{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:43:54Z","timestamp":1788889434972,"version":"build-2803163510"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,14]]},"DOI":"10.7759\/cureus.50522","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T11:31:26Z","timestamp":1702553486000},"source":"Crossref","is-referenced-by-count":24,"title":["The Latest Advances in the Diagnosis and Treatment of Dementia"],"prefix":"10.7759","author":[{"given":"Rehab","family":"Hafiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lama","family":"Alajlani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albatool","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghadah A","family":"Algarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Aljurfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Abdullah M","family":"Alammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Y","family":"Ashqan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanoud","family":"Alkhashan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.51847\/2GfZKuZB1M","article-title":"Impact of palliative care for dementia patients in tertiary hospitals among Saudi Arabia: a systemic review","volume":"13","author":"Al Mani TY","year":"2022","unstructured":"Al Mani TY, Sallam AM, Aldosary RA, AlGhamdi JA, Ghulam BMI, Shamah WF. Impact of palliative care for dementia patients in tertiary hospitals among Saudi Arabia: a systemic review. Arch Pharm Pract. 2022, 13:135. 10.51847\/2GfZKuZB1M","journal-title":"Arch Pharm Pract"},{"key":"ref2","article-title":"Major neurocognitive disorder (dementia)","author":"Emmady PD","year":"2022","unstructured":"Emmady PD, Schoo C, Tadi P. Major neurocognitive disorder (dementia). StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2022."},{"key":"ref3","article-title":"Women awareness of controllable risk of dementia in Riyadh, Saudi Arabia","volume":"33","author":"Alshammari E","year":"2020","unstructured":"Alshammari E. Women awareness of controllable risk of dementia in Riyadh, Saudi Arabia. Pak J Pharm Sci. 2020, 33:1863-70.","journal-title":"Pak J Pharm Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5742\/MEWFM.2021.93975","article-title":"Prevalence of systolic heart failure in patients with dementia in Saudi Arabia: single-center retrospective data review","volume":"7","author":"Basheikh M","year":"2021","unstructured":"Basheikh M, AlQayidi A, Addas M, Al-Zanbaqi M, Abumelha A, Basheikh M. Prevalence of systolic heart failure in patients with dementia in Saudi Arabia: single-center retrospective data review. Middle East J Fam Med. 2021, 7:6-10. 10.5742\/MEWFM.2021.93975","journal-title":"Middle East J Fam Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.12.024","article-title":"Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers","volume":"88","author":"Reitz C","year":"2014","unstructured":"Reitz C, Mayeux R. Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochem Pharmacol. 2014, 88:640-51. 10.1016\/j.bcp.2013.12.024","journal-title":"Biochem Pharmacol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.34578","article-title":"An assessment of dementia knowledge and its associated factors among health college students in Saudi Arabia","volume":"15","author":"Aldharman SS","year":"2023","unstructured":"Aldharman SS, Alayed FT, Aljohani BS, et al.. An assessment of dementia knowledge and its associated factors among health college students in Saudi Arabia. Cureus. 2023, 15:e34578. 10.7759\/cureus.34578","journal-title":"Cureus"},{"key":"ref7","unstructured":"Dementia. (2023). Accessed. November 6, 2023: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/908915","article-title":"Global epidemiology of dementia: Alzheimer's and vascular types","volume":"2014","author":"Rizzi L","year":"2014","unstructured":"Rizzi L, Rosset I, Roriz-Cruz M. Global epidemiology of dementia: Alzheimer's and vascular types. Biomed Res Int. 2014, 2014:908915. 10.1155\/2014\/908915","journal-title":"Biomed Res Int"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.24394","article-title":"Prevalence of dementia and its associated risk factors among geriatric patients visiting primary healthcare centers in Riyadh, Saudi Arabia: a cross-sectional study","volume":"14","author":"Alsebayel FM","year":"2022","unstructured":"Alsebayel FM, Alangari AM, Almubarak FH, Alhamwy R. Prevalence of dementia and its associated risk factors among geriatric patients visiting primary healthcare centers in Riyadh, Saudi Arabia: a cross-sectional study. Cureus. 2022, 14:e24394. 10.7759\/cureus.24394","journal-title":"Cureus"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191092","article-title":"The prevalence of dementia: a systematic review and meta-analysis","volume":"73","author":"Cao Q","year":"2020","unstructured":"Cao Q, Tan CC, Xu W, et al.. The prevalence of dementia: a systematic review and meta-analysis. J Alzheimers Dis. 2020, 73:1157-66. 