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Virulence. 2014, 5:20-6. 10.4161\/viru.27135","journal-title":"Virulence"},{"key":"ref218","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007070744","article-title":"IL-6\/IL-6R axis plays a critical role in acute kidney injury","volume":"19","author":"Nechemia-Arbely Y","year":"2008","unstructured":"Nechemia-Arbely Y, Barkan D, Pizov G, et al.. IL-6\/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol. 2008, 19:1106-15. 10.1681\/ASN.2007070744","journal-title":"J Am Soc Nephrol"},{"key":"ref219","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60602-2","article-title":"Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group","volume":"351","author":"Abraham E","year":"1998","unstructured":"Abraham E, Anzueto A, Gutierrez G, et al.. Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. 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JAMA. 1994, 271:1836-43. 10.1001\/jama.1994.03510470040032","journal-title":"JAMA"},{"key":"ref221","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.4.615","article-title":"Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)","volume":"189","author":"Qureshi ST","year":"1999","unstructured":"Qureshi ST, Lariviere L, Leveque G, et al.. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med. 1999, 189:615-25. 10.1084\/jem.189.4.615","journal-title":"J Exp Med"},{"key":"ref222","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000288082.99980.90","article-title":"Expanding the global epidemiology of sepsis","volume":"35","author":"Cribbs SK","year":"2007","unstructured":"Cribbs SK, Martin GS. Expanding the global epidemiology of sepsis. Crit Care Med. 2007, 35:2646-8. 10.1097\/01.CCM.0000288082.99980.90","journal-title":"Crit Care Med"},{"key":"ref223","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007390","article-title":"Toll-like receptor 4 in acute viral infection: too much of a good thing","volume":"14","author":"Olejnik J","year":"2018","unstructured":"Olejnik J, Hume AJ, Muhlberger E. Toll-like receptor 4 in acute viral infection: too much of a good thing. PLoS Pathog. 2018, 14:1007390. 10.1371\/journal.ppat.1007390","journal-title":"PLoS Pathog"},{"key":"ref224","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00226-17","article-title":"The toll-like receptor 4 antagonist Eritoran protects mice from lethal filovirus challenge","volume":"8","author":"Younan P","year":"2017","unstructured":"Younan P, Ramanathan P, Graber J, et al.. The toll-like receptor 4 antagonist Eritoran protects mice from lethal filovirus challenge. mBio. 2017, 8:e00226-17. 10.1128\/mBio.00226-17","journal-title":"mBio"},{"key":"ref225","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25030627","article-title":"TLR4-targeting therapeutics structural basis and computer-aided drug discovery approaches","volume":"25","author":"Ain QU","year":"2020","unstructured":"Ain QU, Batool M, Choi S. TLR4-targeting therapeutics structural basis and computer-aided drug discovery approaches. Molecules. 2020, 25:627. 10.3390\/molecules25030627","journal-title":"Molecules"},{"key":"ref226","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020816","article-title":"Toll-like receptors in acute kidney injury","volume":"22","author":"Vazquez-Carballo C","year":"2021","unstructured":"Vazquez-Carballo C, Guerrero-Hue M, Garcia-Caballero C, et al.. Toll-like receptors in acute kidney injury. Int J Mol Sci. 2021, 22:816. 10.3390\/ijms22020816","journal-title":"Int J Mol Sci"},{"key":"ref227","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400819","article-title":"Resveratrol attenuates lipopolysaccharide-induced acute kidney injury by suppressing inflammation driven by macrophages","volume":"59","author":"Chen L","year":"2015","unstructured":"Chen L, Yang S, Zumbrun EE, et al.. Resveratrol attenuates lipopolysaccharide-induced acute kidney injury by suppressing inflammation driven by macrophages. Mol Nutr Food Res. 2015, 59:853-64. 