{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:13:19Z","timestamp":1788909199542,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,24]]},"DOI":"10.7759\/cureus.52857","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T14:49:56Z","timestamp":1706107796000},"source":"Crossref","is-referenced-by-count":6,"title":["Antimicrobial and Synergistic Effects of Syzygium cumini, Moringa oleifera, and Tinospora cordifolia Against Different Candida Infections"],"prefix":"10.7759","author":[{"given":"Adedayo O","family":"Adelakun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayoola","family":"Awosika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzochukwu","family":"Adabanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adekunle E","family":"Omole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinyode I","family":"Olopoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel T","family":"Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S351260","article-title":"Immunosuppressed patients with clinically diagnosed invasive fungal infections: The fungal species distribution, antifungal sensitivity, and associated risk factors in a tertiary hospital of Anhui Province","volume":"15","author":"Xia J","year":"2022","unstructured":"Xia J, Wang Z, Li T, Lu F, Sheng D, Huang W. Immunosuppressed patients with clinically diagnosed invasive fungal infections: The fungal species distribution, antifungal sensitivity, and associated risk factors in a tertiary hospital of Anhui Province. Infect Drug Resist. 2022, 15:321-33. 10.2147\/IDR.S351260","journal-title":"Infect Drug Resist"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/jof7020079","article-title":"Candida albicans - the virulence factors and clinical manifestations of infection","volume":"7","author":"Talapko J","year":"2021","unstructured":"Talapko J, Juzba\u0161i\u0107 M, Matijevi\u0107 T, Pustijanac E, Beki\u0107 S, Kotris I, \u0160krlec I. Candida albicans - the virulence factors and clinical manifestations of infection. J Fungi (Basel). 2021, 7:79. 10.3390\/jof7020079","journal-title":"J Fungi (Basel)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-020-03912-w","article-title":"Mechanism of Candida pathogenesis: revisiting the vital drivers","volume":"39","author":"Mba IE","year":"2020","unstructured":"Mba IE, Nweze EI. Mechanism of Candida pathogenesis: revisiting the vital drivers. Eur J Clin Microbiol Infect Dis. 2020, 39:1797-819. 10.1007\/s10096-020-03912-w","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.03.028","article-title":"Resistance of Candida to azoles and echinocandins worldwide","volume":"25","author":"Pristov KE","year":"2019","unstructured":"Pristov KE, Ghannoum MA. Resistance of Candida to azoles and echinocandins worldwide. Clin Microbiol Infect. 2019, 25:792-8. 10.1016\/j.cmi.2019.03.028","journal-title":"Clin Microbiol Infect"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa320","article-title":"Sepsis in immunocompromised patients without human immunodeficiency virus","volume":"222","author":"McCreery RJ","year":"2020","unstructured":"McCreery RJ, Florescu DF, Kalil AC. Sepsis in immunocompromised patients without human immunodeficiency virus. J Infect Dis. 2020, 222:S156-65. 10.1093\/infdis\/jiaa320","journal-title":"J Infect Dis"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2018.10.007","article-title":"Antifungal susceptibility trend and analysis of resistance mechanism for Candida species isolated from bloodstream at a Japanese university hospital","volume":"25","author":"Sakagami T","year":"2019","unstructured":"Sakagami T, Kawano T, Yamashita K, et al.. Antifungal susceptibility trend and analysis of resistance mechanism for Candida species isolated from bloodstream at a Japanese university hospital. J Infect Chemother. 2019, 25:34-40. 10.1016\/j.jiac.2018.10.007","journal-title":"J Infect Chemother"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2019.07.006","article-title":"The epidemiology of Candida species in the Middle East and North Africa","volume":"29","author":"Ghazi S","year":"2019","unstructured":"Ghazi S, Rafei R, Osman M, et al.. The epidemiology of Candida species in the Middle East and North Africa. J Mycol Med. 2019, 29:245-52. 