10.3233\/JAD-191092","journal-title":"J Alzheimers Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.007","article-title":"The global prevalence of dementia: a systematic review and metaanalysis","volume":"9","author":"Prince M","year":"2013","unstructured":"Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013, 9:63-75.e2. 10.1016\/j.jalz.2012.11.007","journal-title":"Alzheimers Dement"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.8.759","article-title":"Oxidative damage is the earliest event in Alzheimer disease","volume":"60","author":"Nunomura A","year":"2001","unstructured":"Nunomura A, Perry G, Aliev G, et al.. Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol. 2001, 60:759-67. 10.1093\/jnen\/60.8.759","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-0173(00)00043-6","article-title":"Evidence that Alzheimer\u2019s disease is a microvascular disorder: the role of constitutive nitric oxide","volume":"34","author":"De la Torre J","year":"2000","unstructured":"De la Torre J, Stefano G. Evidence that Alzheimer\u2019s disease is a microvascular disorder: the role of constitutive nitric oxide. Brain Res Rev. 2000, 34:119-36. 10.1016\/s0165-0173(00)00043-6","journal-title":"Brain Res Rev"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90606","article-title":"Microglia in Alzheimer's disease","volume":"127","author":"Sarlus H","year":"2017","unstructured":"Sarlus H, Heneka MT. Microglia in Alzheimer's disease. J Clin Invest. 2017, 127:3240-9. 10.1172\/JCI90606","journal-title":"J Clin Invest"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2004.6.3\/imckeith","article-title":"Dementia with Lewy bodies","volume":"6","author":"McKeith I","year":"2004","unstructured":"McKeith I. Dementia with Lewy bodies. Dialogues Clin Neurosci. 2004, 6:333-41. 10.31887\/DCNS.2004.6.3\/imckeith","journal-title":"Dialogues Clin Neurosci"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70269-X","article-title":"HIV-associated neurocognitive disorder","volume":"13","author":"Clifford DB","year":"2013","unstructured":"Clifford DB, Ances BM. HIV-associated neurocognitive disorder. Lancet Infect Dis. 2013, 13:976-86. 10.1016\/S1473-3099(13)70269-X","journal-title":"Lancet Infect Dis"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-118664","article-title":"Drink and think: impact of alcohol on cognitive functions and dementia - evidence of dose-related effects","volume":"51","author":"Gutwinski S","year":"2018","unstructured":"Gutwinski S, Schreiter S, Priller J, Henssler J, Wiers CE, Heinz A. Drink and think: impact of alcohol on cognitive functions and dementia - evidence of dose-related effects. Pharmacopsychiatry. 2018, 51:136-43. 10.1055\/s-0043-118664","journal-title":"Pharmacopsychiatry"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-021-00825-x","article-title":"Neuroimaging in dementia","volume":"171","author":"Furtner J","year":"2021","unstructured":"Furtner J, Prayer D. Neuroimaging in dementia. Wien Med Wochenschr. 2021, 171:274-81. 10.1007\/s10354-021-00825-x","journal-title":"Wien Med Wochenschr"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000250326.77323.01","article-title":"Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease","volume":"68","author":"Zhang Y","year":"2007","unstructured":"Zhang Y, Schuff N, Jahng GH, et al.. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease. Neurology. 2007, 68:13-9. 10.1212\/01.wnl.0000250326.77323.01","journal-title":"Neurology"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3233\/BEN-2009-0227","article-title":"Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimaging","volume":"21","author":"Dickerson BC","year":"2009","unstructured":"Dickerson BC, Sperling RA. Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimaging. Behav Neurol. 2009, 21:63-75. 10.3233\/BEN-2009-0227","journal-title":"Behav Neurol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-1762-7","article-title":"Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD","volume":"32","author":"Mosconi L","year":"2005","unstructured":"Mosconi L. Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD. Eur J Nucl Med Mol Imaging. 2005, 32:486-510. 10.1007\/s00259-005-1762-7","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2016.09.006","article-title":"A\u03b2-amyloid and Tau imaging in dementia","volume":"47","author":"Villemagne VL","year":"2017","unstructured":"Villemagne VL, Dor\u00e9 V, Bourgeat P, et al.. A\u03b2-amyloid and Tau imaging in dementia. Semin Nucl Med. 2017, 47:75-88. 10.1053\/j.semnuclmed.2016.09.006","journal-title":"Semin Nucl Med"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018","article-title":"Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion","volume":"59","author":"Power JD","year":"2012","unstructured":"Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE. Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage. 2012, 59:2142-54. 10.1016\/j.neuroimage.2011.10.018","journal-title":"Neuroimage"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1534","article-title":"Diagnostic value of cerebrospinal fluid neurofilament light protein in neurology: a systematic review and meta-analysis","volume":"76","author":"Bridel C","year":"2019","unstructured":"Bridel C, van Wieringen WN, Zetterberg H, et al.. Diagnostic value of cerebrospinal fluid neurofilament light protein in neurology: a systematic review and meta-analysis. JAMA Neurol. 2019, 76:1035-48. 10.1001\/jamaneurol.2019.1534","journal-title":"JAMA Neurol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1221","article-title":"Alzheimer's disease and the amyloid-beta peptide","volume":"19","author":"Murphy MP","year":"2010","unstructured":"Murphy MP, LeVine H 3rd. Alzheimer's disease and the amyloid-beta peptide. J Alzheimers Dis. 2010, 19:311-23. 10.3233\/JAD-2010-1221","journal-title":"J Alzheimers Dis"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141659","article-title":"Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease","volume":"45","author":"Cheung CY","year":"2015","unstructured":"Cheung CY, Ong YT, Hilal S, et al.. Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2015, 45:45-56. 10.3233\/JAD-141659","journal-title":"J Alzheimers Dis"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s12553-020-00426-5","article-title":"A review of dementia screening tools based on mobile application","volume":"10","author":"Thabtah F","year":"2020","unstructured":"Thabtah F, Peebles D, Retzler J, Hathurusingha C. A review of dementia screening tools based on mobile application. Health and Technol. 2020, 10:1011-22. 10.1007\/s12553-020-00426-5","journal-title":"Health and Technol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.12.023","article-title":"Understanding heterogeneity in clinical cohorts using normative models: beyond case-control studies","volume":"80","author":"Marquand AF","year":"2016","unstructured":"Marquand AF, Rezek I, Buitelaar J, Beckmann CF. Understanding heterogeneity in clinical cohorts using normative models: beyond case-control studies. Biol Psychiatry. 2016, 80:552-61. 10.1016\/j.biopsych.2015.12.023","journal-title":"Biol Psychiatry"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2006.05.003","article-title":"Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments","volume":"87","author":"Burger C","year":"2007","unstructured":"Burger C, L\u00f3pez MC, Feller JA, Baker HV, Muzyczka N, Mandel RJ. Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments. Neurobiol Learn Mem. 2007, 87:21-41. 10.1016\/j.nlm.2006.05.003","journal-title":"Neurobiol Learn Mem"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179352","article-title":"Diagnostic accuracy of tablet-based software for the detection of concussion","volume":"12","author":"Yang S","year":"2017","unstructured":"Yang S, Flores B, Magal R, et al.. Diagnostic accuracy of tablet-based software for the detection of concussion. PLoS One. 2017, 12:e0179352. 10.1371\/journal.pone.0179352","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1159\/000316119","article-title":"Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy","volume":"30","author":"Olazar\u00e1n J","year":"2010","unstructured":"Olazar\u00e1n J, Reisberg B, Clare L, et al.. Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy. Dement Geriatr Cogn Disord. 2010, 30:161-78. 10.1159\/000316119","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X18666200528142429","article-title":"Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer\u2019s disease","volume":"18","author":"Khan S","year":"2020","unstructured":"Khan S, Barve KH, Kumar MS. Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer\u2019s disease. Curr Neuropharmacol. 2020, 18:1106-25. 10.2174\/1570159X18666200528142429","journal-title":"Curr Neuropharmacol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1186\/isrctn49545035","article-title":"Donepezil and memantine for moderate-to-severe Alzheimer's disease","volume":"366","author":"Howard R","year":"2012","unstructured":"Howard R, McShane R, Lindesay J, et al.. Donepezil and memantine for moderate-to-severe Alzheimer's disease. New Eng J Med. 2012, 366:893-903. 10.1186\/isrctn49545035","journal-title":"New Eng J Med"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119129","article-title":"A review on advances of treatment modalities for Alzheimer's disease","volume":"276","author":"Se Thoe E","year":"2021","unstructured":"Se Thoe E, Fauzi A, Tang YQ, Chamyuang S, Chia AY. A review on advances of treatment modalities for Alzheimer's disease. Life Sci. 2021, 276:119129. 10.1016\/j.lfs.2021.119129","journal-title":"Life Sci"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive review on Alzheimer's disease: causes and treatment","volume":"25","author":"Breijyeh Z","year":"2020","unstructured":"Breijyeh Z, Karaman R. Comprehensive review on Alzheimer's disease: causes and treatment. Molecules. 