10.1002\/mnfr.201400819","journal-title":"Mol Nutr Food Res"},{"key":"ref228","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16860","article-title":"Resveratrol protects against early polymicrobial sepsis-induced acute kidney injury through inhibiting endoplasmic reticulum stress-activated NF-kappaB pathway","volume":"8","author":"Wang N","year":"2017","unstructured":"Wang N, Mao L, Yang L, et al.. Resveratrol protects against early polymicrobial sepsis-induced acute kidney injury through inhibiting endoplasmic reticulum stress-activated NF-kappaB pathway. Oncotarget. 2017, 8:36449-36461. 10.18632\/oncotarget.16860","journal-title":"Oncotarget"},{"key":"ref229","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.03.123","article-title":"Sulforaphane inhibits the engagement of LPS with TLR4\/MD2 complex by preferential binding to Cys133 in MD2","volume":"434","author":"Koo JE","year":"2013","unstructured":"Koo JE, Park ZY, Kim ND, et al.. Sulforaphane inhibits the engagement of LPS with TLR4\/MD2 complex by preferential binding to Cys133 in MD2. Biochem Biophys Res Commun. 2013, 434:600-5. 10.1016\/j.bbrc.2013.03.123","journal-title":"Biochem Biophys Res Commun"},{"key":"ref230","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2011.02.004","article-title":"Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy","volume":"23","author":"Guerrero-Beltran CE","year":"2012","unstructured":"Guerrero-Beltran CE, Mukhopadhyay P, Horvath B, et al.. Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy. J Nutr Biochem. 2012, 23:494-500. 10.1016\/j.jnutbio.2011.02.004","journal-title":"J Nutr Biochem"},{"key":"ref231","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2803","article-title":"Microtubules and resistance to tubulin-binding agents","volume":"10","author":"Kavallaris M","year":"2010","unstructured":"Kavallaris M. Microtubules and resistance to tubulin-binding agents. Nat Rev Cancer. 2010, 10:194-204. 10.1038\/nrc2803","journal-title":"Nat Rev Cancer"},{"key":"ref232","doi-asserted-by":"publisher","DOI":"10.2174\/138945012804545533","article-title":"Mitosis-targeting natural products for cancer prevention and therapy","volume":"13","author":"Rao CV","year":"2012","unstructured":"Rao CV, Kurkjian CD, Yamada HY. Mitosis-targeting natural products for cancer prevention and therapy. Curr Drug Targets. 2012, 13:1820-30. 10.2174\/138945012804545533","journal-title":"Curr Drug Targets"},{"key":"ref233","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.202481","article-title":"Paclitaxel ameliorates lipopolysaccharide-induced kidney injury by binding myeloid differentiation protein-2 to block Toll-like receptor 4-mediated nuclear factor-kappaB activation and cytokine production","volume":"345","author":"Zhang D","year":"2013","unstructured":"Zhang D, Li Y, Liu Y, et al.. Paclitaxel ameliorates lipopolysaccharide-induced kidney injury by binding myeloid differentiation protein-2 to block Toll-like receptor 4-mediated nuclear factor-kappaB activation and cytokine production. J Pharmacol Exp Ther. 2013, 345:69-75. 10.1124\/jpet.112.202481","journal-title":"J Pharmacol Exp Ther"},{"key":"ref234","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.03.022","article-title":"Inhibition of homodimerization of Toll-like receptor 4 by curcumin","volume":"72","author":"Youn HS","year":"2006","unstructured":"Youn HS, Saitoh SI, Miyake K, et al.. Inhibition of homodimerization of Toll-like receptor 4 by curcumin. Biochem Pharmacol. 2006, 72:62-9. 10.1016\/j.bcp.2006.03.022","journal-title":"Biochem Pharmacol"},{"key":"ref235","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2018.1544565","article-title":"The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats","volume":"40","author":"Zhang J","year":"2018","unstructured":"Zhang J, Tang L, Li GS, et al.. The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats. Ren Fail. 2018, 40:680-6. 10.1080\/0886022X.2018.1544565","journal-title":"Ren Fail"},{"key":"ref236","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01590.x","article-title":"Amelioration of renal ischaemia-reperfusion injury by liposomal delivery of curcumin to renal tubular epithelial and antigen-presenting cells","volume":"166","author":"Rogers NM","year":"2012","unstructured":"Rogers NM, Stephenson MD, Kitching AR, et al.. Amelioration of renal ischaemia-reperfusion injury by liposomal delivery of curcumin to renal tubular epithelial and antigen-presenting cells. Br J Pharmacol. 