{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:58:00Z","timestamp":1780585080091,"version":"3.54.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,22]]},"DOI":"10.7759\/cureus.50968","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T22:46:45Z","timestamp":1703285205000},"source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Probiotics Versus Tetracycline Fibers as Adjuvants to Scaling and Root Planing on Interleukin 1\u03b2 Levels in Type 2 Diabetic Patients With Periodontitis: A Clinical and Biochemical Study"],"prefix":"10.7759","author":[{"given":"Pranavi","family":"Gullapelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha R","family":"Koduganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_590_18","article-title":"Comparison of efficacy of probiotics versus tetracycline fibers as adjuvants to scaling and root planing","volume":"23","author":"Boyeena L","year":"2019","unstructured":"Boyeena L, Koduganti RR, Panthula VR, Jammula SP. Comparison of efficacy of probiotics versus tetracycline fibers as adjuvants to scaling and root planing. J Indian Soc Periodontol. 2019, 23:539-44. 10.4103\/jisp.jisp_590_18","journal-title":"J Indian Soc Periodontol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-02927-8","article-title":"Effects of a full-mouth disinfection protocol on the treatment of type-2 diabetic and non-diabetic subjects with mild-to-moderate periodontitis: one-year clinical outcomes","volume":"24","author":"Almeida ML","year":"2020","unstructured":"Almeida ML, Duarte PM, Figueira EA, Lemos JC, Nobre CM, Miranda TS, de Vasconcelos Gurgel BC. Effects of a full-mouth disinfection protocol on the treatment of type-2 diabetic and non-diabetic subjects with mild-to-moderate periodontitis: one-year clinical outcomes. Clin Oral Investig. 2020, 24:333-41. 10.1007\/s00784-019-02927-8","journal-title":"Clin Oral Investig"},{"key":"ref3","article-title":"Local drug delivery systems in the treatment of periodontitis: a literature review","volume":"17","author":"Da Rocha HA","year":"2015","unstructured":"Da Rocha HA, Silva CF, Santiago FL, Martins LG, Dias PC, De Magalh\u00e3es D. Local drug delivery systems in the treatment of periodontitis: a literature review. J Int Acad Periodontol. 2015, 17:82-90.","journal-title":"J Int Acad Periodontol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-019-0794-5","article-title":"Periodontitis and diabetes","volume":"227","author":"Preshaw PM","year":"2019","unstructured":"Preshaw PM, Bissett SM. Periodontitis and diabetes. Br Dent J. 2019, 227:577-84. 10.1038\/s41415-019-0794-5","journal-title":"Br Dent J"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13081175","article-title":"Periodontitis and systemic disorder-an overview of relation and novel treatment modalities","volume":"13","author":"Jain P","year":"2021","unstructured":"Jain P, Hassan N, Khatoon K, Mirza MA, Naseef PP, Kuruniyan MS, Iqbal Z. Periodontitis and systemic disorder-an overview of relation and novel treatment modalities. Pharmaceutics. 2021, 13:1175. 10.3390\/pharmaceutics13081175","journal-title":"Pharmaceutics"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4955277","article-title":"Impact of periodontitis on glycemic control and metabolic status in diabetes patients: current knowledge on early disease markers and therapeutic perspectives","volume":"2022","author":"Santonocito S","year":"2022","unstructured":"Santonocito S, Polizzi A, Marchetti E, et al.. Impact of periodontitis on glycemic control and metabolic status in diabetes patients: current knowledge on early disease markers and therapeutic perspectives. Mediators Inflamm. 2022, 2022:4955277. 