{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:52:29Z","timestamp":1785282749029,"version":"3.55.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,8]]},"DOI":"10.7759\/cureus.51863","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T14:05:19Z","timestamp":1704722719000},"source":"Crossref","is-referenced-by-count":4,"title":["Accuracy of MRI in Detecting 1p\/19q Co-deletion Status of Gliomas: A Single-Center Retrospective Study"],"prefix":"10.7759","author":[{"given":"Adnan","family":"Naeem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrah","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Nasir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussain Sohail","family":"Rangwala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hareer","family":"Fatima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Mubarak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Oligodendroglioma","author":"Tork CA","year":"2023","unstructured":"Tork CA, Atkinson C. Oligodendroglioma. StatPearls Publishing, Treasure Island, FL; 2023."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO Classification of Tumors of the Central Nervous System: a summary","volume":"23","author":"Louis DN","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P, et al.. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021, 23:1231-51. 10.1093\/neuonc\/noab106","journal-title":"Neuro Oncol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.2844","article-title":"World Health Organization 2021 classification of central nervous system tumors and implications for therapy for adult-type gliomas: a review","volume":"8","author":"Berger TR","year":"2022","unstructured":"Berger TR, Wen PY, Lang-Orsini M, Chukwueke UN. World Health Organization 2021 classification of central nervous system tumors and implications for therapy for adult-type gliomas: a review. JAMA Oncol. 2022, 8:1493-501. 10.1001\/jamaoncol.2022.2844","journal-title":"JAMA Oncol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.16432","article-title":"Role of 1p\/19q codeletion in diffuse low-grade glioma tumour prognosis","volume":"43","author":"Familiari P","year":"2023","unstructured":"Familiari P, Lapolla P, Picotti V, et al.. Role of 1p\/19q codeletion in diffuse low-grade glioma tumour prognosis. Anticancer Res. 2023, 43:2659-70. 10.21873\/anticanres.16432","journal-title":"Anticancer Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.3.636","article-title":"Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas","volume":"18","author":"Smith JS","year":"2000","unstructured":"Smith JS, Perry A, Borell TJ, et al.. Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. J Clin Oncol. 2000, 18:636-45. 10.1200\/JCO.2000.18.3.636","journal-title":"J Clin Oncol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1148\/ryai.2021200301","article-title":"MRI-based identification and classification of major intracranial tumor types by using a 3D convolutional neural network: a retrospective multi-institutional analysis","volume":"3","author":"Chakrabarty S","year":"2021","unstructured":"Chakrabarty S, Sotiras A, Milchenko M, LaMontagne P, Hileman M, Marcus D. MRI-based identification and classification of major intracranial tumor types by using a 3D convolutional neural network: a retrospective multi-institutional analysis. Radiol Artif Intell. 2021, 3:e200301. 10.1148\/ryai.2021200301","journal-title":"Radiol Artif Intell"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15041037","article-title":"Multi-parametric radiomic model to predict 1p\/19q co-deletion in patients with IDH-1 mutant glioma: added value to the T2-FLAIR mismatch sign","volume":"15","author":"Kihira S","year":"2023","unstructured":"Kihira S, Derakhshani A, Leung M, et al.. Multi-parametric radiomic model to predict 1p\/19q co-deletion in patients with IDH-1 mutant glioma: added value to the T2-FLAIR mismatch sign. Cancers (Basel). 2023, 15:1037. 10.3390\/cancers15041037","journal-title":"Cancers (Basel)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5572","article-title":"MRI features can predict 1p\/19q status in intracranial gliomas","volume":"39","author":"Lasocki A","year":"2018","unstructured":"Lasocki A, Gaillard F, Gorelik A, Gonzales M. MRI features can predict 1p\/19q status in intracranial gliomas. AJNR Am J Neuroradiol. 2018, 39:687-92. 10.3174\/ajnr.A5572","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-08607-8","article-title":"Radiogenomic association between the T2-FLAIR mismatch sign and IDH mutation status in adult patients with lower-grade gliomas: an updated systematic review and meta-analysis","volume":"32","author":"Han Z","year":"2022","unstructured":"Han Z, Chen Q, Zhang L, et al.. Radiogenomic association between the T2-FLAIR mismatch sign and IDH mutation status in adult patients with lower-grade gliomas: an updated systematic review and meta-analysis. Eur Radiol. 2022, 32:5339-52. 