{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:19:29Z","timestamp":1773058769520,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,12]]},"DOI":"10.7759\/cureus.52178","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T17:54:33Z","timestamp":1705082073000},"source":"Crossref","is-referenced-by-count":2,"title":["Benzodiazepine and Zolpidem-Induced Bradycardia: A Case Report"],"prefix":"10.7759","author":[{"given":"Ivan","family":"Ivanov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Kirzhner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Sokup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7034a2","article-title":"Trends in nonfatal and fatal overdoses involving benzodiazepines - 38 states and the District of Columbia, 2019-2020","volume":"70","author":"Liu S","year":"2021","unstructured":"Liu S, O'Donnell J, Gladden RM, McGlone L, Chowdhury F. Trends in nonfatal and fatal overdoses involving benzodiazepines - 38 states and the District of Columbia, 2019-2020. MMWR Morb Mortal Wkly Rep. 2021, 70:1136-41. 10.15585\/mmwr.mm7034a2","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref2","article-title":"Goldfrank's Toxicologic Emergencies, 11e","author":"Nelson LS","year":"2019","unstructured":"Nelson LS, Howland M, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS. Goldfrank's Toxicologic Emergencies, 11e. McGraw-Hill Education, New York, NY; 2019."},{"key":"ref3","article-title":"Benzodiazepine pharmacology and central nervous system-mediated effects","volume":"13","author":"Griffin CE 3rd","year":"2013","unstructured":"Griffin CE 3rd, Kaye AM, Bueno FR, Kaye AD. Benzodiazepine pharmacology and central nervous system-mediated effects. Ochsner J. 2013, 13:214-23.","journal-title":"Ochsner J"},{"key":"ref4","article-title":"Evaluation of cardiovascular manifestations in benzodiazepine poisoning","volume":"4","author":"Eizadi-Mood N","year":"2011","unstructured":"Eizadi-Mood N, Montazeri K, Dastjerdi MD. Evaluation of cardiovascular manifestations in benzodiazepine poisoning. Iran J Toxicol. 2011, 4:373-6.","journal-title":"Iran J Toxicol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703717","article-title":"Mechanism of action of the hypnotic zolpidem in vivo","volume":"131","author":"Crestani F","year":"2000","unstructured":"Crestani F, Martin JR, M\u00f6hler H, Rudolph U. Mechanism of action of the hypnotic zolpidem in vivo. Br J Pharmacol. 2000, 131:1251-4. 10.1038\/sj.bjp.0703717","journal-title":"Br J Pharmacol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199807000-00002","article-title":"Safety and tolerance of zolpidem in the treatment of disturbed sleep: a post-marketing surveillance of 16944 cases","volume":"13","author":"Hajak G","year":"1998","unstructured":"Hajak G, Bandelow B. Safety and tolerance of zolpidem in the treatment of disturbed sleep: a post-marketing surveillance of 16944 cases. Int Clin Psychopharmacol. 1998, 13:157-67. 10.1097\/00004850-199807000-00002","journal-title":"Int Clin Psychopharmacol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.52965\/001c.24927","article-title":"Zolpidem: efficacy and side effects for insomnia","volume":"9","author":"Edinoff AN","year":"2021","unstructured":"Edinoff AN, Wu N, Ghaffar YT, et al.. Zolpidem: efficacy and side effects for insomnia. Health Psychol Res. 2021, 9:24927. 10.52965\/001c.24927","journal-title":"Health Psychol Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/2008-2231-21-77","article-title":"Zolpidem-induced suicide attempt: a case report","volume":"21","author":"Mortaz Hejri S","year":"2013","unstructured":"Mortaz Hejri S, Faizi M, Babaeian M. Zolpidem-induced suicide attempt: a case report. Daru. 2013, 21:77. 10.1186\/2008-2231-21-77","journal-title":"Daru"},{"key":"ref9","article-title":"Relationship between zolpidem use and acute myocardial infarction risk: a Taiwanese population-based case-control study","volume":"128","author":"Lin YN","year":"2018","unstructured":"Lin YN, Ko Py, Chang CP, Yang CC, Lin JJ. Relationship between zolpidem use and acute myocardial infarction risk: a Taiwanese population-based case-control study. Circulation. 2018, 128:A10392.","journal-title":"Circulation"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e3181dcf572","article-title":"Benzodiazepine-associated atrioventricular block","volume":"19","author":"Arroyo Plasencia AM","year":"2012","unstructured":"Arroyo Plasencia AM, Ballentine LM, Mowry JB, Kao LW. Benzodiazepine-associated atrioventricular block. Am J Ther. 2012, 19:e48-52. 10.1097\/MJT.0b013e3181dcf572","journal-title":"Am J Ther"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8234-16","article-title":"Clonazepam-associated bradycardia in a disabled elderly woman with multiple complications","volume":"56","author":"Maruyoshi H","year":"2017","unstructured":"Maruyoshi H, Maruyoshi N, Hirosue M, Ikeda K, Shimamoto M. Clonazepam-associated bradycardia in a disabled elderly woman with multiple complications. Intern Med. 2017, 56:2301-5. 