2020, 25:5789. 10.3390\/molecules25245789","journal-title":"Molecules"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199912003-00017","article-title":"Overlap between pathology of Alzheimer disease and vascular dementia","volume":"13 Suppl 3","author":"Kalaria RN","year":"1999","unstructured":"Kalaria RN, Ballard C. Overlap between pathology of Alzheimer disease and vascular dementia. Alzheimer Dis Assoc Disord. 1999, 13 Suppl 3:S115-23. 10.1097\/00002093-199912003-00017","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(15)00258-6","article-title":"Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses","volume":"14","author":"Howard R","year":"2015","unstructured":"Howard R, McShane R, Lindesay J, et al.. Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses. Lancet Neurol. 2015, 14:1171-81. 10.1016\/s1474-4422(15)00258-6","journal-title":"Lancet Neurol"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006504.pub2","article-title":"Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease","volume":"2012","author":"Rolinski M","year":"2012","unstructured":"Rolinski M, Fox C, Maidment I, McShane R. Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease. Cochrane Database Syst Rev. 2012, 2012:CD006504. 10.1002\/14651858.CD006504.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-307659","article-title":"Efficacy and safety of cholinesterase inhibitors and memantine in cognitive impairment in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies: systematic review with meta-analysis and trial sequential analysis","volume":"86","author":"Wang HF","year":"2015","unstructured":"Wang HF, Yu JT, Tang SW, et al.. Efficacy and safety of cholinesterase inhibitors and memantine in cognitive impairment in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies: systematic review with meta-analysis and trial sequential analysis. J Neurol Neurosurg Psychiatry. 2015, 86:135-43. 10.1136\/jnnp-2014-307659","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-94960-0_60","article-title":"Pharmacological management of Lewy body dementia: a systematic review and meta-analysis","author":"Lane CE","year":"2022","unstructured":"Lane CE, Conroy ML. Pharmacological management of Lewy body dementia: a systematic review and meta-analysis. Essential Reviews in Geriatric Psychiatry. Tampi RR, Tampi DJ, Young JJ, Balasubramaniam M, Joshi P (ed): Springer, Cham, Switzerland; 2022. 343-7. 10.1007\/978-3-030-94960-0_60"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1159\/000351672","article-title":"Long-term safety and efficacy of donepezil in patients with dementia with Lewy bodies: results from a 52-week, open-label, multicenter extension study","volume":"36","author":"Ikeda M","year":"2013","unstructured":"Ikeda M, Mori E, Kosaka K, et al.. Long-term safety and efficacy of donepezil in patients with dementia with Lewy bodies: results from a 52-week, open-label, multicenter extension study. Dement Geriatr Cogn Disord. 2013, 36:229-41. 10.1159\/000351672","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-014-0083-0","article-title":"Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled, confirmatory phase III trial","volume":"7","author":"Ikeda M","year":"2015","unstructured":"Ikeda M, Mori E, Matsuo K, Nakagawa M, Kosaka K. Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled, confirmatory phase III trial. Alzheimers Res Ther. 2015, 7:4. 10.1186\/s13195-014-0083-0","journal-title":"Alzheimers Res Ther"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30153-X","article-title":"New evidence on the management of Lewy body dementia","volume":"19","author":"Taylor JP","year":"2020","unstructured":"Taylor JP, McKeith IG, Burn DJ, et al.. New evidence on the management of Lewy body dementia. Lancet Neurol. 2020, 19:157-69. 10.1016\/S1474-4422(19)30153-X","journal-title":"Lancet Neurol"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1159\/000197896","article-title":"Frontotemporal dementia: therapeutic interventions","volume":"24","author":"Mendez MF","year":"2009","unstructured":"Mendez MF. Frontotemporal dementia: therapeutic interventions. Front Neurol Neurosci. 2009, 24:168-78. 10.1159\/000197896","journal-title":"Front Neurol Neurosci"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10l06440gry","article-title":"Pathological stealing in dementia: poor response to SSRI medications","volume":"72","author":"Mendez MF","year":"2011","unstructured":"Mendez MF. Pathological stealing in dementia: poor response to SSRI medications. J Clin Psychiatry. 2011, 72:418-9. 