{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:22:19Z","timestamp":1755696139788},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,25]]},"DOI":"10.7759\/cureus.51088","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T05:25:46Z","timestamp":1703568346000},"source":"Crossref","is-referenced-by-count":1,"title":["Antioxidant Vitamins Attenuate Glyphosate-Induced Development of Type-2 Diabetes Through the Activation of Glycogen Synthase Kinase-3 \u03b2 and Forkhead Box Protein O-1 in the Liver of Adult Male Rats"],"prefix":"10.7759","author":[{"given":"Divaskara","family":"Chandran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selvaraj","family":"Jayaraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavitha","family":"Sankaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishnu Priya","family":"Veeraraghavan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayathri","family":"R","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.962619","article-title":"Current status of pesticide effects on environment, human health and it's eco-friendly management as bioremediation: a comprehensive review","volume":"13","author":"Pathak VM","year":"2022","unstructured":"Pathak VM, Verma VK, Rawat BS, et al.. Current status of pesticide effects on environment, human health and it's eco-friendly management as bioremediation: a comprehensive review. Front Microbiol. 2022, 13:962619. 10.3389\/fmicb.2022.962619","journal-title":"Front Microbiol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-016-7425-3","article-title":"Glyphosate: environmental contamination, toxicity and potential risks to human health via food contamination","volume":"23","author":"Bai SH","year":"2016","unstructured":"Bai SH, Ogbourne SM. Glyphosate: environmental contamination, toxicity and potential risks to human health via food contamination. Environ Sci Pollut Res Int. 2016, 23:18988-9001. 10.1007\/s11356-016-7425-3","journal-title":"Environ Sci Pollut Res Int"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-017-1962-5","article-title":"Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC","volume":"91","author":"Tarazona JV","year":"2017","unstructured":"Tarazona JV, Court-Marques D, Tiramani M, Reich H, Pfeil R, Istace F, Crivellente F. Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC. Arch Toxicol. 2017, 91:2723-43. 10.1007\/s00204-017-1962-5","journal-title":"Arch Toxicol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9112322","article-title":"Glyphosate pollution treatment and microbial degradation alternatives, a review","volume":"9","author":"Castrej\u00f3n-God\u00ednez ML","year":"2021","unstructured":"Castrej\u00f3n-God\u00ednez ML, Tovar-S\u00e1nchez E, Valencia-Cuevas L, Rosas-Ram\u00edrez ME, Rodr\u00edguez A, Mussali-Galante P. Glyphosate pollution treatment and microbial degradation alternatives, a review. Microorganisms. 2021, 9:2322. 10.3390\/microorganisms9112322","journal-title":"Microorganisms"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/su14116868","article-title":"Overview of environmental and health effects related to glyphosate usage","volume":"14","author":"Rivas-Garcia T","year":"2022","unstructured":"Rivas-Garcia T, Espinosa-Calder\u00f3n A, Hern\u00e1ndez-V\u00e1zquez B, Schwentesius-Rindermann R. Overview of environmental and health effects related to glyphosate usage. Sustainability. 2022, 14:6868. 10.3390\/su14116868","journal-title":"Sustainability"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.10.309","article-title":"Environmental and health effects of the herbicide glyphosate","volume":"616-617","author":"Van Bruggen AH","year":"2018","unstructured":"Van Bruggen AH, He MM, Shin K, Mai V, Jeong KC, Finckh MR, Morris JG Jr. Environmental and health effects of the herbicide glyphosate. Sci Total Environ. 2018, 616-617:255-68. 10.1016\/j.scitotenv.2017.10.309","journal-title":"Sci Total Environ"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094605","article-title":"Toxic effects of glyphosate on the nervous system: a systematic review","volume":"23","author":"Costas-Ferreira C","year":"2022","unstructured":"Costas-Ferreira C, Dur\u00e1n R, Faro LR. Toxic effects of glyphosate on the nervous system: a systematic review. Int J Mol Sci. 2022, 23:4605. 10.3390\/ijms23094605","journal-title":"Int J Mol Sci"},{"key":"ref8","article-title":"Antioxidant activity of silver nanoparticles using Picrorhiza Kurroa root extract","volume":"29","author":"Shanmugam SB","year":"2022","unstructured":"Shanmugam SB, Sangeetha S, Rajesh KS, Prathap L. Antioxidant activity of silver nanoparticles using Picrorhiza Kurroa root extract. J Popl Ther Clin Pharmacol. 