S","year":"2023","unstructured":"Ter Borg S, Koopman N, Verkaik-Kloosterman J. An evaluation of food and nutrient intake among pregnant women in the netherlands: a systematic review. Nutrients. 2023, 15:3071. 10.3390\/nu15133071","journal-title":"Nutrients"},{"key":"ref6","unstructured":"Retinol, Aquasol A (vitamin A) dosing, indications, interactions, adverse effects, and more [Internet]. (2023). Accessed. June 28, 2023: https:\/\/reference.medscape.com\/drug\/retinol-aquasol-a-vitamina-344426."},{"key":"ref7","article-title":"Vitamin A toxicity","author":"Olson JM","year":"2023","unstructured":"Olson JM, Ameer MA, Goyal A. Vitamin A toxicity. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2023."},{"key":"ref8","article-title":"Vitamin A","author":"McEldrew EP","unstructured":"McEldrew EP, Lopez MJ, Milstein H. Vitamin A. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL);"},{"key":"ref9","article-title":"Measles","volume":"12","author":"H\u00fcbschen JM","year":"2022","unstructured":"H\u00fcbschen JM, Gouandjika-Vasilache I, Dina J. Measles. Lancet. 2022, 12:678-90.","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114521000246","article-title":"Vitamin A in resistance to and recovery from infection: relevance to SARS-CoV2","volume":"126","author":"Stephensen CB","year":"2021","unstructured":"Stephensen CB, Lietz G. Vitamin A in resistance to and recovery from infection: relevance to SARS-CoV2. Br J Nutr. 2021, 126:1663-72. 10.1017\/S0007114521000246","journal-title":"Br J Nutr"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.2005","article-title":"Periconceptional use of vitamin A and the risk of giving birth to a child with nonsyndromic orofacial clefts - a meta-analysis","volume":"114","author":"Alade A","year":"2022","unstructured":"Alade A, Ismail W, Nair R, et al.. Periconceptional use of vitamin A and the risk of giving birth to a child with nonsyndromic orofacial clefts - a meta-analysis. Birth Defects Res. 2022, 114:467-77. 10.1002\/bdr2.2005","journal-title":"Birth Defects Res"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.51018.2","article-title":"Overlap of vitamin A and vitamin D target genes with CAKUT-related processes","volume":"10","author":"Ozisik O","year":"2021","unstructured":"Ozisik O, Ehrhart F, Evelo CT, Mantovani A, Baudot A. Overlap of vitamin A and vitamin D target genes with CAKUT-related processes. F1000Res. 2021, 10:395. 10.12688\/f1000research.51018.2","journal-title":"F1000Res"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01409-6","article-title":"Low maternal vitamin A intake increases the incidence of teratogen induced congenital diaphragmatic hernia in mice","volume":"91","author":"Rocke AW","year":"2022","unstructured":"Rocke AW, Clarke TG, Dalmer TR, McCluskey SA, Rivas JF, Clugston RD. Low maternal vitamin A intake increases the incidence of teratogen induced congenital diaphragmatic hernia in mice. Pediatr Res. 2022, 91:83-91. 10.1038\/s41390-021-01409-6","journal-title":"Pediatr Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2021.04.003","article-title":"Vitamin A deficiency and association between serum retinol and IGF-1 concentrations in Brazilian children with Down syndrome","volume":"98","author":"Ferraz IS","year":"2022","unstructured":"Ferraz IS, Vieira DM, Ciampo LA Jr, et al.. Vitamin A deficiency and association between serum retinol and IGF-1 concentrations in Brazilian children with Down syndrome. J Pediatr (Rio J). 2022, 98:76-83. 10.1016\/j.jped.2021.04.003","journal-title":"J Pediatr (Rio J)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12594","article-title":"Excess vitamin a might contribute to submucous clefting by inhibiting WNT-mediated bone formation","volume":"26","author":"Krutzen CL","year":"2023","unstructured":"Krutzen CL, Roa LA, Bloemen M, Von den Hoff JW. Excess vitamin a might contribute to submucous clefting by inhibiting WNT-mediated bone formation. Orthod Craniofac Res. 2023, 26:132-9. 