10.4088\/JCP.10l06440gry","journal-title":"J Clin Psychiatry"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1159\/000113034","article-title":"Galantamine in frontotemporal dementia and primary progressive aphasia","volume":"25","author":"Kertesz A","year":"2008","unstructured":"Kertesz A, Morlog D, Light M, Blair M, Davidson W, Jesso S, Brashear R. Galantamine in frontotemporal dementia and primary progressive aphasia. Dement Geriatr Cogn Disord. 2008, 25:178-85. 10.1159\/000113034","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.69","article-title":"Lack of evidence for the efficacy of memantine in mild Alzheimer disease","volume":"68","author":"Schneider LS","year":"2011","unstructured":"Schneider LS, Dagerman KS, Higgins JP, McShane R. Lack of evidence for the efficacy of memantine in mild Alzheimer disease. Arch Neurol. 2011, 68:991-8. 10.1001\/archneurol.2011.69","journal-title":"Arch Neurol"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-005158","article-title":"Treatment effect of memantine on survival in dementia with Lewy bodies and Parkinson's disease with dementia: a prospective study","volume":"4","author":"Stubendorff K","year":"2014","unstructured":"Stubendorff K, Larsson V, Ballard C, Minthon L, Aarsland D, Londos E. Treatment effect of memantine on survival in dementia with Lewy bodies and Parkinson's disease with dementia: a prospective study. BMJ Open. 2014, 4:e005158. 10.1136\/bmjopen-2014-005158","journal-title":"BMJ Open"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002854.pub4","article-title":"Vitamin E for Alzheimer's dementia and mild cognitive impairment","volume":"1","author":"Farina N","year":"2017","unstructured":"Farina N, Llewellyn D, Isaac MG, Tabet N. Vitamin E for Alzheimer's dementia and mild cognitive impairment. Cochrane Database Syst Rev. 2017, 1:CD002854. 10.1002\/14651858.CD002854.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.282834","article-title":"Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial","volume":"311","author":"Dysken MW","year":"2014","unstructured":"Dysken MW, Sano M, Asthana S, et al.. Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA. 2014, 311:33-44. 10.1001\/jama.2013.282834","journal-title":"JAMA"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-014-0319-0","article-title":"Treatment of frontotemporal dementia","volume":"16","author":"Tsai RM","year":"2014","unstructured":"Tsai RM, Boxer AL. Treatment of frontotemporal dementia. Curr Treat Options Neurol. 2014, 16:319. 10.1007\/s11940-014-0319-0","journal-title":"Curr Treat Options Neurol"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.30","article-title":"Lecanemab: appropriate use recommendations","volume":"10","author":"Cummings J","year":"2023","unstructured":"Cummings J, Apostolova L, Rabinovici GD, et al.. Lecanemab: appropriate use recommendations. J Prev Alzheimers Dis. 2023, 10:362-77. 10.14283\/jpad.2023.30","journal-title":"J Prev Alzheimers Dis"},{"key":"ref53","article-title":"Aducanumab","author":"Padda IS","year":"2023","unstructured":"Padda IS, Parmar M. Aducanumab. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2023."},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12944","article-title":"Aducanumab for the treatment of Alzheimer's disease: a systematic review","volume":"23","author":"Rahman A","year":"2023","unstructured":"Rahman A, Hossen MA, Chowdhury MF, et al.. Aducanumab for the treatment of Alzheimer's disease: a systematic review. Psychogeriatrics. 2023, 23:512-22. 10.1111\/psyg.12944","journal-title":"Psychogeriatrics"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer's disease","volume":"388","author":"van Dyck CH","year":"2023","unstructured":"van Dyck CH, Swanson CJ, Aisen P, et al.. Lecanemab in early Alzheimer's disease. N Engl J Med. 2023, 388:9-21. 10.1056\/NEJMoa2212948","journal-title":"N Engl J Med"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01124-2","article-title":"Lecanemab in patients with early Alzheimer's disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study","volume":"14","author":"McDade E","year":"2022","unstructured":"McDade E, Cummings JL, Dhadda S, et al.. Lecanemab in patients with early Alzheimer's disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study. Alzheimers Res Ther. 2022, 14:191. 10.1186\/s13195-022-01124-2","journal-title":"Alzheimers Res Ther"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz150","article-title":"Dietary pattern in midlife and cognitive impairment in late life: a prospective study in Chinese adults","volume":"110","author":"Wu J","year":"2019","unstructured":"Wu J, Song X, Chen GC, et al.. Dietary pattern in midlife and cognitive impairment in late life: a prospective study in Chinese adults. Am J Clin Nutr. 2019, 110:912-20. 10.1093\/ajcn\/nqz150","journal-title":"Am J Clin Nutr"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190722110458","article-title":"Dietary patterns and cognitive decline: key features for prevention","volume":"25","author":"Dominguez LJ","year":"2019","unstructured":"Dominguez LJ, Barbagallo M, Mu\u00f1oz-Garcia M, Godos J, Martinez-Gonzalez MA. Dietary patterns and cognitive decline: key features for prevention. Curr Pharm Des. 2019, 25:2428-42. 