2022, 29:140-47.","journal-title":"J Popl Ther Clin Pharmacol"},{"key":"ref9","article-title":"Antibacterial activity of zinc oxide nanoparticles against Streptococcus mutans using Picrorhiza","volume":"29","author":"Katheeja RS","year":"2022","unstructured":"Katheeja RS, Sangeetha S, Rajeshkumar, Prathap L. Antibacterial activity of zinc oxide nanoparticles against Streptococcus mutans using Picrorhiza. J Popl Ther Clin Pharmacol. 2022, 29:170-8.","journal-title":"J Popl Ther Clin Pharmacol"},{"key":"ref10","article-title":"Antidiabetic activity of Piper longum and stevia herbal formulation","volume":"13","author":"Surya C","year":"2023","unstructured":"Surya C, Rajeshkumar S, Lakshmi T, Roy A. Antidiabetic activity of Piper longum and stevia herbal formulation. J Complement Med Res. 2023, 13:29.","journal-title":"J Complement Med Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.70902","article-title":"Free radicals, antioxidants and functional foods: impact on human health","volume":"4","author":"Lobo V","year":"2010","unstructured":"Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev. 2010, 4:118-26. 10.4103\/0973-7847.70902","journal-title":"Pharmacogn Rev"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3217","article-title":"Natural antioxidants from some fruits, seeds, foods, natural products, and associated health benefits: an update","volume":"11","author":"Rahaman MM","year":"2023","unstructured":"Rahaman MM, Hossain R, Herrera-Bravo J, et al.. Natural antioxidants from some fruits, seeds, foods, natural products, and associated health benefits: an update. Food Sci Nutr. 2023, 11:1657-70. 10.1002\/fsn3.3217","journal-title":"Food Sci Nutr"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1208\/aapsj080112","article-title":"Cytochrome P450s and other enzymes in drug metabolism and toxicity","volume":"8","author":"Guengerich FP","year":"2006","unstructured":"Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. AAPS J. 2006, 8:E101-11. 10.1208\/aapsj080112","journal-title":"AAPS J"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2004.04.008","article-title":"The effects of sub-chronic exposure of Wistar rats to the herbicide Glyphosate-Biocarb","volume":"153","author":"Benedetti AL","year":"2004","unstructured":"Benedetti AL, Vituri Cde L, Trentin AG, Domingues MA, Alvarez-Silva M. The effects of sub-chronic exposure of Wistar rats to the herbicide Glyphosate-Biocarb. Toxicol Lett. 2004, 153:227-32. 10.1016\/j.toxlet.2004.04.008","journal-title":"Toxicol Lett"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.31744\/einstein_journal\/2022AO6778","article-title":"Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring","volume":"20","author":"Gomes ECZ","year":"2022","unstructured":"Gomes ECZ, Teleken JL, Vargas R, Alegre-Maller AC, Amorim JP, Bonfleur ML, Balbo SL. Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring. Einstein (Sao Paulo). 2022, 20:eAO6778. 10.31744\/einstein_journal\/2022AO6778","journal-title":"Einstein (Sao Paulo)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124917","article-title":"Glyphosate potentiates insulin resistance in skeletal muscle through the modulation of IRS-1\/PI3K\/Akt mediated mechanisms: an in vivo and in silico analysis","volume":"242(Pt 2)","author":"Jayaraman S","year":"2023","unstructured":"Jayaraman S, Krishnamoorthy K, Prasad M, et al.. Glyphosate potentiates insulin resistance in skeletal muscle through the modulation of IRS-1\/PI3K\/Akt mediated mechanisms: an in vivo and in silico analysis. Int J Biol Macromol. 2023, 242(Pt 2):124917. 10.1016\/j.ijbiomac.2023.124917","journal-title":"Int J Biol Macromol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm4765","article-title":"Searching for solutions to our soil woes","volume":"374","author":"Richter DD","year":"2021","unstructured":"Richter DD. Searching for solutions to our soil woes. Science. 2021, 374:1452. 10.1126\/science.abm4765","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122436","article-title":"Impact of glyphosate on the development of insulin resistance in experimental diabetic rats: role of NF\u03baB signalling pathways","volume":"11","author":"Prasad M","year":"2022","unstructured":"Prasad M, Gatasheh MK, Alshuniaber MA, et al.. Impact of glyphosate on the development of insulin resistance in experimental diabetic rats: role of NF\u03baB signalling pathways. Antioxidants (Basel). 2022, 11:2436. 