{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:39:37Z","timestamp":1707525577087},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,12]]},"DOI":"10.7759\/cureus.52179","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T19:09:30Z","timestamp":1705086570000},"source":"Crossref","is-referenced-by-count":0,"title":["Cold Agglutinin Syndrome and Hemophagocytic Lymphohistiocytosis: An Unusual Combination Caused by Epstein\u2013Barr Virus Infection"],"prefix":"10.7759","author":[{"given":"Beatriz","family":"Sousa Nunes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Gouveia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Kjollerstrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Farela Neves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318161a9f9","article-title":"A 13-year-old girl with cold agglutinin syndrome caused by anti-i","volume":"30","author":"Mason HM","year":"2008","unstructured":"Mason HM, Arndt PA. A 13-year-old girl with cold agglutinin syndrome caused by anti-i. J Pediatr Hematol Oncol. 2008, 30:543-5. 10.1097\/MPH.0b013e318161a9f9","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14339","article-title":"Severe Epstein-Barr virus infection in primary immunodeficiency and the normal host","volume":"175","author":"Worth AJ","year":"2016","unstructured":"Worth AJ, Houldcroft CJ, Booth C. Severe Epstein-Barr virus infection in primary immunodeficiency and the normal host. Br J Haematol. 2016, 175:559-76. 10.1111\/bjh.14339","journal-title":"Br J Haematol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3722-z","article-title":"Cold type autoimmune hemolytic anemia- a rare manifestation of infectious mononucleosis; serum ferritin as an important biomarker","volume":"19","author":"Dematapitiya C","year":"2019","unstructured":"Dematapitiya C, Perera C, Chinthaka W, et al.. Cold type autoimmune hemolytic anemia- a rare manifestation of infectious mononucleosis; serum ferritin as an important biomarker. BMC Infect Dis. 2019, 19:68. 10.1186\/s12879-019-3722-z","journal-title":"BMC Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.12.2008.1390","article-title":"Infectious mononucleosis with secondary cold agglutinin disease causing autoimmune haemolytic anaemia","volume":"2009","author":"Malhotra V","year":"2009","unstructured":"Malhotra V, Abraham T, Vesona J, Chopra A, Radakrishna N. Infectious mononucleosis with secondary cold agglutinin disease causing autoimmune haemolytic anaemia. BMJ Case Rep. 2009, 2009:10.1136\/bcr.12.2008.1390","journal-title":"BMJ Case Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2020.03.003","article-title":"Diagnosis and management of autoimmune hemolytic anemia in children","volume":"27","author":"Weli M","year":"2020","unstructured":"Weli M, Ben Hlima A, Belhadj R, et al.. Diagnosis and management of autoimmune hemolytic anemia in children. Transfus Clin Biol. 2020, 27:61-4. 10.1016\/j.tracli.2020.03.003","journal-title":"Transfus Clin Biol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000002438","article-title":"Autoimmune hemolytic anemia in children: laboratory investigation, disease associations, and treatment strategies","volume":"44","author":"Blackall D","year":"2022","unstructured":"Blackall D, Dolatshahi L. Autoimmune hemolytic anemia in children: laboratory investigation, disease associations, and treatment strategies. J Pediatr Hematol Oncol. 2022, 44:71-8. 10.1097\/MPH.0000000000002438","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2033982","article-title":"Autoimmune hemolytic anemias","volume":"385","author":"Berentsen S","year":"2021","unstructured":"Berentsen S, Barcellini W. Autoimmune hemolytic anemias. N Engl J Med. 2021, 385:1407-19. 10.1056\/NEJMra2033982","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00590","article-title":"New insights in the pathogenesis and therapy of cold agglutinin-mediated autoimmune hemolytic anemia","volume":"11","author":"Berentsen S","year":"2020","unstructured":"Berentsen S. New insights in the pathogenesis and therapy of cold agglutinin-mediated autoimmune hemolytic anemia. Front Immunol. 2020, 11:590. 10.3389\/fimmu.2020.00590","journal-title":"Front Immunol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2016.00047","article-title":"Hemophagocytic lymphohistiocytosis in children: pathogenesis and treatment","volume":"4","author":"Ishii E","year":"2016","unstructured":"Ishii E. Hemophagocytic lymphohistiocytosis in children: pathogenesis and treatment. Front Pediatr. 2016, 4:47. 