10.2174\/1381612825666190722110458","journal-title":"Curr Pharm Des"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2017.58","article-title":"Mediterranean diet and multiple health outcomes: an umbrella review of meta-analyses of observational studies and randomised trials","volume":"72","author":"Dinu M","year":"2018","unstructured":"Dinu M, Pagliai G, Casini A, Sofi F. Mediterranean diet and multiple health outcomes: an umbrella review of meta-analyses of observational studies and randomised trials. Eur J Clin Nutr. 2018, 72:30-43. 10.1038\/ejcn.2017.58","journal-title":"Eur J Clin Nutr"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.3390\/nu13062028","article-title":"Impact of Mediterranean diet on chronic non-communicable diseases and longevity","volume":"13","author":"Dominguez LJ","year":"2021","unstructured":"Dominguez LJ, Di Bella G, Veronese N, Barbagallo M. Impact of Mediterranean diet on chronic non-communicable diseases and longevity. Nutrients. 2021, 13:2028. 10.3390\/nu13062028","journal-title":"Nutrients"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.051276","article-title":"Prospective study of dietary approaches to stop hypertension- and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County study on memory, health and aging","volume":"98","author":"Wengreen H","year":"2013","unstructured":"Wengreen H, Munger RG, Cutler A, et al.. Prospective study of dietary approaches to stop hypertension- and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County study on memory, health and aging. Am J Clin Nutr. 2013, 98:1263-71. 10.3945\/ajcn.112.051276","journal-title":"Am J Clin Nutr"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.11.026","article-title":"The dietary approaches to stop hypertension diet, cognitive function, and cognitive decline in American older women","volume":"18","author":"Berendsen AA","year":"2017","unstructured":"Berendsen AA, Kang JH, van de Rest O, Feskens EJ, de Groot LC, Grodstein F. The dietary approaches to stop hypertension diet, cognitive function, and cognitive decline in American older women. J Am Med Dir Assoc. 2017, 18:427-32. 10.1016\/j.jamda.2016.11.026","journal-title":"J Am Med Dir Assoc"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3182944410","article-title":"Mediterranean diet, cognitive function, and dementia: a systematic review","volume":"24","author":"Lourida I","year":"2013","unstructured":"Lourida I, Soni M, Thompson-Coon J, Purandare N, Lang IA, Ukoumunne OC, Llewellyn DJ. Mediterranean diet, cognitive function, and dementia: a systematic review. Epidemiology. 2013, 24:479-89. 10.1097\/EDE.0b013e3182944410","journal-title":"Epidemiology"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.08.005","article-title":"A ketogenic diet extends longevity and healthspan in adult mice","volume":"26","author":"Roberts MN","year":"2017","unstructured":"Roberts MN, Wallace MA, Tomilov AA, et al.. A ketogenic diet extends longevity and healthspan in adult mice. Cell Metab. 2017, 26:539-546.e5. 10.1016\/j.cmet.2017.08.005","journal-title":"Cell Metab"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.08.004","article-title":"Ketogenic diet reduces midlife mortality and improves memory in aging mice","volume":"26","author":"Newman JC","year":"2017","unstructured":"Newman JC, Covarrubias AJ, Zhao M, et al.. Ketogenic diet reduces midlife mortality and improves memory in aging mice. Cell Metab. 2017, 26:547-57.e8. 10.1016\/j.cmet.2017.08.004","journal-title":"Cell Metab"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.3390\/life13010173","article-title":"Mediterranean diet, ketogenic diet or MIND diet for aging populations with cognitive decline: a systematic review","volume":"13","author":"Devranis P","year":"2023","unstructured":"Devranis P, Vassilopoulou \u0395, Tsironis V, Sotiriadis PM, Chourdakis M, Aivaliotis M, Tsolaki M. Mediterranean diet, ketogenic diet or MIND diet for aging populations with cognitive decline: a systematic review. Life (Basel). 2023, 13:173. 10.3390\/life13010173","journal-title":"Life (Basel)"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care","volume":"390","author":"Livingston G","year":"2017","unstructured":"Livingston G, Sommerlad A, Orgeta V, et al.. Dementia prevention, intervention, and care. Lancet. 2017, 390:2673-734. 10.1016\/s0140-6736(17)31363-6","journal-title":"Lancet"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.04.006","article-title":"Contributions of modifiable risk factors to dementia incidence: a Bayesian network analysis","volume":"21","author":"Liang JH","year":"2020","unstructured":"Liang JH, Lu L, Li JY, et al.. Contributions of modifiable risk factors to dementia incidence: a Bayesian network analysis. J Am Med Dir Assoc. 2020, 21:1592-9.e13. 