10.1016\/j.mycmed.2019.07.006","journal-title":"J Mycol Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/jof7080667","article-title":"Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival","volume":"7","author":"Hassan Y","year":"2021","unstructured":"Hassan Y, Chew SY, Than LT. Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival. J Fungi (Basel). 2021, 7:667. 10.3390\/jof7080667","journal-title":"J Fungi (Basel)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00067-8","article-title":"Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap","volume":"4","author":"Daneshnia F","year":"2023","unstructured":"Daneshnia F, de Almeida J\u00fanior JN, Ilkit M, et al.. Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap. Lancet Microbe. 2023, 4:e470-80. 10.1016\/S2666-5247(23)00067-8","journal-title":"Lancet Microbe"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.18502\/cmm.8.2.10329","article-title":"High frequency of Candida krusei colonization in critically ill pediatrics: a cross-sectional study in children's medical center, Tehran, Iran","volume":"8","author":"Davari A","year":"2022","unstructured":"Davari A, Jafarzadeh J, Hedayati MT, Shokohi T, Abastabar M, Nikmanesh B, Moazeni M. High frequency of Candida krusei colonization in critically ill pediatrics: a cross-sectional study in children's medical center, Tehran, Iran. Curr Med Mycol. 2022, 8:25-31. 10.18502\/cmm.8.2.10329","journal-title":"Curr Med Mycol"},{"key":"ref11","article-title":"Efficacy of anti-bacterial action on seven medicinal plants' extract against neonatal sepsis-causing bacteria: an in vitro study","volume":"20(2)","author":"Pandit BR","year":"2020","unstructured":"Pandit BR, Vyas A. Efficacy of anti-bacterial action on seven medicinal plants' extract against neonatal sepsis-causing bacteria: an in vitro study. Plant Arch. 2020, 20(2):2487-94.","journal-title":"Plant Arch"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.20286\/nova-jmbs-040245","article-title":"Antimicrobial activities of Syzygium cumini leaf extracts against selected microorganisms","volume":"4(2)","author":"Abdelgadir EA","year":"2015","unstructured":"Abdelgadir EA, Karamallah AA, Abualhassan AM, et al.. Antimicrobial activities of Syzygium cumini leaf extracts against selected microorganisms. Nova J Med Biol Sci. 2015, 4(2):1-10. 10.20286\/nova-jmbs-040245","journal-title":"Nova J Med Biol Sci"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-01006-x","article-title":"The modulatory effects of alkaloid extracts of Cannabis sativa, Datura stramonium, Nicotiana tabacum and male Carica papaya on neurotransmitter, neurotrophic and neuroinflammatory systems linked to anxiety and depression","volume":"30","author":"Fasakin OW","year":"2022","unstructured":"Fasakin OW, Oboh G, Ademosun AO, Lawal AO. The modulatory effects of alkaloid extracts of Cannabis sativa, Datura stramonium, Nicotiana tabacum and male Carica papaya on neurotransmitter, neurotrophic and neuroinflammatory systems linked to anxiety and depression. Inflammopharmacology. 2022, 30:2447-76. 10.1007\/s10787-022-01006-x","journal-title":"Inflammopharmacology"},{"key":"ref14","article-title":"Antimicrobial activity of earthworm (Eudriluseugeniae) paste","volume":"7","author":"Vasanthi K","year":"2013","unstructured":"Vasanthi K, Chairman K, Singh AR. Antimicrobial activity of earthworm (Eudriluseugeniae) paste. Afr J Environ Sci Technol. 2013, 7:789-3.","journal-title":"Afr J Environ Sci Technol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/plants10020252","article-title":"Antibacterial and antifungal activity of the extracts of different parts of Avicennia marina (Forssk.) Vierh","volume":"10","author":"Okla MK","year":"2021","unstructured":"Okla MK, Alatar AA, Al-Amri SS, Soufan WH, Ahmad A, Abdel-Maksoud MA. Antibacterial and antifungal activity of the extracts of different parts of Avicennia marina (Forssk.) Vierh. Plants (Basel). 