10.1111\/ocr.12594","journal-title":"Orthod Craniofac Res"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1709","article-title":"Variations in maternal vitamin A intake modifies phenotypes in a mouse model of 22q11.2 deletion syndrome","volume":"112","author":"Yitsege G","year":"2020","unstructured":"Yitsege G, Stokes BA, Sabatino JA, et al.. Variations in maternal vitamin A intake modifies phenotypes in a mouse model of 22q11.2 deletion syndrome. Birth Defects Res. 2020, 112:1194-208. 10.1002\/bdr2.1709","journal-title":"Birth Defects Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/s0890-6238(97)00102-0","article-title":"Periconceptional vitamin A use: how much is teratogenic?","volume":"12","author":"Miller RK","year":"1998","unstructured":"Miller RK, Hendrickx AG, Mills JL, et al.. Periconceptional vitamin A use: how much is teratogenic?. Reprod Toxicol Elmsford N. 1998, 12:75-88. 10.1016\/s0890-6238(97)00102-0","journal-title":"Reprod Toxicol Elmsford N"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3945\/an.111.001701","article-title":"WHO Guideline: vitamin A supplementation in pregnant women. Geneva: WHO, 2011; WHO Guideline: vitamin A supplementation in postpartum women. Geneva: WHO, 2011","volume":"3","author":"McGuire S","year":"2012","unstructured":"McGuire S. WHO Guideline: vitamin A supplementation in pregnant women. Geneva: WHO, 2011; WHO Guideline: vitamin A supplementation in postpartum women. Geneva: WHO, 2011. Adv Nutr. 2012, 3:215-16. 10.3945\/an.111.001701","journal-title":"Adv Nutr"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.2169","article-title":"Impact of pregnancy and vitamin A supplementation on CYP2D6 activity","volume":"63","author":"Amaeze OU","year":"2023","unstructured":"Amaeze OU, Czuba LC, Yadav AS, et al.. Impact of pregnancy and vitamin A supplementation on CYP2D6 activity. J Clin Pharmacol. 2023, 63:363-72. 10.1002\/jcph.2169","journal-title":"J Clin Pharmacol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/nu13072370","article-title":"Impact of maternal daily oral low-dose vitamin A supplementation on the mother-infant pair: a randomised placebo-controlled trial in China","volume":"13","author":"Ding Y","year":"2021","unstructured":"Ding Y, Hu P, Yang Y, et al.. Impact of maternal daily oral low-dose vitamin A supplementation on the mother-infant pair: a randomised placebo-controlled trial in China. Nutrients. 2021, 13:2370. 10.3390\/nu13072370","journal-title":"Nutrients"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxaa439","article-title":"Small-quantity lipid-based nutrient supplements do not affect plasma or milk retinol concentrations among Malawian mothers, or plasma retinol concentrations among young Malawian or Ghanaian children in two randomized trials","volume":"151","author":"Haskell MJ","year":"2021","unstructured":"Haskell MJ, Young R, Adu-Afaruwah S, et al.. Small-quantity lipid-based nutrient supplements do not affect plasma or milk retinol concentrations among Malawian mothers, or plasma retinol concentrations among young Malawian or Ghanaian children in two randomized trials. J Nutr. 2021, 151:1029-37. 10.1093\/jn\/nxaa439","journal-title":"J Nutr"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232197","article-title":"Effect of a nutrient-rich, food-based supplement given to rural Vietnamese mothers prior to and\/or during pregnancy on birth outcomes: a randomized controlled trial","volume":"15","author":"Nga HT","year":"2020","unstructured":"Nga HT, Quyen PN, Chaffee BW, Diep Anh NT, Ngu T, King JC. Effect of a nutrient-rich, food-based supplement given to rural Vietnamese mothers prior to and\/or during pregnancy on birth outcomes: a randomized controlled trial. PLoS One. 2020, 15:e0232197. 