10.3389\/fped.2016.00047","journal-title":"Front Pediatr"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16013","article-title":"Genetics and pathophysiology of haemophagocytic lymphohistiocytosis","volume":"110","author":"Meeths M","year":"2021","unstructured":"Meeths M, Bryceson YT. Genetics and pathophysiology of haemophagocytic lymphohistiocytosis. Acta Paediatr. 2021, 110:2903-11. 10.1111\/apa.16013","journal-title":"Acta Paediatr"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1152409","article-title":"Presentations and outcomes of familial hemophagocytic lymphohistiocytosis in the pediatric intensive care units (PICUs)","volume":"11","author":"Alsohime F","year":"2023","unstructured":"Alsohime F, Temsah MH, Alotaibi RM, et al.. Presentations and outcomes of familial hemophagocytic lymphohistiocytosis in the pediatric intensive care units (PICUs). Front Pediatr. 2023, 11:1152409. 10.3389\/fped.2023.1152409","journal-title":"Front Pediatr"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001184","article-title":"EBV-related cold agglutinin disease presenting with conjugated hyperbilirubinemia: a pediatric case report and mini review","volume":"41","author":"Mantadakis E","year":"2019","unstructured":"Mantadakis E, Chatzimichael E, Kontekaki E, Panopoulou M, Martinis G, Tsalkidis A. EBV-related cold agglutinin disease presenting with conjugated hyperbilirubinemia: a pediatric case report and mini review. J Pediatr Hematol Oncol. 2019, 41:324-7. 10.1097\/MPH.0000000000001184","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0955-3886(00)00033-3","article-title":"Clinical syndromes associated with cold agglutinins","volume":"22","author":"McNicholl FP","year":"2000","unstructured":"McNicholl FP. Clinical syndromes associated with cold agglutinins. Transfus Sci. 2000, 22:125-133. 10.1016\/s0955-3886(00)00033-3","journal-title":"Transfus Sci"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181f84a52","article-title":"Treatment of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis (EBV-HLH); update 2010","volume":"33","author":"Imashuku S","year":"2011","unstructured":"Imashuku S. Treatment of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis (EBV-HLH); update 2010. J Pediatr Hematol Oncol. 2011, 33:35-9. 10.1097\/MPH.0b013e3181f84a52","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01902","article-title":"Epstein-Barr virus and hemophagocytic lymphohistiocytosis","volume":"8","author":"Marsh RA","year":"2017","unstructured":"Marsh RA. Epstein-Barr virus and hemophagocytic lymphohistiocytosis. Front Immunol. 2017, 8:1902. 10.3389\/fimmu.2017.01902","journal-title":"Front Immunol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26202","article-title":"Clinical characteristics of primary and reactivated Epstein-Barr virus infection in children","volume":"92","author":"Yang Y","year":"2020","unstructured":"Yang Y, Gao F. Clinical characteristics of primary and reactivated Epstein-Barr virus infection in children. J Med Virol. 2020, 92:3709-16. 10.1002\/jmv.26202","journal-title":"J Med Virol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2018.08.159","article-title":"Hemophagocytic lymphohistiocytosis associated with an IgG cold agglutinin","volume":"26","author":"Jouini H","year":"2019","unstructured":"Jouini H, Chouaieb S, Boussetta K, Toumi NE. Hemophagocytic lymphohistiocytosis associated with an IgG cold agglutinin. Transfus Clin Biol. 2019, 26:324-8. 10.1016\/j.tracli.2018.08.159","journal-title":"Transfus Clin Biol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2019.11.043","article-title":"A rare presentation of Epstein-Barr virus infection","volume":"58","author":"Teijido J","year":"2020","unstructured":"Teijido J, Tillotson K, Liu JM. A rare presentation of Epstein-Barr virus infection. J Emerg Med. 2020, 58:e71-3. 10.1016\/j.jemermed.2019.11.043","journal-title":"J Emerg Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/218500-cold-agglutinin-syndrome-and-hemophagocytic-lymphohistiocytosis-an-unusual-combination-caused-by-epstein-barr-virus-infection","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:14:05Z","timestamp":1707509645000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/218500-cold-agglutinin-syndrome-and-hemophagocytic-lymphohistiocytosis-an-unusual-combination-caused-by-epstein-barr-virus-infection"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,12]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.52179","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1,12]]}}}