{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:33:33Z","timestamp":1773005613206,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,12]]},"DOI":"10.7759\/cureus.52177","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T17:53:46Z","timestamp":1705082026000},"source":"Crossref","is-referenced-by-count":5,"title":["The Synthesis, Characterization, and Assessment of Antibacterial Properties of an Orthodontic Adhesive Containing Cerium-Substituted Hydroxyapatite Nanoparticles: An In Vitro Study"],"prefix":"10.7759","author":[{"given":"Swati","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra Kumar","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-11728-7","article-title":"Nanoparticles\u2019 promises and risks: characterization, manipulation, and potential hazards to humanity and the environment","year":"2014","unstructured":"Nanoparticles\u2019 promises and risks. characterization, manipulation, and potential hazards to humanity and the environment. Lungu M, Neculae A, Bunoiu M, Biris C (ed): Springer, Cham, Switzerland; 2014. 10.1007\/978-3-319-11728-7"},{"key":"ref2","article-title":"Toxicity of nanomaterials: environmental and healthcare applications","year":"2019","unstructured":"Toxicity of nanomaterials. environmental and healthcare applications. Pillai SC, Lang Y (ed): CRC Press, Boca Raton, FL; 2019."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.sodo.2023.01.005","article-title":"Nanotechnology in orthodontics","volume":"29","author":"Padmanabhan S","year":"2023","unstructured":"Padmanabhan S. Nanotechnology in orthodontics. Semin Orthod. 2023, 29:79-84. 10.1053\/j.sodo.2023.01.005","journal-title":"Semin Orthod"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1088\/2053-1591\/ab08ff","article-title":"Biosynthesis, characterization of cerium oxide nanoparticles using Ceratonia siliqua and evaluation of antioxidant and cytotoxicity activities","volume":"6","author":"Javadi F","year":"2019","unstructured":"Javadi F, Yazdi ME, Baghani M, Es-haghi A. Biosynthesis, characterization of cerium oxide nanoparticles using Ceratonia siliqua and evaluation of antioxidant and cytotoxicity activities. Mater Res Express. 2019, 6:065408. 10.1088\/2053-1591\/ab08ff","journal-title":"Mater Res Express"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/etc.1786","article-title":"Characterization of cerium oxide nanoparticles-part 2: nonsize measurements","volume":"31","author":"Baalousha M","year":"2012","unstructured":"Baalousha M, Ju-Nam Y, Cole PA, et al.. Characterization of cerium oxide nanoparticles-part 2: nonsize measurements. Environ Toxicol Chem. 2012, 31:994-1003. 10.1002\/etc.1786","journal-title":"Environ Toxicol Chem"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2013.859728","article-title":"Nanoparticles in orthodontics, a review of antimicrobial and anti-caries applications","volume":"72","author":"Borzabadi-Farahani A","year":"2014","unstructured":"Borzabadi-Farahani A, Borzabadi E, Lynch E. Nanoparticles in orthodontics, a review of antimicrobial and anti-caries applications. Acta Odontol Scand. 2014, 72:413-7. 10.3109\/00016357.2013.859728","journal-title":"Acta Odontol Scand"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S107624","article-title":"Demineralization-remineralization dynamics in teeth and bone","volume":"11","author":"Abou Neel EA","year":"2016","unstructured":"Abou Neel EA, Aljabo A, Strange A, et al.. Demineralization-remineralization dynamics in teeth and bone. Int J Nanomedicine. 2016, 11:4743-63. 10.2147\/IJN.S107624","journal-title":"Int J Nanomedicine"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/ma2020399","article-title":"Calcium orthophosphates in nature, biology and medicine","volume":"2","author":"Dorozhkin SV","year":"2009","unstructured":"Dorozhkin SV. Calcium orthophosphates in nature, biology and medicine. Materials (Basel). 2009, 2:399-498. 10.3390\/ma2020399","journal-title":"Materials (Basel)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-013-4898-1","article-title":"Calcium orthophosphates in dentistry","volume":"24","author":"Dorozhkin SV","year":"2013","unstructured":"Dorozhkin SV. Calcium orthophosphates in dentistry. J Mater Sci Mater Med. 2013, 24:1335-63. 10.1007\/s10856-013-4898-1","journal-title":"J Mater Sci Mater Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/dj11020040","article-title":"Potential beneficial effects of hydroxyapatite nanoparticles on caries lesions in vitro-a review of the literature","volume":"11","author":"Imran E","year":"2023","unstructured":"Imran E, Cooper PR, Ratnayake J, Ekambaram M, Mei ML. Potential beneficial effects of hydroxyapatite nanoparticles on caries lesions in vitro-a review of the literature. Dent J (Basel). 2023, 11:40. 10.3390\/dj11020040","journal-title":"Dent J (Basel)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s40510-016-0153-x","article-title":"Evaluation of the antibacterial activity of a conventional orthodontic composite containing silver\/hydroxyapatite nanoparticles","volume":"17","author":"Sodagar A","year":"2016","unstructured":"Sodagar A, Akhavan A, Hashemi E, et al.. Evaluation of the antibacterial activity of a conventional orthodontic composite containing silver\/hydroxyapatite nanoparticles. Prog Orthod. 