2021, 10:252. 10.3390\/plants10020252","journal-title":"Plants (Basel)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.02.011","article-title":"Ethnoveterinary medicine in the search for antimicrobial agents: antifungal activity of some species of Pterocaulon (Asteraceae)","volume":"99","author":"Stein AC","year":"2005","unstructured":"Stein AC, Sortino M, Avancini C, Zacchino S, von Poser G. Ethnoveterinary medicine in the search for antimicrobial agents: antifungal activity of some species of Pterocaulon (Asteraceae). J Ethnopharmacol. 2005, 99:211-4. 10.1016\/j.jep.2005.02.011","journal-title":"J Ethnopharmacol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0167-7012(95)00017-F","article-title":"Methods for the study of rock-inhabiting microorganisms\u2014a mini review","volume":"23","author":"Hirsch P","year":"1995","unstructured":"Hirsch P, Eckhardt FE, Palmer Jr RJ. Methods for the study of rock-inhabiting microorganisms\u2014a mini review. J Microbiol Methods. 1995, 23:143-67. 10.1016\/0167-7012(95)00017-F","journal-title":"J Microbiol Methods"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01934-17","article-title":"CLSI methods development and standardization working group best practices for evaluation of antimicrobial susceptibility tests","volume":"56","author":"Humphries RM","year":"2018","unstructured":"Humphries RM, Ambler J, Mitchell SL, et al.. CLSI methods development and standardization working group best practices for evaluation of antimicrobial susceptibility tests. J Clin Microbiol. 2018, 56:e01934-17. 10.1128\/JCM.01934-17","journal-title":"J Clin Microbiol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/1299\/1\/012131","article-title":"Suitability of spectrophotometric assay for determination of honey microbial inhibition","volume":"1299","author":"Akinduti P","year":"2019","unstructured":"Akinduti P, Motayo B, Idowu O, et al.. Suitability of spectrophotometric assay for determination of honey microbial inhibition. J Phys. 2019, 1299:1-8. 10.1088\/1742-6596\/1299\/1\/012131","journal-title":"J Phys"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/jof7070574","article-title":"Eradication of Candida albicans biofilm viability: in vitro combination therapy of cationic carbosilane dendrons derived from 4-phenylbutyric acid with AgNO(3) and EDTA","volume":"7","author":"G\u00f3mez-Casanova N","year":"2021","unstructured":"G\u00f3mez-Casanova N, Lozano-Cruz T, Soliveri J, Gomez R, Ortega P, Copa-Pati\u00f1o JL, Heredero-Bermejo I. Eradication of Candida albicans biofilm viability: in vitro combination therapy of cationic carbosilane dendrons derived from 4-phenylbutyric acid with AgNO(3) and EDTA. J Fungi (Basel). 2021, 7:3. 10.3390\/jof7070574","journal-title":"J Fungi (Basel)"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-016-2079-2","article-title":"Resazurin-based 96-well plate microdilution method for the determination of minimum inhibitory concentration of biosurfactants","volume":"38","author":"Elshikh M","year":"2016","unstructured":"Elshikh M, Ahmed S, Funston S, Dunlop P, McGaw M, Marchant R, Banat IM. Resazurin-based 96-well plate microdilution method for the determination of minimum inhibitory concentration of biosurfactants. Biotechnol Lett. 2016, 38:1015-9. 10.1007\/s10529-016-2079-2","journal-title":"Biotechnol Lett"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(10)60049-1","article-title":"Antibacterial activity of Rosmarinus officinalis L. alone and in combination with cefuroxime against methicillin-resistant Staphylococcus aureus","volume":"3","author":"Jarrar N","year":"2010","unstructured":"Jarrar N, Abu-Hijleh A, Adwan K. Antibacterial activity of Rosmarinus officinalis L. alone and in combination with cefuroxime against methicillin-resistant Staphylococcus aureus. Asian Pac J Trop Med. 2010, 3:121-3. 