10.1371\/journal.pone.0232197","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2020.21.11.3325","article-title":"Efficacy of oral vitamin A in reducing \u03b2-hCG levels in low-risk gestational trophoblastic neoplasia patients","volume":"21","author":"Hidayat YM","year":"2020","unstructured":"Hidayat YM, Darmadi A E, Rachmayati S, Kusumah WP, Djuwantono T, Pramatirta AY, Suardi D. Efficacy of oral vitamin A in reducing \u03b2-hCG levels in low-risk gestational trophoblastic neoplasia patients. Asian Pac J Cancer Prev. 2020, 21:3325-9. 10.31557\/APJCP.2020.21.11.3325","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174419000485","article-title":"Prenatal and childhood exposures are associated with thymulin concentrations in young adolescent children in rural Nepal","volume":"11","author":"Palmer AC","year":"2020","unstructured":"Palmer AC, Schulze KJ, Khatry SK, West KP. Prenatal and childhood exposures are associated with thymulin concentrations in young adolescent children in rural Nepal. J Dev Orig Health Dis. 2020, 11:127-35. 10.1017\/S2040174419000485","journal-title":"J Dev Orig Health Dis"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7090258","article-title":"Role of vitamin A in the immune system","volume":"7","author":"Huang Z","year":"2018","unstructured":"Huang Z, Liu Y, Qi G, Brand D, Zheng SG. Role of vitamin A in the immune system. J Clin Med. 2018, 7:10.3390\/jcm7090258","journal-title":"J Clin Med"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.11096","article-title":"Effect of vitamin A on maternal, fetal, and neonatal outcomes: an overview of deficiency, excessive intake, and intake recommendations","author":"Ishaq MU","year":"2023","unstructured":"Ishaq MU, Kunwar D, Qadeer A, et al.. Effect of vitamin A on maternal, fetal, and neonatal outcomes: an overview of deficiency, excessive intake, and intake recommendations. Nutr Clin Pract. 2023, 10.1002\/ncp.11096","journal-title":"Nutr Clin Pract"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.6781","article-title":"Oral Vitamin A for Acne Management: a possible substitute for isotretinoin","volume":"21","author":"Cook M","year":"2022","unstructured":"Cook M, Perche P, Feldman S. Oral Vitamin A for Acne Management: a possible substitute for isotretinoin. J Drugs Dermatol. 2022, 21:683-6. 10.36849\/JDD.6781","journal-title":"J Drugs Dermatol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00425.x","article-title":"Vitamin A and clefting: putative biological mechanisms","volume":"69","author":"Ackermans MM","year":"2011","unstructured":"Ackermans MM, Zhou H, Carels CE, Wagener FA, Von den Hoff JW. Vitamin A and clefting: putative biological mechanisms. Nutr Rev. 2011, 69:613-24. 10.1111\/j.1753-4887.2011.00425.x","journal-title":"Nutr Rev"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/nu14050950","article-title":"Global Burden of vitamin A deficiency in 204 countries and territories from 1990-2019","volume":"14","author":"Zhao T","year":"2022","unstructured":"Zhao T, Liu S, Zhang R, et al.. Global Burden of vitamin A deficiency in 204 countries and territories from 1990-2019. Nutrients. 2022, 14:10.3390\/nu14050950","journal-title":"Nutrients"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/203623-vitamin-a-mediated-birth-defects-a-narrative-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:09:56Z","timestamp":1707509396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/203623-vitamin-a-mediated-birth-defects-a-narrative-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,14]]},"references-count":29,"URL":"https:\/\/doi.org\/10.7759\/cureus.50513","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12,14]]}}}