{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T22:30:21Z","timestamp":1775341821180,"version":"3.50.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,3]]},"DOI":"10.7759\/cureus.53495","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T13:42:23Z","timestamp":1706967743000},"source":"Crossref","is-referenced-by-count":1,"title":["A Case of Disseminated Histoplasmosis Presenting in a 65-Year-Old Male Without Apparent Immunodeficiency Successfully Treated With Isavuconazole"],"prefix":"10.7759","author":[{"given":"Colton P","family":"Boney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Hassoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandhya","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabi","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/9781610023511-67","article-title":"Histoplasmosis","year":"2019","unstructured":"Histoplasmosis. Red Book Atlas of Pediatric Infectious Diseases. Baker CJ (ed). American Academy of Pediatrics, Elk Grove Village; 2019. 4:10.1542\/9781610023511-67"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02430-16","article-title":"Laboratory diagnostics for histoplasmosis","volume":"55","author":"Azar MM","year":"2017","unstructured":"Azar MM, Hage CA. Laboratory diagnostics for histoplasmosis. J Clin Microbiol. 2017, 55:1612-20. 10.1128\/JCM.02430-16","journal-title":"J Clin Microbiol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-83822006000100001","article-title":"Diagnosis of histoplasmosis","volume":"37","author":"Guimar\u00e3es AJ","year":"2006","unstructured":"Guimar\u00e3es AJ, Nosanchuk JD, Zancop\u00e9-Oliveira RM. Diagnosis of histoplasmosis. Braz J Microbiol. 2006, 37:1-13. 10.1590\/S1517-83822006000100001","journal-title":"Braz J Microbiol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx130","article-title":"In vitro activity of isavuconazole against fluconazole-resistant isolates of Histoplasma capsulatum","volume":"56","author":"Spec A","year":"2018","unstructured":"Spec A, Connolly P, Montejano R, Wheat LJ. In vitro activity of isavuconazole against fluconazole-resistant isolates of Histoplasma capsulatum. Med Mycol. 2018, 56:834-7. 10.1093\/mmy\/myx130","journal-title":"Med Mycol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx446","article-title":"Tolerability profile of the current antifungal armoury","volume":"73","author":"Mourad A","year":"2018","unstructured":"Mourad A, Perfect JR. Tolerability profile of the current antifungal armoury. J Antimicrob Chemother. 2018, 73:i26-32. 10.1093\/jac\/dkx446","journal-title":"J Antimicrob Chemother"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01159-9","article-title":"Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial","volume":"387","author":"Maertens JA","year":"2016","unstructured":"Maertens JA, Raad II, Marr KA et al.. Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial. Lancet. 2016, 387:760-9. 10.1016\/S0140-6736(15)01159-9","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw305","article-title":"Isavuconazole treatment of cryptococcosis and dimorphic mycoses","volume":"63","author":"Thompson GR 3rd","year":"2016","unstructured":"Thompson GR 3rd, Rendon A, Ribeiro Dos Santos R, et al.. Isavuconazole treatment of cryptococcosis and dimorphic mycoses. Clin Infect Dis. 2016, 63:356-62. 10.1093\/cid\/ciw305","journal-title":"Clin Infect Dis"},{"key":"ref8","article-title":"Histoplasmosis","author":"Akram SM","year":"2023","unstructured":"Akram SM, Koirala J. Histoplasmosis. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2023."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/82_2018_114","article-title":"Histoplasma capsulatum: mechanisms for pathogenesis","volume":"422","author":"Mittal J","year":"2019","unstructured":"Mittal J, Ponce MG, Gendlina I, Nosanchuk JD. Histoplasma capsulatum: mechanisms for pathogenesis. Curr Top Microbiol Immunol. 2019, 422:157-91. 10.1007\/82_2018_114","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318144b1d9","article-title":"Redefining the clinical spectrum of chronic pulmonary histoplasmosis: a retrospective case series of 46 patients","volume":"86","author":"Kennedy CC","year":"2007","unstructured":"Kennedy CC, Limper AH. Redefining the clinical spectrum of chronic pulmonary histoplasmosis: a retrospective case series of 46 patients. Medicine (Baltimore). 