10.1016\/j.jamda.2020.04.006","journal-title":"J Am Med Dir Assoc"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.01.010","article-title":"The impact of pharmacologic and nonpharmacologic interventions to improve physical health outcomes in people with dementia: a meta-review of meta-analyses of randomized controlled trials","volume":"21","author":"Vancampfort D","year":"2020","unstructured":"Vancampfort D, Solmi M, Firth J, Vandenbulcke M, Stubbs B. The impact of pharmacologic and nonpharmacologic interventions to improve physical health outcomes in people with dementia: a meta-review of meta-analyses of randomized controlled trials. J Am Med Dir Assoc. 2020, 21:1410-4.e2. 10.1016\/j.jamda.2020.01.010","journal-title":"J Am Med Dir Assoc"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/367516","article-title":"Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia","volume":"2012","author":"de la Torre JC","year":"2012","unstructured":"de la Torre JC. Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia. Cardiovasc Psychiatry Neurol. 2012, 2012:367516. 10.1155\/2012\/367516","journal-title":"Cardiovasc Psychiatry Neurol"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7807856","article-title":"Potential benefits of physical activity in MCI and dementia","volume":"2020","author":"Nuzum H","year":"2020","unstructured":"Nuzum H, Stickel A, Corona M, Zeller M, Melrose RJ, Wilkins SS. Potential benefits of physical activity in MCI and dementia. Behav Neurol. 2020, 2020:7807856. 10.1155\/2020\/7807856","journal-title":"Behav Neurol"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031168","article-title":"Is sleep disruption a cause or consequence of Alzheimer\u2019s disease? Reviewing its possible role as a biomarker","volume":"21","author":"Lloret MA","year":"2020","unstructured":"Lloret MA, Cervera-Ferri A, Nepomuceno M, Monllor P, Esteve D, Lloret A. Is sleep disruption a cause or consequence of Alzheimer\u2019s disease? Reviewing its possible role as a biomarker. Int J Mol Sci. 2020, 21:1168. 10.3390\/ijms21031168","journal-title":"Int J Mol Sci"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105031","article-title":"It's complicated: the relationship between sleep and Alzheimer's disease in humans","volume":"144","author":"Lucey BP","year":"2020","unstructured":"Lucey BP. It's complicated: the relationship between sleep and Alzheimer's disease in humans. Neurobiol Dis. 2020, 144:105031. 10.1016\/j.nbd.2020.105031","journal-title":"Neurobiol Dis"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-021-03325-x","article-title":"Deciphering the interacting mechanisms of circadian disruption and Alzheimer\u2019s disease","volume":"46","author":"Uddin MS","year":"2021","unstructured":"Uddin MS, Sumsuzzman DM, Jeandet P, Behl T, Rauf A, Amran MS, Ashraf GM. Deciphering the interacting mechanisms of circadian disruption and Alzheimer\u2019s disease. Neurochem Res. 2021, 46:1603-17. 10.1007\/s11064-021-03325-x","journal-title":"Neurochem Res"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.08121844","article-title":"Cognitive effects of atypical antipsychotic medications in patients with Alzheimer's disease: outcomes from CATIE-AD","volume":"168","author":"Vigen CL","year":"2011","unstructured":"Vigen CL, Mack WJ, Keefe RS, et al.. Cognitive effects of atypical antipsychotic medications in patients with Alzheimer's disease: outcomes from CATIE-AD. Am J Psychiatry. 2011, 168:831-9. 10.1176\/appi.ajp.2011.08121844","journal-title":"Am J Psychiatry"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3562","article-title":"Associations of objectively and subjectively measured sleep quality with subsequent cognitive decline in older community-dwelling men: the MrOS sleep study","volume":"37","author":"Blackwell T","year":"2014","unstructured":"Blackwell T, Yaffe K, Laffan A, et al.. Associations of objectively and subjectively measured sleep quality with subsequent cognitive decline in older community-dwelling men: the MrOS sleep study. Sleep. 2014, 37:655-63. 10.5665\/sleep.3562","journal-title":"Sleep"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1111\/ajag.12542","article-title":"People with dementia getting lost in Australia: dementia-related missing person reports in the media","volume":"37","author":"MacAndrew M","year":"2018","unstructured":"MacAndrew M, Schnitker L, Shepherd N, Beattie E. People with dementia getting lost in Australia: dementia-related missing person reports in the media. Australas J Ageing. 2018, 37:E97-E103. 10.1111\/ajag.12542","journal-title":"Australas J Ageing"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1177\/1533317516673155","article-title":"Eating behaviors and dietary changes in patients with dementia","volume":"31","author":"Cipriani G","year":"2016","unstructured":"Cipriani G, Carlesi C, Lucetti C, Danti S, Nuti A. Eating behaviors and dietary changes in patients with dementia. Am J Alzheimers Dis Other Demen. 