{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:55:14Z","timestamp":1790628914705,"version":"4.1.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,17]]},"DOI":"10.7759\/cureus.50691","type":"journal-article","created":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T23:28:20Z","timestamp":1702855700000},"source":"Crossref","is-referenced-by-count":5,"title":["Unexpectedly Prolonged Serotonin Syndrome and Fatal Complications Following a Massive Overdose of Paroxetine Controlled-Release"],"prefix":"10.7759","author":[{"given":"Fumiya","family":"Inoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Ichiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Kashiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Namera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650701285289","article-title":"Selective serotonin reuptake inhibitor poisoning: an evidence-based consensus guideline for out-of-hospital management","volume":"45","author":"Nelson LS","year":"2007","unstructured":"Nelson LS, Erdman AR, Booze LL, et al.. Selective serotonin reuptake inhibitor poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila). 2007, 45:315-32. 10.1080\/15563650701285289","journal-title":"Clin Toxicol (Phila)"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg062","article-title":"Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants","volume":"96","author":"Whyte IM","year":"2003","unstructured":"Whyte IM, Dawson AH, Buckley NA. Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants. QJM. 2003, 96:369-74. 10.1093\/qjmed\/hcg062","journal-title":"QJM"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.51.5.437","article-title":"Serotonin syndrome after a massive overdose of controlled-release paroxetine","volume":"51","author":"Muzyk AJ","year":"2010","unstructured":"Muzyk AJ, Jakel RJ, Preud'homme X. Serotonin syndrome after a massive overdose of controlled-release paroxetine. Psychosomatics. 2010, 51:437-42. 10.1176\/appi.psy.51.5.437","journal-title":"Psychosomatics"},{"key":"ref4","article-title":"SSRI safety in overdose","volume":"58","author":"Barbey JT","year":"1998","unstructured":"Barbey JT, Roose SP. SSRI safety in overdose. J Clin Psychiatry. 1998, 58:42-8.","journal-title":"J Clin Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12796","article-title":"An 11-year retrospective review of cyproheptadine use in serotonin syndrome cases reported to the California Poison Control System","volume":"44","author":"Nguyen H","year":"2019","unstructured":"Nguyen H, Pan A, Smollin C, Cantrell LF, Kearney T. An 11-year retrospective review of cyproheptadine use in serotonin syndrome cases reported to the California Poison Control System. J Clin Pharm Ther. 2019, 44:327-34. 10.1111\/jcpt.12796","journal-title":"J Clin Pharm Ther"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02915-5","article-title":"Revisited: therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics","volume":"24","author":"Schulz M","year":"2020","unstructured":"Schulz M, Schmoldt A, Andresen-Streichert H, Iwersen-Bergmann S. Revisited: therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics. Crit Care. 2020, 24:195. 10.1186\/s13054-020-02915-5","journal-title":"Crit Care"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/31.5.254","article-title":"Reference concentrations of antidepressants. A compilation of postmortem and therapeutic levels","volume":"31","author":"Reis M","year":"2007","unstructured":"Reis M, Aamo T, Ahlner J, Druid H. Reference concentrations of antidepressants. A compilation of postmortem and therapeutic levels. J Anal Toxicol. 2007, 31:254-64. 10.1093\/jat\/31.5.254","journal-title":"J Anal Toxicol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2018.1542702","article-title":"The usefulness of non-contrast abdominal computed tomography for detection of residual drugs in the stomach of patients with acute drug overdose","volume":"57","author":"Cha YS","year":"2019","unstructured":"Cha YS, Cha SW, Kim SJ, Kim YS, Lee Y, Kim H. The usefulness of non-contrast abdominal computed tomography for detection of residual drugs in the stomach of patients with acute drug overdose. Clin Toxicol (Phila). 2019, 57:632-7. 10.1080\/15563650.2018.1542702","journal-title":"Clin Toxicol (Phila)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.24","article-title":"Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: nonlinearity and relation to the sparteine oxidation polymorphism","volume":"51","author":"Sindrup SH","year":"1992","unstructured":"Sindrup SH, Br\u00f8sen K, Gram LF. Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: nonlinearity and relation to the sparteine oxidation polymorphism. Clin Pharmacol Ther. 1992, 51:288-95. 10.1038\/clpt.1992.24","journal-title":"Clin Pharmacol Ther"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e31829ed1f2","article-title":"Pulmonary drug toxicity: presentation of a case of recurrent diffuse alveolar damage caused by paroxetine","volume":"22","author":"Antonello N","year":"2015","unstructured":"Antonello N, Sergio L, Andrea T, Cornelius B. Pulmonary drug toxicity: presentation of a case of recurrent diffuse alveolar damage caused by paroxetine. Am J Ther. 2015, 22:e43-7. 10.1097\/MJT.0b013e31829ed1f2","journal-title":"Am J Ther"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2021.1898631","article-title":"Oral potassium overdose: a case series","volume":"59","author":"Madan A","year":"2021","unstructured":"Madan A, Morris C, Goggin A, Isoardi KZ. Oral potassium overdose: a case series. Clin Toxicol (Phila). 2021, 59:963-8. 10.1080\/15563650.2021.1898631","journal-title":"Clin Toxicol (Phila)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2014.04.002","article-title":"Extended release potassium salts overdose and endoscopic removal of a pharmacobezoar: 2 case report","volume":"1","author":"Guillermo PT","year":"2014","unstructured":"Guillermo PT, Carlos PH, Ivonne BA, Herminio TF, Rub\u00e9n RP. Extended release potassium salts overdose and endoscopic removal of a pharmacobezoar: 2 case report. Toxicol Rep. 2014, 1:209-13. 10.1016\/j.toxrep.2014.04.002","journal-title":"Toxicol Rep"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2022.08.030","article-title":"High risk and low prevalence diseases: serotonin syndrome","volume":"61","author":"Spadaro A","year":"2022","unstructured":"Spadaro A, Scott KR, Koyfman A, Long B. High risk and low prevalence diseases: serotonin syndrome. Am J Emerg Med. 2022, 61:90-7. 10.1016\/j.ajem.2022.08.030","journal-title":"Am J Emerg Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/204350-unexpectedly-prolonged-serotonin-syndrome-and-fatal-complications-following-a-massive-overdose-of-paroxetine-controlled-release","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:10:07Z","timestamp":1707509407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/204350-unexpectedly-prolonged-serotonin-syndrome-and-fatal-complications-following-a-massive-overdose-of-paroxetine-controlled-release"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,17]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.50691","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12,17]]}}}