10.2169\/internalmedicine.8234-16","journal-title":"Intern Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1211\/0022357991772385","article-title":"First-degree atrioventricular block in alprazolam overdose reversed by flumazenil","volume":"51","author":"Mullins ME","year":"1999","unstructured":"Mullins ME. First-degree atrioventricular block in alprazolam overdose reversed by flumazenil. J Pharm Pharmacol. 1999, 51:367-70. 10.1211\/0022357991772385","journal-title":"J Pharm Pharmacol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.63.135","article-title":"Negative inotropic effect of diazepam in isolated guinea pig heart","volume":"63","author":"Hara Y","year":"2001","unstructured":"Hara Y, Kobayashi H, Ooshiro S, et al.. Negative inotropic effect of diazepam in isolated guinea pig heart. J Vet Med Sci. 2001, 63:135-43. 10.1292\/jvms.63.135","journal-title":"J Vet Med Sci"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90991-u","article-title":"Differential inhibition of transient and long-lasting calcium channel currents by benzodiazepines in neuroblastoma cells","volume":"606","author":"Watabe S","year":"1993","unstructured":"Watabe S, Yoshii M, Ogata N, Tsunoo A, Narahashi T. Differential inhibition of transient and long-lasting calcium channel currents by benzodiazepines in neuroblastoma cells. Brain Res. 1993, 606:244-50. 10.1016\/0006-8993(93)90991-u","journal-title":"Brain Res"},{"key":"ref15","article-title":"Effects of diazepam and midazolam on baroreflex control of heart rate and on sympathetic activity in humans","volume":"65","author":"Marty J","year":"1986","unstructured":"Marty J, Gauzit R, Lefevre P, Couderc E, Farinotti R, Henzel C, Desmonts JM. Effects of diazepam and midazolam on baroreflex control of heart rate and on sympathetic activity in humans. Anesth Analg. 1986, 65:113-9.","journal-title":"Anesth Analg"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.1033061","article-title":"Case Report: high doses of zolpidem and QT interval lengthening: is there a relationship? A case series","volume":"13","author":"Campagnari S","year":"2022","unstructured":"Campagnari S, Zamboni L, Fusina F, Casari R, Lugoboni F. Case Report: high doses of zolpidem and QT interval lengthening: is there a relationship? A case series. Front Psychiatry. 2022, 13:1033061. 10.3389\/fpsyt.2022.1033061","journal-title":"Front Psychiatry"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.25259\/IJASM_10_2019","article-title":"Effect of zolpidem on sleep efficiency and heart rate during daytime nap","volume":"63","author":"Sinha B","year":"2019","unstructured":"Sinha B, Yadav CT. Effect of zolpidem on sleep efficiency and heart rate during daytime nap. Indian J Aerosp Med. 2019, 63:83-9. 10.25259\/IJASM_10_2019","journal-title":"Indian J Aerosp Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.1993.tb00244.x","article-title":"Effect of zolpidem during sleep on ventilation and cardiovascular variables in normal subjects","volume":"7","author":"McCann CC","year":"1993","unstructured":"McCann CC, Quera-Salva MA, Boudet J, Frisk M, Barthouil P, Borderies P, Meyer P. Effect of zolpidem during sleep on ventilation and cardiovascular variables in normal subjects. Fundam Clin Pharmacol. 1993, 7:305-10. 10.1111\/j.1472-8206.1993.tb00244.x","journal-title":"Fundam Clin Pharmacol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1994.157","article-title":"Flumazenil antagonizes the central effects of zolpidem, an imidazopyridine hypnotic","volume":"56","author":"Patat A","year":"1994","unstructured":"Patat A, Naef MM, van Gessel E, Forster A, Dubruc C, Rosenzweig P. Flumazenil antagonizes the central effects of zolpidem, an imidazopyridine hypnotic. Clin Pharmacol Ther. 1994, 56:430-6. 10.1038\/clpt.1994.157","journal-title":"Clin Pharmacol Ther"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12434","article-title":"Adverse events associated with flumazenil treatment for the management of suspected benzodiazepine intoxication--a systematic review with meta-analyses of randomised trials","volume":"118","author":"Penninga EI","year":"2016","unstructured":"Penninga EI, Graudal N, Ladekarl MB, J\u00fcrgens G. Adverse events associated with flumazenil treatment for the management of suspected benzodiazepine intoxication--a systematic review with meta-analyses of randomised trials. Basic Clin Pharmacol Toxicol. 2016, 118:37-44. 10.1111\/bcpt.12434","journal-title":"Basic Clin Pharmacol Toxicol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/208683-benzodiazepine-and-zolpidem-induced-bradycardia-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:11:30Z","timestamp":1707509490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/208683-benzodiazepine-and-zolpidem-induced-bradycardia-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,12]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.52178","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1,12]]}}}