10.1007\/s00330-022-08607-8","journal-title":"Eur Radiol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11091620","article-title":"The T2-FLAIR mismatch sign as an imaging indicator of IDH-mutant, 1p\/19q non-codeleted lower grade gliomas: a systematic review and diagnostic accuracy meta-analysis","volume":"11","author":"Adamou A","year":"2021","unstructured":"Adamou A, Beltsios ET, Papanagiotou P. The T2-FLAIR mismatch sign as an imaging indicator of IDH-mutant, 1p\/19q non-codeleted lower grade gliomas: a systematic review and diagnostic accuracy meta-analysis. Diagnostics (Basel). 2021, 11:1620. 10.3390\/diagnostics11091620","journal-title":"Diagnostics (Basel)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-022-02975-0","article-title":"Conventional MRI features can predict the molecular subtype of adult grade 2-3 intracranial diffuse gliomas","volume":"64","author":"Lasocki A","year":"2022","unstructured":"Lasocki A, Buckland ME, Drummond KJ, et al.. Conventional MRI features can predict the molecular subtype of adult grade 2-3 intracranial diffuse gliomas. Neuroradiology. 2022, 64:2295-305. 10.1007\/s00234-022-02975-0","journal-title":"Neuroradiology"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-018-0321-4","article-title":"Radiological characteristics based on isocitrate dehydrogenase mutations and 1p\/19q codeletion in grade II and III gliomas","volume":"35","author":"Yamauchi T","year":"2018","unstructured":"Yamauchi T, Ohno M, Matsushita Y, et al.. Radiological characteristics based on isocitrate dehydrogenase mutations and 1p\/19q codeletion in grade II and III gliomas. Brain Tumor Pathol. 2018, 35:148-58. 10.1007\/s10014-018-0321-4","journal-title":"Brain Tumor Pathol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-023-04244-3","article-title":"Tumor volume and calcifications as indicators for preoperative differentiation of grade II\/III diffuse gliomas","volume":"161","author":"Fukuya Y","year":"2023","unstructured":"Fukuya Y, Tamura M, Nitta M, et al.. Tumor volume and calcifications as indicators for preoperative differentiation of grade II\/III diffuse gliomas. J Neurooncol. 2023, 161:555-62. 10.1007\/s11060-023-04244-3","journal-title":"J Neurooncol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/noajnl\/vdaa044","article-title":"Radiological differences between subtypes of WHO 2016 grade II-III gliomas: a systematic review and meta-analysis","volume":"2","author":"van Lent DI","year":"2020","unstructured":"van Lent DI, van Baarsen KM, Snijders TJ, Robe PA. Radiological differences between subtypes of WHO 2016 grade II-III gliomas: a systematic review and meta-analysis. Neurooncol Adv. 2020, 2:vdaa044. 10.1093\/noajnl\/vdaa044","journal-title":"Neurooncol Adv"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/09727531231191880","article-title":"Losartan and immune checkpoint inhibitors in glioblastoma: an appropriate substitute for steroids. [PREPRINT]","author":"Rangwala BS","year":"2023","unstructured":"Rangwala BS, Shakil A, Mustafa MS, Rangwala HS, Fatima H, Siddiq MA. Losartan and immune checkpoint inhibitors in glioblastoma: an appropriate substitute for steroids. [PREPRINT]. Ann Neurosci. 2023, 10.1177\/09727531231191880","journal-title":"Ann Neurosci"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5070","article-title":"Genetically defined oligodendroglioma is characterized by indistinct tumor borders at MRI","volume":"38","author":"Johnson DR","year":"2017","unstructured":"Johnson DR, Diehn FE, Giannini C, Jenkins RB, Jenkins SM, Parney IF, Kaufmann TJ. Genetically defined oligodendroglioma is characterized by indistinct tumor borders at MRI. AJNR Am J Neuroradiol. 2017, 38:678-84. 10.3174\/ajnr.A5070","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-0100-5","article-title":"High rate of deletion of chromosomes 1p and 19q in insular oligodendroglial tumors","volume":"99","author":"Wu A","year":"2010","unstructured":"Wu A, Aldape K, Lang FF. High rate of deletion of chromosomes 1p and 19q in insular oligodendroglial tumors. J Neurooncol. 2010, 99:57-64. 10.1007\/s11060-009-0100-5","journal-title":"J Neurooncol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.55782\/ane-2007-1638","article-title":"Gliomas: association of histology and molecular genetic analysis of chromosomes 1p, 10q, and 19q","volume":"67","author":"Gresner SM","year":"2007","unstructured":"Gresner SM, Rieske P, Wozniak K, et al.. Gliomas: association of histology and molecular genetic analysis of chromosomes 1p, 10q, and 19q. Acta Neurobiol Exp (Wars). 2007, 67:103-12. 10.55782\/ane-2007-1638","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/64.6.479","article-title":"Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas","volume":"64","author":"Ohgaki H","year":"2005","unstructured":"Ohgaki H, Kleihues P. Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol. 2005, 64:479-89. 