10.3390\/antiox11122436","journal-title":"Antioxidants (Basel)"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.08.022","article-title":"Diethyl hexyl phthalate-induced changes in insulin signaling molecules and the protective role of antioxidant vitamins in gastrocnemius muscle of adult male rat","volume":"257","author":"Srinivasan C","year":"2011","unstructured":"Srinivasan C, Khan AI, Balaji V, Selvaraj J, Balasubramanian K. Diethyl hexyl phthalate-induced changes in insulin signaling molecules and the protective role of antioxidant vitamins in gastrocnemius muscle of adult male rat. Toxicol Appl Pharmacol. 2011, 257:155-64. 10.1016\/j.taap.2011.08.022","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1208","article-title":"Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets","volume":"58","author":"Liu H","year":"2009","unstructured":"Liu H, Remedi MS, Pappan KL, Kwon G, Rohatgi N, Marshall CA, McDaniel ML. Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets. Diabetes. 2009, 58:663-72. 10.2337\/db07-1208","journal-title":"Diabetes"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2174\/1568026620666200516153136","article-title":"Glycogen synthase kinase 3 (GSK3): its role and inhibitors","volume":"20","author":"Wadhwa P","year":"2020","unstructured":"Wadhwa P, Jain P, Jadhav HR. Glycogen synthase kinase 3 (GSK3): its role and inhibitors. Curr Top Med Chem. 2020, 20:1522-34. 10.2174\/1568026620666200516153136","journal-title":"Curr Top Med Chem"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/med.10011","article-title":"Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation","volume":"22","author":"Martinez A","year":"2002","unstructured":"Martinez A, Castro A, Dorronsoro I, Alonso M. Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation. Med Res Rev. 2002, 22:373-84. 10.1002\/med.10011","journal-title":"Med Res Rev"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.09.010","article-title":"FOXO transcription factors as therapeutic targets in human diseases","volume":"43","author":"Orea-Soufi A","year":"2022","unstructured":"Orea-Soufi A, Paik J, Bragan\u00e7a J, Donlon TA, Willcox BJ, Link W. FOXO transcription factors as therapeutic targets in human diseases. Trends Pharmacol Sci. 2022, 43:1070-84. 10.1016\/j.tips.2022.09.010","journal-title":"Trends Pharmacol Sci"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0088-2","article-title":"Therapeutic strategies targeting FOXO transcription factors","volume":"20","author":"Calissi G","year":"2021","unstructured":"Calissi G, Lam EW, Link W. Therapeutic strategies targeting FOXO transcription factors. Nat Rev Drug Discov. 2021, 20:21-38. 10.1038\/s41573-020-0088-2","journal-title":"Nat Rev Drug Discov"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1996.tb04161.x","article-title":"Antioxidant vitamins and health","volume":"36","author":"Gibaldi M","year":"1996","unstructured":"Gibaldi M. Antioxidant vitamins and health. J Clin Pharmacol. 1996, 36:1093-9. 10.1002\/j.1552-4604.1996.tb04161.x","journal-title":"J Clin Pharmacol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.9734\/JPRI\/2021\/v33i51A33501","article-title":"Green synthesis and characterization of silver nanoparticles synthesized using Piper longum and its antioxidant activity","volume":"33","author":"Imtiaz T","year":"2021","unstructured":"Imtiaz T, Priyadharshini R, Rajeshkumar S, Sinduja P. Green synthesis and characterization of silver nanoparticles synthesized using Piper longum and its antioxidant activity. J Pharm Res Int. 2021, 33:342-52. 10.9734\/JPRI\/2021\/v33i51A33501","journal-title":"J Pharm Res Int"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4103\/jiaomr.jiaomr_98_21","article-title":"Anti-inflammatory and antioxidant activity of lycopene, raspberry, green tea herbal formulation mediated silver nanoparticle","volume":"33","author":"Chaithanya MV","year":"2021","unstructured":"Chaithanya MV, Maheswari TN, Rajeshkumar S. Anti-inflammatory and antioxidant activity of lycopene, raspberry, green tea herbal formulation mediated silver nanoparticle. J Indian Acad Oral Med Radiol. 2021, 33:397-400. 10.4103\/jiaomr.jiaomr_98_21","journal-title":"J Indian Acad Oral Med Radiol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/182772-antioxidant-vitamins-attenuate-glyphosate-induced-development-of-type-2-diabetes-through-the-activation-of-glycogen-synthase-kinase-3--and-forkhead-box-protein-o-1-in-the-liver-of-adult-male-rats","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:11:03Z","timestamp":1707509463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/182772-antioxidant-vitamins-attenuate-glyphosate-induced-development-of-type-2-diabetes-through-the-activation-of-glycogen-synthase-kinase-3--and-forkhead-box-protein-o-1-in-the-liver-of-adult-male-rats"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,25]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.51088","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12,25]]}}}