2016, 31:706-16. 10.1177\/1533317516673155","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston G","year":"2020","unstructured":"Livingston G, Huntley J, Sommerlad A, et al.. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020, 396:413-46. 10.1016\/S0140-6736(20)30367-6","journal-title":"Lancet"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-023-04269-3","article-title":"A focus groups study of staff team experiences of providing interdisciplinary rehabilitation for people with dementia and their caregivers-a co-creative journey","volume":"23","author":"Lindel\u00f6f N","year":"2023","unstructured":"Lindel\u00f6f N, Nilsson I, Littbrand H, Gustafson Y, Olofsson B, Fjellman-Wiklund A. A focus groups study of staff team experiences of providing interdisciplinary rehabilitation for people with dementia and their caregivers-a co-creative journey. BMC Geriatr. 2023, 23:572. 10.1186\/s12877-023-04269-3","journal-title":"BMC Geriatr"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.15007","article-title":"Exploring the challenges of medical\/nursing tasks in home care experienced by caregivers of older adults with dementia: an integrative review","volume":"28","author":"Lee M","year":"2019","unstructured":"Lee M, Ryoo JH, Campbell C, Hollen PJ, Williams IC. Exploring the challenges of medical\/nursing tasks in home care experienced by caregivers of older adults with dementia: an integrative review. J Clin Nurs. 2019, 28:4177-89. 10.1111\/jocn.15007","journal-title":"J Clin Nurs"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1177\/1471301213488900","article-title":"Medication management concerns of ethnic minority family caregivers of people living with dementia","volume":"14","author":"Gillespie RJ","year":"2015","unstructured":"Gillespie RJ, Harrison L, Mullan J. Medication management concerns of ethnic minority family caregivers of people living with dementia. Dementia (London). 2015, 14:47-62. 10.1177\/1471301213488900","journal-title":"Dementia (London)"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-9824.2011.01114.x","article-title":"The process of medication management for older adults with dementia","volume":"3","author":"Kaasalainen S","year":"2011","unstructured":"Kaasalainen S, Dolovich L, Papaioannou A, et al.. The process of medication management for older adults with dementia. J Nurs Healthc Res. 2011, 3:407-18. 10.1111\/j.1752-9824.2011.01114.x","journal-title":"J Nurs Healthc Res"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1111\/1747-0080.12107","article-title":"Experiences and nutrition support strategies in dementia care: Lessons from family carers","volume":"72","author":"Ball L","year":"2015","unstructured":"Ball L, Jansen S, Desbrow B, Morgan K, Moyle W, Hughes R. Experiences and nutrition support strategies in dementia care: Lessons from family carers. Nutr Diet. 2015, 72:22-9. 10.1111\/1747-0080.12107","journal-title":"Nutr Diet"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.3928\/00989134-20130220-91","article-title":"Characterizing caregiver-mediated medication management in patients with memory loss","volume":"39","author":"Erlen JA","year":"2013","unstructured":"Erlen JA, Lingler J, Sereika SM, Tamres LK, Happ MB, Tang F. Characterizing caregiver-mediated medication management in patients with memory loss. J Gerontol Nurs. 2013, 39:30-9. 10.3928\/00989134-20130220-91","journal-title":"J Gerontol Nurs"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1111\/ijpp.12158","article-title":"Assisting people with dementia with their medicines: experiences of family carers","volume":"23","author":"Smith F","year":"2015","unstructured":"Smith F, Grijseels MS, Ryan P, Tobiansky R. Assisting people with dementia with their medicines: experiences of family carers. Int J Pharm Pract. 2015, 23:44-51. 10.1111\/ijpp.12158","journal-title":"Int J Pharm Pract"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1590\/S1980-57642014DN83000013","article-title":"Interdisciplinary therapy for patients with dementia","volume":"8","author":"Cera ML","year":"2014","unstructured":"Cera ML, de Abreu DC, Tamanini RA, Arnaut AC, Mandr\u00e1 PP, Santana CD. Interdisciplinary therapy for patients with dementia. Dement Neuropsychol. 2014, 8:285-90. 10.1590\/S1980-57642014DN83000013","journal-title":"Dement Neuropsychol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/210259-the-latest-advances-in-the-diagnosis-and-treatment-of-dementia","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T15:10:01Z","timestamp":1707491401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/210259-the-latest-advances-in-the-diagnosis-and-treatment-of-dementia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,14]]},"references-count":87,"URL":"https:\/\/doi.org\/10.7759\/cureus.50522","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12,14]]}}}