2007, 86:252-8. 10.1097\/MD.0b013e318144b1d9","journal-title":"Medicine (Baltimore)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00027-06","article-title":"Histoplasmosis: a clinical and laboratory update","volume":"20","author":"Kauffman CA","year":"2007","unstructured":"Kauffman CA. Histoplasmosis: a clinical and laboratory update. Clin Microbiol Rev. 2007, 20:115-32. 10.1128\/CMR.00027-06","journal-title":"Clin Microbiol Rev"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011486","article-title":"Disseminated histoplasmosis in an immunocompetent patient from an endemic area: a case report","volume":"97","author":"Ling Q","year":"2018","unstructured":"Ling Q, Zhu W, Lu Q, Jin T, Ding S. Disseminated histoplasmosis in an immunocompetent patient from an endemic area: a case report. Medicine (Baltimore). 2018, 97:e11486. 10.1097\/MD.0000000000011486","journal-title":"Medicine (Baltimore)"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2019.07.012","article-title":"Disseminated histoplasmosis in immunocompetent patients from an arid zone in Western India: A case series","volume":"25","author":"Samaddar A","year":"2019","unstructured":"Samaddar A, Sharma A, Kumar Ph A, Srivastava S, Shrimali T, Gopalakrishnan M, Bohra GK. Disseminated histoplasmosis in immunocompetent patients from an arid zone in Western India: A case series. Med Mycol Case Rep. 2019, 25:49-52. 10.1016\/j.mmcr.2019.07.012","journal-title":"Med Mycol Case Rep"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2017.12.005","article-title":"Oropharyngeal histoplasmosis: the diagnosis lies in the biopsy","volume":"11","author":"Miranda C","year":"2018","unstructured":"Miranda C, Jaker MA, Fitzhugh-Kull VA, Dever LL. Oropharyngeal histoplasmosis: the diagnosis lies in the biopsy. IDCases. 2018, 11:33-5. 10.1016\/j.idcr.2017.12.005","journal-title":"IDCases"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2021.e01243","article-title":"Upper extremity Histoplasma capsulatum treatment with isavuconazole","volume":"25","author":"Le J","year":"2021","unstructured":"Le J, Perkins DR, Sierra-Hoffman M, et al.. Upper extremity Histoplasma capsulatum treatment with isavuconazole. IDCases. 2021, 25:e01243. 10.1016\/j.idcr.2021.e01243","journal-title":"IDCases"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00071-2","article-title":"Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis","volume":"16","author":"Marty FM","year":"2016","unstructured":"Marty FM, Ostrosky-Zeichner L, Cornely OA, et al.. Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis. Lancet Infect Dis. 2016, 16:828-37. 10.1016\/S1473-3099(16)00071-2","journal-title":"Lancet Infect Dis"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2019.12.013","article-title":"HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy","volume":"27","author":"Mazzella A","year":"2020","unstructured":"Mazzella A, Stone NR, Pool ER, Garc\u00eda Mingo A, Bolache S, Wood C. HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy. Med Mycol Case Rep. 2020, 27:42-3. 10.1016\/j.mmcr.2019.12.013","journal-title":"Med Mycol Case Rep"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240374","article-title":"Tolerability of oral itraconazole and voriconazole for the treatment of chronic pulmonary aspergillosis: A systematic review and meta-analysis","volume":"15","author":"Olum R","year":"2020","unstructured":"Olum R, Baluku JB, Kazibwe A, Russell L, Bongomin F. Tolerability of oral itraconazole and voriconazole for the treatment of chronic pulmonary aspergillosis: A systematic review and meta-analysis. PLoS One. 2020, 15:e0240374. 10.1371\/journal.pone.0240374","journal-title":"PLoS One"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/203379-a-case-of-disseminated-histoplasmosis-presenting-in-a-65-year-old-male-without-apparent-immunodeficiency-successfully-treated-with-isavuconazole","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:16:32Z","timestamp":1707509792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/203379-a-case-of-disseminated-histoplasmosis-presenting-in-a-65-year-old-male-without-apparent-immunodeficiency-successfully-treated-with-isavuconazole"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,3]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.53495","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,3]]}}}