10.1155\/2022\/4955277","journal-title":"Mediators Inflamm"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12221","article-title":"Effect of non-surgical periodontal therapy on insulin resistance in patients with type II diabetes mellitus and chronic periodontitis, as assessed by C-peptide and the Homeostasis Assessment Index","volume":"8","author":"Mammen J","year":"2017","unstructured":"Mammen J, Vadakkekuttical RJ, George JM, Kaziyarakath JA, Radhakrishnan C. Effect of non-surgical periodontal therapy on insulin resistance in patients with type II diabetes mellitus and chronic periodontitis, as assessed by C-peptide and the Homeostasis Assessment Index. J Investig Clin Dent. 2017, 8:10.1111\/jicd.12221","journal-title":"J Investig Clin Dent"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12991","article-title":"Effect of two periodontal treatment modalities in patients with uncontrolled type 2 diabetes mellitus: a randomized clinical trial","volume":"45","author":"Quintero AJ","year":"2018","unstructured":"Quintero AJ, Chaparro A, Quirynen M, et al.. Effect of two periodontal treatment modalities in patients with uncontrolled type 2 diabetes mellitus: a randomized clinical trial. J Clin Periodontol. 2018, 45:1098-106. 10.1111\/jcpe.12991","journal-title":"J Clin Periodontol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.08.001","article-title":"Effects on HbA1c in diabetic patients of adjunctive use of systemic antibiotics in nonsurgical periodontal treatment: a systematic review","volume":"66","author":"Lira Junior R","year":"2017","unstructured":"Lira Junior R, Santos CM, Oliveira BH, Fischer RG, Santos AP. Effects on HbA1c in diabetic patients of adjunctive use of systemic antibiotics in nonsurgical periodontal treatment: a systematic review. J Dent. 2017, 66:1-7. 10.1016\/j.jdent.2017.08.001","journal-title":"J Dent"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/1735-3327.215961","article-title":"The clinical and metabolic effects of subgingival application of xanthan-based chlorhexidine gel in type 2 diabetic patients with chronic periodontitis","volume":"14","author":"Faramarzi M","year":"2017","unstructured":"Faramarzi M, Shirmohammadi A, Chitsazi M, Shamami MS, Ghanitab S. The clinical and metabolic effects of subgingival application of xanthan-based chlorhexidine gel in type 2 diabetic patients with chronic periodontitis. Dent Res J (Isfahan). 2017, 14:299-305. 10.4103\/1735-3327.215961","journal-title":"Dent Res J (Isfahan)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0762.142011","article-title":"Effect of tetracycline HCl in the treatment of chronic periodontitis - a clinical study","volume":"4","author":"Sinha S","year":"2014","unstructured":"Sinha S, Kumar S, Dagli N, Dagli RJ. Effect of tetracycline HCl in the treatment of chronic periodontitis - a clinical study. J Int Soc Prev Community Dent. 2014, 4:149-53. 10.4103\/2231-0762.142011","journal-title":"J Int Soc Prev Community Dent"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12111","article-title":"Clinical utility of locally-delivered collagen-based biodegradable tetracycline fibers in periodontal therapy: an in vivo study","volume":"6","author":"Khan FY","year":"2015","unstructured":"Khan FY, Jan SM, Mushtaq M. Clinical utility of locally-delivered collagen-based biodegradable tetracycline fibers in periodontal therapy: an in vivo study. J Investig Clin Dent. 2015, 6:307-12. 10.1111\/jicd.12111","journal-title":"J Investig Clin Dent"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.96816","article-title":"Effect of locally delivered tetracycline hydrochloride as an adjunct to scaling and root planing on Hba1c, C-reactive protein, and lipid profile in type 2 diabetes: a clinico-biochemical study","volume":"3","author":"Dodwad V","year":"2012","unstructured":"Dodwad V, Ahuja S, Kukreja BJ. Effect of locally delivered tetracycline hydrochloride as an adjunct to scaling and root planing on Hba1c, C-reactive protein, and lipid profile in type 2 diabetes: a clinico-biochemical study. Contemp Clin Dent. 2012, 3:150-4. 