10.1093\/jnen\/64.6.479","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64076-X","article-title":"Detection of 1p and 19q loss in oligodendroglioma by quantitative microsatellite analysis, a real-time quantitative polymerase chain reaction assay","volume":"158","author":"Nigro JM","year":"2001","unstructured":"Nigro JM, Takahashi MA, Ginzinger DG, Law M, Passe S, Jenkins RB, Aldape K. Detection of 1p and 19q loss in oligodendroglioma by quantitative microsatellite analysis, a real-time quantitative polymerase chain reaction assay. Am J Pathol. 2001, 158:1253-62. 10.1016\/S0002-9440(10)64076-X","journal-title":"Am J Pathol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21338","article-title":"The prognostic impact of histology and 1p\/19q status in anaplastic oligodendroglial tumors","volume":"104","author":"McDonald JM","year":"2005","unstructured":"McDonald JM, See SJ, Tremont IW, et al.. The prognostic impact of histology and 1p\/19q status in anaplastic oligodendroglial tumors. Cancer. 2005, 104:1468-77. 10.1002\/cncr.21338","journal-title":"Cancer"},{"key":"ref22","article-title":"Molecular analysis of chromosome 1, 10 and 19 abnormalities in human oligodendroglial tumors: relationship between frequency of LOH grade, age and gender","volume":"25","author":"Gresner SM","year":"2006","unstructured":"Gresner SM, Rieske P, Wozniak K, et al.. Molecular analysis of chromosome 1, 10 and 19 abnormalities in human oligodendroglial tumors: relationship between frequency of LOH grade, age and gender. Clin Neuropathol. 2006, 25:18-24.","journal-title":"Clin Neuropathol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3352","article-title":"Multimodal MR imaging (diffusion, perfusion, and spectroscopy): is it possible to distinguish oligodendroglial tumor grade and 1p\/19q codeletion in the pretherapeutic diagnosis?","volume":"34","author":"Fellah S","year":"2013","unstructured":"Fellah S, Caudal D, De Paula AM, et al.. Multimodal MR imaging (diffusion, perfusion, and spectroscopy): is it possible to distinguish oligodendroglial tumor grade and 1p\/19q codeletion in the pretherapeutic diagnosis?. AJNR Am J Neuroradiol. 2013, 34:1326-33. 10.3174\/ajnr.A3352","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4103\/ajns.AJNS_520_20","article-title":"Can apparent diffusion coefficient predict the grade, genotype, or proliferation index of oligodendrogliomas","volume":"16","author":"Ali LA","year":"2021","unstructured":"Ali LA, Usman KM, Fatima M, et al.. Can apparent diffusion coefficient predict the grade, genotype, or proliferation index of oligodendrogliomas. Asian J Neurosurg. 2021, 16:752-8. 10.4103\/ajns.AJNS_520_20","journal-title":"Asian J Neurosurg"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-7-41","article-title":"Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile","volume":"7","author":"Ducray F","year":"2008","unstructured":"Ducray F, Idbaih A, de Reyni\u00e8s A, et al.. Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile. Mol Cancer. 2008, 7:41. 10.1186\/1476-4598-7-41","journal-title":"Mol Cancer"},{"key":"ref26","article-title":"Prognostic value of 1p\/19q chromosomal codeletion in patients with oligodendroglioma","volume":"69","author":"Laghari AA","year":"2019","unstructured":"Laghari AA, Khalid MU, Qadeer N, Shamim MS. Prognostic value of 1p\/19q chromosomal codeletion in patients with oligodendroglioma. J Pak Med Assoc. 2019, 69:132-4.","journal-title":"J Pak Med Assoc"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-017-1839-6","article-title":"IDH mutant and 1p\/19q co-deleted oligodendrogliomas: tumor grade stratification using diffusion-, susceptibility-, and perfusion-weighted MRI","volume":"59","author":"Lin Y","year":"2017","unstructured":"Lin Y, Xing Z, She D, et al.. IDH mutant and 1p\/19q co-deleted oligodendrogliomas: tumor grade stratification using diffusion-, susceptibility-, and perfusion-weighted MRI. Neuroradiology. 2017, 59:555-62. 10.1007\/s00234-017-1839-6","journal-title":"Neuroradiology"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/GH9.0000000000000395","article-title":"Dabrafenib and trametinib as a promising treatment option for pediatric population with low-grade gliomas that have BRAF V600E mutation; a breakthrough in the field of neuro-oncology","volume":"7","author":"Mughal ZUN","year":"2024","unstructured":"Mughal ZUN, Fadlalla Ahmad TK, Haseeb A, Shafique MA, Abbas Ahmdon OE, Mahgoub AMA. Dabrafenib and trametinib as a promising treatment option for pediatric population with low-grade gliomas that have BRAF V600E mutation; a breakthrough in the field of neuro-oncology. Int J Surg Glob Health. 2024, 7:e0395. 10.1097\/GH9.0000000000000395","journal-title":"Int J Surg Glob Health"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/217885-accuracy-of-mri-in-detecting-1p19q-co-deletion-status-of-gliomas-a-single-center-retrospective-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:14:37Z","timestamp":1707509677000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/217885-accuracy-of-mri-in-detecting-1p19q-co-deletion-status-of-gliomas-a-single-center-retrospective-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,8]]},"references-count":28,"URL":"https:\/\/doi.org\/10.7759\/cureus.51863","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1,8]]}}}