2016, 17:40. 10.1186\/s40510-016-0153-x","journal-title":"Prog Orthod"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1039\/d0ra04736h","article-title":"Cerium oxide nanoparticles: properties, biosynthesis and biomedical application","volume":"10","author":"Singh KR","year":"2020","unstructured":"Singh KR, Nayak V, Sarkar T, Singh RP. Cerium oxide nanoparticles: properties, biosynthesis and biomedical application. RSC Adv. 2020, 10:27194-214. 10.1039\/d0ra04736h","journal-title":"RSC Adv"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/nanomanufacturing1030013","article-title":"Cerium oxide nanoparticles: synthesis and characterization for biosafe applications","volume":"1","author":"Tumkur PP","year":"2021","unstructured":"Tumkur PP, Gunasekaran NK, Lamani BR, Nazario Bayon N, Prabhakaran K, Hall JC, Ramesh GT. Cerium oxide nanoparticles: synthesis and characterization for biosafe applications. Nanomanufacturing. 2021, 1:176-89. 10.3390\/nanomanufacturing1030013","journal-title":"Nanomanufacturing"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/1091581814522305","article-title":"Toxicity study of cerium oxide nanoparticles in human neuroblastoma cells","volume":"33","author":"Kumari M","year":"2014","unstructured":"Kumari M, Singh SP, Chinde S, Rahman MF, Mahboob M, Grover P. Toxicity study of cerium oxide nanoparticles in human neuroblastoma cells. Int J Toxicol. 2014, 33:86-97. 10.1177\/1091581814522305","journal-title":"Int J Toxicol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3912290","article-title":"Development of novel antimicrobial dental composite resin with nano cerium oxide fillers","volume":"2022","author":"Varghese EJ","year":"2022","unstructured":"Varghese EJ, Sihivahanan D, Venkatesh KV. Development of novel antimicrobial dental composite resin with nano cerium oxide fillers. Int J Biomater. 2022, 2022:3912290. 10.1155\/2022\/3912290","journal-title":"Int J Biomater"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2298\/JSC150824007C","article-title":"Cerium doped hydroxyapatite nanoparticles synthesized by coprecipitation method","volume":"81","author":"Ciobanu CS","year":"2016","unstructured":"Ciobanu CS, Popa CL, Predoi D. Cerium doped hydroxyapatite nanoparticles synthesized by coprecipitation method. J Serb Chem Soc. 2016, 81:433-46. 10.2298\/JSC150824007C","journal-title":"J Serb Chem Soc"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ortho.2020.01.011","article-title":"An in vitro evaluation of the effects of nanoparticles on shear bond strength and antimicrobial properties of orthodontic adhesives: a systematic review and meta-analysis study","volume":"18","author":"Pourhajibagher M","year":"2020","unstructured":"Pourhajibagher M, Sodagar A, Bahador A. An in vitro evaluation of the effects of nanoparticles on shear bond strength and antimicrobial properties of orthodontic adhesives: a systematic review and meta-analysis study. Int Orthod. 2020, 18:203-13. 10.1016\/j.ortho.2020.01.011","journal-title":"Int Orthod"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjs073","article-title":"Shear bond strength and antibacterial effects of orthodontic composite containing TiO2 nanoparticles","volume":"35","author":"Poosti M","year":"2013","unstructured":"Poosti M, Ramazanzadeh B, Zebarjad M, Javadzadeh P, Naderinasab M, Shakeri MT. Shear bond strength and antibacterial effects of orthodontic composite containing TiO2 nanoparticles. Eur J Orthod. 2013, 35:676-9. 10.1093\/ejo\/cjs073","journal-title":"Eur J Orthod"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s13399-023-04252-3","article-title":"Biocompatible synthesis of magnesium oxide nanoparticles with effective antioxidant, antibacterial, and anti-inflammatory activities using Magnolia champaca extract","author":"Ali S","year":"2023","unstructured":"Ali S, Sudha KG, Thiruvengadam M, Govindasamy R. Biocompatible synthesis of magnesium oxide nanoparticles with effective antioxidant, antibacterial, and anti-inflammatory activities using Magnolia champaca extract. Biomass Conv Bioref. 2023, 1-12. 10.1007\/s13399-023-04252-3","journal-title":"Biomass Conv Bioref"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2013.776107","article-title":"Changes in the supragingival microbiota surrounding brackets of upper central incisors during orthodontic treatment","volume":"71","author":"Torlakovic L","year":"2013","unstructured":"Torlakovic L, Paster BJ, Ogaard B, Olsen I. Changes in the supragingival microbiota surrounding brackets of upper central incisors during orthodontic treatment. Acta Odontol Scand. 2013, 71:1547-54. 10.3109\/00016357.2013.776107","journal-title":"Acta Odontol Scand"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cji094","article-title":"Early biofilm formation and the effects of antimicrobial agents on orthodontic bonding materials in a parallel plate flow chamber","volume":"28","author":"Chin MY","year":"2006","unstructured":"Chin MY, Busscher HJ, Evans R, Noar J, Pratten J. Early biofilm formation and the effects of antimicrobial agents on orthodontic bonding materials in a parallel plate flow chamber. Eur J Orthod. 