10.4103\/0976-237X.96816","journal-title":"Contemp Clin Dent"},{"key":"ref14","article-title":"Surgical vs nonsurgical therapy adjuncted with tetracycline local drug delivery in diabetic patients: a randomized clinical trial","volume":"3","author":"Karnik AV","year":"2015","unstructured":"Karnik AV, Baburaj MD. Surgical vs nonsurgical therapy adjuncted with tetracycline local drug delivery in diabetic patients: a randomized clinical trial. Dent J Adv Stud. 2015, 3:165-73.","journal-title":"Dent J Adv Stud"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10020197","article-title":"Nutrition as a key modifiable factor for periodontitis and main chronic diseases","volume":"10","author":"Martinon P","year":"2021","unstructured":"Martinon P, Fraticelli L, Giboreau A, Dussart C, Bourgeois D, Carrouel F. Nutrition as a key modifiable factor for periodontitis and main chronic diseases. J Clin Med. 2021, 10:197. 10.3390\/jcm10020197","journal-title":"J Clin Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12689","article-title":"Adjunctive efficacy of probiotics in the treatment of experimental peri-implant mucositis with mechanical and photodynamic therapy: a randomized, cross-over clinical trial","volume":"44","author":"Mongardini C","year":"2017","unstructured":"Mongardini C, Pilloni A, Farina R, Di Tanna G, Zeza B. Adjunctive efficacy of probiotics in the treatment of experimental peri-implant mucositis with mechanical and photodynamic therapy: a randomized, cross-over clinical trial. J Clin Periodontol. 2017, 44:410-7. 10.1111\/jcpe.12689","journal-title":"J Clin Periodontol"},{"key":"ref17","article-title":"Comparative evaluation of clinical effectiveness of probiotics and aloe vera gel on periodontal health: a randomized clinical trial","volume":"8","author":"Yawale P","year":"2020","unstructured":"Yawale P, Thakare K, Wankhade S, Rathi N, Agrawal A, Ganvir M. Comparative evaluation of clinical effectiveness of probiotics and aloe vera gel on periodontal health: a randomized clinical trial. J Adv Med Dent Sci Res. 2020, 8:193-7.","journal-title":"J Adv Med Dent Sci Res"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.23812\/21-2supp1-6","article-title":"Role of probiotics in adjunct to non-surgical periodontal therapy in patients with chronic periodontitis: a systematic review and meta-analysis","volume":"35","author":"Mishra S","year":"2021","unstructured":"Mishra S, Misra SR, Panda S, et al.. Role of probiotics in adjunct to non-surgical periodontal therapy in patients with chronic periodontitis: a systematic review and meta-analysis. J Biol Regul Homeost Agents. 2021, 35:67-78. 10.23812\/21-2supp1-6","journal-title":"J Biol Regul Homeost Agents"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-019-0068-8","article-title":"Interleukin-1\u03b2 is a potential therapeutic target for periodontitis: a narrative review","volume":"12","author":"Cheng R","year":"2020","unstructured":"Cheng R, Wu Z, Li M, Shao M, Hu T. Interleukin-1\u03b2 is a potential therapeutic target for periodontitis: a narrative review. Int J Oral Sci. 2020, 12:2. 10.1038\/s41368-019-0068-8","journal-title":"Int J Oral Sci"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2012.01480.x","article-title":"Effect of scaling and root planing on interleukin-1\u03b2, interleukin-8 and MMP-8 levels in gingival crevicular fluid from chronic periodontitis patients","volume":"47","author":"Konopka L","year":"2012","unstructured":"Konopka L, Pietrzak A, Brzezi\u0144ska-B\u0142aszczyk E. Effect of scaling and root planing on interleukin-1\u03b2, interleukin-8 and MMP-8 levels in gingival crevicular fluid from chronic periodontitis patients. J Periodontal Res. 2012, 47:681-8. 10.1111\/j.1600-0765.2012.01480.x","journal-title":"J Periodontal Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/210689-efficacy-of-probiotics-versus-tetracycline-fibers-as-adjuvants-to-scaling-and-root-planing-on-interleukin-1-levels-in-type-2-diabetic-patients-with-periodontitis-a-clinical-and-biochemical-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:11:10Z","timestamp":1707509470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/210689-efficacy-of-probiotics-versus-tetracycline-fibers-as-adjuvants-to-scaling-and-root-planing-on-interleukin-1-levels-in-type-2-diabetic-patients-with-periodontitis-a-clinical-and-biochemical-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,22]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.50968","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12,22]]}}}