2012, 166:194-209. 10.1111\/j.1476-5381.2011.01590.x","journal-title":"Br J Pharmacol"},{"key":"ref237","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(89)90288-8","article-title":"Acute hydrogen sulfide poisoning. Demonstration of selective uptake of sulfide by the brainstem by measurement of brain sulfide levels","volume":"38","author":"Warenycia MW","year":"1989","unstructured":"Warenycia MW, Goodwin LR, Benishin CG, et al.. Acute hydrogen sulfide poisoning. Demonstration of selective uptake of sulfide by the brainstem by measurement of brain sulfide levels. Biochem Pharmacol. 1989, 38:973-81. 10.1016\/0006-2952(89)90288-8","journal-title":"Biochem Pharmacol"},{"key":"ref238","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0510-x","article-title":"Hydrogen sulfide: its production, release and functions","volume":"41","author":"Kimura H","year":"2011","unstructured":"Kimura H. Hydrogen sulfide: its production, release and functions. Amino Acids. 2011, 41:113-21. 10.1007\/s00726-010-0510-x","journal-title":"Amino Acids"},{"key":"ref239","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2371","article-title":"A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells","volume":"4","author":"Shibuya N","year":"2013","unstructured":"Shibuya N, Koike S, Tanaka M, et al.. A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells. Nat Commun. 2013, 4:1366. 10.1038\/ncomms2371","journal-title":"Nat Commun"},{"key":"ref240","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6717212","article-title":"Hydrogen sulfide attenuates LPS-induced acute kidney injury by inhibiting inflammation and oxidative stress","volume":"2018","author":"Chen Y","year":"2018","unstructured":"Chen Y, Jin S, Teng X, et al.. Hydrogen sulfide attenuates LPS-induced acute kidney injury by inhibiting inflammation and oxidative stress. Oxid Med Cell Longev. 2018, 2018:6717212. 10.1155\/2018\/6717212","journal-title":"Oxid Med Cell Longev"},{"key":"ref241","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.002","article-title":"Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran","volume":"130","author":"Kim HM","year":"2007","unstructured":"Kim HM, Park BS, Kim JI, et al.. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell. 2007, 130:906-17. 10.1016\/j.cell.2007.08.002","journal-title":"Cell"},{"key":"ref242","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.044487","article-title":"Inhibition of endotoxin response by e5564, a novel toll-like receptor 4-directed endotoxin antagonist","volume":"304","author":"Mullarkey M","year":"2003","unstructured":"Mullarkey M, Rose JR, Bristol J, et al.. Inhibition of endotoxin response by e5564, a novel toll-like receptor 4-directed endotoxin antagonist. J Pharmacol Exp Ther. 2003, 304:1093-102. 10.1124\/jpet.102.044487","journal-title":"J Pharmacol Exp Ther"},{"key":"ref243","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb.7100102","article-title":"Targeting toll-like receptors for drug development: a summary of commercial approaches","volume":"85","author":"Gearing AJ","year":"2007","unstructured":"Gearing AJ. Targeting toll-like receptors for drug development: a summary of commercial approaches. Immunol Cell Biol. 2007, 85:490-4. 10.1038\/sj.icb.7100102","journal-title":"Immunol Cell Biol"},{"key":"ref244","doi-asserted-by":"publisher","DOI":"10.1038\/nature12118","article-title":"The TLR4 antagonist Eritoran protects mice from lethal influenza infection","volume":"497","author":"Shirey KA","year":"2013","unstructured":"Shirey KA, Lai W, Scott AJ, et al.. The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature. 2013, 497:498-502. 10.1038\/nature12118","journal-title":"Nature"},{"key":"ref245","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.03.133","article-title":"Protective effects of toll-like receptor 4 inhibitor Eritoran on renal ischemia-reperfusion injury","volume":"42","author":"Liu M","year":"2010","unstructured":"Liu M, Gu M, Xu D, et al.. Protective effects of toll-like receptor 4 inhibitor Eritoran on renal ischemia-reperfusion injury. 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