2006, 28:1-7. 10.1093\/ejo\/cji094","journal-title":"Eur J Orthod"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021401","article-title":"Application of silver nanoparticles to improve the antibacterial activity of orthodontic adhesives: an in vitro study","volume":"24","author":"Trist\u00e1n-L\u00f3pez JD","year":"2023","unstructured":"Trist\u00e1n-L\u00f3pez JD, Ni\u00f1o-Mart\u00ednez N, Kolosovas-Machuca ES, Pati\u00f1o-Mar\u00edn N, De Alba-Montero I, Bach H, Mart\u00ednez-Casta\u00f1\u00f3n GA. Application of silver nanoparticles to improve the antibacterial activity of orthodontic adhesives: an in vitro study. Int J Mol Sci. 2023, 24:1401. 10.3390\/ijms24021401","journal-title":"Int J Mol Sci"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1590\/2177-6709.27.3.e222116.oar","article-title":"Experimental composite containing silicon dioxide-coated silver nanoparticles for orthodontic bonding: antimicrobial activity and shear bond strength","volume":"27","author":"Aguiar RC","year":"2022","unstructured":"Aguiar RC, Nunes LP, Batista ES, Viana MM, Rodrigues MC, Bueno-Silva B, Roscoe MG. Experimental composite containing silicon dioxide-coated silver nanoparticles for orthodontic bonding: antimicrobial activity and shear bond strength. Dental Press J Orthod. 2022, 27:e222116. 10.1590\/2177-6709.27.3.e222116.oar","journal-title":"Dental Press J Orthod"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2008.06.002","article-title":"Experimental antimicrobial orthodontic adhesives using nanofillers and silver nanoparticles","volume":"25","author":"Ahn SJ","year":"2009","unstructured":"Ahn SJ, Lee SJ, Kook JK, Lim BS. Experimental antimicrobial orthodontic adhesives using nanofillers and silver nanoparticles. Dent Mater. 2009, 25:206-13. 10.1016\/j.dental.2008.06.002","journal-title":"Dent Mater"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/4\/3\/034104","article-title":"Effect of nano-hydroxyapatite concentration on remineralization of initial enamel lesion in vitro","volume":"4","author":"Huang SB","year":"2009","unstructured":"Huang SB, Gao SS, Yu HY. Effect of nano-hydroxyapatite concentration on remineralization of initial enamel lesion in vitro. Biomed Mater. 2009, 4:034104. 10.1088\/1748-6041\/4\/3\/034104","journal-title":"Biomed Mater"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3897\/folmed.64.e60418","article-title":"\ufeffPhysico-mechanical properties, antimicrobial activities, and anti-biofilm potencies of orthodontic adhesive containing cerium oxide nanoparticles against Streptococcus mutans","volume":"64","author":"Pourhajibagher M","year":"2022","unstructured":"Pourhajibagher M, Bahador A. \ufeffPhysico-mechanical properties, antimicrobial activities, and anti-biofilm potencies of orthodontic adhesive containing cerium oxide nanoparticles against Streptococcus mutans. Folia Med (Plovdiv). 2022, 64:252-9. 10.3897\/folmed.64.e60418","journal-title":"Folia Med (Plovdiv)"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.rinp.2018.08.012","article-title":"Structural characterization of cerium-doped hydroxyapatite nanoparticles synthesized by an ultrasonic-assisted sol-gel technique","volume":"10","author":"Phatai P","year":"2018","unstructured":"Phatai P, Futalan CM, Utara S, Khemthong P, Kamonwannasit S. Structural characterization of cerium-doped hydroxyapatite nanoparticles synthesized by an ultrasonic-assisted sol-gel technique. Results Phys. 2018, 10:956-63. 10.1016\/j.rinp.2018.08.012","journal-title":"Results Phys"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s10971-018-4910-9","article-title":"Structural characterization and antibacterial activity of hydroxyapatite synthesized via sol-gel method using glutinous rice as a template","volume":"89","author":"Phatai P","year":"2019","unstructured":"Phatai P, Futalan CM, Kamonwannasit S, Khemthong P. Structural characterization and antibacterial activity of hydroxyapatite synthesized via sol-gel method using glutinous rice as a template. J Sol-Gel Sci Technol. 2019, 89:764-75. 10.1007\/s10971-018-4910-9","journal-title":"J Sol-Gel Sci Technol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/204032-the-synthesis-characterization-and-assessment-of-antibacterial-properties-of-an-orthodontic-adhesive-containing-cerium-substituted-hydroxyapatite-nanoparticles-an-in-vitro-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:14:28Z","timestamp":1707509668000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/204032-the-synthesis-characterization-and-assessment-of-antibacterial-properties-of-an-orthodontic-adhesive-containing-cerium-substituted-hydroxyapatite-nanoparticles-an-in-vitro-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,12]]},"references-count":28,"URL":"https:\/\/doi.org\/10.7759\/cureus.52177","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1,12]]}}}