10.1016\/S1995-7645(10)60049-1","journal-title":"Asian Pac J Trop Med"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-018-9591-z","article-title":"Comprehensive review of antimicrobial activities of plant flavonoids","volume":"18","author":"G\u00f3rniak I","year":"2019","unstructured":"G\u00f3rniak I, Bartoszewski R, Kr\u00f3liczewski J. Comprehensive review of antimicrobial activities of plant flavonoids. Phytochem Rev. 2019, 18:241-72. 10.1007\/s11101-018-9591-z","journal-title":"Phytochem Rev"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6814215","article-title":"Potential and prophylactic use of plants containing saponin-type compounds as antibiofilm agents against respiratory tract infections","volume":"2021","author":"Tatli Cankaya II","year":"2021","unstructured":"Tatli Cankaya II, Somuncuoglu EI. Potential and prophylactic use of plants containing saponin-type compounds as antibiofilm agents against respiratory tract infections. Evid Based Complement Alternat Med. 2021, 2021:6814215. 10.1155\/2021\/6814215","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref25","article-title":"Recent advances in pharmacological potential of Syzygiumcumini: a review","volume":"7","author":"Katiyar D","year":"2016","unstructured":"Katiyar D, Singh V, Ali M. Recent advances in pharmacological potential of Syzygiumcumini: a review. Adv Appl Sci Res. 2016, 7:1-2.","journal-title":"Adv Appl Sci Res"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3329\/ajmbr.v2i4.30989","article-title":"Medicinal use of the unique plant Tinospora cordifolia: evidence from the traditional medicine and recent research","volume":"2","author":"Khan MM","year":"2016","unstructured":"Khan MM, dul Haque MS, Chowdhury MS. Medicinal use of the unique plant Tinospora cordifolia: evidence from the traditional medicine and recent research. Asian J Med Biol Res. 2016, 2:508-12. 10.3329\/ajmbr.v2i4.30989","journal-title":"Asian J Med Biol Res"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00108","article-title":"Moringa genus: A review of phytochemistry and pharmacology","volume":"9","author":"Abd Rani NZ","year":"2018","unstructured":"Abd Rani NZ, Husain K, Kumolosasi E. Moringa genus: A review of phytochemistry and pharmacology. Front Pharmacol. 2018, 9:108. 10.3389\/fphar.2018.00108","journal-title":"Front Pharmacol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20237-z","article-title":"Formulation, evaluation and bioactive potential of Xylaria primorskensis terpenoid nanoparticles from its major compound xylaranic acid","volume":"8","author":"Adnan M","year":"2018","unstructured":"Adnan M, Patel M, Reddy MN, Alshammari E. Formulation, evaluation and bioactive potential of Xylaria primorskensis terpenoid nanoparticles from its major compound xylaranic acid. Sci Rep. 2018, 8:1740. 10.1038\/s41598-018-20237-z","journal-title":"Sci Rep"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/jof7090731","article-title":"Role of antifungal combinations in difficult to treat Candida infections","volume":"7","author":"Vitale RG","year":"2021","unstructured":"Vitale RG. Role of antifungal combinations in difficult to treat Candida infections. J Fungi (Basel). 2021, 7:731. 10.3390\/jof7090731","journal-title":"J Fungi (Basel)"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.19045\/bspab.2016.50025","article-title":"Antifungal activity of Syzygium cumini L. against Rhizoctonia solani","volume":"5","author":"Khan A","year":"2016","unstructured":"Khan A, Jabeen K, Iqbal S. Antifungal activity of Syzygium cumini L. against Rhizoctonia solani. Pure Appl Biol. 2016, 5:193-9. 10.19045\/bspab.2016.50025","journal-title":"Pure Appl Biol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/220549-antimicrobial-and-synergistic-effects-of-syzygium-cumini-moringa-oleifera-and-tinospora-cordifolia-against-different-candida-infections","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:14:09Z","timestamp":1707509649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/220549-antimicrobial-and-synergistic-effects-of-syzygium-cumini-moringa-oleifera-and-tinospora-cordifolia-against-different-candida-infections"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.52857","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1,24]]}}}